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Daunomycin-polypeptide conjugates with antitumor activity.
Szabó R, Bánóczi Z, Mezo G, Láng O, Kohidai L, Hudecz F. Szabó R, et al. Biochim Biophys Acta. 2010 Dec;1798(12):2209-16. doi: 10.1016/j.bbamem.2010.07.023. Epub 2010 Jul 24. Biochim Biophys Acta. 2010. PMID: 20659420 Free article.
We have developed a group of water-soluble drug conjugates in which daunomycin (Dau) is coupled to cationic, amphoteric or anionic branched polypeptides and a new conjugate containing a cationic polypeptide carrier modified with a cell penetrati …
We have developed a group of water-soluble drug conjugates in which daunomycin (Dau) is coupled to cationic, amphoteric or ani …
Development of novel cyclic NGR peptide-daunomycin conjugates with dual targeting property.
Tripodi AAP, Tóth S, Enyedi KN, Schlosser G, Szakács G, Mező G. Tripodi AAP, et al. Beilstein J Org Chem. 2018 Apr 25;14:911-918. doi: 10.3762/bjoc.14.78. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 29765472 Free PMC article.
Cyclic NGR peptides as homing devices are good candidates for the development of drug conjugates for targeted tumor therapy. In our previous study we reported that the Dau=Aoa-GFLGK(c[KNGRE]-GG-)-NH(2) conjugate has a significant antitumor activity …
Cyclic NGR peptides as homing devices are good candidates for the development of drug conjugates for targeted tumor therapy. I …
Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids.
Lajkó E, Spring S, Hegedüs R, Biri-Kovács B, Ingebrandt S, Mező G, Kőhidai L. Lajkó E, et al. Beilstein J Org Chem. 2018 Sep 26;14:2495-2509. doi: 10.3762/bjoc.14.226. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 30344773 Free PMC article.
In this study our aim was (i) to analyze the effects of GnRH-drug conjugates on melanoma cell proliferation, adhesion and migration, (ii) to study the mechanisms of tumor cell responses, and (iii) to compare the activities of conjugates with the free drug. .. …
In this study our aim was (i) to analyze the effects of GnRH-drug conjugates on melanoma cell proliferation, adhesion and migration, …
Synthesis and cellular characterization of various nano-assemblies of cell penetrating peptide-epirubicin-polyglutamate conjugates for the enhancement of antitumor activity.
Mohammadi S, Zakeri-Milani P, Golkar N, Farkhani SM, Shirani A, Shahbazi Mojarrad J, Nokhodchi A, Valizadeh H. Mohammadi S, et al. Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1572-1585. doi: 10.1080/21691401.2017.1379016. Epub 2017 Sep 21. Artif Cells Nanomed Biotechnol. 2018. PMID: 28933182
A new class of cell penetrating peptides (CPPs) named peptide amphiphile was designed to improve the intracellular uptake and the antitumor activity of epirubicin (EPR). ...Cellular uptake of K3W4K3-E8, K2W4K2-E8 and W3K4W3-E8 reached 100% with no difference …
A new class of cell penetrating peptides (CPPs) named peptide amphiphile was designed to improve the intracellular uptake and the …
Antitumor activity of IL-2/anti-IL-2 mAb immunocomplexes exerts synergism with that of N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugate due to its low immunosuppressive activity.
Tomala J, Chmelova H, Strohalm J, Ulbrich K, Sirova M, Rihova B, Kovar M. Tomala J, et al. Int J Cancer. 2011 Oct 15;129(8):2002-12. doi: 10.1002/ijc.25859. Epub 2011 Apr 13. Int J Cancer. 2011. PMID: 21165950 Free article.
Importantly, we show that the conjugate has significantly lower immunosuppressive activity than free doxorubicin when using dosage with comparable antitumor activity, thus eliminating the majority of tumor cells while leaving the immune system mostly u …
Importantly, we show that the conjugate has significantly lower immunosuppressive activity than free doxorubicin when using do …
NGR-peptide-drug conjugates with dual targeting properties.
