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111 results

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Activation of cultured vascular endothelial cells by antiphospholipid antibodies.
Simantov R, LaSala JM, Lo SK, Gharavi AE, Sammaritano LR, Salmon JE, Silverstein RL. Simantov R, et al. J Clin Invest. 1995 Nov;96(5):2211-9. doi: 10.1172/JCI118276. J Clin Invest. 1995. PMID: 7593607 Free PMC article.
We have demonstrated the activation of cultured human umbilical vein endothelial cells (HUVEC) by IgG from patients with anticardiolipin antibodies (aCL). ...These data support the hypothesis that aPL activate vascular endotheli …
We have demonstrated the activation of cultured human umbilical vein endothelial cells (HUVEC) by IgG from patie …
Antiphospholipid antibodies induce proinflammatory and procoagulant pathways in endothelial cells.
Patsouras M, Alexopoulou E, Foutadakis S, Tsiki E, Karagianni P, Agelopoulos M, Vlachoyiannopoulos PG. Patsouras M, et al. J Transl Autoimmun. 2023 May 2;6:100202. doi: 10.1016/j.jtauto.2023.100202. eCollection 2023. J Transl Autoimmun. 2023. PMID: 37216142 Free PMC article.
Antiphospholipid syndrome (APS) is an autoimmune thrombophilia characterized by recurrent thrombotic events and/or pregnancy morbidity in the presence of antiphospholipid antibodies detected either as anti-cardiolipin, anti-beta2 Glycoprotein I (anti-beta2GPI …
Antiphospholipid syndrome (APS) is an autoimmune thrombophilia characterized by recurrent thrombotic events and/or pregnancy morbidit …
Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors.
Allen KL, Hamik A, Jain MK, McCrae KR. Allen KL, et al. Blood. 2011 Jun 9;117(23):6383-91. doi: 10.1182/blood-2010-10-313072. Epub 2011 Apr 11. Blood. 2011. PMID: 21482710 Free PMC article.
The majority of APLAs are directed against phospholipid-binding proteins, particularly beta2-glycoprotein I (beta2GPI). Anti-beta2GPI antibodies activate endothelial cells in a beta2GPI-dependent manner through a pathway that involves NF-kappaB. Kruppe …
The majority of APLAs are directed against phospholipid-binding proteins, particularly beta2-glycoprotein I (beta2GPI). Anti-beta2GPI ant …
Antiphospholipid-mediated thrombosis: interplay between anticardiolipin antibodies and vascular cells.
López-Pedrera C, Buendía P, Barbarroja N, Siendones E, Velasco F, Cuadrado MJ. López-Pedrera C, et al. Clin Appl Thromb Hemost. 2006 Jan;12(1):41-5. doi: 10.1177/107602960601200107. Clin Appl Thromb Hemost. 2006. PMID: 16444433 Free article. Review.
Different theories have been proposed, including the effect of aPL on endothelial cells, monocytes, and platelets. aPL are able to recognize, injure, or activate cultured vascular endothelial cells. Cultured endothelial …
Different theories have been proposed, including the effect of aPL on endothelial cells, monocytes, and platelets. aPL are abl …
A novel pathway of cellular activation mediated by antiphospholipid antibody-induced extracellular vesicles.
Wu M, Barnard J, Kundu S, McCrae KR. Wu M, et al. J Thromb Haemost. 2015 Oct;13(10):1928-40. doi: 10.1111/jth.13072. Epub 2015 Sep 15. J Thromb Haemost. 2015. PMID: 26264622 Free PMC article.
BACKGROUND: Elevated levels of endothelial cell (EC)-derived extracellular vesicles (EVs) circulate in patients with antiphospholipid antibodies (APLAs), and APLAs, particularly those against beta2 -glycoprotein I (beta2 GPI), stimulate EV release from ECs. . …
BACKGROUND: Elevated levels of endothelial cell (EC)-derived extracellular vesicles (EVs) circulate in patients with antiphospholi …
Endothelial Cell-Activating Antibodies in COVID-19.
