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Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy.
Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M, Lewis CE. Burke B, et al. J Pathol. 2002 Feb;196(2):204-12. doi: 10.1002/path.1029. J Pathol. 2002. PMID: 11793372
However, the present study shows that human macrophages accumulate higher levels of HIF-1 than HIF-2 when exposed to tumour-specific levels of hypoxia in vitro; that macrophages in human tumours express abundant HIF-1; and that express …
However, the present study shows that human macrophages accumulate higher levels of HIF-1 than HIF-2 when exposed to tumour-sp …
Activated HIF1alpha of tumor cells promotes chemoresistance development via recruiting GDF15-producing tumor-associated macrophages in gastric cancer.
Yu S, Li Q, Yu Y, Cui Y, Li W, Liu T, Liu F. Yu S, et al. Cancer Immunol Immunother. 2020 Oct;69(10):1973-1987. doi: 10.1007/s00262-020-02598-5. Epub 2020 May 9. Cancer Immunol Immunother. 2020. PMID: 32388677 Free PMC article.
The treatments of anti-tumor chemo-agents recruit more tumor-associated macrophages (TAMs) which are highly implicated in the chemoresistance development, but the underlying molecular mechanism is unclear. ...Mechanistically, in the GC cells under the 5-FU treatment …
The treatments of anti-tumor chemo-agents recruit more tumor-associated macrophages (TAMs) which are highly implicated in the …
Tumor-derived LIF promotes chemoresistance via activating tumor-associated macrophages in gastric cancers.
Yu S, Li Q, Wang Y, Cui Y, Yu Y, Li W, Liu F, Liu T. Yu S, et al. Exp Cell Res. 2021 Sep 1;406(1):112734. doi: 10.1016/j.yexcr.2021.112734. Epub 2021 Jul 13. Exp Cell Res. 2021. PMID: 34265288
Alternatively activated or M2-type tumor associated macrophages (TAMs) are recruited under chemotherapy and are highly implicated in the chemoresistance development, but underlying molecular mechanism for TAM activation is largely unknown. ...Further study revealed …
Alternatively activated or M2-type tumor associated macrophages (TAMs) are recruited under chemotherapy and are highly implicated …
Casdatifan (AB521) is a novel and potent allosteric small molecule inhibitor of protumourigenic HIF-2α dependent transcription.
Schweickert PG, Piovesan D, Mitchell CG, Zepeda-Carranza B, Zhu WS, Lopez Espinoza AY, Rocha L, Singh J, Malgapo MIP, Meleza C, Northington KR, Ray RD, Zhao X, Lawson KV, Walters MJ, Sivick KE. Schweickert PG, et al. Br J Pharmacol. 2025 Sep;182(17):4147-4167. doi: 10.1111/bph.70075. Epub 2025 May 21. Br J Pharmacol. 2025. PMID: 40400177
BACKGROUND AND PURPOSE: Hypoxia-inducible factor 2alpha (HIF-2alpha) is a transcription factor that mediates the expression of genes critical for cell adaptation and survival in low oxygen (hypoxic) conditions. ...KEY RESULTS: AB521 inhibited HIF-2alpha-mediated tra …
BACKGROUND AND PURPOSE: Hypoxia-inducible factor 2alpha (HIF-2alpha) is a transcription factor that mediates the expression of …