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Considerations regarding use of solvents in in vitro cell based assays.
Timm M, Saaby L, Moesby L, Hansen EW. Timm M, et al. Cytotechnology. 2013 Oct;65(5):887-94. doi: 10.1007/s10616-012-9530-6. Epub 2013 Jan 18. Cytotechnology. 2013. PMID: 23328992 Free PMC article.
Cell culture systems are widely used for the investigation of in vitro immunomodulatory effects of medicines and natural products. ...Furthermore, these results show the importance of keeping solvent concentrations constant in serial dilution of any co
Cell culture systems are widely used for the investigation of in vitro immunomodulatory effects of medicines and natura
AI-based structure prediction empowers integrative structural analysis of human nuclear pores.
Mosalaganti S, Obarska-Kosinska A, Siggel M, Taniguchi R, Turoňová B, Zimmerli CE, Buczak K, Schmidt FH, Margiotta E, Mackmull MT, Hagen WJH, Hummer G, Kosinski J, Beck M. Mosalaganti S, et al. Science. 2022 Jun 10;376(6598):eabm9506. doi: 10.1126/science.abm9506. Epub 2022 Jun 10. Science. 2022. PMID: 35679397
A synergistic combination of complementary approaches has turned out to be critical. In situ structural biology techniques were used to reveal the overall layout of the NPC scaffold that defines the spatial reference for molecular modeling. High-resolution structures of ma …
A synergistic combination of complementary approaches has turned out to be critical. In situ structural biology techniques were used …
In vitro anti-leukemic assessment and sustained release behaviour of cytarabine loaded biodegradable polymer based nanoparticles.
Jan N, Madni A, Rahim MA, Khan NU, Jamshaid T, Khan A, Jabar A, Khan S, Shah H. Jan N, et al. Life Sci. 2021 Feb 15;267:118971. doi: 10.1016/j.lfs.2020.118971. Epub 2020 Dec 29. Life Sci. 2021. PMID: 33385406
AIMS: The study aimed to develop, characterize, and evaluate poly (e-caprolactone) (PCL) based nanoparticles for the sustained release behaviour of cytarabine and to investigate the in vitro anti-cancer influence on KG-1 leukemic cell line. ...In
AIMS: The study aimed to develop, characterize, and evaluate poly (e-caprolactone) (PCL) based nanoparticles for the sustained releas …
In Vitro and In Vivo Studies on HPMA-Based Polymeric Micelles Loaded with Curcumin.
Bagheri M, Fens MH, Kleijn TG, Capomaccio RB, Mehn D, Krawczyk PM, Scutigliani EM, Gurinov A, Baldus M, van Kronenburg NCH, Kok RJ, Heger M, van Nostrum CF, Hennink WE. Bagheri M, et al. Mol Pharm. 2021 Mar 1;18(3):1247-1263. doi: 10.1021/acs.molpharmaceut.0c01114. Epub 2021 Jan 19. Mol Pharm. 2021. PMID: 33464911 Free PMC article.
In vitro analyses revealed that the curcumin-loaded mPEG(5kDa)-b-p(HPMA-Bz)(17.1kDa) micelles were internalized by different types of cancer cells, resulting in curcumin-induced cell death. ...The faster clearance of curcumin in vivo compared to in
In vitro analyses revealed that the curcumin-loaded mPEG(5kDa)-b-p(HPMA-Bz)(17.1kDa) micelles were internalized by different t
Therapeutic potential of toleragens in the management of antiphospholipid syndrome.
Cockerill KA, Iverson GM, Jones DS, Linnik MD. Cockerill KA, et al. BioDrugs. 2004;18(5):297-305. doi: 10.2165/00063030-200418050-00002. BioDrugs. 2004. PMID: 15377172 Review.
The relation between autoantibodies and the pathophysiology of APS is not clearly understood, but numerous in vitro studies have characterized the effects of antiphospholipid autoantibodies on various components of the coagulation cascade, including tissue factor an …
The relation between autoantibodies and the pathophysiology of APS is not clearly understood, but numerous in vitro studies ha …
In vitro and in vivo antileishmanial activity of the hanging sedge flavonoids based on bio- guided fractionation assay.
