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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1972 1
1973 1
1974 2
1975 3
1976 3
1977 3
1978 1
1979 1
1980 4
1982 2
1983 2
1984 7
1985 5
1986 5
1987 3
1988 9
1989 6
1990 8
1991 11
1992 6
1993 12
1994 4
1995 3
1996 7
1997 3
1998 10
1999 3
2000 10
2001 8
2002 6
2003 11
2004 9
2005 3
2006 4
2007 8
2008 5
2009 8
2010 9
2011 4
2012 5
2013 3
2014 3
2015 4
2016 5
2017 6
2018 1
2019 2
2020 0
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227 results
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Antimycobacterial activity of 2-methyl-adenosine.
Barrow EW, Westbrook L, Bansal N, Suling WJ, Maddry JA, Parker WB, Barrow WW. Barrow EW, et al. J Antimicrob Chemother. 2003 Nov;52(5):801-8. doi: 10.1093/jac/dkg444. Epub 2003 Oct 16. J Antimicrob Chemother. 2003. PMID: 14563890
A hypoxic shift-down model was used to evaluate the effect of 2-methyl-adenosine on M. tuberculosis in a persistent state. Mechanism-of-action studies were conducted by examining the effect of 2-methyl-adenosine on the uptake of appropria …
A hypoxic shift-down model was used to evaluate the effect of 2-methyl-adenosine on M. tuberculosis in a persistent sta …
2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity.
Malnuit V, Slavětínská LP, Nauš P, Džubák P, Hajdúch M, Stolaříková J, Snášel J, Pichová I, Hocek M. Malnuit V, et al. ChemMedChem. 2015 Jun;10(6):1079-93. doi: 10.1002/cmdc.201500081. Epub 2015 Apr 16. ChemMedChem. 2015. PMID: 25882678
A series of 6-(hetero)aryl- or 6-methyl-7-deazapurine ribonucleosides bearing a substituent at position 2 (Cl, F, NH2, or CH3) were prepared by cross-coupling reactions at position 6 and functional group transformations at position 2. ...The antimycobacter
A series of 6-(hetero)aryl- or 6-methyl-7-deazapurine ribonucleosides bearing a substituent at position 2 (Cl, F, NH2, or CH3) …
K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling.
Katsnelson MA, Rucker LG, Russo HM, Dubyak GR. Katsnelson MA, et al. J Immunol. 2015 Apr 15;194(8):3937-52. doi: 10.4049/jimmunol.1402658. Epub 2015 Mar 11. J Immunol. 2015. PMID: 25762778 Free PMC article.
The study provides three major findings relevant to this unresolved area of NLRP3 regulation. First, increased cytosolic [Ca(2+)] was neither a necessary nor sufficient signal for the NLRP3 inflammasome cascade during activation by endogenous ATP-gated P2X7 receptor …
The study provides three major findings relevant to this unresolved area of NLRP3 regulation. First, increased cytosolic [Ca(2+)] was …
The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats.
Yildirim M, Marangoz AH, Ayyildiz M, Ankarali S, Marangoz C. Yildirim M, et al. Acta Neurobiol Exp (Wars). 2011;71(2):208-19. Acta Neurobiol Exp (Wars). 2011. PMID: 21731075 Free article.
In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. ...The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rat …
In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examin …
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Concas A, Santoro G, Mascia MP, Maciocco E, Dazzi L, Ongini E, Biggio G. Concas A, et al. J Pharmacol Exp Ther. 1993 Nov;267(2):844-51. J Pharmacol Exp Ther. 1993. PMID: 8246158
The possible relationship between A1 adenosine receptors and the gamma-aminobutyric acid (GABAA) receptor complex was evaluated in the mouse brain. ...CCPA (2.8-8.3 mumol/kg i.p.) antagonized the convulsions induced by pentylenetetrazol (398 mumol/kg i.p.), methy
The possible relationship between A1 adenosine receptors and the gamma-aminobutyric acid (GABAA) receptor complex was evaluated in th …
Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester.
