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Distinct inflammatory profiles in HIV-infected individuals under antiretroviral therapy using cannabis, cocaine or cannabis plus cocaine.
Castro FOF, Silva JM, Dorneles GP, Barros JBS, Ribeiro CB, Noronha I, Barbosa GR, Souza LCS, Guilarde AO, Pereira AJCS, Guimarães RF, Oliveira TF, Oliveira SEF, Peres A, Romão PRT, Pfrimer IAH, Fonseca SGD. Castro FOF, et al. AIDS. 2019 Oct 1;33(12):1831-1842. doi: 10.1097/QAD.0000000000002296. AIDS. 2019. PMID: 31490211
OBJECTIVES: To evaluate the effects of cannabis and/or cocaine use on inflammatory, oxidative stress status and circulating monocyte subsets in HIV-infected individuals under antiretroviral therapy. ...CONCLUSION: In HIV
OBJECTIVES: To evaluate the effects of cannabis and/or cocaine use on inflammatory, oxidative stress status and circula …
The concomitant use of cannabis and cocaine coexists with increased LPS levels and systemic inflammation in male drug users.
Ribeiro CB, Castro FOF, Dorneles GP, de Sousa Barros JB, Silva JM, Tavares C, Carvalho HR, Carlos da Cunha L, Nagib P, Hoffmann C, Peres A, Torres Romão PR, Pfrimer IAH, Fonseca SGD. Ribeiro CB, et al. Cytokine. 2021 May;141:155472. doi: 10.1016/j.cyto.2021.155472. Epub 2021 Feb 19. Cytokine. 2021. PMID: 33618152 Clinical Trial.
The use of cannabis plus cocaine leads to higher systemic levels of LPS, CRP, IL-6 and higher IL-6/IL-10 ratio, characterizing a proinflammatory profile. ...In conclusion, our results indicate that the use of cannabis contributes to an anti
The use of cannabis plus cocaine leads to higher systemic levels of LPS, CRP, IL-6 and higher IL-6/IL-10 ratio, charact …
Behavioural and molecular effects of cannabidiolic acid in mice.
Alegre-Zurano L, Martín-Sánchez A, Valverde O. Alegre-Zurano L, et al. Life Sci. 2020 Oct 15;259:118271. doi: 10.1016/j.lfs.2020.118271. Epub 2020 Aug 13. Life Sci. 2020. PMID: 32798553
AIMS: Cannabidiolic acid (CBDA) is one of the most abundant phytocannabinoid acids in the Cannabis sativa plant. It has been shown that it is able to exert some therapeutic effects such as antiemetic, anti-inflammatory, anxiolytic or antidepressant, although …
AIMS: Cannabidiolic acid (CBDA) is one of the most abundant phytocannabinoid acids in the Cannabis sativa plant. It has been shown th …
Co-exposure of cocaine and cannabinoids and its association with select biological, behavioural and health outcomes: A systematic scoping review of multi-disciplinary studies.
Daldegan-Bueno D, Maia LO, Glass M, Jutras-Aswad D, Fischer B. Daldegan-Bueno D, et al. Eur Neuropsychopharmacol. 2021 Oct;51:106-131. doi: 10.1016/j.euroneuro.2021.06.002. Epub 2021 Jul 15. Eur Neuropsychopharmacol. 2021. PMID: 34273801 Free article. Review.
Qualitative data-based studies reported cannabis use as a substitute for or to alleviate harms of crack-cocaine use. ...Cannabis co-use by cocaine users commonly presents a risk factor, entailing enhanced harms for users. ...
Qualitative data-based studies reported cannabis use as a substitute for or to alleviate harms of crack-cocaine use. ...Can
Variation of drugs involved in acute drug toxicity presentations based on age and sex: an epidemiological approach based on European emergency departments.
