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Antiphospholipid antibodies induce proinflammatory and procoagulant pathways in endothelial cells.
Patsouras M, Alexopoulou E, Foutadakis S, Tsiki E, Karagianni P, Agelopoulos M, Vlachoyiannopoulos PG. Patsouras M, et al. J Transl Autoimmun. 2023 May 2;6:100202. doi: 10.1016/j.jtauto.2023.100202. eCollection 2023. J Transl Autoimmun. 2023. PMID: 37216142 Free PMC article.
Endothelial deregulation characterizes the syndrome. To address gene expression changes accompanying the development of autoimmune phenotype in endothelial cells in the context of APS, we performed transcriptomics analysis in Human Umbilical Vein Endotheli
Endothelial deregulation characterizes the syndrome. To address gene expression changes accompanying the development of autoimmune ph
Activation of cultured vascular endothelial cells by antiphospholipid antibodies.
Simantov R, LaSala JM, Lo SK, Gharavi AE, Sammaritano LR, Salmon JE, Silverstein RL. Simantov R, et al. J Clin Invest. 1995 Nov;96(5):2211-9. doi: 10.1172/JCI118276. J Clin Invest. 1995. PMID: 7593607 Free PMC article.
We have demonstrated the activation of cultured human umbilical vein endothelial cells (HUVEC) by IgG from patients with anticardiolipin antibodies (aCL). ...These data support the hypothesis that aPL activate vascular endotheli
We have demonstrated the activation of cultured human umbilical vein endothelial cells (HUVEC) by IgG from patie …
Antiphospholipid-mediated thrombosis: interplay between anticardiolipin antibodies and vascular cells.
López-Pedrera C, Buendía P, Barbarroja N, Siendones E, Velasco F, Cuadrado MJ. López-Pedrera C, et al. Clin Appl Thromb Hemost. 2006 Jan;12(1):41-5. doi: 10.1177/107602960601200107. Clin Appl Thromb Hemost. 2006. PMID: 16444433 Free article. Review.
Different theories have been proposed, including the effect of aPL on endothelial cells, monocytes, and platelets. aPL are able to recognize, injure, or activate cultured vascular endothelial cells. Cultured endothelial
Different theories have been proposed, including the effect of aPL on endothelial cells, monocytes, and platelets. aPL are abl …
Endothelial cell-activating antibodies in COVID-19.
Shi H, Zuo Y, Navaz S, Harbaugh A, Hoy CK, Gandhi AA, Sule G, Yalavarthi S, Gockman K, Madison JA, Wang J, Zuo M, Shi Y, Maile MD, Knight JS, Kanthi Y. Shi H, et al. medRxiv. 2022 Feb 2:2021.01.18.21250041. doi: 10.1101/2021.01.18.21250041. Preprint. medRxiv. 2022. PMID: 33501469 Free PMC article. Updated.
Our aim was to identify circulating factors contributing to endothelial cell activation and dysfunction in COVID-19. METHODS: Human endothelial cells were cultured in the presence of serum or plasma from 244 patients hospitalized with COVID-19 a …
Our aim was to identify circulating factors contributing to endothelial cell activation and dysfunction in COVID-19. METHODS: …
Endothelial Cell-Activating Antibodies in COVID-19.
Shi H, Zuo Y, Navaz S, Harbaugh A, Hoy CK, Gandhi AA, Sule G, Yalavarthi S, Gockman K, Madison JA, Wang J, Zuo M, Shi Y, Maile MD, Knight JS, Kanthi Y. Shi H, et al. Arthritis Rheumatol. 2022 Jul;74(7):1132-1138. doi: 10.1002/art.42094. Epub 2022 May 27. Arthritis Rheumatol. 2022. PMID: 35174669 Free PMC article.
This study was undertaken to identify circulating factors contributing to endothelial cell activation and dysfunction in COVID-19. METHODS: Human endothelial cells were cultured in the presence of serum or plasma from 244 patients hospitalized w …
This study was undertaken to identify circulating factors contributing to endothelial cell activation and dysfunction in COVID …
A novel pathway of cellular activation mediated by antiphospholipid antibody-induced extracellular vesicles.
