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Page 1
Nonivamide induces brown fat-like characteristics in porcine subcutaneous adipocytes.
Zhao Y, Li X, Tian Y, Zhao J, Yu W, Zhang L, Wei W, Chen J. Zhao Y, et al. Biochem Biophys Res Commun. 2022 Sep 3;619:68-75. doi: 10.1016/j.bbrc.2022.06.047. Epub 2022 Jun 16. Biochem Biophys Res Commun. 2022. PMID: 35738067
First, we found 25 muM nonivamide promoted apoptosis of porcine subcutaneous pre-adipocytes. ...Additionally, thermogenesis gene markers Cpt1a and Cpt1b were significantly up-regulated by nonivamide. Furthermore, nonivamide promoted mitochondrial biogenesis b …
First, we found 25 muM nonivamide promoted apoptosis of porcine subcutaneous pre-adipocytes. ...Additionally, thermogenesis gene mark …
No Influence of Nonivamide-nicoboxil on the Peak Power Output in Competitive Sportsmen.
Schörkmaier T, Wahl Y, Brinkmann C, Bloch W, Wahl P. Schörkmaier T, et al. Int J Sports Med. 2021 Nov;42(12):1092-1097. doi: 10.1055/a-1403-2701. Epub 2021 Apr 15. Int J Sports Med. 2021. PMID: 33860476 Free PMC article.
Recent studies have shown that the oxygenated hemoglobin level can be enhanced during rest through the application of nonivamide-nicoboxil cream. However, the effect of nonivamide-nicoboxil cream on oxygenation and endurance performance under hypoxic conditions is u …
Recent studies have shown that the oxygenated hemoglobin level can be enhanced during rest through the application of nonivamide-nico …
Efficacy and safety of nicoboxil/nonivamide ointment for the treatment of acute pain in the low back - A randomized, controlled trial.
Gaubitz M, Schiffer T, Holm C, Richter E, Pisternick-Ruf W, Weiser T. Gaubitz M, et al. Eur J Pain. 2016 Feb;20(2):263-73. doi: 10.1002/ejp.719. Epub 2015 Apr 30. Eur J Pain. 2016. PMID: 25929250 Free PMC article. Clinical Trial.
RESULTS: Patients (n = 805), 18-74 years of age were treated for up to 4 days with nicoboxil 2.5%/nonivamide 0.4%, nicoboxil 2.5%, nonivamide 0.4% or placebo ointment. Pre-dose baseline pain intensity (6.6 on a 0- to 10-point numerical rating sc …
RESULTS: Patients (n = 805), 18-74 years of age were treated for up to 4 days with nicoboxil 2.5%/nonivamide 0.4%, nico …
Engineering Saccharomyces cerevisiae for production of the capsaicinoid nonivamide.
Muratovska N, Grey C, Carlquist M. Muratovska N, et al. Microb Cell Fact. 2022 May 28;21(1):106. doi: 10.1186/s12934-022-01831-3. Microb Cell Fact. 2022. PMID: 35643562 Free PMC article.
A yeast strain expressing CaAT and IpfF produced 10.6 mg L(-1) nonivamide in a controlled bioreactor setup, demonstrating nonivamide biosynthesis by S. cerevisiae for the first time. CONCLUSIONS: Baker's yeast was engineered for production of nonivamide as a …
A yeast strain expressing CaAT and IpfF produced 10.6 mg L(-1) nonivamide in a controlled bioreactor setup, demonstrating nonivami
Capsaicin and nonivamide similarly modulate outcome measures of mitochondrial energy metabolism in HepG2 and 3T3-L1 cells.
Hochkogler CM , Lieder B , Schachner D , Heiss E , Schröter A , Hans J , Ley JP , Krammer GE , Somoza V . Hochkogler CM , et al. Food Funct. 2018 Feb 21;9(2):1123-1132. doi: 10.1039/c7fo01626c. Food Funct. 2018. PMID: 29362767

Lipid accumulation was reduced to a similar extent after treatment with both test substances during the maturation of 3T3-L1 cells by up to 6.91% for capsaicin and up to 4.89% for nonivamide (p < 0.01) at a concentration of 0.1 muM or 1 muM, respectively. ...The

Lipid accumulation was reduced to a similar extent after treatment with both test substances during the maturation of 3T3-L1 cells by up to …
Nonivamide, a capsaicin analogue, exhibits anti-inflammatory properties in peripheral blood mononuclear cells and U-937 macrophages.
