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A single-cell atlas of the peripheral immune response in patients with severe COVID-19.
Wilk AJ, Rustagi A, Zhao NQ, Roque J, Martínez-Colón GJ, McKechnie JL, Ivison GT, Ranganath T, Vergara R, Hollis T, Simpson LJ, Grant P, Subramanian A, Rogers AJ, Blish CA. Wilk AJ, et al. Nat Med. 2020 Jul;26(7):1070-1076. doi: 10.1038/s41591-020-0944-y. Epub 2020 Jun 8. Nat Med. 2020. PMID: 32514174 Free PMC article.
To elucidate pathways in peripheral immune cells that might lead to immunopathology or protective immunity in severe COVID-19, we applied single-cell RNA sequencing (scRNA-seq) to profile peripheral blood monon …
To elucidate pathways in peripheral immune cells that might lead to immunopathology or protective immunity in …
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.
Ren X, Wen W, Fan X, Hou W, Su B, Cai P, Li J, Liu Y, Tang F, Zhang F, Yang Y, He J, Ma W, He J, Wang P, Cao Q, Chen F, Chen Y, Cheng X, Deng G, Deng X, Ding W, Feng Y, Gan R, Guo C, Guo W, He S, Jiang C, Liang J, Li YM, Lin J, Ling Y, Liu H, Liu J, Liu N, Liu SQ, Luo M, Ma Q, Song Q, Sun W, Wang G, Wang F, Wang Y, Wen X, Wu Q, Xu G, Xie X, Xiong X, Xing X, Xu H, Yin C, Yu D, Yu K, Yuan J, Zhang B, Zhang P, Zhang T, Zhao J, Zhao P, Zhou J, Zhou W, Zhong S, Zhong X, Zhang S, Zhu L, Zhu P, Zou B, Zou J, Zuo Z, Bai F, Huang X, Zhou P, Jiang Q, Huang Z, Bei JX, Wei L, Bian XW, Liu X, Cheng T, Li X, Zhao P, Wang FS, Wang H, Su B, Zhang Z, Qu K, Wang X, Chen J, Jin R, Zhang Z. Ren X, et al. Cell. 2021 Apr 1;184(7):1895-1913.e19. doi: 10.1016/j.cell.2021.01.053. Epub 2021 Feb 3. Cell. 2021. PMID: 33657410 Free PMC article.
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent immune cells is not complete. ...Severe …
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a recurrent the …
A single-cell atlas of the peripheral immune response to severe COVID-19.
Wilk AJ, Rustagi A, Zhao NQ, Roque J, Martinez-Colon GJ, McKechnie JL, Ivison GT, Ranganath T, Vergara R, Hollis T, Simpson LJ, Grant P, Subramanian A, Rogers AJ, Blish CA. Wilk AJ, et al. medRxiv. 2020 Apr 23:2020.04.17.20069930. doi: 10.1101/2020.04.17.20069930. Preprint. medRxiv. 2020. PMID: 32511639 Free PMC article. Updated.
There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2. ...Collectively, we provide the most thorough cell atlas to date of th …
There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the glo …
Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infection.
Wang Y, Wang X, Luu LDW, Li J, Cui X, Yao H, Chen S, Fu J, Wang L, Wang C, Yuan R, Cai Q, Huang X, Huang J, Li Z, Li S, Zhu X, Tai J. Wang Y, et al. J Med Virol. 2022 Nov;94(11):5304-5324. doi: 10.1002/jmv.28012. Epub 2022 Jul 30. J Med Virol. 2022. PMID: 35859327 Free PMC article.
However, the underlying mechanisms of the inactivated COVID-19 vaccine-induced immune response remain unclear, and little is known about its features compared to (Severe acute respiratory syndrome coronavirus 2 …
However, the underlying mechanisms of the inactivated COVID-19 vaccine-induced immune response remain unclear, a …
Downregulation of the Protein C Signaling System Is Associated with COVID-19 Hypercoagulability-A Single-Cell Transcriptomics Analysis.
