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Chronic myelomonocytic leukemia as a transformation from polycythemia vera.
Andrei M, Pandey A, Avezbakiyev B, Wang JC. Andrei M, et al. Leuk Res Rep. 2019 Mar 14;11:14-16. doi: 10.1016/j.lrr.2019.03.004. eCollection 2019. Leuk Res Rep. 2019. PMID: 30949429 Free PMC article.
The hallmark of Polycythemia vera (PV) is the presence of JAK2(V617F) mutation and increased RBC mass. Chronic myelomonocytic leukemia (CMML) is defined as persistent blood absolute monocyte count (AMC) >/= 1 10(9)/L for at least 3 months wit …
The hallmark of Polycythemia vera (PV) is the presence of JAK2(V617F) mutation and increased RBC mass. Chronic myelo
Comparison and Implications of Mutational Profiles of Myelodysplastic Syndromes, Myeloproliferative Neoplasms, and Myelodysplastic/Myeloproliferative Neoplasms: A Meta-Analysis.
Wan Z, Han B. Wan Z, et al. Front Oncol. 2020 Oct 7;10:579221. doi: 10.3389/fonc.2020.579221. eCollection 2020. Front Oncol. 2020. PMID: 33117717 Free PMC article.
Chronic myelomonocytic leukemia and atypical chronic myeloid leukemia were similar entities but showed several mutational differences. A heat map demonstrated that juvenile myelomonocytic leukemia and MDS/MPN with ring sideroblasts
Chronic myelomonocytic leukemia and atypical chronic myeloid leukemia were similar entities but showed se
Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1.
Tefferi A. Tefferi A. Leukemia. 2010 Jun;24(6):1128-38. doi: 10.1038/leu.2010.69. Epub 2010 Apr 29. Leukemia. 2010. PMID: 20428194 Free PMC article. Review.
JAK2 and MPL mutations appear to exert a phenotype-modifying effect and are distinctly associated with polycythemia vera, essential thrombocythemia and primary myelofibrosis; the corresponding mutational frequencies are approximately 99, 55 and 65% for JAK2 and 0, 3 …
JAK2 and MPL mutations appear to exert a phenotype-modifying effect and are distinctly associated with polycythemia vera, esse …
Chronic myelomonocytic leukemia transformation in polycythemia vera.
Holcombe RF, Treseler PA, Rosenthal DS. Holcombe RF, et al. Leukemia. 1991 Jul;5(7):606-10. Leukemia. 1991. PMID: 2072746
Myelodysplasia is an increasingly recognized complication of polycythemia vera (PCV) which often precedes leukemic transformation. This paper describes two patients with aggressive chronic myelomonocytic leukemia, previously undescribed a …
Myelodysplasia is an increasingly recognized complication of polycythemia vera (PCV) which often precedes leukemic transfor
Hematopoietic cell transplantation for chronic myeloproliferative disorders.
Tse W, Deeg HJ. Tse W, et al. Arch Immunol Ther Exp (Warsz). 2006 Nov-Dec;54(6):375-80. doi: 10.1007/s00005-006-0044-9. Epub 2006 Nov 21. Arch Immunol Ther Exp (Warsz). 2006. PMID: 17122883 Review.
Myeloproliferative disorders, including chronic idiopathic myelofibrosis (CIMF), polycythemia vera (PV), essential thrombocythemia (ET), and chronic myelomonocytic leukemia (CMML), are clonal diseases of hematopoietic stem or precursor ce …
Myeloproliferative disorders, including chronic idiopathic myelofibrosis (CIMF), polycythemia vera (PV), essential thro …
The role of Janus Kinase 2 V617F mutation in extramedullary hematopoiesis of the spleen in neoplastic myeloid disorders.
Hsieh PP, Olsen RJ, O'Malley DP, Konoplev SN, Hussong JW, Dunphy CH, Perkins SL, Cheng L, Lin P, Chang CC. Hsieh PP, et al. Mod Pathol. 2007 Sep;20(9):929-35. doi: 10.1038/modpathol.3800826. Epub 2007 Jul 20. Mod Pathol. 2007. PMID: 17643100
Extramedullary hematopoiesis (EMH) in the spleen is a characteristic feature of the chronic myeloproliferative disorders (CMPDs) and various other neoplastic or reactive myeloid conditions. ...JAK2(V617F) was detected by real-time PCR melting curve analysis in 22 specimens …
Extramedullary hematopoiesis (EMH) in the spleen is a characteristic feature of the chronic myeloproliferative disorders (CMPDs) and …
Clinical significance of Y chromosome loss in hematologic disease.
Wiktor A, Rybicki BA, Piao ZS, Shurafa M, Barthel B, Maeda K, Van Dyke DL. Wiktor A, et al. Genes Chromosomes Cancer. 2000 Jan;27(1):11-6. Genes Chromosomes Cancer. 2000. PMID: 10564581
The patients comprised a control group with no evidence of hematologic disease and four disease case groups: 1) myelodysplastic syndrome (MDS), refractory anemia, refractory anemia with excess blasts (RAEB), RAEB in transformation, and chronic myelomonocytic
The patients comprised a control group with no evidence of hematologic disease and four disease case groups: 1) myelodysplastic syndrome (MD …
Genomic aberrations of myeloproliferative and myelodysplastic/myeloproliferative neoplasms in chronic phase and during disease progression.
Hahm C, Huh HJ, Mun YC, Seong CM, Chung WS, Huh J. Hahm C, et al. Int J Lab Hematol. 2015 Apr;37(2):181-9. doi: 10.1111/ijlh.12257. Epub 2014 May 21. Int J Lab Hematol. 2015. PMID: 24845343
INTRODUCTION: Myeloproliferative neoplasms (MPN) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) may transform into secondary myelofibrosis (MF) or evolve into acute myeloid leukemia (AML). ...METHODS: The study group included 13 MPN and four MDS/MPN pati …
INTRODUCTION: Myeloproliferative neoplasms (MPN) and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) may transform into second …
Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes.
Wulfert M, Küpper AC, Tapprich C, Bottomley SS, Bowen D, Germing U, Haas R, Gattermann N. Wulfert M, et al. Exp Hematol. 2008 May;36(5):577-86. doi: 10.1016/j.exphem.2008.01.004. Exp Hematol. 2008. PMID: 18439489
MATERIALS AND METHODS: Analysis included 104 patients with MDS (24 refractory anemia, 32 refractory anemia with ringed sideroblasts, 34 refractory anemia with excess of blasts, 7 refractory anemia with excess of blasts in transformation to acute leukemia, and 7 c
MATERIALS AND METHODS: Analysis included 104 patients with MDS (24 refractory anemia, 32 refractory anemia with ringed sideroblasts, 34 refr …
Extra translocation +der(1q9p) is a prognostic indicator in myeloproliferative disorders.
Rege-Cambrin G, Speleman F, Kerim S, Scaravaglio P, Carozzi F, Dal Cin P, Michaux JL, Offner F, Saglio G, Van den Berghe H. Rege-Cambrin G, et al. Leukemia. 1991 Dec;5(12):1059-63. Leukemia. 1991. PMID: 1774954 Review.
An identical extra derivative chromosome resulting from a translocation between the long arm of chromosome 1 and the short arm of chromosome 9, +der(1q9p), has been observed in three patients with a myeloproliferative disorder. Two patients had polycythemia vera in …
An identical extra derivative chromosome resulting from a translocation between the long arm of chromosome 1 and the short arm of chromosome …
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