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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 2
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1985 3
1986 2
1987 3
1989 2
1990 7
1991 8
1992 4
1993 8
1994 6
1995 10
1996 3
1997 5
1998 12
1999 8
2000 9
2001 14
2002 10
2003 10
2004 8
2005 8
2006 10
2007 15
2008 14
2009 14
2010 24
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2018 13
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2020 18
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Page 1
5-Lipoxygenase: mechanisms of regulation.
Rådmark O, Samuelsson B. Rådmark O, et al. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S40-5. doi: 10.1194/jlr.R800062-JLR200. Epub 2008 Nov 5. J Lipid Res. 2009. PMID: 18987389 Free PMC article.
5-lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). ...Furthermore, possible effects of 5-LO metabolites in relation to tumorigenesis have emerg
5-lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflamma
5-Lipoxygenase: regulation of expression and enzyme activity.
Rådmark O, Werz O, Steinhilber D, Samuelsson B. Rådmark O, et al. Trends Biochem Sci. 2007 Jul;32(7):332-41. doi: 10.1016/j.tibs.2007.06.002. Epub 2007 Jun 18. Trends Biochem Sci. 2007. PMID: 17576065 Review.
5-Lipoxygenase (5-LO) catalyzes the first two steps in the biosynthesis of leukotrienes, a group of pro-inflammatory lipid mediators derived from arachidonic acid. ...Recent advances have expanded our understanding of the regulatory mechanisms underlyi
5-Lipoxygenase (5-LO) catalyzes the first two steps in the biosynthesis of leukotrienes, a group of pro-inflammatory li
The targets of curcumin.
Zhou H, Beevers CS, Huang S. Zhou H, et al. Curr Drug Targets. 2011 Mar 1;12(3):332-47. doi: 10.2174/138945011794815356. Curr Drug Targets. 2011. PMID: 20955148 Free PMC article. Review.
The underlying mechanisms of these effects are diverse and appear to involve the regulation of various molecular targets, including transcription factors (such as nuclear factor-kB), growth factors (such as vascular endothelial cell growth factor), inflammatory cyto …
The underlying mechanisms of these effects are diverse and appear to involve the regulation of various molecular targets, incl …
Decoding cell death signals in liver inflammation.
Brenner C, Galluzzi L, Kepp O, Kroemer G. Brenner C, et al. J Hepatol. 2013 Sep;59(3):583-94. doi: 10.1016/j.jhep.2013.03.033. Epub 2013 Apr 6. J Hepatol. 2013. PMID: 23567086 Free article. Review.
In this review, we discuss the cellular and molecular mechanisms that account for the most deleterious effect of hepatic inflammation at the cellular level, that is, the initiation of a massive cell death response among hepatocytes....
In this review, we discuss the cellular and molecular mechanisms that account for the most deleterious effect of hepatic inflammation …
Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.
Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ. Fettel J, et al. FASEB J. 2019 Feb;33(2):1711-1726. doi: 10.1096/fj.201800221R. Epub 2018 Sep 6. FASEB J. 2019. PMID: 30188757
S1P treatment resulted in intracellular Ca(2+) mobilization, perinuclear translocation, and finally irreversible suicide inactivation of the LT biosynthesis key enzyme 5-lipoxygenase (5-LO). ...Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory ef …
S1P treatment resulted in intracellular Ca(2+) mobilization, perinuclear translocation, and finally irreversible suicide inactivation of the …
5-Lipoxygenase: enzyme expression and regulation of activity.
Steinhilber D. Steinhilber D. Pharm Acta Helv. 1994 Jul;69(1):3-14. doi: 10.1016/0031-6865(94)90024-8. Pharm Acta Helv. 1994. PMID: 7938075 Review.
In mature cells, 5-lipoxygenase activity is tightly regulated and seems to be under the control of additional cellular components. ...This review focuses on the regulation of gene expression and activity of 5-lipoxygenase....
In mature cells, 5-lipoxygenase activity is tightly regulated and seems to be under the control of additional ce …
The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms.
Silverman ES, Drazen JM. Silverman ES, et al. Proc Assoc Am Physicians. 1999 Nov-Dec;111(6):525-36. doi: 10.1046/j.1525-1381.1999.t01-1-99231.x. Proc Assoc Am Physicians. 1999. PMID: 10591081 Review.
5-Lipoxygenase (5-LO) catalyzes the two-step conversion of arachidonic acid to leukotriene A4 (LTA4). The first step consists of the oxidation of arachidonic acid to the unstable intermediate 5-hydroperoxyeicosatetraenoic acid (5-HPETE), and the
5-Lipoxygenase (5-LO) catalyzes the two-step conversion of arachidonic acid to leukotriene A4 (LTA4). The first step co
Epigenetic regulation of 5-lipoxygenase in the phenotypic plasticity of valvular interstitial cells associated with aortic valve stenosis.
Nagy E, Bäck M. Nagy E, et al. FEBS Lett. 2012 May 7;586(9):1325-9. doi: 10.1016/j.febslet.2012.03.039. Epub 2012 Apr 3. FEBS Lett. 2012. PMID: 22616993 Free article.
This phenotypic plasticity is a key feature of aortic valve stenosis, but the role of epigenetic mechanisms has not previously been explored. ...Calcified tissue exhibited decreased DNA-methylation in the promoter of the gene encoding the proinflammatory enzyme 5- …
This phenotypic plasticity is a key feature of aortic valve stenosis, but the role of epigenetic mechanisms has not previously been e …
Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells.
Sarveswaran S, Chakraborty D, Chitale D, Sears R, Ghosh J. Sarveswaran S, et al. J Biol Chem. 2015 Feb 20;290(8):4994-5006. doi: 10.1074/jbc.M114.599035. Epub 2014 Dec 24. J Biol Chem. 2015. PMID: 25540201 Free PMC article.
We reported earlier that arachidonate 5-lipoxygenase (5-Lox) plays an important role in the survival and growth of prostate cancer cells, although details of the underlying mechanisms have yet to be characterized. ...These findings indicate that …
We reported earlier that arachidonate 5-lipoxygenase (5-Lox) plays an important role in the survival and growth …
Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells.
Bennett CF, Chiang MY, Monia BP, Crooke ST. Bennett CF, et al. Biochem J. 1993 Jan 1;289 ( Pt 1)(Pt 1):33-9. doi: 10.1042/bj2890033. Biochem J. 1993. PMID: 8380989 Free PMC article.
5-Lipoxygenase performs the first two enzymic reactions in the biosynthetic pathway for the leukotrienes. We have utilized HL-60 cells to study the mechanisms regulating expression of 5-lipoxygenase and the recently described 18 kDa membr
5-Lipoxygenase performs the first two enzymic reactions in the biosynthetic pathway for the leukotrienes. We have utilized HL-
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