Wu M, Barnard J, Kundu S, McCrae KR. Wu M, et al. J Thromb Haemost. 2015 Oct;13(10):1928-40. doi: 10.1111/jth.13072. Epub 2015 Sep 15. J Thromb Haemost. 2015. PMID: 26264622 Free PMC article.
OBJECTIVE: To determine the mechanism by which EVs released from ECs by anti-beta2 GPI antibodies activate unstimulated ECs. PATIENTS/METHODS: We used interleukin (IL)-1 receptor inhibitors, small interfering RNA (siRNA) against Toll-like receptors (TLRs) and microR …
OBJECTIVE: To determine the mechanism by which EVs released from ECs by anti-beta2 GPI antibodies activate unstimulated ECs. P …
Platelet Activation by Antiphospholipid Antibodies Depends on Epitope Specificity and is Prevented by mTOR Inhibitors.
Hollerbach A, Müller-Calleja N, Ritter S, Häuser F, Canisius A, Orning C, Jurk K, Lackner KJ. Hollerbach A, et al. Thromb Haemost. 2019 Jul;119(7):1147-1153. doi: 10.1055/s-0039-1685453. Epub 2019 Apr 24. Thromb Haemost. 2019. PMID: 31018220
Antiphospholipid antibodies (aPL) have been reported to activate platelets. ...This extends previous data showing that mTOR is involved in signaling of anti-beta2GPI in monocytes and endothelial cells. In conclusion, anti-beta2GPI aPL activat
Antiphospholipid antibodies (aPL) have been reported to activate platelets. ...This extends previous data showing that
Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors.
Allen KL, Hamik A, Jain MK, McCrae KR. Allen KL, et al. Blood. 2011 Jun 9;117(23):6383-91. doi: 10.1182/blood-2010-10-313072. Epub 2011 Apr 11. Blood. 2011. PMID: 21482710 Free PMC article.
The majority of APLAs are directed against phospholipid-binding proteins, particularly beta2-glycoprotein I (beta2GPI). Anti-beta2GPI antibodies activate endothelial cells in a beta2GPI-dependent manner through a pathway that involves NF-kappaB. Kruppe …
The majority of APLAs are directed against phospholipid-binding proteins, particularly beta2-glycoprotein I (beta2GPI). Anti-beta2GPI ant
Antiphospholipid antibodies prolong the activation of endothelial cells induced by necrotic trophoblastic debris: implications for the pathogenesis of preeclampsia.
Chen Q, Guo F, Hensby-Bennett S, Stone P, Chamley L. Chen Q, et al. Placenta. 2012 Oct;33(10):810-5. doi: 10.1016/j.placenta.2012.07.019. Epub 2012 Aug 16. Placenta. 2012. PMID: 22902008
Antiphospholipid antibodies alone did not active untreated endothelial cells, but did prolong the activation of endothelial cells which had been activated by pre-treatment with necrotic trophoblastic debris. When expo
Antiphospholipid antibodies alone did not active untreated endothelial cells, but did prolong the acti
Characterization of Antiphospholipid Syndrome Atherothrombotic Risk by Unsupervised Integrated Transcriptomic Analyses.
Pérez-Sánchez L, Patiño-Trives AM, Aguirre-Zamorano MÁ, Luque-Tévar M, Ábalos-Aguilera MC, Arias-de la Rosa I, Seguí P, Velasco-Gimena F, Barbarroja N, Escudero-Contreras A, Collantes-Estévez E, Pérez-Sánchez C, López-Pedrera C. Pérez-Sánchez L, et al. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):865-877. doi: 10.1161/ATVBAHA.120.315346. Epub 2020 Dec 24. Arterioscler Thromb Vasc Biol. 2021. PMID: 33356391 Free article.
Transfection studies and luciferase assays established the relationship between specific miRNAs and their identified target genes and proteins, along with their involvement in the regulation of monocytes procoagulant activity and cell adhesion. Correlation analyses showed …
Transfection studies and luciferase assays established the relationship between specific miRNAs and their identified target genes and protei …
110 results