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A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.
Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F. Bahr C, et al. Nature. 2018 Jan 25;553(7689):515-520. doi: 10.1038/nature25193. Epub 2018 Jan 17. Nature. 2018. PMID: 29342133
Here we show that an evolutionarily conserved region located 1.7 megabases downstream of the Myc gene that has previously been labelled as a 'super-enhancer' is essential for the regulation of Myc expression levels in both normal haematopoietic …
Here we show that an evolutionarily conserved region located 1.7 megabases downstream of the Myc gene that has previously been …
Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23).
Martino V, Tonelli R, Montemurro L, Franzoni M, Marino F, Fazzina R, Pession A. Martino V, et al. Oncol Rep. 2006 Jan;15(1):207-11. Oncol Rep. 2006. PMID: 16328057
In AML-M5 THP-1 cells carrying t(9;11) (p22;q23) and expressing MLL-AF9, we previously showed that MLL-AF9 expression is down-regulated during monocyte-macrophage maturatio …
In AML-M5 THP-1 cells carrying t(9;11) (p22;q23) and expressing MLL-AF9 …
Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement.
Zhang H, Cheng J, Li Z, Xi Y. Zhang H, et al. PeerJ. 2019 Aug 28;7:e7628. doi: 10.7717/peerj.7628. eCollection 2019. PeerJ. 2019. PMID: 31523525 Free PMC article.
Infant acute lymphoblastic leukemia (ALL) with the mixed lineage leukemia (MLL) gene rearrangement (MLL-R) is considered a distinct leukemia from childhood or non-MLL-R infant ALL. To detect key genes and elucidate the molec …
Infant acute lymphoblastic leukemia (ALL) with the mixed lineage leukemia (MLL) gene rearrangement (ML …
Polycomb repressive complex 2 is required for MLL-AF9 leukemia.
Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA. Neff T, et al. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5028-33. doi: 10.1073/pnas.1202258109. Epub 2012 Mar 6. Proc Natl Acad Sci U S A. 2012. PMID: 22396593 Free PMC article.
We used conditional alleles for the PRC2 components enhancer of zeste 2 (Ezh2) and embryonic ectoderm development (Eed) to characterize the role of PRC2 function in leukemia development and progression. Compared with wild-type leukemia, Ezh2-null MLL-AF9 …
We used conditional alleles for the PRC2 components enhancer of zeste 2 (Ezh2) and embryonic ectoderm development (Eed) to characterize the …
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