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A CD14-independent LPS receptor cluster.
Triantafilou K, Triantafilou M, Dedrick RL. Triantafilou K, et al. Nat Immunol. 2001 Apr;2(4):338-45. doi: 10.1038/86342. Nat Immunol. 2001. PMID: 11276205
Although CD14 has been identified as the main LPS receptor, accumulating evidence has suggested the possible existence of other functional receptor(s). In this study, using affinity chromatography, peptide mass fingerprinting and fluorescence resonance …
Although CD14 has been identified as the main LPS receptor, accumulating evidence has suggested the possible existence …
Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response.
O'Callaghan P, Li JP, Lannfelt L, Lindahl U, Zhang X. O'Callaghan P, et al. J Biol Chem. 2015 Jun 12;290(24):14904-14. doi: 10.1074/jbc.M114.634337. Epub 2015 Apr 13. J Biol Chem. 2015. PMID: 25869127 Free PMC article.
To elucidate the relevance of microglial HSPGs in a pro-inflammatory response we isolated microglia from mice overexpressing heparanase (Hpa-tg), the HS-degrading endoglucuronidase, and challenged them with lipopolysaccharide (LPS), a bacterial endotoxin. Prior to …
To elucidate the relevance of microglial HSPGs in a pro-inflammatory response we isolated microglia from mice overexpressing heparanase (Hpa …
Adhesion-promoting receptors on phagocytes.
Wright SD, Detmers PA. Wright SD, et al. J Cell Sci Suppl. 1988;9:99-120. doi: 10.1242/jcs.1988.supplement_9.5. J Cell Sci Suppl. 1988. PMID: 2978519 Review.
LFA-1 mediates the binding of killer T cells to targets, CR3 mediates binding of phagocytes to iC3b-coated surfaces and to endothelial cells, and LFA-1, CR3, and p150,95 each mediate the binding of bacterial lipopolysaccharide. Here we review the structure and function of …
LFA-1 mediates the binding of killer T cells to targets, CR3 mediates binding of phagocytes to iC3b-coated surfaces and to endothelial cells …
Structural biology of the LPS recognition.
Jerala R. Jerala R. Int J Med Microbiol. 2007 Sep;297(5):353-63. doi: 10.1016/j.ijmm.2007.04.001. Epub 2007 May 3. Int J Med Microbiol. 2007. PMID: 17481951 Review.
Bacterial endotoxin (lipopolysaccharide - LPS) as one of the most potent inducers of the immune system is recognized by a complex cascade of extracellular "pattern recognition receptors", which chaperone the LPS from the bacterial membrane to the trans …
Bacterial endotoxin (lipopolysaccharide - LPS) as one of the most potent inducers of the immune system is recognized by a comp …
CD14, TLR4 and TRAM Show Different Trafficking Dynamics During LPS Stimulation.
Klein DC, Skjesol A, Kers-Rebel ED, Sherstova T, Sporsheim B, Egeberg KW, Stokke BT, Espevik T, Husebye H. Klein DC, et al. Traffic. 2015 Jul;16(7):677-90. doi: 10.1111/tra.12274. Epub 2015 Mar 24. Traffic. 2015. PMID: 25707286 Free article.
We have investigated the dynamics of TLR4 and TRAM during lipopolysaccharide (LPS) stimulation. We found that LPS induced a CD14-dependent immobile fraction of TLR4 in the plasma membrane. ...Moreover, CD14/LPS but not TRAM was immobilize …
We have investigated the dynamics of TLR4 and TRAM during lipopolysaccharide (LPS) stimulation. We found that LPS induc …
Mucosal immunoregulation: environmental lipopolysaccharide and GALT T lymphocytes regulate the IgA response.
McGhee JR, Michalek SM, Kiyono H, Eldridge JH, Colwell DE, Williamson SI, Wannemuehler MJ, Jirillo E, Mosteller LM, Spalding DM, et al. McGhee JR, et al. Microbiol Immunol. 1984;28(3):261-80. doi: 10.1111/j.1348-0421.1984.tb00679.x. Microbiol Immunol. 1984. PMID: 6234450 Free article. Review.