Enyedi KN, Tóth S, Szakács G, Mező G. Enyedi KN, et al. PLoS One. 2017 Jun 2;12(6):e0178632. doi: 10.1371/journal.pone.0178632. eCollection 2017. PLoS One. 2017. PMID: 28575020 Free PMC article.
We synthesized small cyclic NGR peptide-daunomycin conjugates using NGR peptides of varying stability (c[KNGRE]-NH2, Ac-c[CNGRC]-NH2 and the thioether bond containing c[CH2-CO-NGRC]-NH2, c[CH2-CO-KNGRC]-NH2). ...Our results confirm the influence of structure …
We synthesized small cyclic NGR peptide-daunomycin conjugates using NGR peptides of varying stability (c[KNGRE]-NH2, Ac …
Anti-hepatoma human single-chain Fv antibody and adriamycin conjugates with potent antitumor activity.
Chen L, Liu YH, Li YH, Jiang Y, Xie PL, Zhou GH, Li GC. Chen L, et al. Int Immunopharmacol. 2014 Jan;18(1):20-6. doi: 10.1016/j.intimp.2013.11.002. Epub 2013 Nov 12. Int Immunopharmacol. 2014. PMID: 24239629
It was purified using a His-Tag Ni-Agarose column and identified by western blot. The activity of Trx-ScFv-SA3 was verified by enzyme-linked immunosorbent assay (ELISA) and immunocytochemistry to confirm that it specifically binds to the hepatocellular carcinoma cell line …
It was purified using a His-Tag Ni-Agarose column and identified by western blot. The activity of Trx-ScFv-SA3 was verified by enzyme …
Galactosylated α,β-poly[(2-hydroxyethyl)-L-aspartamide]-bound doxorubicin: improved antitumor activity against hepatocellular carcinoma with reduced hepatotoxicity.
Cheng X, Gao F, Xiang J, Jiang X, Chen J, Zhang J. Cheng X, et al. Anticancer Drugs. 2011 Feb;22(2):136-47. doi: 10.1097/CAD.0b013e3283406e85. Anticancer Drugs. 2011. PMID: 20966743
Gal-PHEA-DOX exhibited comparable antitumor activity with PHEA-DOX in the S180-bearing mice, but more effective than PHEA-DOX or DOX in the Heps-bearing mice with negligible detrimental effect in the liver remnant. ...These results suggest that the Gal-PHEA-DOX c …
Gal-PHEA-DOX exhibited comparable antitumor activity with PHEA-DOX in the S180-bearing mice, but more effective than PHEA-DOX …
Structural Characterization of Daunomycin-Peptide Conjugates by Various Tandem Mass Spectrometric Techniques.
Borbély A, Pethő L, Szabó I, Al-Majidi M, Steckel A, Nagy T, Kéki S, Kalló G, Csősz É, Mező G, Schlosser G. Borbély A, et al. Int J Mol Sci. 2021 Feb 6;22(4):1648. doi: 10.3390/ijms22041648. Int J Mol Sci. 2021. PMID: 33562082 Free PMC article.
The use of peptide-drug conjugates has generated wide interest as targeted antitumor therapeutics. The anthracycline antibiotic, daunomycin, is a widely used anticancer agent and it is often conjugated to different tumor homing peptides. ...
The use of peptide-drug conjugates has generated wide interest as targeted antitumor therapeutics. The anthracycline antibioti …
Interleukin-2: use in solid tumors.
Bukowski RM, McLain D, Olencki T, Budd GT, Murthy SA. Bukowski RM, et al. Stem Cells. 1993 Jan;11(1):26-32. doi: 10.1002/stem.5530110106. Stem Cells. 1993. PMID: 8457777 Review.
This series of clinical studies demonstrates the role of rIL-2 in various malignancies and documents the activity in patients with malignant melanoma and renal cell carcinoma. Additional studies to investigate potential mechanisms of antitumor activity and re …
This series of clinical studies demonstrates the role of rIL-2 in various malignancies and documents the activity in patients with ma …
196 results