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Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies.
Zhang J, McCrae KR. Zhang J, et al. Blood. 2005 Mar 1;105(5):1964-9. doi: 10.1182/blood-2004-05-1708. Epub 2004 Oct 7. Blood. 2005. PMID: 15471954
In this report, we confirm that anti-beta2GPI antibodies activate endothelial cells in the presence of beta2GPI, and demonstrate that anti-annexin A2 antibodies directly cause endothelial cell activat …
In this report, we confirm that anti-beta2GPI antibodies activate endothelial cells in the presence of be …
A novel pathway for human endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies.
Allen KL, Fonseca FV, Betapudi V, Willard B, Zhang J, McCrae KR. Allen KL, et al. Blood. 2012 Jan 19;119(3):884-93. doi: 10.1182/blood-2011-03-344671. Epub 2011 Nov 21. Blood. 2012. PMID: 22106343 Free PMC article.
These Abs are primarily directed against phospholipid-binding proteins, particularly beta(2)GPI, and activate endothelial cells (ECs) in a beta(2)GPI-dependent manner after binding of beta(2)GPI to EC annexin …
These Abs are primarily directed against phospholipid-binding proteins, particularly beta(2)GPI, and activate endoth …
Annexin A2 mediates anti-beta 2 GPI/beta 2 GPI-induced tissue factor expression on monocytes.
Zhou H, Wang H, Li N, Yu Y, Huang H, Yan Y, Wang T. Zhou H, et al. Int J Mol Med. 2009 Oct;24(4):557-62. doi: 10.3892/ijmm_00000265. Int J Mol Med. 2009. PMID: 19724897
Annexin A2 (ANX2), a mediator of cell surface-specific plasmin generation, was identified to mediate endothelial cell activation by anti-beta2-glycoprotein I (anti-beta 2 GPI) antibody …
Annexin A2 (ANX2), a mediator of cell surface-specific plasmin generation, was identified to mediate e …
High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II.
Ma K, Simantov R, Zhang JC, Silverstein R, Hajjar KA, McCrae KR. Ma K, et al. J Biol Chem. 2000 May 19;275(20):15541-8. doi: 10.1074/jbc.275.20.15541. J Biol Chem. 2000. PMID: 10809787 Free article.
Beta(2)-glycoprotein I (beta(2)GPI) is an abundant plasma phospholipid-binding protein and an autoantigen in the antiphospholipid antibody syndrome. Binding of beta(2)GPI to endothelial cells targets the …
Beta(2)-glycoprotein I (beta(2)GPI) is an abundant plasma phospholipid-binding protein and an autoantigen …
Annexin A2: biology and relevance to the antiphospholipid syndrome.
Cockrell E, Espinola RG, McCrae KR. Cockrell E, et al. Lupus. 2008 Oct;17(10):943-51. doi: 10.1177/0961203308095329. Lupus. 2008. PMID: 18827060 Free PMC article. Review.
We extended these observations by defining annexin A2 as an endothelial beta(2)GPI binding site. We also observed that annexin A2 plays a critical role in endothelial cell activation induced by anti-b …
We extended these observations by defining annexin A2 as an endothelial beta(2)GPI binding site. We also …
Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo.
Romay-Penabad Z, Montiel-Manzano MG, Shilagard T, Papalardo E, Vargas G, Deora AB, Wang M, Jacovina AT, Garcia-Latorre E, Reyes-Maldonado E, Hajjar KA, Pierangeli SS. Romay-Penabad Z, et al. Blood. 2009 Oct 1;114(14):3074-83. doi: 10.1182/blood-2008-11-188698. Epub 2009 Jul 23. Blood. 2009. PMID: 19628708 Free PMC article.
Antiphospholipid (aPL) antibodies recognize receptor-bound beta(2) glycoprotein I (beta(2)GPI) on target cells, and induce an intracellular signaling and a procoagulant/proinflammatory phenotype that leads to thrombosis. Evi …
Antiphospholipid (aPL) antibodies recognize receptor-bound beta(2) glycoprotein I (beta(2)G …
Toll-like receptor 4 and beta2 glycoprotein I interaction on endothelial cells.
Borghi MO, Raschi E, Grossi C, Chighizola CB, Meroni PL. Borghi MO, et al. Lupus. 2014 Oct;23(12):1302-4. doi: 10.1177/0961203314536479. Lupus. 2014. PMID: 25228733
In monocytes, platelets and endothelial cells (ECs), the interaction of circulating aPL with membrane-bound beta2GPI results in cell activation, and EC perturbation provides an important player in clotting. ...Conversely, our findings in ECs demonstrat …
In monocytes, platelets and endothelial cells (ECs), the interaction of circulating aPL with membrane-bound beta2GPI results i …
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