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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1970 3
1971 1
1972 1
1973 6
1974 5
1975 11
1976 20
1977 19
1978 26
1979 45
1980 43
1981 73
1982 49
1983 83
1984 133
1985 158
1986 174
1987 186
1988 193
1989 190
1990 177
1991 193
1992 225
1993 220
1994 222
1995 191
1996 187
1997 152
1998 155
1999 133
2000 143
2001 111
2002 142
2003 123
2004 135
2005 154
2006 148
2007 137
2008 150
2009 130
2010 142
2011 137
2012 155
2013 160
2014 186
2015 182
2016 195
2017 173
2018 182
2019 167
2020 183
2021 201
2022 168
2023 152
2024 143
2025 143
2026 49

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6,925 results

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1 article found by citation matching

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The following term was not found in PubMed: ngiocidin
Page 1
Fusion gene depletion eliminates stemness and induces bidirectional differentiation of acute myeloid leukemia.
Derevyanko PK, Swart LE, Mata Casimiro LD, van Oort A, du Plessis M, van den Brink L, Ashtiani M, Zwaan CM, Krippner-Heidenreich A, Bonifer C, Schiffelers R, Vormoor J, Kellaway SG, Heidenreich O. Derevyanko PK, et al. Blood. 2025 Dec 11;146(24):2963-2978. doi: 10.1182/blood.2025028988. Blood. 2025. PMID: 40991849 Free PMC article.
Chromosomal rearrangements that generate novel fusion genes are a hallmark of acute myeloid leukemia (AML). Depletion experiments in cell line models have suggested that their continued expression is required for maintaining their leukemic phenotype an …
Chromosomal rearrangements that generate novel fusion genes are a hallmark of acute myeloid leukemia (AML). Depletion e …
ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.
Maes T, Mascaró C, Tirapu I, Estiarte A, Ciceri F, Lunardi S, Guibourt N, Perdones A, Lufino MMP, Somervaille TCP, Wiseman DH, Duy C, Melnick A, Willekens C, Ortega A, Martinell M, Valls N, Kurz G, Fyfe M, Castro-Palomino JC, Buesa C. Maes T, et al. Cancer Cell. 2018 Mar 12;33(3):495-511.e12. doi: 10.1016/j.ccell.2018.02.002. Epub 2018 Mar 1. Cancer Cell. 2018. PMID: 29502954 Free article.
The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute myeloid leukemia (AML). ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differen …
The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute myeloid leukemia (AML). …
Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation.
Hosseini A, Dhall A, Ikonen N, Sikora N, Nguyen S, Shen Y, Amaral MLJ, Jiao A, Wallner F, Sergeev P, Lim Y, Yang Y, Vick B, Kawabata KC, Melnick A, Vyas P, Ren B, Jeremias I, Psaila B, Heckman CA, Blanco MA, Shi Y. Hosseini A, et al. Nature. 2025 Jun;642(8067):508-518. doi: 10.1038/s41586-025-08915-1. Epub 2025 Apr 16. Nature. 2025. PMID: 40240608 Free PMC article.
Impaired differentiation is a hallmark of myeloid malignancies(1,2). Therapies that enable cells to circumvent the differentiation block, such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), are by and large curative in acute promy …
Impaired differentiation is a hallmark of myeloid malignancies(1,2). Therapies that enable cells to circumvent the d …
Angiocidin induces differentiation of acute myeloid leukemia cells.
Tuszynski GP, Rothman VL. Tuszynski GP, et al. Exp Mol Pathol. 2013 Dec;95(3):249-54. doi: 10.1016/j.yexmp.2013.08.001. Epub 2013 Sep 13. Exp Mol Pathol. 2013. PMID: 24036285
Acute myeloid leukemia (AML) is a malignant proliferative disorder in which leukemic cells fail to terminally differentiate and accumulate in the blood and bone marrow. ...We previously reported that the novel angiogenic inhibitor, angiocidin, …
Acute myeloid leukemia (AML) is a malignant proliferative disorder in which leukemic cells fail to terminally …
Inhibition of mitochondrial complex III induces differentiation in acute myeloid leukemia.
Zhang Y, Luo T, Ding X, Chang Y, Liu C, Zhang Y, Hao S, Yin Q, Jiang B. Zhang Y, et al. Biochem Biophys Res Commun. 2021 Apr 2;547:162-168. doi: 10.1016/j.bbrc.2021.02.027. Epub 2021 Feb 18. Biochem Biophys Res Commun. 2021. PMID: 33610916
