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Year Number of Results
1997 1
2004 1
2005 1
2007 1
2008 2
2009 1
2010 5
2011 5
2012 5
2013 1
2014 3
2015 2
2016 5
2017 4
2018 2
2019 3
2020 5
2021 4
2022 1
2023 1

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48 results

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Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.
Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI. Rangaraju S, et al. Mol Neurodegener. 2018 May 21;13(1):24. doi: 10.1186/s13024-018-0254-8. Mol Neurodegener. 2018. PMID: 29784049 Free PMC article.
BACKGROUND: Disease-associated-microglia (DAM) represent transcriptionally-distinct and neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's disease (AD). An understanding of heterogeneity within DAM and their key regulators …
BACKGROUND: Disease-associated-microglia (DAM) represent transcriptionally-distinct and neurodegeneration-specific microglial profile …
Epigenetic Signatures of Cigarette Smoking.
Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L, DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ. Joehanes R, et al. Circ Cardiovasc Genet. 2016 Oct;9(5):436-447. doi: 10.1161/CIRCGENETICS.116.001506. Epub 2016 Sep 20. Circ Cardiovasc Genet. 2016. PMID: 27651444 Free PMC article.
Genes annotated to these CpGs were enriched for associations with several smoking-related traits in genome-wide studies including pulmonary function, cancers, inflammatory diseases, and heart disease. ...Many of the differentially methylated …
Genes annotated to these CpGs were enriched for associations with several smoking-related traits in genome-wide studies includ …
Discovery and analysis of inflammatory disease-related genes using cDNA microarrays.
Heller RA, Schena M, Chai A, Shalon D, Bedilion T, Gilmore J, Woolley DE, Davis RW. Heller RA, et al. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2150-5. doi: 10.1073/pnas.94.6.2150. Proc Natl Acad Sci U S A. 1997. PMID: 9122163 Free PMC article.
cDNA microarray technology is used to profile complex diseases and discover novel disease-related genes. ...We have monitored gene expression in this disease state with a microarray of selected human genes of probable signif …
cDNA microarray technology is used to profile complex diseases and discover novel disease-related genes. …
The role of inflammation-related genes in osteoarthritis.
Rogers EL, Reynard LN, Loughlin J. Rogers EL, et al. Osteoarthritis Cartilage. 2015 Nov;23(11):1933-8. doi: 10.1016/j.joca.2015.01.003. Osteoarthritis Cartilage. 2015. PMID: 26521739 Free article. Review.
In this review article we examine the role of inflammation-related genes in osteoarthritis (OA) from the perspective of genetics, epigenetics and gene expression. ...Inflammatory-related genes sit firmly in the candidate camp based on pri …
In this review article we examine the role of inflammation-related genes in osteoarthritis (OA) from the perspective of geneti …
Completing the genetic spectrum influencing coronary artery disease: from germline to somatic variation.
Patel AP, Natarajan P. Patel AP, et al. Cardiovasc Res. 2019 Apr 15;115(5):830-843. doi: 10.1093/cvr/cvz032. Cardiovasc Res. 2019. PMID: 30789660 Free PMC article. Review.
Mapping of the human genome and advancement in sequencing technology sparked further discovery of novel genetic associations through exome sequencing and genome wide association analysis in increasingly larger populations. ...Hypercholesterolaemic mice with Tet2 bon …
Mapping of the human genome and advancement in sequencing technology sparked further discovery of novel genetic associations through …
Microarray technology and applications in the arena of genome-wide association.
Grant SF, Hakonarson H. Grant SF, et al. Clin Chem. 2008 Jul;54(7):1116-24. doi: 10.1373/clinchem.2008.105395. Epub 2008 May 22. Clin Chem. 2008. PMID: 18499899 Review.
This has enabled large-scale genome-wide association (GWA) studies in complex diseases, such as diabetes, asthma, and inflammatory bowel disease, to be undertaken for the first time. CONTENT: the GWA approach serves the critical need for a comprehensive and u …
This has enabled large-scale genome-wide association (GWA) studies in complex diseases, such as diabetes, asthma, and inflammatory …
Exome Analysis of Rare and Common Variants within the NOD Signaling Pathway.
Andreoletti G, Shakhnovich V, Christenson K, Coelho T, Haggarty R, Afzal NA, Batra A, Petersen BS, Mort M, Beattie RM, Ennis S. Andreoletti G, et al. Sci Rep. 2017 Apr 19;7:46454. doi: 10.1038/srep46454. Sci Rep. 2017. PMID: 28422189 Free PMC article.
Pediatric inflammatory bowel disease (pIBD) is a chronic heterogeneous disorder. ...The identification of this novel gene provides a wider role for the inhibitor of apoptosis gene family in IBD pathogenesis....
Pediatric inflammatory bowel disease (pIBD) is a chronic heterogeneous disorder. ...The identification of this novel gene …
Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk.
