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454 results

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Page 1
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid.
Bürkert E, Szellas D, Rådmark O, Steinhilber D, Werz O. Bürkert E, et al. J Leukoc Biol. 2003 Jan;73(1):191-200. doi: 10.1189/jlb.0702354. J Leukoc Biol. 2003. PMID: 12525578
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. We show that stimulation of polymorphonuclear leukocytes (PMNL), rat basophilic leukemia (RBL)-1, or transfected HeLa cells with arachidonic acid …
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. We show that stimulation o …
Oncogenic PIK3CA recruits myeloid-derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5-lipoxygenase-dependent arachidonic acid pathway.
Li X, Chen G, Wang F, Guo X, Zhang R, Liu P, Dong L, Yu W, Wang H, Wang H, Yu J. Li X, et al. Clin Transl Med. 2023 Nov;13(11):e1483. doi: 10.1002/ctm2.1483. Clin Transl Med. 2023. PMID: 37965796 Free PMC article.
RESULTS: PIK3CA(mut) LBC cells can induce an immunosuppressive TIME by recruiting myeloid-derived suppressor cells (MDSCs) and excluding cytotoxic T cells via the arachidonic acid (AA) metabolism pathway. Mechanistically, PIK3CA(mut) activate …
RESULTS: PIK3CA(mut) LBC cells can induce an immunosuppressive TIME by recruiting myeloid-derived suppressor cells (MDSCs) and …
Complement-mediated arachidonate metabolism.
Clancy RM, Dahinden CA, Hugli TE. Clancy RM, et al. Prog Biochem Pharmacol. 1985;20:120-31. Prog Biochem Pharmacol. 1985. PMID: 2986155 Review.
Each cell type produces different quantities and types of leukotrienes in response to ionophore (A23187) activation. A common feature shared by each of these cells is control of arachidonic acid metabolism at the level of the 5- …
Each cell type produces different quantities and types of leukotrienes in response to ionophore (A23187) activation. A …
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes.
Werz O, Bürkert E, Samuelsson B, Rådmark O, Steinhilber D. Werz O, et al. Blood. 2002 Feb 1;99(3):1044-52. doi: 10.1182/blood.v99.3.1044. Blood. 2002. PMID: 11807011 Free article.
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. ...In parallel, cell stress led to activation of p38 MAPK (mitogen-activated protein kinase) and mitogen-activated protein kinase-activ …
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. ...In parallel, cell …
5-lipoxygenase-dependent biosynthesis of novel 20:4 n-3 metabolites with anti-inflammatory activity.
Gagnon KJ, Lefort N, Poirier SJ, Barnett DA, Surette ME. Gagnon KJ, et al. Prostaglandins Leukot Essent Fatty Acids. 2018 Nov;138:38-44. doi: 10.1016/j.plefa.2018.10.005. Epub 2018 Oct 16. Prostaglandins Leukot Essent Fatty Acids. 2018. PMID: 30392579
5-lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into pro-inflammatory leukotrienes. ...Stearidonic acid (18:4 n-3, SDA) is a plant source of n-3 PUFA that is elongated to 20:4 n-3, an analogue of AA. ...
5-lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into pro-inflammatory leukotriene …
The role of the LTB4-BLT1 axis in health and disease.
He R, Chen Y, Cai Q. He R, et al. Pharmacol Res. 2020 Aug;158:104857. doi: 10.1016/j.phrs.2020.104857. Epub 2020 May 18. Pharmacol Res. 2020. PMID: 32439596 Review.
Leukotriene B4 (LTB4) is a major type of lipid mediator that is rapidly generated from arachidonic acid through sequential action of 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTA4 hydrolase ( …
Leukotriene B4 (LTB4) is a major type of lipid mediator that is rapidly generated from arachidonic acid through sequent …
5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation.
Catalano A, Rodilossi S, Caprari P, Coppola V, Procopio A. Catalano A, et al. EMBO J. 2005 Jan 12;24(1):170-9. doi: 10.1038/sj.emboj.7600502. Epub 2004 Dec 16. EMBO J. 2005. PMID: 15616590 Free PMC article.
5-Lipoxygenase (5LO) is involved in the production of leukotrienes and reactive oxygen species (ROS) from arachidonic acid. Its strong activation has been associated with several diseases like cancer and neurodegeneration. Here we show that 5LO …
5-Lipoxygenase (5LO) is involved in the production of leukotrienes and reactive oxygen species (ROS) from arachidonic …
Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils.
Flamand N, Lefebvre J, Surette ME, Picard S, Borgeat P. Flamand N, et al. J Biol Chem. 2006 Jan 6;281(1):129-36. doi: 10.1074/jbc.M506513200. Epub 2005 Nov 7. J Biol Chem. 2006. PMID: 16275640 Free article.
Elevation of the intracellular cAMP concentration in agonist-activated human neutrophils (PMN) leads to the concomitant inhibitions of arachidonic acid (AA) release, 5-lipoxygenase (5-LO) translocation, and leukotriene (LT) biosynthesis. …
Elevation of the intracellular cAMP concentration in agonist-activated human neutrophils (PMN) leads to the concomitant inhibitions o …
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).
Werz O, Szellas D, Steinhilber D, Rådmark O. Werz O, et al. J Biol Chem. 2002 Apr 26;277(17):14793-800. doi: 10.1074/jbc.M111945200. Epub 2002 Feb 13. J Biol Chem. 2002. PMID: 11844797 Free article.
HeLa cells expressing wild type 5-LO or S271A-5-LO, showed prominent 5-LO activity when incubated with Ca(2+)-ionophore plus arachidonate. However, when stimulated with only exogenous arachidonic acid, activity for the S271A mutant …
HeLa cells expressing wild type 5-LO or S271A-5-LO, showed prominent 5-LO activity when incubated with Ca(2+)-ionophore …
Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD).
Kim HY, Kang YJ, Kim DH, Jang J, Lee SJ, Kim G, Koh HB, Ko YE, Shin HM, Lee H, Yoo TH, Lee WW. Kim HY, et al. Elife. 2024 Jul 9;12:RP87316. doi: 10.7554/eLife.87316. Elife. 2024. PMID: 38980302 Free PMC article.
Mechanistically, the aryl hydrocarbon receptor (AhR) contributes to IS-trained immunity by enhancing the expression of arachidonic acid (AA) metabolism-related genes such as arachidonate 5-lipoxygenase (ALOX5) and ALOX5 activating protein …
Mechanistically, the aryl hydrocarbon receptor (AhR) contributes to IS-trained immunity by enhancing the expression of arachidonic …
454 results