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Year Number of Results
1997 1
2004 1
2005 1
2007 1
2008 2
2009 1
2010 5
2011 5
2012 5
2013 1
2014 3
2015 2
2016 5
2017 4
2018 2
2019 3
2020 0
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Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.
Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI. Rangaraju S, et al. Mol Neurodegener. 2018 May 21;13(1):24. doi: 10.1186/s13024-018-0254-8. Mol Neurodegener. 2018. PMID: 29784049 Free PMC article.
BACKGROUND: Disease-associated-microglia (DAM) represent transcriptionally-distinct and neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's disease (AD). An understanding of heterogeneity within DAM and their key regulators …
BACKGROUND: Disease-associated-microglia (DAM) represent transcriptionally-distinct and neurodegeneration-specific microglial profile …
Epigenetic Signatures of Cigarette Smoking.
Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L, DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ. Joehanes R, et al. Circ Cardiovasc Genet. 2016 Oct;9(5):436-447. doi: 10.1161/CIRCGENETICS.116.001506. Epub 2016 Sep 20. Circ Cardiovasc Genet. 2016. PMID: 27651444 Free PMC article.
Genes annotated to these CpGs were enriched for associations with several smoking-related traits in genome-wide studies including pulmonary function, cancers, inflammatory diseases, and heart disease. ...Many of the differentially methylated
Genes annotated to these CpGs were enriched for associations with several smoking-related traits in genome-wide studies includ
Discovery and analysis of inflammatory disease-related genes using cDNA microarrays.
Heller RA, Schena M, Chai A, Shalon D, Bedilion T, Gilmore J, Woolley DE, Davis RW. Heller RA, et al. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2150-5. doi: 10.1073/pnas.94.6.2150. Proc Natl Acad Sci U S A. 1997. PMID: 9122163 Free PMC article.
cDNA microarray technology is used to profile complex diseases and discover novel disease-related genes. ...We have monitored gene expression in this disease state with a microarray of selected human genes of probable signif
cDNA microarray technology is used to profile complex diseases and discover novel disease-related genes.
Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behcet's disease susceptibility.
Takeuchi M, Mizuki N, Meguro A, Ombrello MJ, Kirino Y, Satorius C, Le J, Blake M, Erer B, Kawagoe T, Ustek D, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sousa I, Davatchi F, Francisco V, Shahram F, Abdollahi BS, Nadji A, Shafiee NM, Ghaderibarmi F, Ohno S, Ueda A, Ishigatsubo Y, Gadina M, Oliveira SA, Gül A, Kastner DL, Remmers EF. Takeuchi M, et al. Nat Genet. 2017 Mar;49(3):438-443. doi: 10.1038/ng.3786. Epub 2017 Feb 6. Nat Genet. 2017. PMID: 28166214 Free PMC article.
We analyzed 1,900 Turkish Behcet's disease cases and 1,779 controls genotyped with the Immunochip. ...ABO non-secretor genotypes for two ancestry-specific FUT2 SNPs showed strong disease association (P = 5.89 10(-15)). Our findings extend the list of suscepti …
We analyzed 1,900 Turkish Behcet's disease cases and 1,779 controls genotyped with the Immunochip. ...ABO non-secretor genotyp …
Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease.
Wojcik GL, Marie C, Abhyankar MM, Yoshida N, Watanabe K, Mentzer AJ, Carstensen T, Mychaleckyj J, Kirkpatrick BD, Rich SS, Concannon P, Haque R, Tsokos GC, Petri WA Jr, Duggal P. Wojcik GL, et al. mBio. 2018 Sep 18;9(5):e01668-18. doi: 10.1128/mBio.01668-18. mBio. 2018. PMID: 30228239 Free PMC article.
The most strongly associated single nucleotide polymorphism (SNP) within a gene was in an intron of CREM (rs58468612; P(meta) = 8.94 10(-8)), which has been implicated as a susceptibility locus for inflammatory bowel disease (IBD). Gene expression reso …
The most strongly associated single nucleotide polymorphism (SNP) within a gene was in an intron of CREM (rs58468612; P(meta) = 8.94 …
Identifying key genes in rheumatoid arthritis by weighted gene co-expression network analysis.
Ma C, Lv Q, Teng S, Yu Y, Niu K, Yi C. Ma C, et al. Int J Rheum Dis. 2017 Aug;20(8):971-979. doi: 10.1111/1756-185X.13063. Epub 2017 Apr 25. Int J Rheum Dis. 2017. PMID: 28440025
PURPOSE: This study aimed to identify rheumatoid arthritis (RA) related genes based on microarray data using the WGCNA (weighted gene co-expression network analysis) method. ...Genes in the disease-related gene co-expression …
PURPOSE: This study aimed to identify rheumatoid arthritis (RA) related genes based on microarray data using the WGCNA (weight …
Global, pathway and gene coverage of three Illumina arrays with respect to inflammatory and immune-related pathways.
