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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1983 5
1984 7
1985 12
1986 15
1987 13
1988 16
1989 14
1990 25
1991 17
1992 18
1993 24
1994 11
1995 15
1996 12
1997 14
1998 19
1999 12
2000 10
2001 12
2002 11
2003 12
2004 17
2005 19
2006 19
2007 12
2008 17
2009 10
2010 6
2011 8
2012 8
2013 5
2014 5
2015 7
2016 7
2017 5
2018 4
2019 4
2020 4
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431 results
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5-lipoxygenase-dependent biosynthesis of novel 20:4 n-3 metabolites with anti-inflammatory activity.
Gagnon KJ, Lefort N, Poirier SJ, Barnett DA, Surette ME. Gagnon KJ, et al. Prostaglandins Leukot Essent Fatty Acids. 2018 Nov;138:38-44. doi: 10.1016/j.plefa.2018.10.005. Epub 2018 Oct 16. Prostaglandins Leukot Essent Fatty Acids. 2018. PMID: 30392579
5-lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into pro-inflammatory leukotrienes. N-3 PUFA like eicosapentaenoic acid are subject to a similar metabolism and are precursors of pro-resolving mediators. ...In this
5-lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into pro-inflammatory leukotriene
N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E(2) to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.
Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR. Karuppagounder SS, et al. Ann Neurol. 2018 Dec;84(6):854-872. doi: 10.1002/ana.25356. Epub 2018 Nov 29. Ann Neurol. 2018. PMID: 30294906 Free PMC article.
Chemical biology, targeted lipidomics, arachidonate 5-lipoxygenase (ALOX5) knockout mice, and viral-gene transfer were used to gain insight into the pharmacological targets and mechanism of action of NAC. RESULTS: NAC prevented hemin-induced ferroptosis by ne …
Chemical biology, targeted lipidomics, arachidonate 5-lipoxygenase (ALOX5) knockout mice, and viral-gene transfer were …
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid.
Bürkert E, Szellas D, Rådmark O, Steinhilber D, Werz O. Bürkert E, et al. J Leukoc Biol. 2003 Jan;73(1):191-200. doi: 10.1189/jlb.0702354. J Leukoc Biol. 2003. PMID: 12525578
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. We show that stimulation of polymorphonuclear leukocytes (PMNL), rat basophilic leukemia (RBL)-1, or transfected HeLa cells with arachidonic acid
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. We show that stimulation o
Edaravone, a free radical scavenger, protects neuronal cells' mitochondria from ischemia by inactivating another new critical factor of the 5-lipoxygenase pathway affecting the arachidonic acid metabolism.
Song Y, Bei Y, Xiao Y, Tong HD, Wu XQ, Chen MT. Song Y, et al. Brain Res. 2018 Jul 1;1690:96-104. doi: 10.1016/j.brainres.2018.03.006. Epub 2018 Mar 15. Brain Res. 2018. PMID: 29551652
To investigate the neuroprotective effect of edaravone was dependent on 5-lipoxygenase (5-LOX) signalling pathway or not. Middle cerebral artery occlusion (MCAO) and oxygen glucose deprivation (OGD) were established in SD rats and PC12 cells to …
To investigate the neuroprotective effect of edaravone was dependent on 5-lipoxygenase (5-LOX) signalling pathwa …
Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation.
Lim HJ, Park J, Um JY, Lee SS, Kwak HJ. Lim HJ, et al. Cells. 2019 Sep 30;8(10):1182. doi: 10.3390/cells8101182. Cells. 2019. PMID: 31575085 Free PMC article.
The arachidonic acid metabolism through 5-lipoxygenase (5-LO) pathways is involved in modulating both tumorigenesis and angiogenesis. Although anti-carcinogenic activities of certain 5-LO inhibitors have been reported, the role of …
The arachidonic acid metabolism through 5-lipoxygenase (5-LO) pathways is involved in modulating both tum …
Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E(2) and D(2) by activated human leukocytes.
Giménez-Bastida JA, Shibata T, Uchida K, Schneider C. Giménez-Bastida JA, et al. FASEB J. 2017 May;31(5):1867-1878. doi: 10.1096/fj.201601136R. Epub 2017 Jan 17. FASEB J. 2017. PMID: 28096231 Free PMC article.
HKs result from the rearrangement of a di-endoperoxide intermediate formed in the COX-2-dependent oxygenation of 5S-hydroxyeicosatetraenoic acid (5S-HETE). ...Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E(2) and D(2) …
HKs result from the rearrangement of a di-endoperoxide intermediate formed in the COX-2-dependent oxygenation of 5S-hydroxyeicosatetr …
Metabolic profiling of human plasma reveals the activation of 5-lipoxygenase in the acute attack of gouty arthritis.
Luo Y, Wang L, Peng A, Liu JY. Luo Y, et al. Rheumatology (Oxford). 2019 Feb 1;58(2):345-351. doi: 10.1093/rheumatology/key284. Rheumatology (Oxford). 2019. PMID: 30247644
This was supported by significantly increased transcriptional levels of 5-lipoxygenase and CYP4F3 in whole blood cells from AG patients compared with those of controls, and the uric acid-caused dose-relevant and time-dependent activation
This was supported by significantly increased transcriptional levels of 5-lipoxygenase and CYP4F3 in whole blood cells
Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway.
Penzo D, Petronilli V, Angelin A, Cusan C, Colonna R, Scorrano L, Pagano F, Prato M, Di Lisa F, Bernardi P. Penzo D, et al. J Biol Chem. 2004 Jun 11;279(24):25219-25. doi: 10.1074/jbc.M310381200. Epub 2004 Apr 7. J Biol Chem. 2004. PMID: 15070903 Free article.
The number of cells killed by A23187 was doubled by treatment with 0.5 microm MK886 and 5 microm indomethacin, which inhibit arachidonic acid metabolism through the 5-lipoxygenase and cyclooxygenase pathway, respectively. ...These …
The number of cells killed by A23187 was doubled by treatment with 0.5 microm MK886 and 5 microm indomethacin, which in …
Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils.
Flamand N, Lefebvre J, Surette ME, Picard S, Borgeat P. Flamand N, et al. J Biol Chem. 2006 Jan 6;281(1):129-36. doi: 10.1074/jbc.M506513200. Epub 2005 Nov 7. J Biol Chem. 2006. PMID: 16275640 Free article.
Elevation of the intracellular cAMP concentration in agonist-activated human neutrophils (PMN) leads to the concomitant inhibitions of arachidonic acid (AA) release, 5-lipoxygenase (5-LO) translocation, and leukotriene (LT) biosynthesis. …
Elevation of the intracellular cAMP concentration in agonist-activated human neutrophils (PMN) leads to the concomitant inhibitions o …
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes.
Werz O, Bürkert E, Samuelsson B, Rådmark O, Steinhilber D. Werz O, et al. Blood. 2002 Feb 1;99(3):1044-52. doi: 10.1182/blood.v99.3.1044. Blood. 2002. PMID: 11807011
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. This study showed that various forms of cell stress, such as chemical stress (sodium arsenite), osmotic stress, or heat shock lead to substantial formation of
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. This study showed that var
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