Although acute myeloid leukemia (AML) is a highly heterogeneous disease with diverse genetic subsets, one hallmark of AML blasts is myeloid differentiation blockade. Extensive evidence has indicated that differentiation induction therapy …
Although acute myeloid leukemia (AML) is a highly heterogeneous disease with diverse genetic subsets, one hallmark of A …
Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells.
Liu Y, Li H, Zhao Y, Li D, Zhang Q, Fu J, Fan S. Liu Y, et al. Biochem Cell Biol. 2022 Aug 1;100(4):301-308. doi: 10.1139/bcb-2021-0507. Epub 2022 Aug 2. Biochem Cell Biol. 2022. PMID: 35916339
This study aims to investigate the role and precise mechanisms of FHL1 in acute myeloid leukemia (AML). Here, we found that FHL1 was highly expressed in AML. CCK8, flow cytometry, and Western blot analysis of cell cycle-related proteins showed that ove …
This study aims to investigate the role and precise mechanisms of FHL1 in acute myeloid leukemia (AML). Here, we found …
Combined Application of Salinomycin and ATRA Induces Apoptosis and Differentiation of Acute Myeloid Leukemia Cells by Inhibiting WNT/beta-Catenin Pathway.
Xi HM, Lu H, Weng XQ, Sheng Y, Wu J, Li L, Cai X. Xi HM, et al. Anticancer Agents Med Chem. 2023;23(9):1074-1084. doi: 10.2174/1871520623666230110121629. Anticancer Agents Med Chem. 2023. PMID: 36627782
BACKGROUND AND OBJECTIVE: All-trans retinoic acid (ATRA) is only effective in acute promyelocytic leukemia (APL), but not in other subtype of acute myeloid leukemia (AML). ...Here, we investigate the effect of the combination of salinomycin and …
BACKGROUND AND OBJECTIVE: All-trans retinoic acid (ATRA) is only effective in acute promyelocytic leukemia (APL), but not in o …
Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells.
Chlebowska-Tuz J, Sokolowska O, Gaj P, Lazniewski M, Firczuk M, Borowiec K, Sas-Nowosielska H, Bajor M, Malinowska A, Muchowicz A, Ramji K, Stawinski P, Sobczak M, Pilch Z, Rodziewicz-Lurzynska A, Zajac M, Giannopoulos K, Juszczynski P, Basak GW, Plewczynski D, Ploski R, Golab J, Nowis D. Chlebowska-Tuz J, et al. Haematologica. 2018 Nov;103(11):1843-1852. doi: 10.3324/haematol.2018.190231. Epub 2018 Jul 12. Haematologica. 2018. PMID: 30002127 Free PMC article.
A cute myeloid leukemia is a malignant disease of immature myeloid cells. Despite significant therapeutic effects of differentiation-inducing agents in some acute myeloid leukemia subtypes, the disease remains incurab …
A cute myeloid leukemia is a malignant disease of immature myeloid cells. Despite significant therapeutic effect …
Bone marrow stromal cells enhance differentiation of acute myeloid leukemia induced by pyrimidine synthesis inhibitors.
Smoljo T, Lalic H, Dembitz V, Tomic B, Batinic J, Vrhovac R, Bedalov A, Visnjic D. Smoljo T, et al. Am J Physiol Cell Physiol. 2024 Nov 1;327(5):C1202-C1218. doi: 10.1152/ajpcell.00413.2024. Epub 2024 Sep 16. Am J Physiol Cell Physiol. 2024. PMID: 39279497 Free PMC article.
Acute myeloid leukemia (AML) is a heterogeneous group of hematological malignancies characterized by differentiation arrest, high relapse rates, and poor survival. ...In conclusion, our study highlights the supportive role of human BM MSCs in enhancing …
Acute myeloid leukemia (AML) is a heterogeneous group of hematological malignancies characterized by differentiation …
5-Aminoimidazole-4-carboxamide ribonucleoside induces differentiation of acute myeloid leukemia cells.
Lalic H, Dembitz V, Lukinovic-Skudar V, Banfic H, Visnjic D. Lalic H, et al. Leuk Lymphoma. 2014 Oct;55(10):2375-83. doi: 10.3109/10428194.2013.876633. Epub 2014 Feb 24. Leuk Lymphoma. 2014. PMID: 24359245
Adenosine monophosphate (AMP)-activated kinase (AMPK) modulators have been shown to exert cytotoxic activity in hematological malignancies, but their role in the differentiation of acute myeloid leukemia (AML) is less explored. In this study, the effec …
Adenosine monophosphate (AMP)-activated kinase (AMPK) modulators have been shown to exert cytotoxic activity in hematological malignancies, …
6,925 results