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Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways.
Suryadevara V, Ramchandran R, Kamp DW, Natarajan V. Suryadevara V, et al. Int J Mol Sci. 2020 Jun 15;21(12):4257. doi: 10.3390/ijms21124257. Int J Mol Sci. 2020. PMID: 32549377 Free PMC article. Review.
The molecular mechanisms involved in the pathophysiology of IPF are incompletely defined. Several lung cell types including alveolar epithelial cells, fibroblasts, monocyte-derived macrophages, and endothelial cells have been implicated in the developm …
The molecular mechanisms involved in the pathophysiology of IPF are incompletely defined. Several lung cell types including alveolar …
Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate.
Fueller M, Wang DA, Tigyi G, Siess W. Fueller M, et al. Cell Signal. 2003 Apr;15(4):367-75. doi: 10.1016/s0898-6568(02)00117-1. Cell Signal. 2003. PMID: 12618211
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are serum-borne lipid mediators with potential proinflammatory and atherogenic properties. ...Notably, serum and minimally modified LDL (mm-LDL) evoked [Ca(2+)](i) increases that were
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are serum-borne lipid mediators with potent
Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate.
Siess W. Siess W. Biochim Biophys Acta. 2002 May 23;1582(1-3):204-15. doi: 10.1016/s1388-1981(02)00173-7. Biochim Biophys Acta. 2002. PMID: 12069830 Review.
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are potent bioactive phospholipids with specific and multiple effects on blood cells and cells of the vessel wall. ...Most importantly, as LPA and S1P bind to and act
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are potent bioactive phospholipids with spe
Lysophospholipid regulation of mononuclear phagocytes.
Lee H, Liao JJ, Graeler M, Huang MC, Goetzl EJ. Lee H, et al. Biochim Biophys Acta. 2002 May 23;1582(1-3):175-7. doi: 10.1016/s1388-1981(02)00153-1. Biochim Biophys Acta. 2002. PMID: 12069826 Review.
Blood monocytes and tissue macrophages derived from monocyte differentiation in tissues are central elements of innate immunity in host defense against numerous pathogens and other challenges. ...Pathological perversion of their physiological roles leads to particip …
Blood monocytes and tissue macrophages derived from monocyte differentiation in tissues are central elements of innate immunit …
Review of the Third Domain Receptor Binding Fragment of Alphafetoprotein (AFP): Plausible Binding of AFP to Lysophospholipid Receptor Targets.
Mizejewski GJ. Mizejewski GJ. Curr Drug Targets. 2017;18(7):874-886. doi: 10.2174/1389450117666160201105245. Curr Drug Targets. 2017. PMID: 26844573 Review.
The LPLs consist of either sphingosine-1-phosphate or lysophosphatidic acid, and mostly their choline, ethanolamine, serine or inositol derivatives. ...The LPLs bind to four different classes of G-protein coupled receptors described herein which …
The LPLs consist of either sphingosine-1-phosphate or lysophosphatidic acid, and mostly their choline, et …
Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease.
Kamanna VS, Bassa BV, Ganji SH, Roh DD. Kamanna VS, et al. Histol Histopathol. 2005 Apr;20(2):603-13. doi: 10.14670/HH-20.603. Histol Histopathol. 2005. PMID: 15736064 Review.
Lysophosphatidic acid (LPA), lyso-phosphatidylcholine (LPC), and sphingosine-1-phosphate (S1P) are major biologically active lysophospholipids (LPLs) that are produced by activated platelets, monocyte/macrophages, and many t
Lysophosphatidic acid (LPA), lyso-phosphatidylcholine (LPC), and sphingosine-1-phosphate (S1P) are major
Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages.
Duong CQ, Bared SM, Abu-Khader A, Buechler C, Schmitz A, Schmitz G. Duong CQ, et al. Biochim Biophys Acta. 2004 Jun 1;1682(1-3):112-9. doi: 10.1016/j.bbalip.2004.03.002. Biochim Biophys Acta. 2004. PMID: 15158762
Some of the biological effects of lipoproteins have been attributed to their association with lysophosphatidic acid (LPA), lysophosphatidylcholine (LPC), sphingosine-1-phosphate (S1P) and sphingosylphosphorylcholine (SPC). ...Altogether, these d …
Some of the biological effects of lipoproteins have been attributed to their association with lysophosphatidic acid (LPA), lys …
Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction.
Rizza C, Leitinger N, Yue J, Fischer DJ, Wang DA, Shih PT, Lee H, Tigyi G, Berliner JA. Rizza C, et al. Lab Invest. 1999 Oct;79(10):1227-35. Lab Invest. 1999. PMID: 10532586
However no previous studies have examined the effects of LPA on endothelial cell leukocyte interactions. We have examined the ability of LPA to activate human aortic endothelial cells (HAEC) to bind monocytes, neutrophils, and HL60 cells
However no previous studies have examined the effects of LPA on endothelial cell leukocyte interactions. We have examined the ability …
Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism.
Lin CI, Chen CN, Chen JH, Lee H. Lin CI, et al. J Cell Biochem. 2006 Nov 1;99(4):1216-32. doi: 10.1002/jcb.20963. J Cell Biochem. 2006. PMID: 16795034
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are both low-molecular-weight lysophospholipid (LPL) ligands which are recognized by the Edg family of G protein-coupled receptors (GPCRs). In endothelial cells, these two liga
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are both low-molecular-weight lysophospholi
Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism.
Lee H, Lin CI, Liao JJ, Lee YW, Yang HY, Lee CY, Hsu HY, Wu HL. Lee H, et al. Am J Physiol Cell Physiol. 2004 Dec;287(6):C1657-66. doi: 10.1152/ajpcell.00172.2004. Epub 2004 Aug 4. Am J Physiol Cell Physiol. 2004. PMID: 15294853 Free article.
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S-1-P) are both low molecular weight lysophospholipid (LPL) ligands that are recognized by the Edg family of G protein-coupled receptors. ...This study showed that LPA and
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S-1-P) are both low molecular weig