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A whole genome screen for HIV restriction factors.
Liu L, Oliveira NM, Cheney KM, Pade C, Dreja H, Bergin AM, Borgdorff V, Beach DH, Bishop CL, Dittmar MT, McKnight A. Liu L, et al. Retrovirology. 2011 Nov 14;8:94. doi: 10.1186/1742-4690-8-94. Retrovirology. 2011. PMID: 22082156 Free PMC article.
BACKGROUND: Upon cellular entry retroviruses must avoid innate restriction factors produced by the host cell. For human immunodeficiency virus (HIV) human restriction factors, APOBEC3 (apolipoprotein-B-mRNA-editing-enzyme), p21 and tetherin are …
BACKGROUND: Upon cellular entry retroviruses must avoid innate restriction factors produced by the host cell. For human immuno …
HIV-CRISPR: A CRISPR/Cas9 Screening Method to Identify Genes Affecting HIV Replication.
Roesch F, OhAinle M. Roesch F, et al. Bio Protoc. 2020 May 5;10(9):e3614. doi: 10.21769/BioProtoc.3614. eCollection 2020 May 5. Bio Protoc. 2020. PMID: 33659577 Free PMC article.
Screening with CRISPR/Cas9 technology has already led to significant discoveries in the fields of cancer biology, cell biology and virology. Because of the relatively low false discovery rates and the ability to perform high-throughput, pooled approaches, it has rap
Screening with CRISPR/Cas9 technology has already led to significant discoveries in the fields of cancer biology, cell biology
RNA-Associated Early-Stage Antiviral Factor Is a Major Component of Lv2 Restriction.
Marno KM, O'Sullivan E, Jones CE, Díaz-Delfín J, Pardieu C, Sloan RD, McKnight Á. Marno KM, et al. J Virol. 2017 Apr 28;91(10):e01228-16. doi: 10.1128/JVI.01228-16. Print 2017 May 15. J Virol. 2017. PMID: 28275184 Free PMC article.
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication in human cells is restricted at early postentry steps by host inhibitory factors. ...We subsequently reported a whole-genome small interfering RNA s
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication in human cells is restricted at earl
Transmission of Extensively Drug-Resistant Tuberculosis in South Africa.
Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR. Shah NS, et al. N Engl J Med. 2017 Jan 19;376(3):243-253. doi: 10.1056/NEJMoa1604544. N Engl J Med. 2017. PMID: 28099825 Free PMC article.
METHODS: We conducted a prospective study involving 404 participants in KwaZulu-Natal Province, South Africa, with a diagnosis of XDR tuberculosis between 2011 and 2014. Interviews and medical-record reviews were used to elicit information on the participants' history of t …
METHODS: We conducted a prospective study involving 404 participants in KwaZulu-Natal Province, South Africa, with a diagnosis of XDR …
Novel restriction factor RNA-associated early-stage anti-viral factor (REAF) inhibits human and simian immunodeficiency viruses.
Marno KM, Ogunkolade BW, Pade C, Oliveira NM, O'Sullivan E, McKnight Á. Marno KM, et al. Retrovirology. 2014 Jan 10;11:3. doi: 10.1186/1742-4690-11-3. Retrovirology. 2014. PMID: 24410916 Free PMC article.
BACKGROUND: The discovery of novel anti-viral restriction factors illuminates unknown aspects of innate sensing and immunity. We identified RNA-associated Early-stage Anti-viral Factor (REAF) using a whole genome siRNA screen for …
BACKGROUND: The discovery of novel anti-viral restriction factors illuminates unknown aspects of innate sensing and immunity. …