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58 results

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Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease.
Chen J, Ruan X, Sun Y, Lu S, Hu S, Yuan S, Li X. Chen J, et al. EBioMedicine. 2024 Jan;99:104934. doi: 10.1016/j.ebiom.2023.104934. Epub 2023 Dec 16. EBioMedicine. 2024. PMID: 38103512 Free PMC article.
BACKGROUND: Mitochondrial dysfunction has been linked to the development of inflammatory bowel disease (IBD), but the genetic pathophysiology was not fully elucidated. ...We obtained genetic associations with IBD and its two subtypes from the Inflammatory Bow …
BACKGROUND: Mitochondrial dysfunction has been linked to the development of inflammatory bowel disease (IBD), but the genetic …
Epigenetic Signatures of Cigarette Smoking.
Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L, DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ. Joehanes R, et al. Circ Cardiovasc Genet. 2016 Oct;9(5):436-447. doi: 10.1161/CIRCGENETICS.116.001506. Epub 2016 Sep 20. Circ Cardiovasc Genet. 2016. PMID: 27651444 Free PMC article.
Genes annotated to these CpGs were enriched for associations with several smoking-related traits in genome-wide studies including pulmonary function, cancers, inflammatory diseases, and heart disease. ...CONCLUSIONS: Cigarette smoking has a broa …
Genes annotated to these CpGs were enriched for associations with several smoking-related traits in genome-wide studies includ …
Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.
Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI. Rangaraju S, et al. Mol Neurodegener. 2018 May 21;13(1):24. doi: 10.1186/s13024-018-0254-8. Mol Neurodegener. 2018. PMID: 29784049 Free PMC article.
An understanding of heterogeneity within DAM and their key regulators may guide pre-clinical experimentation and drug discovery. METHODS: Weighted co-expression network analysis (WGCNA) was applied to existing microglial transcriptomic datasets from neuroinflammator …
An understanding of heterogeneity within DAM and their key regulators may guide pre-clinical experimentation and drug discovery. METH …
Identification of immune-inflammation targets for intracranial aneurysms: a multiomics and epigenome-wide study integrating summary-data-based Mendelian randomization, single-cell-type expression analysis, and DNA methylation regulation.
Lin PW, Lin ZR, Wang WW, Guo AS, Chen YX. Lin PW, et al. Int J Surg. 2025 Jan 1;111(1):346-359. doi: 10.1097/JS9.0000000000001990. Int J Surg. 2025. PMID: 39051921 Free PMC article.
This study aimed to explore the genetic associations of immune-related and inflammation-related genes (IIRGs) with IAs and their subtypes using Mendelian randomization, colocalization test, and integrated multiomics functional analysis. ...This anal …
This study aimed to explore the genetic associations of immune-related and inflammation-related genes (IIRGs) with IAs …
Discovery and analysis of inflammatory disease-related genes using cDNA microarrays.
Heller RA, Schena M, Chai A, Shalon D, Bedilion T, Gilmore J, Woolley DE, Davis RW. Heller RA, et al. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2150-5. doi: 10.1073/pnas.94.6.2150. Proc Natl Acad Sci U S A. 1997. PMID: 9122163 Free PMC article.
cDNA microarray technology is used to profile complex diseases and discover novel disease-related genes. ...Comparisons between tissue samples of rheumatoid arthritis and inflammatory bowel disease verified the involvement of many …
cDNA microarray technology is used to profile complex diseases and discover novel disease-related genes. …
The role of inflammation-related genes in osteoarthritis.
Rogers EL, Reynard LN, Loughlin J. Rogers EL, et al. Osteoarthritis Cartilage. 2015 Nov;23(11):1933-8. doi: 10.1016/j.joca.2015.01.003. Osteoarthritis Cartilage. 2015. PMID: 26521739 Free article. Review.
Inflammatory-related genes sit firmly in the candidate camp based on prior observations that the OA disease process can have an inflammatory component. ...There is, however, compelling evidence that epigenetic effects involving inflammatory …
Inflammatory-related genes sit firmly in the candidate camp based on prior observations that the OA disease proc …
Genome-wide genetic links between amyotrophic lateral sclerosis and autoimmune diseases.
Li CY, Yang TM, Ou RW, Wei QQ, Shang HF. Li CY, et al. BMC Med. 2021 Feb 5;19(1):27. doi: 10.1186/s12916-021-01903-y. BMC Med. 2021. PMID: 33541344 Free PMC article.
However, little is known about their shared genetic architecture. METHODS: To examine the relation between ALS and 10 autoimmune diseases, including asthma, celiac disease (CeD), Crohn's disease (CD), inflammatory bowel disease (IBD), mul …
However, little is known about their shared genetic architecture. METHODS: To examine the relation between ALS and 10 autoimmune d …
Characterizing the polygenic overlap and shared loci between rheumatoid arthritis and cardiovascular diseases.
Sun X, Qian Y, Cheng W, Ye D, Liu B, Zhou D, Wen C, Andreassen OA, Mao Y. Sun X, et al. BMC Med. 2024 Apr 8;22(1):152. doi: 10.1186/s12916-024-03376-1. BMC Med. 2024. PMID: 38589871 Free PMC article.
Furthermore, we explored specific shared genetic loci by conjunctional false discovery rate analysis and association analysis based on subsets. RESULTS: Compared with the general population, RA patients showed a higher incidence of CVD (hazard ratio [HR] = 1. …
Furthermore, we explored specific shared genetic loci by conjunctional false discovery rate analysis and association analys …
Genomic study of taste perception genes in African Americans reveals SNPs linked to Alzheimer's disease.
Joseph PV, Abbas M, Goodney G, Diallo A, Gaye A. Joseph PV, et al. Sci Rep. 2024 Sep 16;14(1):21560. doi: 10.1038/s41598-024-71669-9. Sci Rep. 2024. PMID: 39284855 Free PMC article.
While previous research has shown the potential links between taste perception pathways and brain-related conditions, the area involving Alzheimer's disease remains incompletely understood. ...Nevertheless, the translation of these genetic insights into clinical pra …
While previous research has shown the potential links between taste perception pathways and brain-related conditions, the area involv …
Widespread transposable element dysregulation in human aging brains with Alzheimer's disease.
Feng Y, Yang X, Hou Y, Zhou Y, Leverenz JB, Eng C, Pieper AA, Goate A, Shen Y, Cheng F. Feng Y, et al. Alzheimers Dement. 2024 Nov;20(11):7495-7517. doi: 10.1002/alz.14164. Epub 2024 Oct 2. Alzheimers Dement. 2024. PMID: 39356058 Free PMC article.
DISCUSSION: We identified widespread TE dysregulation in human AD brains and teQTLs offer a complementary analytic approach to identify likely AD risk genes. HIGHLIGHTS: Widespread transposable element (TE) dysregulations are observed in human aging brains with degrees of …
DISCUSSION: We identified widespread TE dysregulation in human AD brains and teQTLs offer a complementary analytic approach to identify like …
58 results