Silva BRS, Jara CP, Sidarta-Oliveira D, Velloso LA, Velander WH, Araújo EP. Silva BRS, et al. Viruses. 2022 Dec 9;14(12):2753. doi: 10.3390/v14122753. Viruses. 2022. PMID: 36560757 Free PMC article.
Single-cell RNA-sequencing data from patients with COVID-19 and healthy subjects were obtained from the COVID-19 Cell Atlas database. ...Protein C could play a mechanistic role in the hypercoagulability syndrome affec …
Single-cell RNA-sequencing data from patients with COVID-19 and healthy subjects were obtained from the COVID …
Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients With Different Severities.
Li X, Garg M, Jia T, Liao Q, Yuan L, Li M, Wu Z, Wu W, Bi Y, George N, Papatheodorou I, Brazma A, Luo H, Fang S, Miao Z, Shu Y. Li X, et al. Front Immunol. 2022 Jan 3;12:781432. doi: 10.3389/fimmu.2021.781432. eCollection 2021. Front Immunol. 2022. PMID: 35046942 Free PMC article.
Despite many studies on the immune characteristics of Coronavirus disease 2019 (COVID-19) patients in the progression stage, a detailed understanding of pertinent immune cells in recovered patients is lacking. ...Further, the immun …
Despite many studies on the immune characteristics of Coronavirus disease 2019 (COVID-19) patients in the …
Functional Roles and Targets of COVID-19 in Blood Cells Determined Using Bioinformatics Analyses.
Sohn EJ. Sohn EJ. Bioinform Biol Insights. 2022 Feb 23;16:11779322221080266. doi: 10.1177/11779322221080266. eCollection 2022. Bioinform Biol Insights. 2022. PMID: 35221679 Free PMC article.
BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global epidemic with a high mortality rate. ...Peroxisome …
BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by novel severe acute respiratory …
Comprehensive analysis to identify the influences of SARS-CoV-2 infections to inflammatory bowel disease.
Zhang C, Ma Z, Nan X, Wang W, Zeng X, Chen J, Cai Z, Wang J. Zhang C, et al. Front Immunol. 2023 Feb 3;14:1024041. doi: 10.3389/fimmu.2023.1024041. eCollection 2023. Front Immunol. 2023. PMID: 36817436 Free PMC article.
BACKGROUND: Coronavirus disease 2019 (COVID-19) and inflammatory bowel disease (IBD) are both caused by a disordered immune response and have direct and profound impacts on health care services. ...Two single-cell RNA sequen …
BACKGROUND: Coronavirus disease 2019 (COVID-19) and inflammatory bowel disease (IBD) are both caused by a disord …
Single-cell transcriptomic atlas of distinct early immune responses induced by SARS-CoV-2 Proto or its variants in rhesus monkey.
Yang Y, Du T, Yu W, Zhou Y, Yang C, Kuang D, Wang J, Tang C, Wang H, Zhao Y, Yang H, Huang Q, Wu D, Li B, Sun Q, Liu H, Lu S, Peng X. Yang Y, et al. MedComm (2020). 2023 Nov 20;4(6):e432. doi: 10.1002/mco2.432. eCollection 2023 Dec. MedComm (2020). 2023. PMID: 38020713 Free PMC article.
Immune responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection play a critical role in the pathogenesis and outcome of coronavirus disease 2019 (COVID- …
Immune responses induced by severe acute respiratory syndrome coronavirus 2 (SARS- …
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
Bui LT, Winters NI, Chung MI, Joseph C, Gutierrez AJ, Habermann AC, Adams TS, Schupp JC, Poli S, Peter LM, Taylor CJ, Blackburn JB, Richmond BW, Nicholson AG, Rassl D, Wallace WA, Rosas IO, Jenkins RG, Kaminski N, Kropski JA, Banovich NE; Human Cell Atlas Lung Biological Network. Bui LT, et al. Nat Commun. 2021 Jul 14;12(1):4314. doi: 10.1038/s41467-021-24467-0. Nat Commun. 2021. PMID: 34262047 Free PMC article.
Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of 611,398 single cells isolated from healthy and CLD lungs to iden …
Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19 …
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