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Daunomycin-polypeptide conjugates with antitumor activity.
Szabó R, Bánóczi Z, Mezo G, Láng O, Kohidai L, Hudecz F. Szabó R, et al. Biochim Biophys Acta. 2010 Dec;1798(12):2209-16. doi: 10.1016/j.bbamem.2010.07.023. Epub 2010 Jul 24. Biochim Biophys Acta. 2010. PMID: 20659420 Free article.
We have developed a group of water-soluble drug conjugates in which daunomycin (Dau) is coupled to cationic, amphoteric or anionic branched polypeptides and a new conjugate containing a cationic polypeptide carrier modified with a cell penetrati …
We have developed a group of water-soluble drug conjugates in which daunomycin (Dau) is coupled to cationic, amphoteric or ani …
Engineering Endogenous Tumor-Associated Macrophage-Targeted Biomimetic Nano-RBC to Reprogram Tumor Immunosuppressive Microenvironment for Enhanced Chemo-Immunotherapy.
Wang Y, Yu J, Luo Z, Shi Q, Liu G, Wu F, Wang Z, Huang Y, Zhou D. Wang Y, et al. Adv Mater. 2021 Oct;33(39):e2103497. doi: 10.1002/adma.202103497. Epub 2021 Aug 13. Adv Mater. 2021. PMID: 34387375
The presence of tumor-associated macrophages (TAMs) and tumor hypoxia correlates significantly with potent immunosuppressive activity. Here, a hemoglobin-poly(epsilon-caprolactone) (Hb-PCL) conjugate self-assembled biomimetic nano red blood cell (nano-RBC) system (V …
The presence of tumor-associated macrophages (TAMs) and tumor hypoxia correlates significantly with potent immunosuppressive activity
Development of novel cyclic NGR peptide-daunomycin conjugates with dual targeting property.
Tripodi AAP, Tóth S, Enyedi KN, Schlosser G, Szakács G, Mező G. Tripodi AAP, et al. Beilstein J Org Chem. 2018 Apr 25;14:911-918. doi: 10.3762/bjoc.14.78. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 29765472 Free PMC article.
Cyclic NGR peptides as homing devices are good candidates for the development of drug conjugates for targeted tumor therapy. In our previous study we reported that the Dau=Aoa-GFLGK(c[KNGRE]-GG-)-NH(2) conjugate has a significant antitumor activity
Cyclic NGR peptides as homing devices are good candidates for the development of drug conjugates for targeted tumor therapy. I …
Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids.
Lajkó E, Spring S, Hegedüs R, Biri-Kovács B, Ingebrandt S, Mező G, Kőhidai L. Lajkó E, et al. Beilstein J Org Chem. 2018 Sep 26;14:2495-2509. doi: 10.3762/bjoc.14.226. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 30344773 Free PMC article.
In this study our aim was (i) to analyze the effects of GnRH-drug conjugates on melanoma cell proliferation, adhesion and migration, (ii) to study the mechanisms of tumor cell responses, and (iii) to compare the activities of conjugates with the free drug. .. …
In this study our aim was (i) to analyze the effects of GnRH-drug conjugates on melanoma cell proliferation, adhesion and migration, …
Structural Characterization of Daunomycin-Peptide Conjugates by Various Tandem Mass Spectrometric Techniques.
Borbély A, Pethő L, Szabó I, Al-Majidi M, Steckel A, Nagy T, Kéki S, Kalló G, Csősz É, Mező G, Schlosser G. Borbély A, et al. Int J Mol Sci. 2021 Feb 6;22(4):1648. doi: 10.3390/ijms22041648. Int J Mol Sci. 2021. PMID: 33562082 Free PMC article.
The use of peptide-drug conjugates has generated wide interest as targeted antitumor therapeutics. The anthracycline antibiotic, daunomycin, is a widely used anticancer agent and it is often conjugated to different tumor homing peptides. ...
The use of peptide-drug conjugates has generated wide interest as targeted antitumor therapeutics. The anthracycline antibioti …
Synthesis and cellular characterization of various nano-assemblies of cell penetrating peptide-epirubicin-polyglutamate conjugates for the enhancement of antitumor activity.
