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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1972 1
1973 1
1974 2
1975 3
1976 3
1977 3
1978 1
1979 1
1980 4
1982 2
1983 2
1984 7
1985 5
1986 5
1987 3
1988 9
1989 6
1990 8
1991 11
1992 6
1993 12
1994 4
1995 3
1996 8
1997 3
1998 10
1999 3
2000 10
2001 8
2002 6
2003 11
2004 9
2005 2
2006 3
2007 8
2008 5
2009 8
2010 9
2011 4
2012 5
2013 3
2014 3
2015 4
2016 5
2017 6
2018 1
2019 3
2020 4
2021 4
2022 5
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239 results
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Antimycobacterial activity of 2-methyl-adenosine.
Barrow EW, Westbrook L, Bansal N, Suling WJ, Maddry JA, Parker WB, Barrow WW. Barrow EW, et al. J Antimicrob Chemother. 2003 Nov;52(5):801-8. doi: 10.1093/jac/dkg444. Epub 2003 Oct 16. J Antimicrob Chemother. 2003. PMID: 14563890
A hypoxic shift-down model was used to evaluate the effect of 2-methyl-adenosine on M. tuberculosis in a persistent state. Mechanism-of-action studies were conducted by examining the effect of 2-methyl-adenosine on the uptake of appropria …
A hypoxic shift-down model was used to evaluate the effect of 2-methyl-adenosine on M. tuberculosis in a persistent sta …
A synthetic antibiotic class overcoming bacterial multidrug resistance.
Mitcheltree MJ, Pisipati A, Syroegin EA, Silvestre KJ, Klepacki D, Mason JD, Terwilliger DW, Testolin G, Pote AR, Wu KJY, Ladley RP, Chatman K, Mankin AS, Polikanov YS, Myers AG. Mitcheltree MJ, et al. Nature. 2021 Nov;599(7885):507-512. doi: 10.1038/s41586-021-04045-6. Epub 2021 Oct 27. Nature. 2021. PMID: 34707295 Free PMC article.
When properly designed, fully synthetic routes can easily address these shortcomings(2). Here we report the structure-guided design and component-based synthesis of a rigid oxepanoproline scaffold which, when linked to the aminooctose residue of clindamycin, produces an an …
When properly designed, fully synthetic routes can easily address these shortcomings(2). Here we report the structure-guided design a …
2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity.
Malnuit V, Slavětínská LP, Nauš P, Džubák P, Hajdúch M, Stolaříková J, Snášel J, Pichová I, Hocek M. Malnuit V, et al. ChemMedChem. 2015 Jun;10(6):1079-93. doi: 10.1002/cmdc.201500081. Epub 2015 Apr 16. ChemMedChem. 2015. PMID: 25882678
A series of 6-(hetero)aryl- or 6-methyl-7-deazapurine ribonucleosides bearing a substituent at position 2 (Cl, F, NH2, or CH3) were prepared by cross-coupling reactions at position 6 and functional group transformations at position 2. ...The antimycobacter
A series of 6-(hetero)aryl- or 6-methyl-7-deazapurine ribonucleosides bearing a substituent at position 2 (Cl, F, NH2, or CH3) …
The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats.
Yildirim M, Marangoz AH, Ayyildiz M, Ankarali S, Marangoz C. Yildirim M, et al. Acta Neurobiol Exp (Wars). 2011;71(2):208-19. Acta Neurobiol Exp (Wars). 2011. PMID: 21731075 Free article.
In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. ...The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rat …
In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examin …
Structural basis of O-methylation of (2-heptyl-)1-hydroxyquinolin-4(1H)-one and related compounds by the heterocyclic toxin methyltransferase Rv0560c of Mycobacterium tuberculosis.
Sartor P, Denkhaus L, Gerhardt S, Einsle O, Fetzner S. Sartor P, et al. J Struct Biol. 2021 Dec;213(4):107794. doi: 10.1016/j.jsb.2021.107794. Epub 2021 Sep 21. J Struct Biol. 2021. PMID: 34506908
Structural and biochemical data suggest that H139 and T136 are key active site residues, with H139 acting as general base that activates the methyl-accepting hydroxy group. Our structural data may contribute to the design of Htm inhibitors or of antimycoba
Structural and biochemical data suggest that H139 and T136 are key active site residues, with H139 acting as general base that act
Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester.