Tozzi V, Rosenberger A, Kube D, Bickeböller H. Tozzi V, et al. Eur J Hum Genet. 2019 Nov;27(11):1716-1723. doi: 10.1038/s41431-019-0441-2. Epub 2019 Jun 21. Eur J Hum Genet. 2019. PMID: 31227809 Free PMC article.
Genome-wide association studies have led in the past to the discovery of susceptibility genes for many diseases including cancer and inflammatory conditions. ...Global coverage was found to range between 12.2 and 14.2% whereas coverage for a selected p …
Genome-wide association studies have led in the past to the discovery of susceptibility genes for many diseases includi …
Gene network approach reveals co-expression patterns in nasal and bronchial epithelium.
Imkamp K, Bernal V, Grzegorzcyk M, Horvatovich P, Vermeulen CJ, Heijink IH, Guryev V, Kerstjens HAM, van den Berge M, Faiz A. Imkamp K, et al. Sci Rep. 2019 Nov 1;9(1):15835. doi: 10.1038/s41598-019-50963-x. Sci Rep. 2019. PMID: 31676779 Free PMC article. Clinical Trial.
Network analysis of correlated genes showed pro-inflammatory pathways to be similar between the two locations. Focusing on smoking-related genes, cytochrome-P450 pathway related genes were found to be similar, supporting the concep …
Network analysis of correlated genes showed pro-inflammatory pathways to be similar between the two locations. Focusing …
Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases.
Tajuddin SM, Schick UM, Eicher JD, Chami N, Giri A, Brody JA, Hill WD, Kacprowski T, Li J, Lyytikäinen LP, Manichaikul A, Mihailov E, O'Donoghue ML, Pankratz N, Pazoki R, Polfus LM, Smith AV, Schurmann C, Vacchi-Suzzi C, Waterworth DM, Evangelou E, Yanek LR, Burt A, Chen MH, van Rooij FJ, Floyd JS, Greinacher A, Harris TB, Highland HM, Lange LA, Liu Y, Mägi R, Nalls MA, Mathias RA, Nickerson DA, Nikus K, Starr JM, Tardif JC, Tzoulaki I, Velez Edwards DR, Wallentin L, Bartz TM, Becker LC, Denny JC, Raffield LM, Rioux JD, Friedrich N, Fornage M, Gao H, Hirschhorn JN, Liewald DC, Rich SS, Uitterlinden A, Bastarache L, Becker DM, Boerwinkle E, de Denus S, Bottinger EP, Hayward C, Hofman A, Homuth G, Lange E, Launer LJ, Lehtimäki T, Lu Y, Metspalu A, O'Donnell CJ, Quarells RC, Richard M, Torstenson ES, Taylor KD, Vergnaud AC, Zonderman AB, Crosslin DR, Deary IJ, Dörr M, Elliott P, Evans MK, Gudnason V, Kähönen M, Psaty BM, Rotter JI, Slater AJ, Dehghan A, White HD, Ganesh SK, Loos RJ, Esko T, Faraday N, Wilson JG, Cushman M, Johnson AD, Edwards TL, Zakai NA, Lettre G, Reiner AP, Auer PL. Tajuddin SM, et al. Am J Hum Genet. 2016 Jul 7;99(1):22-39. doi: 10.1016/j.ajhg.2016.05.003. Epub 2016 Jun 23. Am J Hum Genet. 2016. PMID: 27346689 Free PMC article.
We performed an exome array-based meta-analysis of total WBC and subtype counts (neutrophils, monocytes, lymphocytes, basophils, and eosinophils) in a multi-ancestry discovery and replication sample of 157,622 individuals from 25 studies. ...These association …
We performed an exome array-based meta-analysis of total WBC and subtype counts (neutrophils, monocytes, lymphocytes, basophil …
The role of inflammation-related genes in osteoarthritis.
Rogers EL, Reynard LN, Loughlin J. Rogers EL, et al. Osteoarthritis Cartilage. 2015 Nov;23(11):1933-8. doi: 10.1016/j.joca.2015.01.003. Osteoarthritis Cartilage. 2015. PMID: 26521739 Free article. Review.
In this review article we examine the role of inflammation-related genes in osteoarthritis (OA) from the perspective of genetics, epigenetics and gene expression. ...Inflammatory-related genes sit firmly in the candidate camp based on pri …
In this review article we examine the role of inflammation-related genes in osteoarthritis (OA) from the perspective of geneti …
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