In this review, we have emphasized: 1) bacterial lipopolysaccharide (LPS) involvement in IgA responses to orally administered thymic-dependent (TD) antigens; 2) characterization of Peyer's patch (PP) lymphoreticular cells; and 3) gastrointestinal immunization with g …
In this review, we have emphasized: 1) bacterial lipopolysaccharide (LPS) involvement in IgA responses to orally administered …
O-Antigen-Dependent Colicin Insensitivity of Uropathogenic Escherichia coli.
Sharp C, Boinett C, Cain A, Housden NG, Kumar S, Turner K, Parkhill J, Kleanthous C. Sharp C, et al. J Bacteriol. 2019 Jan 28;201(4):e00545-18. doi: 10.1128/JB.00545-18. Print 2019 Feb 15. J Bacteriol. 2019. PMID: 30510143 Free PMC article.
Previous studies have documented high rates of nonspecific resistance (insensitivity) of various E. coli strains toward colicins that is independent of colicin-specific immunity and is instead associated with lipopolysaccharide (LPS) in the outer membrane. .. …
Previous studies have documented high rates of nonspecific resistance (insensitivity) of various E. coli strains toward colicins that is …
Increased risk of hypercholesterolemia in a French and Lebanese population due to an interaction between rs2569190 in CD14 and gender.
El Shamieh S, Salami A, Stathopoulou MG, Chedid P, Visvikis-Siest S. El Shamieh S, et al. Clin Chim Acta. 2020 Oct;509:172-176. doi: 10.1016/j.cca.2020.06.020. Epub 2020 Jun 13. Clin Chim Acta. 2020. PMID: 32544432
RATIONALE: Since identifying gender-specific genetic associations may have a significant impact on public health, we studied the interaction between rs2569190 in CD14 (cluster of differentiation 14) and gender in relation to the lipid traits in two independent
RATIONALE: Since identifying gender-specific genetic associations may have a significant impact on public health, we studied the interaction …
IL21R expressing CD14(+)CD16(+) monocytes expand in multiple myeloma patients leading to increased osteoclasts.
Bolzoni M, Ronchetti D, Storti P, Donofrio G, Marchica V, Costa F, Agnelli L, Toscani D, Vescovini R, Todoerti K, Bonomini S, Sammarelli G, Vecchi A, Guasco D, Accardi F, Palma BD, Gamberi B, Ferrari C, Neri A, Aversa F, Giuliani N. Bolzoni M, et al. Haematologica. 2017 Apr;102(4):773-784. doi: 10.3324/haematol.2016.153841. Epub 2017 Jan 5. Haematologica. 2017. PMID: 28057743 Free PMC article.
Interestingly, sorted bone marrow CD14(+)CD16(+) cells from myeloma patients were more pro-osteoclastogenic than CD14(+)CD16-cells in cultures ex vivo Moreover, transcriptional analysis demonstrated that bone marrow CD14(+) cells from patients with mul …
Interestingly, sorted bone marrow CD14(+)CD16(+) cells from myeloma patients were more pro-osteoclastogenic than CD14(+)CD16-c …
CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.
Rajaiah R, Perkins DJ, Ireland DD, Vogel SN. Rajaiah R, et al. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6. doi: 10.1073/pnas.1424980112. Epub 2015 Jun 23. Proc Natl Acad Sci U S A. 2015. PMID: 26106158 Free PMC article.
Recently, Zanoni et al. [(2011) Cell 147(4):868-880] reported that cluster of differentiation 14 (CD14) is required for LPS-/Escherichia coli- induced TLR4 internalization into endosomes and activation of TRIF-mediated signaling in macrophages. ...Furthermore …
Recently, Zanoni et al. [(2011) Cell 147(4):868-880] reported that cluster of differentiation 14 (CD14) is required for LPS
49 results