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Distinct inflammatory profiles in HIV-infected individuals under antiretroviral therapy using cannabis, cocaine or cannabis plus cocaine.
Castro FOF, Silva JM, Dorneles GP, Barros JBS, Ribeiro CB, Noronha I, Barbosa GR, Souza LCS, Guilarde AO, Pereira AJCS, Guimarães RF, Oliveira TF, Oliveira SEF, Peres A, Romão PRT, Pfrimer IAH, Fonseca SGD. Castro FOF, et al. AIDS. 2019 Oct 1;33(12):1831-1842. doi: 10.1097/QAD.0000000000002296. AIDS. 2019. PMID: 31490211
OBJECTIVES: To evaluate the effects of cannabis and/or cocaine use on inflammatory, oxidative stress status and circulating monocyte subsets in HIV-infected individuals under antiretroviral therapy. ...CONCLUSION: In HIV
OBJECTIVES: To evaluate the effects of cannabis and/or cocaine use on inflammatory, oxidative stress status and circula …
Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle.
Gonzalez-Cuevas G, Martin-Fardon R, Kerr TM, Stouffer DG, Parsons LH, Hammell DC, Banks SL, Stinchcomb AL, Weiss F. Gonzalez-Cuevas G, et al. Neuropsychopharmacology. 2018 Sep;43(10):2036-2045. doi: 10.1038/s41386-018-0050-8. Epub 2018 Mar 22. Neuropsychopharmacology. 2018. PMID: 29686308 Free PMC article.
Cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa, has received attention for therapeutic potential in treating neurologic and psychiatric disorders. ...Rats with alcohol or cocaine self-administration histories received transdermal CBD at …
Cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa, has received attention for therapeutic potential in tre …
Behavioural and molecular effects of cannabidiolic acid in mice.
Alegre-Zurano L, Martín-Sánchez A, Valverde O. Alegre-Zurano L, et al. Life Sci. 2020 Oct 15;259:118271. doi: 10.1016/j.lfs.2020.118271. Epub 2020 Aug 13. Life Sci. 2020. PMID: 32798553
AIMS: Cannabidiolic acid (CBDA) is one of the most abundant phytocannabinoid acids in the Cannabis sativa plant. It has been shown that it is able to exert some therapeutic effects such as antiemetic, anti-inflammatory, anxiolytic or antidepressant, although …
AIMS: Cannabidiolic acid (CBDA) is one of the most abundant phytocannabinoid acids in the Cannabis sativa plant. It has been shown th …
Dopamine and sense of agency: Determinants in personality and substance use.
Render A, Jansen P. Render A, et al. PLoS One. 2019 Mar 19;14(3):e0214069. doi: 10.1371/journal.pone.0214069. eCollection 2019. PLoS One. 2019. PMID: 30889224 Free PMC article.
Sense of agency refers to the feeling of control over one's own actions. The strength of this sense varies inter-individually. ...The study involved 210 participants who were tested for the experiment (intentional binding paradigm for sense of agency, hand paradigm …
Sense of agency refers to the feeling of control over one's own actions. The strength of this sense varies inter-individually. …
Effects of an acute cannabidiol treatment on cocaine self-administration and cue-induced cocaine seeking in male rats.
Mahmud A, Gallant S, Sedki F, D'Cunha T, Shalev U. Mahmud A, et al. J Psychopharmacol. 2017 Jan;31(1):96-104. doi: 10.1177/0269881116667706. Epub 2016 Sep 26. J Psychopharmacol. 2017. PMID: 27624146
Here we investigated the effects of an acute treatment with cannabidiol on cocaine self-administration and cue-induced cocaine seeking in rats. Rats were trained to press a lever to self-administer cocaine (0.5 mg/kg/infusion), first under a fixed interval 20 …
Here we investigated the effects of an acute treatment with cannabidiol on cocaine self-administration and cue-induced cocaine
Drivers who tested positive for cannabis in oral fluid: a longitudinal analysis of administrative data for Spain between 2011 and 2016.