Shi H, Zuo Y, Navaz S, Harbaugh A, Hoy CK, Gandhi AA, Sule G, Yalavarthi S, Gockman K, Madison JA, Wang J, Zuo M, Shi Y, Maile MD, Knight JS, Kanthi Y. Shi H, et al. Arthritis Rheumatol. 2022 Jul;74(7):1132-1138. doi: 10.1002/art.42094. Epub 2022 May 27. Arthritis Rheumatol. 2022. PMID: 35174669 Free PMC article.
This study was undertaken to identify circulating factors contributing to endothelial cell activation and dysfunction in COVID-19. METHODS: Human endothelial cells were cultured in the presence of serum or plasma from 244 patients hospitalized w …
This study was undertaken to identify circulating factors contributing to endothelial cell activation and dysfunction in COVID …
Endothelial cell-activating antibodies in COVID-19.
Shi H, Zuo Y, Navaz S, Harbaugh A, Hoy CK, Gandhi AA, Sule G, Yalavarthi S, Gockman K, Madison JA, Wang J, Zuo M, Shi Y, Maile MD, Knight JS, Kanthi Y. Shi H, et al. medRxiv [Preprint]. 2022 Feb 2:2021.01.18.21250041. doi: 10.1101/2021.01.18.21250041. medRxiv. 2022. Update in: Arthritis Rheumatol. 2022 Jul;74(7):1132-1138. doi: 10.1002/art.42094. PMID: 33501469 Free PMC article. Updated. Preprint.
Our aim was to identify circulating factors contributing to endothelial cell activation and dysfunction in COVID-19. METHODS: Human endothelial cells were cultured in the presence of serum or plasma from 244 patients hospitalized with COVID-19 a …
Our aim was to identify circulating factors contributing to endothelial cell activation and dysfunction in COVID-19. METHODS: …
Aspirin inhibits endothelial cell activation induced by antiphospholipid antibodies.
Dunoyer-Geindre S, Kruithof EK, Boehlen F, Satta-Poschung N, Reber G, de Moerloose P. Dunoyer-Geindre S, et al. J Thromb Haemost. 2004 Jul;2(7):1176-81. doi: 10.1111/j.1538-7836.2004.00801.x. J Thromb Haemost. 2004. PMID: 15219202 Free article.
BACKGROUND: Antiphospholipid antibodies (APLA) have been shown to activate endothelial cells (EC) in vitro, as documented by an increased expression of tissue factor as well as leukocyte adhesion molecules such as intercellular adhesion molecule …
BACKGROUND: Antiphospholipid antibodies (APLA) have been shown to activate endothelial cells (EC) in vitr …
Platelet Activation by Antiphospholipid Antibodies Depends on Epitope Specificity and is Prevented by mTOR Inhibitors.
Hollerbach A, Müller-Calleja N, Ritter S, Häuser F, Canisius A, Orning C, Jurk K, Lackner KJ. Hollerbach A, et al. Thromb Haemost. 2019 Jul;119(7):1147-1153. doi: 10.1055/s-0039-1685453. Epub 2019 Apr 24. Thromb Haemost. 2019. PMID: 31018220
Antiphospholipid antibodies (aPL) have been reported to activate platelets. This is considered to be one of the pathogenic properties of aPL. ...This extends previous data showing that mTOR is involved in signaling of anti-beta2GPI in monocytes and endothe …
Antiphospholipid antibodies (aPL) have been reported to activate platelets. This is considered to be one of the pathoge …
Review: where is the maternofetal interface?
Chamley LW, Holland OJ, Chen Q, Viall CA, Stone PR, Abumaree M. Chamley LW, et al. Placenta. 2014 Feb;35 Suppl:S74-80. doi: 10.1016/j.placenta.2013.10.014. Epub 2013 Nov 4. Placenta. 2014. PMID: 24239157 Review.
We have found that trophoblast debris from normal placentae shows markers of apoptosis and is phagocytosed by macrophages or endothelial cells, producing a tolerant phenotype in the phagocyte. Whereas, when we culture normal placental explants with factors su …
We have found that trophoblast debris from normal placentae shows markers of apoptosis and is phagocytosed by macrophages or endothelial …
111 results