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A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.
Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F. Bahr C, et al. Nature. 2018 Jan 25;553(7689):515-520. doi: 10.1038/nature25193. Epub 2018 Jan 17. Nature. 2018. PMID: 29342133
Here we show that an evolutionarily conserved region located 1.7 megabases downstream of the Myc gene that has previously been labelled as a 'super-enhancer' is essential for the regulation of Myc expression levels in both normal haematopoietic …
Here we show that an evolutionarily conserved region located 1.7 megabases downstream of the Myc gene that has previously been …
Polycomb repressive complex 2 is required for MLL-AF9 leukemia.
Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA. Neff T, et al. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5028-33. doi: 10.1073/pnas.1202258109. Epub 2012 Mar 6. Proc Natl Acad Sci U S A. 2012. PMID: 22396593 Free PMC article.
We used conditional alleles for the PRC2 components enhancer of zeste 2 (Ezh2) and embryonic ectoderm development (Eed) to characterize the role of PRC2 function in leukemia development and progression. Compared with wild-type leukemia, Ezh2-null MLL-AF9 …
We used conditional alleles for the PRC2 components enhancer of zeste 2 (Ezh2) and embryonic ectoderm development (Eed) to characterize the …
Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.
Lopusna K, Nowialis P, Opavska J, Abraham A, Riva A, Opavsky R. Lopusna K, et al. EBioMedicine. 2021 Jan;63:103191. doi: 10.1016/j.ebiom.2020.103191. Epub 2021 Jan 6. EBioMedicine. 2021. PMID: 33418509 Free PMC article.
METHODS: We used a mouse model expressing catalytically inactive Dnmt3b (Dnmt3b(CI)) to study a role of Dnmt3b's CA in development and cancer. ...The lack of Dnmt3b's CA promoted fibroblasts transformation in vitro, accelerated MLL-AF9 driven …
METHODS: We used a mouse model expressing catalytically inactive Dnmt3b (Dnmt3b(CI)) to study a role of Dnmt3b's CA in develop …
Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement.
Zhang H, Cheng J, Li Z, Xi Y. Zhang H, et al. PeerJ. 2019 Aug 28;7:e7628. doi: 10.7717/peerj.7628. eCollection 2019. PeerJ. 2019. PMID: 31523525 Free PMC article.
Infant acute lymphoblastic leukemia (ALL) with the mixed lineage leukemia (MLL) gene rearrangement (MLL-R) is considered a distinct leukemia from childhood or non-MLL-R infant ALL. To detect key genes and elucidate the molec …
Infant acute lymphoblastic leukemia (ALL) with the mixed lineage leukemia (MLL) gene rearrangement (ML …