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Your search for Co culture Systems of Drug Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study retrieved no results
Co-culture Systems of Drug-Treated Acute Myeloid Leukemia Cells and T Cells for In Vitro and In Vivo Study.
Li Y, Su R, Chen J. Li Y, et al. STAR Protoc. 2020 Sep 18;1(2):100097. doi: 10.1016/j.xpro.2020.100097. Epub 2020 Aug 28. STAR Protoc. 2020. PMID: 32995754 Free PMC article.
A combination of immunotherapy and chemotherapy strategies could strengthen antitumor effects. This protocol elucidates a robust method via co-culturing drug pre-treated acute myeloid leukemia cells with CD3(+) T cells, deri …
A combination of immunotherapy and chemotherapy strategies could strengthen antitumor effects. This protocol elucidates a robust method via …
Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing.
Dhami SPS, Kappala SS, Thompson A, Szegezdi E. Dhami SPS, et al. Drug Discov Today. 2016 Sep;21(9):1464-1471. doi: 10.1016/j.drudis.2016.04.019. Epub 2016 Apr 27. Drug Discov Today. 2016. PMID: 27130156 Review.
Classical AML cell cultures fail to mimic the BMM and, therefore, drug discovery studies are dominated by in vivo models. However, animal models are time consuming, labour intensive, provide limited mechanistic insight, and are unsuited for high-throug …
Classical AML cell cultures fail to mimic the BMM and, therefore, drug discovery studies are dominated by in vivo
Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition.
Dzama MM, Steiner M, Rausch J, Sasca D, Schönfeld J, Kunz K, Taubert MC, McGeehan GM, Chen CW, Mupo A, Hähnel P, Theobald M, Kindler T, Koche RP, Vassiliou GS, Armstrong SA, Kühn MWM. Dzama MM, et al. Blood. 2020 Nov 19;136(21):2442-2456. doi: 10.1182/blood.2020005037. Blood. 2020. PMID: 32589720 Free PMC article.
Primary acute myeloid leukemia (AML) cells harvested from patients with NPM1mutFLT3mut AML showed significantly better responses to combined menin and FLT3 inhibition than to single-drug or vehicle control treatment, whereas AML cells wit …
Primary acute myeloid leukemia (AML) cells harvested from patients with NPM1mutFLT3mut AML showed significantly …
Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.
Barbier V, Erbani J, Fiveash C, Davies JM, Tay J, Tallack MR, Lowe J, Magnani JL, Pattabiraman DR, Perkins AC, Lisle J, Rasko JEJ, Levesque JP, Winkler IG. Barbier V, et al. Nat Commun. 2020 Apr 27;11(1):2042. doi: 10.1038/s41467-020-15817-5. Nat Commun. 2020. PMID: 32341362 Free PMC article.
We now report in contrast, E-selectin directly triggers signaling pathways that promote malignant cell survival and regeneration. Using acute myeloid leukemia (AML) mouse models, we show AML blasts release inflammatory mediators that upregulate endothelial ni …
We now report in contrast, E-selectin directly triggers signaling pathways that promote malignant cell survival and regeneration. Using a
Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells.
Chen F, Ishikawa Y, Akashi A, Naoe T, Kiyoi H. Chen F, et al. Oncotarget. 2016 Jul 26;7(30):47018-47032. doi: 10.18632/oncotarget.10147. Oncotarget. 2016. PMID: 27331411 Free PMC article.
FLT3 mutation is found in about 30% of acute myeloid leukemia (AML) patients and is associated with a poor prognosis. ...We demonstrated that FL-stimulation much more strongly reduced growth inhibitory effects of FLT3 inhibitors on Wt- and mutant-FLT3 co
FLT3 mutation is found in about 30% of acute myeloid leukemia (AML) patients and is associated with a poor prognosis. . …