Moradian N, Hatam G, Hamedi A, Pasdaran A. Moradian N, et al. Chem Biol Drug Des. 2023 Jun;101(6):1425-1434. doi: 10.1111/cbdd.14226. Epub 2023 Mar 26. Chem Biol Drug Des. 2023. PMID: 36892494
Natural products also should be regarded as one of the most valuable applications for CL infection drug development. In this study, we assessed the in vitro and in vivo antileishmanial potential of Carex pendula Huds. ...According to the findings of this study, the …
Natural products also should be regarded as one of the most valuable applications for CL infection drug development. In this study, we asses …
Synthesis, in vitro cytotoxic activity and molecular docking study of androstene and estrone derivatives.
Mistry S, Thakkar M, Singh AK, Patel D. Mistry S, et al. Steroids. 2023 Sep;197:109259. doi: 10.1016/j.steroids.2023.109259. Epub 2023 Jun 17. Steroids. 2023. PMID: 37336339
Subsequently, the 16-arylidene estrone reacted with acid chloride in presence of quaternary amine in halogenated solvent resulting in the steroidal arylidene derivatives. Synthesis, Characterization and in vitro cytotoxic activity of arylidenes are rationaliz …
Subsequently, the 16-arylidene estrone reacted with acid chloride in presence of quaternary amine in halogenated solvent resulting in …
Methacrylic-based nanogels for the pH-sensitive delivery of 5-fluorouracil in the colon.
Ashwanikumar N, Kumar NA, Nair SA, Kumar GV. Ashwanikumar N, et al. Int J Nanomedicine. 2012;7:5769-79. doi: 10.2147/IJN.S31201. Epub 2012 Nov 15. Int J Nanomedicine. 2012. PMID: 23172988 Free PMC article.
In vitro drug-release studies using phosphate-buffered saline at different pH levels demonstrated the sustained release of 5-FU and its pH dependence. Cell proliferation assay of a human colon tumor colon cancer cell line (HCT-116) was performed
In vitro drug-release studies using phosphate-buffered saline at different pH levels demonstrated the sustained release of 5-F
Macrophage-Targeting and Complete Lysosomal Degradation of Self-assembled Two-Dimensional Poly(ε-caprolactone) Platelet Particles.
Ganda S, Wong CK, Biazik J, Raveendran R, Zhang L, Chen F, Ariotti N, Stenzel MH. Ganda S, et al. ACS Appl Mater Interfaces. 2022 Aug 10;14(31):35333-35343. doi: 10.1021/acsami.2c06555. Epub 2022 Jul 27. ACS Appl Mater Interfaces. 2022. PMID: 35895018
However, considerable efforts have been directed toward understanding the cell uptake mechanism and trafficking of spherical particles. ...Here, we used polymeric two-dimensional platelets based on poly(epsilon-caprolactone) (PCL) prepared by living crystalli …
However, considerable efforts have been directed toward understanding the cell uptake mechanism and trafficking of spherical p …
Polycaprolactone/gelatin-based scaffolds with tailored performance: in vitro and in vivo validation.
Gil-Castell O, Badia JD, Ontoria-Oviedo I, Castellano D, Sepúlveda P, Ribes-Greus A. Gil-Castell O, et al. Mater Sci Eng C Mater Biol Appl. 2020 Feb;107:110296. doi: 10.1016/j.msec.2019.110296. Epub 2019 Oct 14. Mater Sci Eng C Mater Biol Appl. 2020. PMID: 31761169
During in vitro biocompatibility tests, higher cell adhesion and proliferation were found for the 60/40, 50/50 and 40/60 PCL/Ge compositions that was corroborated by MTT assay, fluorescence and microscopy. A weakened structure, more labile to the in
During in vitro biocompatibility tests, higher cell adhesion and proliferation were found for the 60/40, 50/50 and 40/6 …
76 results