Walker J, Ley JP, Schwerzler J, Lieder B, Beltran L, Ziemba PM, Hatt H, Hans J, Widder S, Krammer GE, Somoza V. Walker J, et al. Mol Nutr Food Res. 2017 Feb;61(2). doi: 10.1002/mnfr.201600474. Epub 2016 Nov 15. Mol Nutr Food Res. 2017. PMID: 27666931
Known trigeminally active compounds found in black or red pepper are the tingling t-pellitorine, the pungent capsaicin, and the less pungent nonivamide. The presented study compares the anti-inflammatory potential of nonivamide to the two known anti-inflammatory com …
Known trigeminally active compounds found in black or red pepper are the tingling t-pellitorine, the pungent capsaicin, and the less pungent …
A 12-week intervention with nonivamide, a TRPV1 agonist, prevents a dietary-induced body fat gain and increases peripheral serotonin in moderately overweight subjects.
Hochkogler CM, Lieder B, Rust P, Berry D, Meier SM, Pignitter M, Riva A, Leitinger A, Bruk A, Wagner S, Hans J, Widder S, Ley JP, Krammer GE, Somoza V. Hochkogler CM, et al. Mol Nutr Food Res. 2017 May;61(5). doi: 10.1002/mnfr.201600731. Epub 2017 Feb 22. Mol Nutr Food Res. 2017. PMID: 28012242 Clinical Trial.
SCOPE: A bolus administration of 0.15 mg nonivamide has previously been demonstrated to reduce energy intake in moderately overweight men. ...Participants were instructed to consume 0.15 mg nonivamide per day in 450 mL of a milk shake additionally to their habitual …
SCOPE: A bolus administration of 0.15 mg nonivamide has previously been demonstrated to reduce energy intake in moderately overweight …
Production of capsaicinoid nonivamide from plant oil and vanillylamine via whole-cell biotransformation.
Ge J, Zhang J, Wang X, Bai Y, Wang Y, Wang Y, Tu T, Qin X, Su X, Luo H, Yao B, Huang H. Ge J, et al. Bioresour Technol. 2023 Dec;390:129883. doi: 10.1016/j.biortech.2023.129883. Epub 2023 Oct 21. Bioresour Technol. 2023. PMID: 37871741
Here, the biotransformation of renewable plant oil and vanillylamine into capsaicinoid nonivamide was investigated. Nonivamide biosynthesis using nonanoic acid and vanillylamine as substrates was achieved in Escherichia coli by heterologous expression of genes encod …
Here, the biotransformation of renewable plant oil and vanillylamine into capsaicinoid nonivamide was investigated. Nonivamide
Toxic effects of environment-friendly antifoulant nonivamide on Phaeodactylum tricornutum.
Zhou J, Yang C, Wang J, Sun P, Fan P, Tian K, Liu S, Xia C. Zhou J, et al. Environ Toxicol Chem. 2013 Apr;32(4):802-9. doi: 10.1002/etc.2132. Epub 2013 Mar 1. Environ Toxicol Chem. 2013. PMID: 23341258
Nonivamide, a synthetic derivate of natural capsaicin, has an effective antifouling activity. ...Under a 1.5 10(5) cells/ml of initial algal density (IAD), the effective concentration causing 50% inhibition at 4- d (4 d-EC50) value of nonivamide was 5.
Nonivamide, a synthetic derivate of natural capsaicin, has an effective antifouling activity. ...Under a 1.5 10(5) cells/ml of initia
Nonivamide inhibits proliferation of human corneal epithelial cells by inducing cell cycle arrest and oxidative stress.
Li H, Zhang Q, Zhang Y, Zhang S, Zhang R, Chen D, Shi J, Xu J, Li L. Li H, et al. Toxicology. 2023 Dec;500:153674. doi: 10.1016/j.tox.2023.153674. Epub 2023 Nov 19. Toxicology. 2023. PMID: 37989449
Next, we described the mechanisms of action of nonivamide. Nonivamide caused cell cycle arrest by increasing p21 and decreasing cyclin D1. ...Our data demonstrate the corneal toxicity of nonivamide and explain the mechanisms underlying nonivamide-induc …
Next, we described the mechanisms of action of nonivamide. Nonivamide caused cell cycle arrest by increasing p21 and decreasin …
134 results