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Role of L-arginine/nitric oxide pathway in the antinociceptive activities of morphine and mepyramine in mice.
Abacioğlu N, Ozmen R, Cakici I, Tunçtan B, Kanzik I. Abacioğlu N, et al. Arzneimittelforschung. 2001;51(12):977-83. doi: 10.1055/s-0031-1300148. Arzneimittelforschung. 2001. PMID: 11799845
Mepyramine (ED50: 5.6 mg/kg) and morphine (ED50: 0.13 mg/kg) produced antinociceptive effects. The NO precursor L-arginine (CAS 1119-34-2) (50 mg/kg) also produced antinociception similar to mepyramine, but significantly less than morphine. ...
Mepyramine (ED50: 5.6 mg/kg) and morphine (ED50: 0.13 mg/kg) produced antinociceptive effects. The NO precursor L-arginine (CAS 1119- …
The role of L-arginine/nitric oxide pathway in the antinociceptive activity of pyridoxine in mouse.
Abacioğlu N, Tunçtan B, Cakici I, Akbulut E, Uludağ O, Kanzik I. Abacioğlu N, et al. Arzneimittelforschung. 2001 Oct;51(10):832-8. doi: 10.1055/s-0031-1300122. Arzneimittelforschung. 2001. PMID: 11715636
Pyridoxine (CAS 58-56-0) displayed dose-dependent antinociceptive activity at 0.0625-1 mg/kg (s.c.) doses. L-arginine (CAS 1119-34-2), a NO precursor, displayed a triphasic pattern as antinociception-nociception-antinociception (61.8 +/- 7.8, -36.5 +/- 12.7 a …
Pyridoxine (CAS 58-56-0) displayed dose-dependent antinociceptive activity at 0.0625-1 mg/kg (s.c.) doses. L-arginine (CAS 1119-34 …