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Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4.
Hartmann P, Zhou Z, Natarelli L, Wei Y, Nazari-Jahantigh M, Zhu M, Grommes J, Steffens S, Weber C, Schober A. Hartmann P, et al. Nat Commun. 2016 Feb 3;7:10521. doi: 10.1038/ncomms10521. Nat Commun. 2016. PMID: 26837267 Free PMC article.
Endothelial Dicer deficiency reduces the expression of unstable miRNAs, such as miR-103, and promotes Kruppel-like factor 4 (KLF4)-dependent gene expression in murine atherosclerotic arteries. ...Overall, our study suggests that Dicer
Endothelial Dicer deficiency reduces the expression of unstable miRNAs, such as miR-103, and promotes Kru