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Considerations regarding use of solvents in in vitro cell based assays.
Timm M, Saaby L, Moesby L, Hansen EW. Timm M, et al. Cytotechnology. 2013 Oct;65(5):887-94. doi: 10.1007/s10616-012-9530-6. Epub 2013 Jan 18. Cytotechnology. 2013. PMID: 23328992 Free PMC article.
Since many pharmacological relevant compounds are water-insoluble, solvents are frequently used in cell based assays. Although many reports describe the cellular effects of solvents at high concentrations, only a few relate the effects of sol
Since many pharmacological relevant compounds are water-insoluble, solvents are frequently used in cell based assays
In Vitro and In Vivo Studies on HPMA-Based Polymeric Micelles Loaded with Curcumin.
Bagheri M, Fens MH, Kleijn TG, Capomaccio RB, Mehn D, Krawczyk PM, Scutigliani EM, Gurinov A, Baldus M, van Kronenburg NCH, Kok RJ, Heger M, van Nostrum CF, Hennink WE. Bagheri M, et al. Mol Pharm. 2021 Mar 1;18(3):1247-1263. doi: 10.1021/acs.molpharmaceut.0c01114. Epub 2021 Jan 19. Mol Pharm. 2021. PMID: 33464911 Free PMC article.
In vitro analyses revealed that the curcumin-loaded mPEG(5kDa)-b-p(HPMA-Bz)(17.1kDa) micelles were internalized by different types of cancer cells, resulting in curcumin-induced cell death. ...The faster clearance of curcumin in vivo compared to in vitro
In vitro analyses revealed that the curcumin-loaded mPEG(5kDa)-b-p(HPMA-Bz)(17.1kDa) micelles were internalized by different types of …
In vitro anti-leukemic assessment and sustained release behaviour of cytarabine loaded biodegradable polymer based nanoparticles.
Jan N, Madni A, Rahim MA, Khan NU, Jamshaid T, Khan A, Jabar A, Khan S, Shah H. Jan N, et al. Life Sci. 2021 Feb 15;267:118971. doi: 10.1016/j.lfs.2020.118971. Epub 2020 Dec 29. Life Sci. 2021. PMID: 33385406
AIMS: The study aimed to develop, characterize, and evaluate poly (e-caprolactone) (PCL) based nanoparticles for the sustained release behaviour of cytarabine and to investigate the in vitro anti-cancer influence on KG-1 leukemic cell line. ...The flow cytome …
AIMS: The study aimed to develop, characterize, and evaluate poly (e-caprolactone) (PCL) based nanoparticles for the sustained releas …
Polycaprolactone/gelatin-based scaffolds with tailored performance: in vitro and in vivo validation.
Gil-Castell O, Badia JD, Ontoria-Oviedo I, Castellano D, Sepúlveda P, Ribes-Greus A. Gil-Castell O, et al. Mater Sci Eng C Mater Biol Appl. 2020 Feb;107:110296. doi: 10.1016/j.msec.2019.110296. Epub 2019 Oct 14. Mater Sci Eng C Mater Biol Appl. 2020. PMID: 31761169
During in vitro biocompatibility tests, higher cell adhesion and proliferation were found for the 60/40, 50/50 and 40/60 PCL/Ge compositions that was corroborated by MTT assay, fluorescence and microscopy. A weakened structure, more labile to the in vitro
During in vitro biocompatibility tests, higher cell adhesion and proliferation were found for the 60/40, 50/50 and 40/60 PCL/G …
Silicon Tetrapyrazinoporphyrazine Derivatives-Incorporated Carbohydrate-Based Block Copolymer Micelles for Photodynamic Therapy.
Park JM, Jung CY, Jang WD, Jaung JY. Park JM, et al. ACS Appl Bio Mater. 2021 Mar 15;4(3):1988-2000. doi: 10.1021/acsabm.0c00256. Epub 2020 Jun 2. ACS Appl Bio Mater. 2021. PMID: 35014324
In this study, axially substituted nonaggregated silicon tetrapyrazinoporphyrazine (SiTPyzPz) derivatives in carbohydrate-based block glycopolymer-based PMs were designed and used as PSs for PDT. ...Consequently, the PM systems of nonaggregated PSs and carbohydrate- …
In this study, axially substituted nonaggregated silicon tetrapyrazinoporphyrazine (SiTPyzPz) derivatives in carbohydrate-based block …
Biosynthesis of Copper Oxide Nanoparticles with Potential Biomedical Applications.
