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Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate.
Fueller M, Wang DA, Tigyi G, Siess W. Fueller M, et al. Cell Signal. 2003 Apr;15(4):367-75. doi: 10.1016/s0898-6568(02)00117-1. Cell Signal. 2003. PMID: 12618211
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are serum-borne lipid mediators with potential proinflammatory and atherogenic properties. We studied the effects of LPA and S1P on [Ca(2+)](i), a second messenger of cellular acti …
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are serum-borne lipid mediators with potent …
Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate.
Siess W. Siess W. Biochim Biophys Acta. 2002 May 23;1582(1-3):204-15. doi: 10.1016/s1388-1981(02)00173-7. Biochim Biophys Acta. 2002. PMID: 12069830 Review.
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are potent bioactive phospholipids with specific and multiple effects on blood cells and cells of the vessel wall. ...Most importantly, as LPA and S1P bind to and act …
Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are potent bioactive phospholipids with spe …
Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease.
Kamanna VS, Bassa BV, Ganji SH, Roh DD. Kamanna VS, et al. Histol Histopathol. 2005 Apr;20(2):603-13. doi: 10.14670/HH-20.603. Histol Histopathol. 2005. PMID: 15736064 Review.
Lysophosphatidic acid (LPA), lyso-phosphatidylcholine (LPC), and sphingosine-1-phosphate (S1P) are major biologically active lysophospholipids (LPLs) that are produced by activated platelets, monocyte/macrophages, and many t …
Lysophosphatidic acid (LPA), lyso-phosphatidylcholine (LPC), and sphingosine-1-phosphate (S1P) are major …
Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction.
Rizza C, Leitinger N, Yue J, Fischer DJ, Wang DA, Shih PT, Lee H, Tigyi G, Berliner JA. Rizza C, et al. Lab Invest. 1999 Oct;79(10):1227-35. Lab Invest. 1999. PMID: 10532586
We have examined the ability of LPA to activate human aortic endothelial cells (HAEC) to bind monocytes, neutrophils, and HL60 cells (a neutrophil surrogate). ...Exposure of HAEC to sphingosine-1-phosphate, another Edg-1 rec …
We have examined the ability of LPA to activate human aortic endothelial cells (HAEC) to bind monocytes, neutrop …
Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways.
Suryadevara V, Ramchandran R, Kamp DW, Natarajan V. Suryadevara V, et al. Int J Mol Sci. 2020 Jun 15;21(12):4257. doi: 10.3390/ijms21124257. Int J Mol Sci. 2020. PMID: 32549377 Free PMC article. Review.
Several lung cell types including alveolar epithelial cells, fibroblasts, monocyte-derived macrophages, and endothelial cells have been implicated in the development and progression of fibrosis. Regardless of the cell types involved, changes in gene expressio …
Several lung cell types including alveolar epithelial cells, fibroblasts, monocyte-derived macrophages, and endothelial cel …
Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism.
Lin CI, Chen CN, Chen JH, Lee H. Lin CI, et al. J Cell Biochem. 2006 Nov 1;99(4):1216-32. doi: 10.1002/jcb.20963. J Cell Biochem. 2006. PMID: 16795034
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are both low-molecular-weight lysophospholipid (LPL) ligands which are recognized by the Edg family of G protein-coupled receptors (GPCRs). In endothelial cells, these two liga …
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are both low-molecular-weight lysophospholi …
Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophages.
Duong CQ, Bared SM, Abu-Khader A, Buechler C, Schmitz A, Schmitz G. Duong CQ, et al. Biochim Biophys Acta. 2004 Jun 1;1682(1-3):112-9. doi: 10.1016/j.bbalip.2004.03.002. Biochim Biophys Acta. 2004. PMID: 15158762
Some of the biological effects of lipoproteins have been attributed to their association with lysophosphatidic acid (LPA), lysophosphatidylcholine (LPC), sphingosine-1-phosphate (S1P) and sphingosylphosphorylcholine (SPC). ...The expression of t …
Some of the biological effects of lipoproteins have been attributed to their association with lysophosphatidic acid (LPA), lys …
Review of the Third Domain Receptor Binding Fragment of Alphafetoprotein (AFP): Plausible Binding of AFP to Lysophospholipid Receptor Targets.
Mizejewski GJ. Mizejewski GJ. Curr Drug Targets. 2017;18(7):874-886. doi: 10.2174/1389450117666160201105245. Curr Drug Targets. 2017. PMID: 26844573 Review.
Lysophospholipids (LPLs) are plasma membrane-derived bioactive lipid signaling mediators composed of a small molecular weight single acyl carbon chain (palmitic, oleic acid) attached to a polar headgroup; they range in molecular mass from 250-750 daltons. The LPLs consist of eith …
Lysophospholipids (LPLs) are plasma membrane-derived bioactive lipid signaling mediators composed of a small molecular weight single acyl ca …
Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism.
Lee H, Lin CI, Liao JJ, Lee YW, Yang HY, Lee CY, Hsu HY, Wu HL. Lee H, et al. Am J Physiol Cell Physiol. 2004 Dec;287(6):C1657-66. doi: 10.1152/ajpcell.00172.2004. Epub 2004 Aug 4. Am J Physiol Cell Physiol. 2004. PMID: 15294853 Free article.
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S-1-P) are both low molecular weight lysophospholipid (LPL) ligands that are recognized by the Edg family of G protein-coupled receptors. In endothelial cells, these two ligands …
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S-1-P) are both low molecular weight lysophospho …
Lysophospholipid regulation of mononuclear phagocytes.
Lee H, Liao JJ, Graeler M, Huang MC, Goetzl EJ. Lee H, et al. Biochim Biophys Acta. 2002 May 23;1582(1-3):175-7. doi: 10.1016/s1388-1981(02)00153-1. Biochim Biophys Acta. 2002. PMID: 12069826 Review.
Blood monocytes and tissue macrophages derived from monocyte differentiation in tissues are central elements of innate immunity in host defense against numerous pathogens and other challenges. ...Pathological perversion of their physiological roles leads to particip …
Blood monocytes and tissue macrophages derived from monocyte differentiation in tissues are central elements of innate immunit …