Lee GY, Chang TS, Lee KS, Khil LY, Kim D, Chung JH, Kim YC, Lee BH, Moon CH, Moon CK. Lee GY, et al. Thromb Res. 2005;115(4):309-18. doi: 10.1016/j.thromres.2004.09.018. Epub 2004 Oct 27. Thromb Res. 2005. PMID: 15668191
Brazilin (7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6H)-tetrol), the major component of Caesalpinia sappan L., was reported to show antiplatelet activity through the inhibition of phospholipase A2 (PLA2) activity and the increase in intracellular free …
Brazilin (7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6H)-tetrol), the major component of Caesalpinia sappan L., was reported t …
Expression of Concentrative Nucleoside Transporters ( SLC28A) in the Human Placenta: Effects of Gestation Age and Prototype Differentiation-Affecting Agents.
Jiraskova L, Cerveny L, Karbanova S, Ptackova Z, Staud F. Jiraskova L, et al. Mol Pharm. 2018 Jul 2;15(7):2732-2741. doi: 10.1021/acs.molpharmaceut.8b00238. Epub 2018 May 25. Mol Pharm. 2018. PMID: 29782174
Moreover, we studied in choriocarcinoma-derived BeWo cells whether SLC29A and SLC28A mRNA levels can be modulated by activity of adenylyl cyclase, retinoic acid receptor activation, CpG islands methylation, or histone acetylation, using forskolin, all- trans- …
Moreover, we studied in choriocarcinoma-derived BeWo cells whether SLC29A and SLC28A mRNA levels can be modulated by activity of aden …
Structure-activity relationship for nucleoside analogs as inhibitors or substrates of adenosine kinase from Mycobacterium tuberculosis. I. Modifications to the adenine moiety.
Long MC, Parker WB. Long MC, et al. Biochem Pharmacol. 2006 Jun 14;71(12):1671-82. doi: 10.1016/j.bcp.2006.03.006. Epub 2006 Mar 10. Biochem Pharmacol. 2006. PMID: 16620788
Adenosine kinase (Ado kinase, EC 2.7.1.20) is a purine salvage enzyme that phosphorylates adenosine (Ado) to AMP. Ado kinase from Mycobacterium tuberculosis also catalyzes an essential step in the conversion of 2-methyl-Ado to a compound with se
Adenosine kinase (Ado kinase, EC 2.7.1.20) is a purine salvage enzyme that phosphorylates adenosine (Ado) to AMP. Ado k
Adenosine suppresses the response of neurons to gaba in the superficial laminae of the rat spinal dorsal horn.
Wu L, Li H, Li YQ. Wu L, et al. Neuroscience. 2003;119(1):145-54. doi: 10.1016/s0306-4522(03)00074-5. Neuroscience. 2003. PMID: 12763076
The results showed that: (1) GABA acted on GABA(A) receptor and elicited inward Cl(-) currents (I(GABA)) at a holding potential (V(H)) of -40 mV; (2) adenosine suppressed GABA-induced Cl(-) current with affecting neither the reversal potential of I(GABA) nor the app …
The results showed that: (1) GABA acted on GABA(A) receptor and elicited inward Cl(-) currents (I(GABA)) at a holding potential (V(H)) of -4 …
Purine metabolism in Mycobacterium tuberculosis as a target for drug development.
Parker WB, Long MC. Parker WB, et al. Curr Pharm Des. 2007;13(6):599-608. doi: 10.2174/138161207780162863. Curr Pharm Des. 2007. PMID: 17346177 Review.
We have identified several purine nucleoside analogs that exhibit selective activity against Mycobacterium tuberculosis. The lead compound in this series is 2-methyl-adenosine (methyl-Ado), which is active against proliferating and nonpro …
We have identified several purine nucleoside analogs that exhibit selective activity against Mycobacterium tuberculosis. The lead com …
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