Wang X, Su YR, Petersen PS, Bien S, Schmit SL, Drew DA, Albanes D, Berndt SI, Brenner H, Campbell PT, Casey G, Chang-Claude J, Gallinger SJ, Gruber SB, Haile RW, Harrison TA, Hoffmeister M, Jacobs EJ, Jenkins MA, Joshi AD, Li L, Lin Y, Lindor NM, Marchand LL, Martin V, Milne R, Maclnnis R, Moreno V, Nan H, Newcomb PA, Potter JD, Rennert G, Rennert H, Slattery ML, Thibodeau SN, Weinstein SJ, Woods MO, Chan AT, White E, Hsu L, Peters U. Wang X, et al. Cancer Epidemiol Biomarkers Prev. 2020 Sep;29(9):1800-1808. doi: 10.1158/1055-9965.EPI-19-1018. Epub 2020 Jul 10. Cancer Epidemiol Biomarkers Prev. 2020. PMID: 32651213 Free PMC article.
Genome-wide interaction analysis on single variants (G E) has identified several SNPs that may interact with NSAIDs to confer colorectal cancer risk, but variations in gene expression levels may also modify the effect of NSAID use. Therefore, we tested interactions …
Genome-wide interaction analysis on single variants (G E) has identified several SNPs that may interact with NSAIDs to confer colorec …
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
Franceschini N, van Rooij FJ, Prins BP, Feitosa MF, Karakas M, Eckfeldt JH, Folsom AR, Kopp J, Vaez A, Andrews JS, Baumert J, Boraska V, Broer L, Hayward C, Ngwa JS, Okada Y, Polasek O, Westra HJ, Wang YA, Del Greco M F, Glazer NL, Kapur K, Kema IP, Lopez LM, Schillert A, Smith AV, Winkler CA, Zgaga L; LifeLines Cohort Study; Bandinelli S, Bergmann S, Boban M, Bochud M, Chen YD, Davies G, Dehghan A, Ding J, Doering A, Durda JP, Ferrucci L, Franco OH, Franke L, Gunjaca G, Hofman A, Hsu FC, Kolcic I, Kraja A, Kubo M, Lackner KJ, Launer L, Loehr LR, Li G, Meisinger C, Nakamura Y, Schwienbacher C, Starr JM, Takahashi A, Torlak V, Uitterlinden AG, Vitart V, Waldenberger M, Wild PS, Kirin M, Zeller T, Zemunik T, Zhang Q, Ziegler A, Blankenberg S, Boerwinkle E, Borecki IB, Campbell H, Deary IJ, Frayling TM, Gieger C, Harris TB, Hicks AA, Koenig W, O' Donnell CJ, Fox CS, Pramstaller PP, Psaty BM, Reiner AP, Rotter JI, Rudan I, Snieder H, Tanaka T, van Duijn CM, Vollenweider P, Waeber G, Wilson JF, Witteman JC, Wolffenbuttel BH, Wright AF, Wu Q, Liu Y, Jenny NS, North KE, Felix JF, Alizadeh BZ, Cupples LA, Perry JR, Morris AP. Franceschini N, et al. Am J Hum Genet. 2012 Oct 5;91(4):744-53. doi: 10.1016/j.ajhg.2012.08.021. Epub 2012 Sep 27. Am J Hum Genet. 2012. PMID: 23022100 Free PMC article.
We demonstrated a functional role for the most strongly associated serum albumin locus, HPN, for which Hpn knockout mice manifest low plasma albumin concentrations. Other loci associated with serum albumin harbor genes related to ribosome function, protein translati …
We demonstrated a functional role for the most strongly associated serum albumin locus, HPN, for which Hpn knockout mice manifest low plasma …
Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma.
Buas MF, He Q, Johnson LG, Onstad L, Levine DM, Thrift AP, Gharahkhani P, Palles C, Lagergren J, Fitzgerald RC, Ye W, Caldas C, Bird NC, Shaheen NJ, Bernstein L, Gammon MD, Wu AH, Hardie LJ, Pharoah PD, Liu G, Iyer P, Corley DA, Risch HA, Chow WH, Prenen H, Chegwidden L, Love S, Attwood S, Moayyedi P, MacDonald D, Harrison R, Watson P, Barr H, deCaestecker J, Tomlinson I, Jankowski J, Whiteman DC, MacGregor S, Vaughan TL, Madeleine MM. Buas MF, et al. Gut. 2017 Oct;66(10):1739-1747. doi: 10.1136/gutjnl-2016-311622. Epub 2016 Aug 2. Gut. 2017. PMID: 27486097 Free PMC article.
A principal components-based analytic framework was employed to evaluate pathway-level and gene-level associations with disease risk. RESULTS: We identified a significant signal for the COX pathway in relation to BE risk (p=0.0059, false discovery rate …
A principal components-based analytic framework was employed to evaluate pathway-level and gene-level associations with disease …
48 results