Herrera-Gómez F, García-Mingo M, Colás M, González-Luque JC, Alvarez FJ. Herrera-Gómez F, et al. BMJ Open. 2019 Aug 26;9(8):e026648. doi: 10.1136/bmjopen-2018-026648. BMJ Open. 2019. PMID: 31455697 Free PMC article.
PRIMARY AND SECONDARY OUTCOME MEASURES: Frequencies of positivity for THC, THC alone and THC plus non-THC substances (stratification by age and gender in 2016) and THC concentration were obtained. ...Men were associated with higher THC concentrations (OR 1.394; 95% CI 1.18 …
PRIMARY AND SECONDARY OUTCOME MEASURES: Frequencies of positivity for THC, THC alone and THC plus non-THC substances (stratification …
Does accumulating exposure to illicit drugs bring forward the age at onset in schizophrenia?
Power BD, Dragovic M, Jablensky A, Stefanis NC. Power BD, et al. Aust N Z J Psychiatry. 2013 Jan;47(1):51-8. doi: 10.1177/0004867412461957. Epub 2012 Oct 5. Aust N Z J Psychiatry. 2013. PMID: 23042939
Participants were categorized into four groups: no illicit substance use (n = 65), cannabis use (n = 68), cannabis plus amphetamine use (n = 25), and cocaine plus cannabis/cocaine plus cannabis plus amphetamine …
Participants were categorized into four groups: no illicit substance use (n = 65), cannabis use (n = 68), cannabis plus
Prevalence of alcohol and other psychoactive substances in motor vehicle drivers in Spain, 2018: Cross-sectional dataset analysis with studies from 2008 and 2013.
Herrera-Gómez F, García-Mingo M, Álvarez FJ. Herrera-Gómez F, et al. Forensic Sci Int. 2020 Aug;313:110266. doi: 10.1016/j.forsciint.2020.110266. Epub 2020 Mar 28. Forensic Sci Int. 2020. PMID: 32480287
In 2018, alcohol was detected in 3.9 % of the cases, alcohol plus another substance(s) was found in 0.8 % of the cases, only one drug (excluding alcohol) made up 5.1 % of the cases and drivers testing positives to more than one drug at a time (apart from alcohol) co …
In 2018, alcohol was detected in 3.9 % of the cases, alcohol plus another substance(s) was found in 0.8 % of the cases, only o …
Adolescent Exposure to the Synthetic Cannabinoid WIN 55212-2 Modifies Cocaine Withdrawal Symptoms in Adult Mice.
Aguilar MA, Ledesma JC, Rodríguez-Arias M, Penalva C, Manzanedo C, Miñarro J, Arenas MC. Aguilar MA, et al. Int J Mol Sci. 2017 Jun 21;18(6):1326. doi: 10.3390/ijms18061326. Int J Mol Sci. 2017. PMID: 28635664 Free PMC article.
The aim of the present research was to study the consequences of adolescent exposure to cannabis on the psychiatric-like effects promoted by cocaine withdrawal in adult mice. We pre-treated juvenile mice with the cannabinoid CB1 receptor agonist WIN 55212-2 (WIN) an …
The aim of the present research was to study the consequences of adolescent exposure to cannabis on the psychiatric-like effects prom …
The concomitant use of cannabis and cocaine coexists with increased LPS levels and systemic inflammation in male drug users.
Ribeiro CB, Castro FOF, Dorneles GP, de Sousa Barros JB, Silva JM, Tavares C, Carvalho HR, Carlos da Cunha L, Nagib P, Hoffmann C, Peres A, Torres Romão PR, Pfrimer IAH, Fonseca SGD. Ribeiro CB, et al. Cytokine. 2021 May;141:155472. doi: 10.1016/j.cyto.2021.155472. Epub 2021 Feb 19. Cytokine. 2021. PMID: 33618152
The use of cannabis plus cocaine leads to higher systemic levels of LPS, CRP, IL-6 and higher IL-6/IL-10 ratio, characterizing a proinflammatory profile. ...In conclusion, our results indicate that the use of cannabis contributes to an anti
The use of cannabis plus cocaine leads to higher systemic levels of LPS, CRP, IL-6 and higher IL-6/IL-10 ratio, charact …
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