Rabiee N, Bagherzadeh M, Kiani M, Ghadiri AM, Etessamifar F, Jaberizadeh AH, Shakeri A. Rabiee N, et al. Int J Nanomedicine. 2020 Jun 9;15:3983-3999. doi: 10.2147/IJN.S255398. eCollection 2020. Int J Nanomedicine. 2020. PMID: 32606660 Free PMC article.
Biological activity of the synthesized nanoparticles was evaluated in terms of antibacterial and anti-fungal assessments against Staphylococcus aureus, M. tuberculosis, E. coli, K. pneumoniae, P. mirabili, C. diphtheriae and S. pyogenes bacteria's and G. albi
Biological activity of the synthesized nanoparticles was evaluated in terms of antibacterial and anti-fungal assessments against Stap
Therapeutic potential of toleragens in the management of antiphospholipid syndrome.
Cockerill KA, Iverson GM, Jones DS, Linnik MD. Cockerill KA, et al. BioDrugs. 2004;18(5):297-305. doi: 10.2165/00063030-200418050-00002. BioDrugs. 2004. PMID: 15377172 Review.
The fine specificity of autoantibodies to beta2GPI is a subject of considerable debate; however, a body of evidence may offer resolution by integrating concepts of antibody affinity and assay sensitivity with carefully designed molecular studies. An investigational …
The fine specificity of autoantibodies to beta2GPI is a subject of considerable debate; however, a body of evidence may offer resolut …
Folate-Targeted Polyethylene Glycol-Modified Photosensitizers for Photodynamic Therapy.
Liu Q, Wang J, Li S, Li G, Chen Q, Hong Z. Liu Q, et al. J Pharm Sci. 2019 Jun;108(6):2102-2111. doi: 10.1016/j.xphs.2019.01.014. Epub 2019 Jan 21. J Pharm Sci. 2019. PMID: 30677421
In our former work, the prepared folic acid (FA)-Pyro conjugates showed considerably improved tumor accumulation and photodynamic therapy (PDT) activity in cell- and animal-based studies. ...Therefore, we chose various lengths of PEGs as linkers to optimize t …
In our former work, the prepared folic acid (FA)-Pyro conjugates showed considerably improved tumor accumulation and photodynamic the …
Methacrylic-based nanogels for the pH-sensitive delivery of 5-fluorouracil in the colon.
Ashwanikumar N, Kumar NA, Nair SA, Kumar GV. Ashwanikumar N, et al. Int J Nanomedicine. 2012;7:5769-79. doi: 10.2147/IJN.S31201. Epub 2012 Nov 15. Int J Nanomedicine. 2012. PMID: 23172988 Free PMC article.
Cell proliferation assay of a human colon tumor colon cancer cell line (HCT-116) was performed and showed that the nanogels containing 5-FU exhibited considerable cytotoxicity in comparison with free 5-FU. Cell uptake of the nanogels was also mo
Cell proliferation assay of a human colon tumor colon cancer cell line (HCT-116) was performed and showed that the nano
Comparative cytotoxicity of plant protection products and their active ingredients.
Adler-Flindt S, Martin S. Adler-Flindt S, et al. Toxicol In Vitro. 2019 Feb;54:354-366. doi: 10.1016/j.tiv.2018.10.020. Epub 2018 Oct 31. Toxicol In Vitro. 2019. PMID: 30389606 Free article.
However 31% of classified products were not identified revealing a considerable inaccuracy of this method. Based on these results ten PPPs and corresponding ASs were further tested in a cytotoxicity assay employing 3T3 and hFF cells (one PPP and corres …
However 31% of classified products were not identified revealing a considerable inaccuracy of this method. Based on these resu …
67 results