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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 2
1984 1
1985 3
1986 2
1987 3
1989 2
1990 7
1991 8
1992 4
1993 8
1994 6
1995 10
1996 3
1997 5
1998 12
1999 8
2000 9
2001 14
2002 10
2003 10
2004 8
2005 8
2006 10
2007 15
2008 14
2009 14
2010 24
2011 26
2012 21
2013 26
2014 22
2015 16
2016 19
2017 18
2018 13
2019 13
2020 18
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Decoding cell death signals in liver inflammation.
Brenner C, Galluzzi L, Kepp O, Kroemer G. Brenner C, et al. J Hepatol. 2013 Sep;59(3):583-94. doi: 10.1016/j.jhep.2013.03.033. Epub 2013 Apr 6. J Hepatol. 2013. PMID: 23567086 Free article. Review.
In turn, dying hepatocytes release damage-associated molecular patterns that-upon binding to evolutionary conserved pattern recognition receptors-activate cells of the innate immune system to further stimulate inflammatory responses, hence establishing a highly hepatotoxic feedfo …
In turn, dying hepatocytes release damage-associated molecular patterns that-upon binding to evolutionary conserved pattern recognition rece …
5-Lipoxygenase: mechanisms of regulation.
Rådmark O, Samuelsson B. Rådmark O, et al. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S40-5. doi: 10.1194/jlr.R800062-JLR200. Epub 2008 Nov 5. J Lipid Res. 2009. PMID: 18987389 Free PMC article.
5-lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). LT antagonists are used in treatment of asthma; more recently a potential role also in atherosclero
5-lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflamma
Kinetic investigation of human 5-lipoxygenase with arachidonic acid.
Mittal M, Kumar RB, Balagunaseelan N, Hamberg M, Jegerschöld C, Rådmark O, Haeggström JZ, Rinaldo-Matthis A. Mittal M, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3547-51. doi: 10.1016/j.bmcl.2016.06.025. Epub 2016 Jun 11. Bioorg Med Chem Lett. 2016. PMID: 27363940
Human 5-lipoxygenase (5-LOX) is responsible for the formation of leukotriene (LT)A4, a pivotal intermediate in the biosynthesis of the leukotrienes, a family of proinflammatory lipid mediators. 5-LOX has thus gained attention as a potential drug target …
Human 5-lipoxygenase (5-LOX) is responsible for the formation of leukotriene (LT)A4, a pivotal intermediate in the bios …
Identification and Characterization of a New Protein Isoform of Human 5-Lipoxygenase.
Häfner AK, Beilstein K, Graab P, Ball AK, Saul MJ, Hofmann B, Steinhilber D. Häfner AK, et al. PLoS One. 2016 Nov 17;11(11):e0166591. doi: 10.1371/journal.pone.0166591. eCollection 2016. PLoS One. 2016. PMID: 27855198 Free PMC article.
Leukotrienes (LTs) are inflammatory mediators that play a pivotal role in many diseases like asthma bronchiale, atherosclerosis and in various types of cancer. The key enzyme for generation of LTs is the 5-lipoxygenase (5-LO). Here, we present a novel putativ …
Leukotrienes (LTs) are inflammatory mediators that play a pivotal role in many diseases like asthma bronchiale, atherosclerosis and in vario …
Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?
Roos J, Grösch S, Werz O, Schröder P, Ziegler S, Fulda S, Paulus P, Urbschat A, Kühn B, Maucher I, Fettel J, Vorup-Jensen T, Piesche M, Matrone C, Steinhilber D, Parnham MJ, Maier TJ. Roos J, et al. Pharmacol Ther. 2016 Jan;157:43-64. doi: 10.1016/j.pharmthera.2015.11.001. Epub 2015 Nov 6. Pharmacol Ther. 2016. PMID: 26549540 Review.
Furthermore, we found a direct link between the 5-lipoxygenase and Wnt signaling pathways, which is essential for the maintenance of leukemic stem cells. ...We believe that 5-lipoxygenase inhibitors might represent a novel type of Wnt inhibitor activat …
Furthermore, we found a direct link between the 5-lipoxygenase and Wnt signaling pathways, which is essential for the maintena …
Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B(4) pathway by high-density lipoprotein in macrophages.
