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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1983 5
1984 7
1985 12
1986 15
1987 13
1988 16
1989 14
1990 25
1991 17
1992 18
1993 24
1994 11
1995 15
1996 12
1997 14
1998 19
1999 12
2000 10
2001 12
2002 11
2003 12
2004 17
2005 19
2006 19
2007 12
2008 17
2009 10
2010 6
2011 8
2012 8
2013 5
2014 5
2015 7
2016 7
2017 5
2018 4
2019 4
2020 6
2021 2
2022 0
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434 results
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N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E(2) to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.
Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR. Karuppagounder SS, et al. Ann Neurol. 2018 Dec;84(6):854-872. doi: 10.1002/ana.25356. Epub 2018 Nov 29. Ann Neurol. 2018. PMID: 30294906 Free PMC article.
Striatal infusion of collagenase was used to model intracerebral hemorrhage (ICH) in mice and rats. Chemical biology, targeted lipidomics, arachidonate 5-lipoxygenase (ALOX5) knockout mice, and viral-gene transfer were used to gain insight into the pharmacolo …
Striatal infusion of collagenase was used to model intracerebral hemorrhage (ICH) in mice and rats. Chemical biology, targeted lipidomics, …
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid.
Bürkert E, Szellas D, Rådmark O, Steinhilber D, Werz O. Bürkert E, et al. J Leukoc Biol. 2003 Jan;73(1):191-200. doi: 10.1189/jlb.0702354. J Leukoc Biol. 2003. PMID: 12525578
We show that stimulation of polymorphonuclear leukocytes (PMNL), rat basophilic leukemia (RBL)-1, or transfected HeLa cells with arachidonic acid (AA) caused prominent 5-LO product formation that coincided with the activity of extracellular sign …
We show that stimulation of polymorphonuclear leukocytes (PMNL), rat basophilic leukemia (RBL)-1, or transfected HeLa cells with a
Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation.
Lim HJ, Park J, Um JY, Lee SS, Kwak HJ. Lim HJ, et al. Cells. 2019 Sep 30;8(10):1182. doi: 10.3390/cells8101182. Cells. 2019. PMID: 31575085 Free PMC article.
The arachidonic acid metabolism through 5-lipoxygenase (5-LO) pathways is involved in modulating both tumorigenesis and angiogenesis. Although anti-carcinogenic activities of certain 5-LO inhibitors have been reported, the role of …
The arachidonic acid metabolism through 5-lipoxygenase (5-LO) pathways is involved in modulating both tum …
The role of the LTB4-BLT1 axis in health and disease.
He R, Chen Y, Cai Q. He R, et al. Pharmacol Res. 2020 Aug;158:104857. doi: 10.1016/j.phrs.2020.104857. Epub 2020 May 18. Pharmacol Res. 2020. PMID: 32439596 Review.
Leukotriene B4 (LTB4) is a major type of lipid mediator that is rapidly generated from arachidonic acid through sequential action of 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTA4 hydrolase ( …
Leukotriene B4 (LTB4) is a major type of lipid mediator that is rapidly generated from arachidonic acid through sequent …
Edaravone, a free radical scavenger, protects neuronal cells' mitochondria from ischemia by inactivating another new critical factor of the 5-lipoxygenase pathway affecting the arachidonic acid metabolism.
Song Y, Bei Y, Xiao Y, Tong HD, Wu XQ, Chen MT. Song Y, et al. Brain Res. 2018 Jul 1;1690:96-104. doi: 10.1016/j.brainres.2018.03.006. Epub 2018 Mar 15. Brain Res. 2018. PMID: 29551652
To investigate the neuroprotective effect of edaravone was dependent on 5-lipoxygenase (5-LOX) signalling pathway or not. Middle cerebral artery occlusion (MCAO) and oxygen glucose deprivation (OGD) were established in SD rats and PC12 cells to …
To investigate the neuroprotective effect of edaravone was dependent on 5-lipoxygenase (5-LOX) signalling pathwa …
5-lipoxygenase-dependent biosynthesis of novel 20:4 n-3 metabolites with anti-inflammatory activity.
Gagnon KJ, Lefort N, Poirier SJ, Barnett DA, Surette ME. Gagnon KJ, et al. Prostaglandins Leukot Essent Fatty Acids. 2018 Nov;138:38-44. doi: 10.1016/j.plefa.2018.10.005. Epub 2018 Oct 16. Prostaglandins Leukot Essent Fatty Acids. 2018. PMID: 30392579
5-lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into pro-inflammatory leukotrienes. ...However, no 5-LO metabolites of 20:4 n-3 have been reported. In this study, control and 5-LO-expressing HEK293 cells
5-lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into pro-inflammatory leukotriene
Targeting the OXE receptor as a potential novel therapy for asthma.
Powell WS, Rokach J. Powell WS, et al. Biochem Pharmacol. 2020 Sep;179:113930. doi: 10.1016/j.bcp.2020.113930. Epub 2020 Mar 30. Biochem Pharmacol. 2020. PMID: 32240653 Review.
5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is an arachidonic acid metabolite formed by oxidation of the 5-lipoxygenase (5-LO) product 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5S-HETE) by the NADP(+)-depen
5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is an arachidonic acid metabolite formed by oxidation o
Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils.
Flamand N, Lefebvre J, Surette ME, Picard S, Borgeat P. Flamand N, et al. J Biol Chem. 2006 Jan 6;281(1):129-36. doi: 10.1074/jbc.M506513200. Epub 2005 Nov 7. J Biol Chem. 2006. PMID: 16275640 Free article.
Elevation of the intracellular cAMP concentration in agonist-activated human neutrophils (PMN) leads to the concomitant inhibitions of arachidonic acid (AA) release, 5-lipoxygenase (5-LO) translocation, and leukotriene (LT) biosynthesis. …
Elevation of the intracellular cAMP concentration in agonist-activated human neutrophils (PMN) leads to the concomitant inhibitions o …
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes.
Werz O, Bürkert E, Samuelsson B, Rådmark O, Steinhilber D. Werz O, et al. Blood. 2002 Feb 1;99(3):1044-52. doi: 10.1182/blood.v99.3.1044. Blood. 2002. PMID: 11807011 Free article.
In parallel, cell stress led to activation of p38 MAPK (mitogen-activated protein kinase) and mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) kinases, which can phosphorylate 5-LO in vitro. ...These data show that …
In parallel, cell stress led to activation of p38 MAPK (mitogen-activated protein kinase) and mitogen-activated
Blockade of cytosolic phospholipase A(2) and 5-lipoxygenase activation in neutrophils by a natural isoflavanquinone abruquinone A.
Hsu MF, Chang LC, Chen SC, Kuo SC, Lee HY, Lu MC, Wang JP. Hsu MF, et al. Eur J Pharmacol. 2008 Nov 19;598(1-3):123-31. doi: 10.1016/j.ejphar.2008.09.007. Epub 2008 Sep 22. Eur J Pharmacol. 2008. PMID: 18834875
Abruquinone A, a natural isoflavanquinone, suppressed A23187- and formyl-Met-Leu-Phe (fMLP)-induced production of thromboxane B(2) and leukotriene B(4) from rat neutrophils. This compound failed to inhibit the enzymatic activity of ram seminal vesicles cyclooxygenase (COX) …
Abruquinone A, a natural isoflavanquinone, suppressed A23187- and formyl-Met-Leu-Phe (fMLP)-induced production of thromboxane B(2) and leuko …
434 results