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Branched lipid chains to prepare cationic amphiphiles producing hexagonal aggregates: supramolecular behavior and application to gene delivery.
Bouraoui A, Ghanem R, Berchel M, Deschamps L, Vié V, Paboeuf G, Le Gall T, Montier T, Jaffrès PA. Bouraoui A, et al. Org Biomol Chem. 2020 Jan 2;18(2):337-345. doi: 10.1039/c9ob02381j. Org Biomol Chem. 2020. PMID: 31845706
A ramified lipid alcohol, 2-hexyldecanol, was used as a hydrophobic moiety to prepare cationic amphiphiles on a gram scale in 3 to 4 steps, featuring either a trimethylammonium 5, dimethylhydroxyethylammonium 6 or N-methylimidazolium 7 polar head group. ...
A ramified lipid alcohol, 2-hexyldecanol, was used as a hydrophobic moiety to prepare cationic amphiphiles on a gram scale in 3 to 4 …
A regulator of ubiquitin-proteasome activity, 2-hexyldecanol, suppresses melanin synthesis and the appearance of facial hyperpigmented spots.
Hakozaki T, Laughlin T, Zhao S, Wang J, Deng D, Jewell-Motz E, Elstun L. Hakozaki T, et al. Br J Dermatol. 2013 Jul;169 Suppl 2:39-44. doi: 10.1111/bjd.12364. Br J Dermatol. 2013. PMID: 23786619 Clinical Trial.
RESULTS: In submerged cell culture, 2-hexyldecanol upregulated proteolytic activity and decreased melanin synthesis. These effects were antagonized by the proteasome-specific inhibitor MG132. MG132, tested in the absence of 2-hexyldecanol, increased melanin producti …
RESULTS: In submerged cell culture, 2-hexyldecanol upregulated proteolytic activity and decreased melanin synthesis. These effects we …