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Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.
Radomska HS, Bassères DS, Zheng R, Zhang P, Dayaram T, Yamamoto Y, Sternberg DW, Lokker N, Giese NA, Bohlander SK, Schnittger S, Delmotte MH, Davis RJ, Small D, Hiddemann W, Gilliland DG, Tenen DG. Radomska HS, et al. J Exp Med. 2006 Feb 20;203(2):371-81. doi: 10.1084/jem.20052242. Epub 2006 Jan 30. J Exp Med. 2006. PMID: 16446383 Free PMC article.
Mutations constitutively activating FLT3 kinase are detected in approximately 30% of acute myelogenous leukemia (AML) patients and affect downstream pathways such as extracellular signal-regulated kinase (ERK)1/2. We found that activation …
Mutations constitutively activating FLT3 kinase are detected in approximately 30% of acute myelogenous leukem …
Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPalpha.
Radomska HS, Alberich-Jordà M, Will B, Gonzalez D, Delwel R, Tenen DG. Radomska HS, et al. J Clin Invest. 2012 Aug;122(8):2955-66. doi: 10.1172/JCI43354. Epub 2012 Jul 17. J Clin Invest. 2012. PMID: 22797303 Free PMC article.
Mutations that activate the fms-like tyrosine kinase 3 (FLT3) receptor are among the most prevalent mutations in acute myeloid leukemias. ...Importantly, we found that inhibition of CDK1 activity relieves the differentiation blo …
Mutations that activate the fms-like tyrosine kinase 3 (FLT3) receptor are among the most prevalent mutations in …
RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation.
Schwäble J, Choudhary C, Thiede C, Tickenbrock L, Sargin B, Steur C, Rehage M, Rudat A, Brandts C, Berdel WE, Müller-Tidow C, Serve H. Schwäble J, et al. Blood. 2005 Mar 1;105(5):2107-14. doi: 10.1182/blood-2004-03-0940. Epub 2004 Nov 9. Blood. 2005. PMID: 15536149 Free article.
Activating fetal liver tyrosine kinase 3 (Flt3) mutations represent the most common genetic aberrations in acute myeloid leukemia (AML). ...In addition, RGS2 reinduced the expression of Flt3-ITD-repressed CCAAT/enhancer …
Activating fetal liver tyrosine kinase 3 (Flt3) mutations represent the most common genetic aberrations in acute …
Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPalpha expression.
Zheng R, Friedman AD, Levis M, Li L, Weir EG, Small D. Zheng R, et al. Blood. 2004 Mar 1;103(5):1883-90. doi: 10.1182/blood-2003-06-1978. Epub 2003 Oct 30. Blood. 2004. PMID: 14592841 Free article.
Constitutively activating mutations of FMS-like tyrosine kinase 3 (FLT3) occur in approximately one third of patients with acute myeloid leukemia (AML) and are associated with poor prognosis. ...In this report we investigated the mechanis …
Constitutively activating mutations of FMS-like tyrosine kinase 3 (FLT3) occur in approximately one third of patients w …