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Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus.
Bloor S, Maelfait J, Krumbach R, Beyaert R, Randow F. Bloor S, et al. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6970-5. doi: 10.1073/pnas.0908536107. Epub 2010 Mar 29. Proc Natl Acad Sci U S A. 2010. PMID: 20351288 Free PMC article.
Here we demonstrate that infection with VSV and innate immunity via Toll-like receptors (TLRs) require a shared component, the endoplasmic reticulum chaperone gp96. ...Cells deficient in gp96 also lack functional TLRs, which …
Here we demonstrate that infection with VSV and innate immunity via Toll-like receptors (TLRs) require a shared compone …
Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells.
Peters LR, Raghavan M. Peters LR, et al. J Immunol. 2011 Jul 15;187(2):919-31. doi: 10.4049/jimmunol.1100690. Epub 2011 Jun 13. J Immunol. 2011. PMID: 21670312 Free PMC article.
A number of immunological functions are ascribed to cell surface-expressed forms of the endoplasmic reticulum (ER) chaperone calreticulin (CRT). ...Incubation of bone marrow-derived dendritic cells with THP-treated fibroblasts enhanced sterile IL-6 pro …
A number of immunological functions are ascribed to cell surface-expressed forms of the endoplasmic reticulum (ER) c
Somatic cell genetics for the study of NF-kappaB signaling in innate immunity.
Krumbach R, Bloor S, Ryzhakov G, Randow F. Krumbach R, et al. Sci Signal. 2008 Sep 30;1(39):pt7. doi: 10.1126/scisignal.139pt7. Sci Signal. 2008. PMID: 18827221
Compared with the use of whole animals in genetic screens, somatic cell genetics allows the isolation of genes required for innate immunity, even if these genes also have an essential function in development. Our discovery of an essential role for the …
Compared with the use of whole animals in genetic screens, somatic cell genetics allows the isolation of genes required for …
Drosophila canopy b is a cochaperone of glycoprotein 93.
Morales C, Li Z. Morales C, et al. J Biol Chem. 2017 Apr 21;292(16):6657-6666. doi: 10.1074/jbc.M116.755538. Epub 2017 Mar 8. J Biol Chem. 2017. PMID: 28275054 Free PMC article.
Drosophila gp93 was identified as the ortholog of the mammalian endoplasmic reticulum-resident chaperone gp96. gp93 was found capable of rescuing gp96 client proteins, such as Toll-like receptors (TLRs) and integrins, in a gp96-deficient …
Drosophila gp93 was identified as the ortholog of the mammalian endoplasmic reticulum-resident chaperone gp96. g …
Extracellular targeting of endoplasmic reticulum chaperone glucose-regulated protein 170 enhances tumor immunity to a poorly immunogenic melanoma.
Wang XY, Arnouk H, Chen X, Kazim L, Repasky EA, Subjeck JR. Wang XY, et al. J Immunol. 2006 Aug 1;177(3):1543-51. doi: 10.4049/jimmunol.177.3.1543. J Immunol. 2006. PMID: 16849461
We have demonstrated previously that immunization with tumor-derived endoplasmic reticulum (ER) chaperone glucose-regulated protein 170 (grp170) elicits potent antitumor immunity. ...Both the secreted and endogenous grp170, when purified from the B16 t …
We have demonstrated previously that immunization with tumor-derived endoplasmic reticulum (ER) chaperone glucose-regul …
Cell surface expression of the endoplasmic reticular heat shock protein gp96 is phylogenetically conserved.
Robert J, Ménoret A, Cohen N. Robert J, et al. J Immunol. 1999 Oct 15;163(8):4133-9. J Immunol. 1999. PMID: 10510348
By itself, however, gp96 can evoke responses that are characteristic of innate immunity. ...Our data reveal that gp96, most likely containing the endoplasmic reticulum retention motif (KDEL), is expressed on the surface of three different …
By itself, however, gp96 can evoke responses that are characteristic of innate immunity. ...Our data reveal that gp9