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Increased expression of triggering receptor expressed on myeloid cells 1 and 2 in inflamed human gingiva.
Chen SS, Wang K, Zhao J, Wu WC, Wu YF, Zhao L. Chen SS, et al. J Periodontal Res. 2017 Jun;52(3):512-521. doi: 10.1111/jre.12417. Epub 2016 Sep 14. J Periodontal Res. 2017. PMID: 27624412
BACKGROUND AND OBJECTIVE: Periodontitis is an infectious disease in which the host immune and inflammatory responses play essential roles in resistance to bacterial infection, as well as the induction of tissue destruction if the immune response is dysregulated. The triggering
BACKGROUND AND OBJECTIVE: Periodontitis is an infectious disease in which the host immune and inflammatory responses play essential roles in …
Expression and regulation of triggering receptor expressed on myeloid cells 1 in periodontal diseases.
Willi M, Belibasakis GN, Bostanci N. Willi M, et al. Clin Exp Immunol. 2014 Oct;178(1):190-200. doi: 10.1111/cei.12397. Clin Exp Immunol. 2014. PMID: 24924298 Free PMC article.
'red complex' bacteria) are characteristic subgingival biofilm species. The triggering receptor expressed on myeloid cells 1 (TREM-1) is a cell surface receptor of the immunoglobulin superfamily, with a role in the amplifica …
'red complex' bacteria) are characteristic subgingival biofilm species. The triggering receptor expressed on
[Expression of triggering receptors expressed by myeloid cells-1 in macrophages stimulated by Porphyromonas gingivalis-lipopolysaccharide].
Yang Y, Chen SS, Xu CM, Wu YF, Zhao L. Yang Y, et al. Hua Xi Kou Qiang Yi Xue Za Zhi. 2018 Oct 1;36(5):475-481. doi: 10.7518/hxkq.2018.05.003. Hua Xi Kou Qiang Yi Xue Za Zhi. 2018. PMID: 30465338 Free PMC article. Chinese.
OBJECTIVE: Soluble triggering receptors expressed by myeloid cells-1 (sTREM-1) and inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) in macrophage cells were stimulated by Porphyromonas gingivalis-lipopolysaccharide (Pg-LPS) to inves …
OBJECTIVE: Soluble triggering receptors expressed by myeloid cells-1 (sTREM-1) and inflammatory cytokine …
Therapeutic delivery of CCL2 modulates immune response and restores host-microbe homeostasis.
Shehabeldin M, Gao J, Cho Y, Chong R, Tabib T, Li L, Smardz M, Gaffen SL, Diaz PI, Lafyatis R, Little SR, Sfeir C. Shehabeldin M, et al. Proc Natl Acad Sci U S A. 2024 Sep 3;121(36):e2400528121. doi: 10.1073/pnas.2400528121. Epub 2024 Aug 26. Proc Natl Acad Sci U S A. 2024. PMID: 39186644
Many chronic inflammatory diseases are attributed to disturbances in host-microbe interactions, which drive immune-mediated tissue damage. ...Furthermore, single-cell ribonucleic acid (RNA) sequencing indicated that CCL2 therapy reversed disease-associated transcriptomic p …
Many chronic inflammatory diseases are attributed to disturbances in host-microbe interactions, which drive immune-mediated tissue da …
Regulation of Salivary Peptidoglycan Recognition Protein 1 in Adolescents.
Raivisto T, Heikkinen AM, Silbereisen A, Kovanen L, Ruokonen H, Tervahartiala T, Haukka J, Sorsa T, Bostanci N. Raivisto T, et al. JDR Clin Trans Res. 2020 Oct;5(4):332-341. doi: 10.1177/2380084419894287. Epub 2019 Dec 20. JDR Clin Trans Res. 2020. PMID: 31860804
Recently, PGLYRP1 was identified as a ligand for triggering receptor expressed on myeloid cells 1 (TREM-1). Although PGLYRP1 is involved in immune and inflammatory responses, its levels in initial stages of periodontal disea …
Recently, PGLYRP1 was identified as a ligand for triggering receptor expressed on myeloid cells
Regulation of PGLYRP1 and TREM-1 during Progression and Resolution of Gingival Inflammation.
Silbereisen A, Hallak AK, Nascimento GG, Sorsa T, Belibasakis GN, Lopez R, Bostanci N. Silbereisen A, et al. JDR Clin Trans Res. 2019 Oct;4(4):352-359. doi: 10.1177/2380084419844937. Epub 2019 Apr 23. JDR Clin Trans Res. 2019. PMID: 31013451
INTRODUCTION: The triggering receptor expressed on myeloid cells 1 (TREM-1) signaling pathway is stimulated by bacteria and, together with its putative ligand peptidoglycan recognition protein 1 (PGLYRP1), propagates proinflammator …
INTRODUCTION: The triggering receptor expressed on myeloid cells 1 (TREM-1) signaling pathw …
Increased gingival crevicular fluid levels of soluble triggering receptor expressed on myeloid cells (sTREM) -1 in severe periodontitis.
Bisson C, Massin F, Lefevre PA, Thilly N, Miller N, Gibot S. Bisson C, et al. J Clin Periodontol. 2012 Dec;39(12):1141-8. doi: 10.1111/jcpe.12008. Epub 2012 Oct 16. J Clin Periodontol. 2012. PMID: 23067264
AIM: This study was designed to evaluate the presence of a new regulator of innate immunity in periodontitis: the soluble form of triggering receptor on myeloid cells-1 (sTREM-1) in gingival crevicular fluid (GCF). ...RESULTS: The mean sT …
AIM: This study was designed to evaluate the presence of a new regulator of innate immunity in periodontitis: the soluble form of …
Trem1 Induces Periodontal Inflammation via Regulating M1 Polarization.
Wu D, Weng Y, Feng Y, Liang B, Wang H, Li L, Wang Z. Wu D, et al. J Dent Res. 2022 Apr;101(4):437-447. doi: 10.1177/00220345211044681. Epub 2021 Nov 1. J Dent Res. 2022. PMID: 34719965
This study evaluated the role of Trem1 (triggering receptors expressed on myeloid cells 1) in periodontitis by influencing polarization of M1 macrophages through the STAT3/HIF-1alpha signaling pathway. ...Moreover, inhibition of Trem1 and HIF-1a …
This study evaluated the role of Trem1 (triggering receptors expressed on myeloid cells 1) in periodontit …
TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and RANKL Expression and Suppresses Bone loss.
Bostanci N, Abe T, Belibasakis GN, Hajishengallis G. Bostanci N, et al. J Clin Med. 2019 Oct 1;8(10):1579. doi: 10.3390/jcm8101579. J Clin Med. 2019. PMID: 31581596 Free PMC article.
AIM: Triggering receptor expressed on myeloid cells-1 (TREM-1) is a modifier of local and systemic inflammation. ...To elucidate the impact of LP17 on the host response, we analyzed the expression of a number of immune-modul …
AIM: Triggering receptor expressed on myeloid cells-1 (TREM-1) is a modifier of local and s …