Miró Ò, Waring WS, Dargan PI, Wood DM, Dines AM, Yates C, Giraudon I, Moughty A, O'Connor N, Heyerdahl F, Hovda KE, Vallersnes OM, Paasma R, Pold K, Jürgens G, Megarbane B, Anand JS, Liakoni E, Liechti M, Eyer F, Zacharov S, Caganova B, Bonnici J, Radenkova-Saeva J, Galicia M; Euro-DEN Plus Research Group. Miró Ò, et al. Clin Toxicol (Phila). 2021 Oct;59(10):896-904. doi: 10.1080/15563650.2021.1884693. Epub 2021 Mar 16. Clin Toxicol (Phila). 2021. PMID: 33724118
Drugs were grouped as: opioids, cocaine, cannabis, amphetamines, gamma-hydroxybutyrate (GHB), hallucinogens, new psychoactive substances (NPS), benzodiazepines and ketamine. ...The relative proportion of each drug group was different at every age strata and some pat …
Drugs were grouped as: opioids, cocaine, cannabis, amphetamines, gamma-hydroxybutyrate (GHB), hallucinogens, new psychoactive …
Effects of an acute cannabidiol treatment on cocaine self-administration and cue-induced cocaine seeking in male rats.
Mahmud A, Gallant S, Sedki F, D'Cunha T, Shalev U. Mahmud A, et al. J Psychopharmacol. 2017 Jan;31(1):96-104. doi: 10.1177/0269881116667706. Epub 2016 Sep 26. J Psychopharmacol. 2017. PMID: 27624146
Here we investigated the effects of an acute treatment with cannabidiol on cocaine self-administration and cue-induced cocaine seeking in rats. Rats were trained to press a lever to self-administer cocaine (0.5 mg/kg/infusion), first under a fixed interval 20 …
Here we investigated the effects of an acute treatment with cannabidiol on cocaine self-administration and cue-induced cocaine
Dopamine and sense of agency: Determinants in personality and substance use.
Render A, Jansen P. Render A, et al. PLoS One. 2019 Mar 19;14(3):e0214069. doi: 10.1371/journal.pone.0214069. eCollection 2019. PLoS One. 2019. PMID: 30889224 Free PMC article.
Sense of agency refers to the feeling of control over one's own actions. The strength of this sense varies inter-individually. ...The study involved 210 participants who were tested for the experiment (intentional binding paradigm for sense of agency, hand paradigm …
Sense of agency refers to the feeling of control over one's own actions. The strength of this sense varies inter-individually. …
Adolescent Exposure to the Synthetic Cannabinoid WIN 55212-2 Modifies Cocaine Withdrawal Symptoms in Adult Mice.
Aguilar MA, Ledesma JC, Rodríguez-Arias M, Penalva C, Manzanedo C, Miñarro J, Arenas MC. Aguilar MA, et al. Int J Mol Sci. 2017 Jun 21;18(6):1326. doi: 10.3390/ijms18061326. Int J Mol Sci. 2017. PMID: 28635664 Free PMC article.
The aim of the present research was to study the consequences of adolescent exposure to cannabis on the psychiatric-like effects promoted by cocaine withdrawal in adult mice. We pre-treated juvenile mice with the cannabinoid CB1 receptor agonist WIN 55212-2 (WIN) an …
The aim of the present research was to study the consequences of adolescent exposure to cannabis on the psychiatric-like effects prom …
Safety and efficacy of a digital therapeutic for substance use disorder: Secondary analysis of data from a NIDA clinical trials network study.
Maricich YA, Nunes EV, Campbell ANC, Botbyl JD, Luderer HF. Maricich YA, et al. Subst Abus. 2022;43(1):937-942. doi: 10.1080/08897077.2022.2060425. Subst Abus. 2022. PMID: 35420979 Clinical Trial.
Methods: Secondary analysis of patients with substance use disorders related to alcohol, cannabis, cocaine, or other stimulants (n = 399, patients with OUD excluded) from a previously-published randomized controlled trial. Patients received 12-weeks of outpatient tr …
Methods: Secondary analysis of patients with substance use disorders related to alcohol, cannabis, cocaine, or other stimulant …
Does accumulating exposure to illicit drugs bring forward the age at onset in schizophrenia?
Power BD, Dragovic M, Jablensky A, Stefanis NC. Power BD, et al. Aust N Z J Psychiatry. 2013 Jan;47(1):51-8. doi: 10.1177/0004867412461957. Epub 2012 Oct 5. Aust N Z J Psychiatry. 2013. PMID: 23042939
Participants were categorized into four groups: no illicit substance use (n = 65), cannabis use (n = 68), cannabis plus amphetamine use (n = 25), and cocaine plus cannabis/cocaine plus cannabis plus amphetamine …
Participants were categorized into four groups: no illicit substance use (n = 65), cannabis use (n = 68), cannabis plus
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