Tsuda S, Shinohara M, Oshita T, Nagao M, Tanaka N, Mori T, Hara T, Irino Y, Toh R, Ishida T, Hirata KI. Tsuda S, et al. Sci Rep. 2017 Oct 11;7(1):12989. doi: 10.1038/s41598-017-13154-0. Sci Rep. 2017. PMID: 29021582 Free PMC article.
HDL(Healthy) treatment enhanced the proteasome-mediated degradation of the LTB(4)-producing enzyme 5-lipoxygenase (LO) in activated macrophages; however, HDL(CAD) did not show these anti-inflammatory effects. HDL(Healthy) was engulfed by macrophages via clathrin-med …
HDL(Healthy) treatment enhanced the proteasome-mediated degradation of the LTB(4)-producing enzyme 5-lipoxygenase (LO) in acti …
5-Lipoxygenase: regulation of expression and enzyme activity.
Rådmark O, Werz O, Steinhilber D, Samuelsson B. Rådmark O, et al. Trends Biochem Sci. 2007 Jul;32(7):332-41. doi: 10.1016/j.tibs.2007.06.002. Epub 2007 Jun 18. Trends Biochem Sci. 2007. PMID: 17576065 Review.
5-Lipoxygenase (5-LO) catalyzes the first two steps in the biosynthesis of leukotrienes, a group of pro-inflammatory lipid mediators derived from arachidonic acid. ...Recent advances have expanded our understanding of the regulatory mechanisms underlyi
5-Lipoxygenase (5-LO) catalyzes the first two steps in the biosynthesis of leukotrienes, a group of pro-inflammatory li
Induction of a 5-lipoxygenase product by daidzein is involved in the regulation of influenza virus replication.
Horio Y, Sogabe R, Shichiri M, Ishida N, Morimoto R, Ohshima A, Isegawa Y. Horio Y, et al. J Clin Biochem Nutr. 2020 Jan;66(1):36-42. doi: 10.3164/jcbn.19-70. Epub 2020 Jan 1. J Clin Biochem Nutr. 2020. PMID: 32001954 Free PMC article.
Moreover, virus replication was regulated by treatment with 5-hydroperoxyeicosatetraenoic acid, a precursor of 5-hydroxyeicosatetraenoic acid and 5-lipoxygenase primary product. These results suggest that daidzein regulates virus replicat …
Moreover, virus replication was regulated by treatment with 5-hydroperoxyeicosatetraenoic acid, a precursor of 5-hydrox …
5-lipoxygenase activation is involved in the mechanisms of chronic hepatic injury in a rat model of chronic aluminum overload exposure.
Mai S, He Q, Wang H, Hu X, Luo Y, Yang Y, Kuang S, Tian X, Ma J, Yang J. Mai S, et al. Toxicol Appl Pharmacol. 2016 Aug 15;305:259-266. doi: 10.1016/j.taap.2016.06.029. Epub 2016 Jun 29. Toxicol Appl Pharmacol. 2016. PMID: 27368151
In this study, we investigated changes in the 5-lipoxygenase (5-LO) signaling pathway and its effect on liver injury in aluminum-overloaded rats. ...Our results indicate that 5-lipoxygenase activation is mechanistically involved in chronic hepat …
In this study, we investigated changes in the 5-lipoxygenase (5-LO) signaling pathway and its effect on liver injury in …
5-lipoxygenase: a promising drug target against inflammatory diseases-biochemical and pharmacological regulation.
Anwar Y, Sabir JS, Qureshi MI, Saini KS. Anwar Y, et al. Curr Drug Targets. 2014 Apr;15(4):410-22. doi: 10.2174/1389450114666131209110745. Curr Drug Targets. 2014. PMID: 24313690 Review.
5-Lipoxygenase (5-LO) is the key enzyme involved in the synthesis of pro-inflammatory leukotrienes (LTs) and has become a prime target for new drug discovery research and development efforts by the pharmaceutical and biotech industry. ...Elucidation of molecu
5-Lipoxygenase (5-LO) is the key enzyme involved in the synthesis of pro-inflammatory leukotrienes (LTs) and has become
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