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Expansion of Fcgamma Receptor IIIa-Positive Macrophages, Ficolin 1-Positive Monocyte-Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis.
Xue D, Tabib T, Morse C, Yang Y, Domsic RT, Khanna D, Lafyatis R. Xue D, et al. Arthritis Rheumatol. 2022 Feb;74(2):329-341. doi: 10.1002/art.41813. Epub 2022 Jan 18. Arthritis Rheumatol. 2022. PMID: 34042322 Free PMC article.
One SSc-associated macrophage cluster, highly expressing Fcgamma receptor IIIA, was suggested on pseudotime analysis to be derived from normal CCR1+ and MARCO+ macrophages. A second SSc-associated myeloid population highly expressed monocyte mar …
One SSc-associated macrophage cluster, highly expressing Fcgamma receptor IIIA, was suggested on pseudotime analysis to be der …
Expression of M-Ficolin in human monocytes and macrophages.
Frankenberger M, Schwaeble W, Ziegler-Heitbrock L. Frankenberger M, et al. Mol Immunol. 2008 Mar;45(5):1424-30. doi: 10.1016/j.molimm.2007.08.014. Epub 2007 Oct 10. Mol Immunol. 2008. PMID: 17928056
M-Ficolin is a member of the ficolin family of proteins, which is expressed by monocytes. ...Monocyte-derived macrophages generated by in vitro culture for 5 days strongly reduced M-Ficolin mRNA and protein. ...
M-Ficolin is a member of the ficolin family of proteins, which is expressed by monocytes. ...Monocyte-der
The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma.
Honoré C, Rørvig S, Munthe-Fog L, Hummelshøj T, Madsen HO, Borregaard N, Garred P. Honoré C, et al. Mol Immunol. 2008 May;45(10):2782-9. doi: 10.1016/j.molimm.2008.02.005. Epub 2008 Mar 17. Mol Immunol. 2008. PMID: 18343499
Ficolin-1 (M-Ficolin) is a pattern recognition molecule of the complement system that is expressed by myeloid cells and type II alveolar epithelial cells. ...In this study we explored the possibility that Ficolin-1 may be secreted from monocytes, ma
Ficolin-1 (M-Ficolin) is a pattern recognition molecule of the complement system that is expressed by myeloid cells and …
Serum opsonin ficolin-A enhances host-fungal interactions and modulates cytokine expression from human monocyte-derived macrophages and neutrophils following Aspergillus fumigatus challenge.
Bidula S, Sexton DW, Schelenz S. Bidula S, et al. Med Microbiol Immunol. 2016 Apr;205(2):133-42. doi: 10.1007/s00430-015-0435-9. Epub 2015 Sep 4. Med Microbiol Immunol. 2016. PMID: 26337048
Using human monocyte-derived macrophages and neutrophils isolated from healthy donors, we investigated conidial association and fungal viability by flow cytometry and microscopy. ...Ficolin-A opsonization was observed to significantly enhance association of c …
Using human monocyte-derived macrophages and neutrophils isolated from healthy donors, we investigated conidial associa …
Ficolin-1 is up-regulated in leukocytes and glomeruli from microscopic polyangiitis patients.
Muso E, Okuzaki D, Kobayashi S, Iwasaki Y, Sakurai MA, Ito A, Nojima H. Muso E, et al. Autoimmunity. 2013 Dec;46(8):513-24. doi: 10.3109/08916934.2013.822073. Epub 2013 Aug 15. Autoimmunity. 2013. PMID: 23944633
Compared to normal control, several genes were up- or down-regulated in MPA patients, including up-regulation of the mRNA level of ficolin-1 (FCN1 or M-ficolin), an innate pattern recognition complement molecule. ...Many of the ficolin-1 dots were also positive for …
Compared to normal control, several genes were up- or down-regulated in MPA patients, including up-regulation of the mRNA level of ficolin-1 …
Ficolin-2 amplifies inflammation in macrophage-smooth muscle cell cross-talk and increases monocyte transmigration by mechanisms involving IL-1beta and IL-6.
Macarie RD, Tucureanu MM, Ciortan L, Gan AM, Butoi E, Mânduțeanu I. Macarie RD, et al. Sci Rep. 2023 Nov 8;13(1):19431. doi: 10.1038/s41598-023-46770-0. Sci Rep. 2023. PMID: 37940674 Free PMC article.
We hypothesize that it could influence plaque vulnerability by interfering in the cross-talk between macrophages (MO) and smooth muscle cells (SMC). To examine its role and mechanism of action, we exposed an in-vitro co-culture system of SMC and MO to ficolin-2 (10 g/mL) a …
We hypothesize that it could influence plaque vulnerability by interfering in the cross-talk between macrophages (MO) and smooth musc …
M-ficolin is expressed on monocytes and is a lectin binding to N-acetyl-D-glucosamine and mediates monocyte adhesion and phagocytosis of Escherichia coli.
Teh C, Le Y, Lee SH, Lu J. Teh C, et al. Immunology. 2000 Oct;101(2):225-32. doi: 10.1046/j.1365-2567.2000.00099.x. Immunology. 2000. PMID: 11012776 Free PMC article.
M-ficolin mRNA was expressed in monocytes but not in the more differentiated macrophages and dendritic cells. ...Therefore, M-ficolin might act as a phagocytic receptor or adaptor on circulating monocytes for micro-organism
M-ficolin mRNA was expressed in monocytes but not in the more differentiated macrophages and dendritic ce
Biosynthesis of human ficolin, an Escherichia coli-binding protein, by monocytes: comparison with the synthesis of two macrophage-specific proteins, C1q and the mannose receptor.
Lu J, Le Y, Kon OL, Chan J, Lee SH. Lu J, et al. Immunology. 1996 Oct;89(2):289-94. doi: 10.1046/j.1365-2567.1996.d01-732.x. Immunology. 1996. PMID: 8943728 Free PMC article.
This finding suggested that blood monocytes also normally synthesize human ficolin. Peripheral blood monocytes from adult human donors were harvested at serial time-points (0-20 hr) after adhesion to tissue culture plates, and total RNA was isolated an …
This finding suggested that blood monocytes also normally synthesize human ficolin. Peripheral blood monocytes from adu …
Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain.
Honoré C, Rørvig S, Hummelshøj T, Skjoedt MO, Borregaard N, Garred P. Honoré C, et al. J Leukoc Biol. 2010 Jul;88(1):145-58. doi: 10.1189/jlb.1209802. Epub 2010 Apr 16. J Leukoc Biol. 2010. PMID: 20400674
Three Ficolins have been identified in humans: Ficolin-1 (M-Ficolin), Ficolin-2 (L-Ficolin), and Ficolin-3 (H-Ficolin). Ficolin-1 is the least-described of the Ficolins and is expressed by monocytes, granulocytes, and in the lungs. …
Three Ficolins have been identified in humans: Ficolin-1 (M-Ficolin), Ficolin-2 (L-Ficolin), and Ficolin-3 (H-Fi …
Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse.
Liu Y, Endo Y, Homma S, Kanno K, Yaginuma H, Fujita T. Liu Y, et al. Mol Immunol. 2005 Jul;42(11):1265-73. doi: 10.1016/j.molimm.2004.11.019. Epub 2005 Jan 5. Mol Immunol. 2005. PMID: 15950722
The other human ficolin, M-ficolin, is a non-serum-type ficolin that is expressed in monocytes. Little is known about the physiological roles of ficolins. In this study, we delineated the ontogeny and cell types that express fic
The other human ficolin, M-ficolin, is a non-serum-type ficolin that is expressed in monocytes. Little is …
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