Mohammadi S, Zakeri-Milani P, Golkar N, Farkhani SM, Shirani A, Shahbazi Mojarrad J, Nokhodchi A, Valizadeh H. Mohammadi S, et al. Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1572-1585. doi: 10.1080/21691401.2017.1379016. Epub 2017 Sep 21. Artif Cells Nanomed Biotechnol. 2018. PMID: 28933182
A new class of cell penetrating peptides (CPPs) named peptide amphiphile was designed to improve the intracellular uptake and the antitumor activity of epirubicin (EPR). ...Cellular uptake of K3W4K3-E8, K2W4K2-E8 and W3K4W3-E8 reached 100% with no difference …
A new class of cell penetrating peptides (CPPs) named peptide amphiphile was designed to improve the intracellular uptake and the …
Antitumor activity of IL-2/anti-IL-2 mAb immunocomplexes exerts synergism with that of N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugate due to its low immunosuppressive activity.
Tomala J, Chmelova H, Strohalm J, Ulbrich K, Sirova M, Rihova B, Kovar M. Tomala J, et al. Int J Cancer. 2011 Oct 15;129(8):2002-12. doi: 10.1002/ijc.25859. Epub 2011 Apr 13. Int J Cancer. 2011. PMID: 21165950 Free article.
Importantly, we show that the conjugate has significantly lower immunosuppressive activity than free doxorubicin when using dosage with comparable antitumor activity, thus eliminating the majority of tumor cells while leaving the immune system mostly u …
Importantly, we show that the conjugate has significantly lower immunosuppressive activity than free doxorubicin when using do …
Anti-hepatoma human single-chain Fv antibody and adriamycin conjugates with potent antitumor activity.
Chen L, Liu YH, Li YH, Jiang Y, Xie PL, Zhou GH, Li GC. Chen L, et al. Int Immunopharmacol. 2014 Jan;18(1):20-6. doi: 10.1016/j.intimp.2013.11.002. Epub 2013 Nov 12. Int Immunopharmacol. 2014. PMID: 24239629
It was purified using a His-Tag Ni-Agarose column and identified by western blot. The activity of Trx-ScFv-SA3 was verified by enzyme-linked immunosorbent assay (ELISA) and immunocytochemistry to confirm that it specifically binds to the hepatocellular carcinoma cell line …
It was purified using a His-Tag Ni-Agarose column and identified by western blot. The activity of Trx-ScFv-SA3 was verified by enzyme …
NGR-peptide-drug conjugates with dual targeting properties.
Enyedi KN, Tóth S, Szakács G, Mező G. Enyedi KN, et al. PLoS One. 2017 Jun 2;12(6):e0178632. doi: 10.1371/journal.pone.0178632. eCollection 2017. PLoS One. 2017. PMID: 28575020 Free PMC article.
We synthesized small cyclic NGR peptide-daunomycin conjugates using NGR peptides of varying stability (c[KNGRE]-NH2, Ac-c[CNGRC]-NH2 and the thioether bond containing c[CH2-CO-NGRC]-NH2, c[CH2-CO-KNGRC]-NH2). ...Our results confirm the influence of structure …
We synthesized small cyclic NGR peptide-daunomycin conjugates using NGR peptides of varying stability (c[KNGRE]-NH2, Ac …
Na+/K+ ATPase-targeted delivery to metastatic breast cancer models.
Araste F, Abnous K, Hashemi M, Dehshahri A, Detampel P, Alibolandi M, Ramezani M. Araste F, et al. Eur J Pharm Sci. 2020 Feb 15;143:105207. doi: 10.1016/j.ejps.2019.105207. Epub 2019 Dec 20. Eur J Pharm Sci. 2020. PMID: 31870814
Comparative in vitro cytotoxicity experiments demonstrated that the S3-conjugated nanoparticles (S3-PLGA-DOX NPs) had higher antiproliferative activity. ...In vivo study in 4T1 tumor-bearing BALB/C mice revealed that the S3-functionalized DOX-loaded NPs improved …
Comparative in vitro cytotoxicity experiments demonstrated that the S3-conjugated nanoparticles (S3-PLGA-DOX NPs) had higher antiprol …
187 results