5-Lipoxygenase: mechanisms of regulation.
J Lipid Res. 2009.
PMID: 18987389
Free PMC article.
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Page 1
Decoding cell death signals in liver inflammation.
J Hepatol. 2013 Sep;59(3):583-94. doi: 10.1016/j.jhep.2013.03.033. Epub 2013 Apr 6.
J Hepatol. 2013.
PMID: 23567086
Free article.
Review.
In this review, we discuss the cellular and molecular mechanisms that account for the most deleterious effect of hepatic inflammation at the cellular level, that is, the initiation of a massive cell death response among hepatocytes....
In this review, we discuss the cellular and molecular mechanisms that account for the most deleterious effect of hepatic inflammation …
5-Lipoxygenase: mechanisms of regulation.
J Lipid Res. 2009 Apr;50 Suppl(Suppl):S40-5. doi: 10.1194/jlr.R800062-JLR200. Epub 2008 Nov 5.
J Lipid Res. 2009.
PMID: 18987389
Free PMC article.
5-lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA). ...
5-lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation de …
Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities.
Semin Cancer Biol. 2022 May;80:39-57. doi: 10.1016/j.semcancer.2020.01.015. Epub 2020 Feb 4.
Semin Cancer Biol. 2022.
PMID: 32027979
We conducted a systematic review on the anti-inflammatory and anti-cancer activities of Boswellia species and their chemical ingredients (e.g. 3-O-acetyl-11-keto-beta boswellic acid, alpha- and beta-boswellic acids, 11-keto-beta-boswellic acid and other boswellic acids, lupeolic …
We conducted a systematic review on the anti-inflammatory and anti-cancer activities of Boswellia species and their chemical ingredients (e. …
5-Lipoxygenase: regulation of expression and enzyme activity.
Trends Biochem Sci. 2007 Jul;32(7):332-41. doi: 10.1016/j.tibs.2007.06.002. Epub 2007 Jun 18.
Trends Biochem Sci. 2007.
PMID: 17576065
Review.
5-Lipoxygenase (5-LO) catalyzes the first two steps in the biosynthesis of leukotrienes, a group of pro-inflammatory lipid mediators derived from arachidonic acid. ...Recent advances have expanded our understanding of the regulatory mechanisms underlying the …
5-Lipoxygenase (5-LO) catalyzes the first two steps in the biosynthesis of leukotrienes, a group of pro-inflammatory lipid med …
The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms.
Proc Assoc Am Physicians. 1999 Nov-Dec;111(6):525-36. doi: 10.1046/j.1525-1381.1999.t01-1-99231.x.
Proc Assoc Am Physicians. 1999.
PMID: 10591081
Review.
5-Lipoxygenase (5-LO) catalyzes the two-step conversion of arachidonic acid to leukotriene A4 (LTA4). ...These events are the first committed reactions leading to the synthesis of all leukotrienes and play a critical role in controlling leukotriene production. 5-LO …
5-Lipoxygenase (5-LO) catalyzes the two-step conversion of arachidonic acid to leukotriene A4 (LTA4). ...These events are the …
On the expression and regulation of 5-lipoxygenase in human lymphocytes.
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3521-5. doi: 10.1073/pnas.89.8.3521.
Proc Natl Acad Sci U S A. 1992.
PMID: 1314391
Free PMC article.
The expression of arachidonate 5-lipoxygenase (arachidonate:oxygen 5-oxidoreductase, EC 1.13.11.34) and the 5-lipoxygenase-activating protein (FLAP) genes in human tonsillar B cells and lymphoblastoid B-cell lines was demonstrated at the …
The expression of arachidonate 5-lipoxygenase (arachidonate:oxygen 5-oxidoreductase, EC 1.13.11.34) and the 5 …
5-Lipoxygenase: enzyme expression and regulation of activity.
Pharm Acta Helv. 1994 Jul;69(1):3-14. doi: 10.1016/0031-6865(94)90024-8.
Pharm Acta Helv. 1994.
PMID: 7938075
Review.
During hematopoiesis the competence of these cells for leukotriene biosynthesis is supposed to be upregulated. In mature cells, 5-lipoxygenase activity is tightly regulated and seems to be under the control of additional cellular components. ...This re …
During hematopoiesis the competence of these cells for leukotriene biosynthesis is supposed to be upregulated. In mature cells, 5- …
Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?
Pharmacol Ther. 2016 Jan;157:43-64. doi: 10.1016/j.pharmthera.2015.11.001. Epub 2015 Nov 6.
Pharmacol Ther. 2016.
PMID: 26549540
Review.
Furthermore, we found a direct link between the 5-lipoxygenase and Wnt signaling pathways, which is essential for the maintenance of leukemic stem cells. ...We believe that 5-lipoxygenase inhibitors might represent a novel type of Wnt inhibitor activat …
Furthermore, we found a direct link between the 5-lipoxygenase and Wnt signaling pathways, which is essential for the maintena …
Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity.
Immunity. 2020 Mar 17;52(3):528-541.e7. doi: 10.1016/j.immuni.2020.02.005. Epub 2020 Mar 10.
Immunity. 2020.
PMID: 32160525
Free PMC article.
ILC2 activation requires tuft-cell-derived interleukin-25 (IL-25), but whether additional signals regulate the circuit is unclear. Here, we show that tuft cells secrete cysteinyl leukotrienes (cysLTs) to rapidly activate type 2 immunity following chemosensing of helminth i …
ILC2 activation requires tuft-cell-derived interleukin-25 (IL-25), but whether additional signals regulate the circuit is unclear. He …
Induction of a 5-lipoxygenase product by daidzein is involved in the regulation of influenza virus replication.
J Clin Biochem Nutr. 2020 Jan;66(1):36-42. doi: 10.3164/jcbn.19-70. Epub 2020 Jan 1.
J Clin Biochem Nutr. 2020.
PMID: 32001954
Free PMC article.
Zileuton (5-lipoxygenase inhibitor) and 5-lipoxygenase knockdown reduced the daidzein-induced antiviral effect. ...These results suggest that daidzein regulates virus replication via signal transduction through 5-lipoxygenase produ …
Zileuton (5-lipoxygenase inhibitor) and 5-lipoxygenase knockdown reduced the daidzein-induced antiviral effect. …
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