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Year Number of Results
1976 1
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1984 1
1986 1
1991 1
1992 1
1993 2
1994 1
1995 1
1997 2
1998 1
1999 3
2000 10
2001 5
2002 3
2003 2
2004 4
2005 3
2006 6
2007 3
2009 4
2010 6
2011 8
2012 7
2013 10
2014 17
2015 20
2016 27
2017 16
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2019 15
2020 1
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Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids.
Lajkó E, Spring S, Hegedüs R, Biri-Kovács B, Ingebrandt S, Mező G, Kőhidai L. Lajkó E, et al. Beilstein J Org Chem. 2018 Sep 26;14:2495-2509. doi: 10.3762/bjoc.14.226. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 30344773 Free PMC article.
In this study our aim was (i) to analyze the effects of GnRH-drug conjugates on melanoma cell proliferation, adhesion and migration, (ii) to study the mechanisms of tumor cell responses, and (iii) to compare the activities of conjugates with the free drug. .. …
In this study our aim was (i) to analyze the effects of GnRH-drug conjugates on melanoma cell proliferation, adhesion and migration, …
Development of novel cyclic NGR peptide-daunomycin conjugates with dual targeting property.
Tripodi AAP, Tóth S, Enyedi KN, Schlosser G, Szakács G, Mező G. Tripodi AAP, et al. Beilstein J Org Chem. 2018 Apr 25;14:911-918. doi: 10.3762/bjoc.14.78. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 29765472 Free PMC article.
Cyclic NGR peptides as homing devices are good candidates for the development of drug conjugates for targeted tumor therapy. In our previous study we reported that the Dau=Aoa-GFLGK(c[KNGRE]-GG-)-NH(2) conjugate has a significant antitumor activity
Cyclic NGR peptides as homing devices are good candidates for the development of drug conjugates for targeted tumor therapy. I …
Daunomycin-polypeptide conjugates with antitumor activity.
Szabó R, Bánóczi Z, Mezo G, Láng O, Kohidai L, Hudecz F. Szabó R, et al. Biochim Biophys Acta. 2010 Dec;1798(12):2209-16. doi: 10.1016/j.bbamem.2010.07.023. Epub 2010 Jul 24. Biochim Biophys Acta. 2010. PMID: 20659420 Free article.
We have developed a group of water-soluble drug conjugates in which daunomycin (Dau) is coupled to cationic, amphoteric or anionic branched polypeptides and a new conjugate containing a cationic polypeptide carrier modified with a cell penetrati …
We have developed a group of water-soluble drug conjugates in which daunomycin (Dau) is coupled to cationic, amphoteric or ani …
NGR-peptide-drug conjugates with dual targeting properties.
Enyedi KN, Tóth S, Szakács G, Mező G. Enyedi KN, et al. PLoS One. 2017 Jun 2;12(6):e0178632. doi: 10.1371/journal.pone.0178632. eCollection 2017. PLoS One. 2017. PMID: 28575020 Free PMC article.
We synthesized small cyclic NGR peptide-daunomycin conjugates using NGR peptides of varying stability (c[KNGRE]-NH2, Ac-c[CNGRC]-NH2 and the thioether bond containing c[CH2-CO-NGRC]-NH2, c[CH2-CO-KNGRC]-NH2). ...Our results confirm the influence of structure …
We synthesized small cyclic NGR peptide-daunomycin conjugates using NGR peptides of varying stability (c[KNGRE]-NH2, Ac …
Bufalin-loaded vitamin E succinate-grafted-chitosan oligosaccharide/RGD conjugated TPGS mixed micelles demonstrated improved antitumor activity against drug-resistant colon cancer.
Yuan Z, Yuan Y, Han L, Qiu Y, Huang X, Gao F, Fan G, Zhang Y, Tang X, He X, Xu K, Yin P. Yuan Z, et al. Int J Nanomedicine. 2018 Nov 15;13:7533-7548. doi: 10.2147/IJN.S170692. eCollection 2018. Int J Nanomedicine. 2018. PMID: 30532537 Free PMC article.
Bufalin (BU) is one of the most effective antitumor active constituents in Chansu. Our previous study found that BU can effectively reverse P-glycoprotein (P-gp)-mediated MDR in colon cancer. ...CONCLUSION: Our results demonstrated that VeC/T-RGD MM could be develop …
Bufalin (BU) is one of the most effective antitumor active constituents in Chansu. Our previous study found that BU can effect …
Synthesis and cellular characterization of various nano-assemblies of cell penetrating peptide-epirubicin-polyglutamate conjugates for the enhancement of antitumor activity.
