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5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.
Werz O, Klemm J, Samuelsson B, Rådmark O. Werz O, et al. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5261-6. doi: 10.1073/pnas.050588997. Proc Natl Acad Sci U S A. 2000. PMID: 10779545 Free PMC article.
For all stimuli, 5-LO kinase activation was counteracted by SB203580 (3 microM or less), an inhibitor of p38 kinase. At least two p38-dependent 5-LO kinase activities were found. ...The other appeared to be MAPKAP
For all stimuli, 5-LO kinase activation was counteracted by SB203580 (3 microM or less), an inhibitor of p38 kinase
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).
Werz O, Szellas D, Steinhilber D, Rådmark O. Werz O, et al. J Biol Chem. 2002 Apr 26;277(17):14793-800. doi: 10.1074/jbc.M111945200. Epub 2002 Feb 13. J Biol Chem. 2002. PMID: 11844797 Free article.
We demonstrated previously that 5-lipoxygenase (5-LO), a key enzyme in leukotriene biosynthesis, can be phosphorylated by p38 MAPK-regulated MAPKAP kinases (MKs). ...Compared with heat shock protein 27 (Hsp-27), 5-LO was a w …
We demonstrated previously that 5-lipoxygenase (5-LO), a key enzyme in leukotriene biosynthesis, can be phosphorylat
A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis.
Kalhan R, Smith LJ, Nlend MC, Nair A, Hixon JL, Sporn PH. Kalhan R, et al. Clin Exp Allergy. 2008 Jan;38(1):103-12. doi: 10.1111/j.1365-2222.2007.02862.x. Epub 2007 Nov 2. Clin Exp Allergy. 2008. PMID: 17979994 Free PMC article. Clinical Trial.
RESULTS: Genistein inhibited eosinophil LTC(4) synthesis (IC(50) 80 nm), blocked phosphorylation of p38 MAP kinase and its downstream target MAPKAP-2, and reduced translocation of 5-LO to the nuclear membrane. ...CONCLUSION: At physiologically r …
RESULTS: Genistein inhibited eosinophil LTC(4) synthesis (IC(50) 80 nm), blocked phosphorylation of p38 MAP kinase and …
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