Lee GY, Chang TS, Lee KS, Khil LY, Kim D, Chung JH, Kim YC, Lee BH, Moon CH, Moon CK. Lee GY, et al. Thromb Res. 2005;115(4):309-18. doi: 10.1016/j.thromres.2004.09.018. Epub 2004 Oct 27. Thromb Res. 2005. PMID: 15668191
Brazilin (7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6H)-tetrol), the major component of Caesalpinia sappan L., was reported to show antiplatelet activity through the inhibition of phospholipase A2 (PLA2) activity and the increase in intracellular free …
Brazilin (7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6H)-tetrol), the major component of Caesalpinia sappan L., was reported t …
Purine metabolism in Mycobacterium tuberculosis as a target for drug development.
Parker WB, Long MC. Parker WB, et al. Curr Pharm Des. 2007;13(6):599-608. doi: 10.2174/138161207780162863. Curr Pharm Des. 2007. PMID: 17346177 Review.
We have identified several purine nucleoside analogs that exhibit selective activity against Mycobacterium tuberculosis. The lead compound in this series is 2-methyl-adenosine (methyl-Ado), which is active against proliferating and nonpro …
We have identified several purine nucleoside analogs that exhibit selective activity against Mycobacterium tuberculosis. The lead com …
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Concas A, Santoro G, Mascia MP, Maciocco E, Dazzi L, Ongini E, Biggio G. Concas A, et al. J Pharmacol Exp Ther. 1993 Nov;267(2):844-51. J Pharmacol Exp Ther. 1993. PMID: 8246158
The possible relationship between A1 adenosine receptors and the gamma-aminobutyric acid (GABAA) receptor complex was evaluated in the mouse brain. ...CCPA (2.8-8.3 mumol/kg i.p.) antagonized the convulsions induced by pentylenetetrazol (398 mumol/kg i.p.), methy
The possible relationship between A1 adenosine receptors and the gamma-aminobutyric acid (GABAA) receptor complex was evaluated in th …
Antibacterial and ATP Synthesis Modulating Compounds from Salvia tingitana.
Bisio A, Schito AM, Pedrelli F, Danton O, Reinhardt JK, Poli G, Tuccinardi T, Bürgi T, De Riccardis F, Giacomini M, Calzia D, Panfoli I, Schito GC, Hamburger M, De Tommasi N. Bisio A, et al. J Nat Prod. 2020 Apr 24;83(4):1027-1042. doi: 10.1021/acs.jnatprod.9b01024. Epub 2020 Mar 17. J Nat Prod. 2020. PMID: 32182064 Free PMC article.
The structures of the new compounds were established by 1D and 2D NMR spectroscopy, HRESIMS, and VCD data and Mosher's esters analysis. The antimicrobial activity of compounds was evaluated against 30 human pathogens including 27 clinical strains and three isolates …
The structures of the new compounds were established by 1D and 2D NMR spectroscopy, HRESIMS, and VCD data and Mosher's esters analysi …
Structure-activity relationship for nucleoside analogs as inhibitors or substrates of adenosine kinase from Mycobacterium tuberculosis. I. Modifications to the adenine moiety.
Long MC, Parker WB. Long MC, et al. Biochem Pharmacol. 2006 Jun 14;71(12):1671-82. doi: 10.1016/j.bcp.2006.03.006. Epub 2006 Mar 10. Biochem Pharmacol. 2006. PMID: 16620788
Adenosine kinase (Ado kinase, EC 2.7.1.20) is a purine salvage enzyme that phosphorylates adenosine (Ado) to AMP. Ado kinase from Mycobacterium tuberculosis also catalyzes an essential step in the conversion of 2-methyl-Ado to a compound with se
Adenosine kinase (Ado kinase, EC 2.7.1.20) is a purine salvage enzyme that phosphorylates adenosine (Ado) to AMP. Ado k
239 results