Mohammadi S, Zakeri-Milani P, Golkar N, Farkhani SM, Shirani A, Shahbazi Mojarrad J, Nokhodchi A, Valizadeh H. Mohammadi S, et al. Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1572-1585. doi: 10.1080/21691401.2017.1379016. Epub 2017 Sep 21. Artif Cells Nanomed Biotechnol. 2018. PMID: 28933182
A new class of cell penetrating peptides (CPPs) named peptide amphiphile was designed to improve the intracellular uptake and the antitumor activity of epirubicin (EPR). ...The anti-proliferative activity of EPR was enhanced following conjugation
A new class of cell penetrating peptides (CPPs) named peptide amphiphile was designed to improve the intracellular uptake and the …
Antitumor activity of IL-2/anti-IL-2 mAb immunocomplexes exerts synergism with that of N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugate due to its low immunosuppressive activity.
Tomala J, Chmelova H, Strohalm J, Ulbrich K, Sirova M, Rihova B, Kovar M. Tomala J, et al. Int J Cancer. 2011 Oct 15;129(8):2002-12. doi: 10.1002/ijc.25859. Epub 2011 Apr 13. Int J Cancer. 2011. PMID: 21165950 Free article.
Importantly, we show that the conjugate has significantly lower immunosuppressive activity than free doxorubicin when using dosage with comparable antitumor activity, thus eliminating the majority of tumor cells while leaving the immune system mostly u …
Importantly, we show that the conjugate has significantly lower immunosuppressive activity than free doxorubicin when using do …
Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.
Ranđelović I, Schuster S, Kapuvári B, Fossati G, Steinkühler C, Mező G, Tóvári J. Ranđelović I, et al. Int J Mol Sci. 2019 Sep 25;20(19):4763. doi: 10.3390/ijms20194763. Int J Mol Sci. 2019. PMID: 31557968 Free PMC article.
The anti-tumor activity of the previously developed GnRH-III-[(4)Lys(Bu),(8)Lys(Dau=Aoa)] conjugate and the novel synthesized GnRH-III-[(2)ΔHis,(3)d-Tic,(4)Lys(Bu),(8)Lys(Dau=Aoa)] conjugate, containing the anti-cancer drug daunorubicin, were evaluated …
The anti-tumor activity of the previously developed GnRH-III-[(4)Lys(Bu),(8)Lys(Dau=Aoa)] conjugate and the novel synthesized …
PD-1 Blockade for Improving the Antitumor Efficiency of Polymer-Doxorubicin Nanoprodrug.
Gao F, Zhang C, Qiu WX, Dong X, Zheng DW, Wu W, Zhang XZ. Gao F, et al. Small. 2018 Sep;14(37):e1802403. doi: 10.1002/smll.201802403. Epub 2018 Aug 20. Small. 2018. PMID: 30129176
The nanoprodrugs are fabricated by conjugating doxorubicin (DOX) to an anionic polymer hyaluronic acid (HA) via a tumor overexpressed matrix metalloproteinase sensitive peptide (CPLGLAGG) for tumor targeting and enzyme-activated drug release. Once accumulated at the …
The nanoprodrugs are fabricated by conjugating doxorubicin (DOX) to an anionic polymer hyaluronic acid (HA) via a tumor overexpressed …
Sequence modification of heptapeptide selected by phage display as homing device for HT-29 colon cancer cells to improve the anti-tumour activity of drug delivery systems.
Kiss K, Biri-Kovács B, Szabó R, Ranđelović I, Enyedi KN, Schlosser G, Orosz Á, Kapuvári B, Tóvári J, Mező G. Kiss K, et al. Eur J Med Chem. 2019 Aug 15;176:105-116. doi: 10.1016/j.ejmech.2019.05.016. Epub 2019 May 7. Eur J Med Chem. 2019. PMID: 31100648
Daunomycin was conjugated to the N-terminus of the peptide directly or through Cathepsin B cleavable spacers. Conjugates showed moderate in vitro cytostatic effect. ...Nevertheless, the Phe-containing conjugate was more active in all cases compa
Daunomycin was conjugated to the N-terminus of the peptide directly or through Cathepsin B cleavable spacers. Conjugates
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