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Acute alcohol inhibits TNF-alpha processing in human monocytes by inhibiting TNF/TNF-alpha-converting enzyme interactions in the cell membrane.
Zhao XJ, Marrero L, Song K, Oliver P, Chin SY, Simon H, Schurr JR, Zhang Z, Thoppil D, Lee S, Nelson S, Kolls JK. Zhao XJ, et al. J Immunol. 2003 Mar 15;170(6):2923-31. doi: 10.4049/jimmunol.170.6.2923. J Immunol. 2003. PMID: 12626543 Free article.
Here we show in human primary monocytes and cell lines that alcohol suppresses LPS-induced TNF secretion post-transcriptionally by inhibiting cellular processing by TNF-alpha-converting enzyme (TACE). .. …
Here we show in human primary monocytes and cell lines that alcohol suppresses LPS-induced TNF secretion …
Alcohol reversibly disrupts TNF-alpha/TACE interactions in the cell membrane.
Song K, Zhao XJ, Marrero L, Oliver P, Nelson S, Kolls JK. Song K, et al. Respir Res. 2005 Oct 24;6(1):123. doi: 10.1186/1465-9921-6-123. Respir Res. 2005. PMID: 16246259 Free PMC article.
We have previously shown that alcohol in part inhibits TNF-alpha processing by TNF converting enzyme (TACE) in human monocytes. ...The effect of ethanol, a 2-carbon alcohol was reversible. CONCLUS …
We have previously shown that alcohol in part inhibits TNF-alpha processing by TNF converting
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