Expression of properdin in human monocytes.
Eur J Biochem. 1994.
PMID: 8112326
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Expression of properdin in human monocytes.
Eur J Biochem. 1994 Feb 1;219(3):759-64. doi: 10.1111/j.1432-1033.1994.tb18555.x.
Eur J Biochem. 1994.
PMID: 8112326
Free article.
Northern blot analysis of cell lines derived from fibroblasts, B-cells, hepatoma cells, and cells of the monocyte-macrophage lineage revealed properdin expression only in the myelomonocytic cell line HL-60, in the monoblastic cell line U-937 and in the mon …
Northern blot analysis of cell lines derived from fibroblasts, B-cells, hepatoma cells, and cells of the monocyte-macrophage lineage …
Protective role for properdin in progression of experimental murine atherosclerosis.
PLoS One. 2014 Mar 25;9(3):e92404. doi: 10.1371/journal.pone.0092404. eCollection 2014.
PLoS One. 2014.
PMID: 24667818
Free PMC article.
Atherosclerosis was assessed after feeding low fat (LFD) or high fat (HFD) Western type diets to newly generated LDLR(-/-) Properdin(KO) (LDLR(-/-)P(KO)) and LDLR-/-PWT mice. Lipids, lymphocytes and monocytes were similar among genotypes, genders and diets. ...All m …
Atherosclerosis was assessed after feeding low fat (LFD) or high fat (HFD) Western type diets to newly generated LDLR(-/-) Properdin( …
Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutations.
J Clin Immunol. 1998 Jul;18(4):272-82. doi: 10.1023/a:1027385806871.
J Clin Immunol. 1998.
PMID: 9710744
In type I deficiency no intracellular or secreted properdin was found, indicating rapid intracellular degradation. Monocytes from the males with type II deficiency expressed and secreted properdin normally. ...Analysis of properdin expression …
In type I deficiency no intracellular or secreted properdin was found, indicating rapid intracellular degradation. Monocytes f …
Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator.
J Neuroinflammation. 2017 Jan 5;14(1):4. doi: 10.1186/s12974-016-0776-3.
J Neuroinflammation. 2017.
PMID: 28086806
Free PMC article.
Biolayer interferometry defined protein interactions. Furthermore, endogenous ARMS2 gene expression was studied in human blood derived monocytes and in human induced pluripotent stem cell-derived microglia (iPSdM) by PCR and LSM. ...We also demo …
Biolayer interferometry defined protein interactions. Furthermore, endogenous ARMS2 gene expression was studied in human …
Expression of the components and regulatory proteins of the alternative complement pathway and the membrane attack complex in normal and diseased synovium.
Rheumatol Int. 1993;13(4):139-46. doi: 10.1007/BF00301260.
Rheumatol Int. 1993.
PMID: 8310205
Monocytes secreted properdin, C3, and factor H but not factor B, factor I, C5, C6, C7, C8 or C9. Fibroblasts and endothelial cells secreted factor B, factor H and factor I, but not properdin, C5, C6, C7, C8 or C9. Lymphocytes did not secrete any of these comp …
Monocytes secreted properdin, C3, and factor H but not factor B, factor I, C5, C6, C7, C8 or C9. Fibroblasts and endothelial c …
Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils.
J Immunol. 1997 May 1;158(9):4444-51.
J Immunol. 1997.
PMID: 9127010
In contrast to most other components of complement, biosynthesis of properdin is restricted to a few cell types only, i.e., monocytes/macrophages and peripheral blood T cells. This report demonstrates the presence of properdin mRNA in peripheral blood granulo …
In contrast to most other components of complement, biosynthesis of properdin is restricted to a few cell types only, i.e., monocy …
Human monocyte-derived dendritic cells are a source of several complement proteins.
Inflamm Res. 2006 May;55(5):179-84. doi: 10.1007/s00011-006-0068-y.
Inflamm Res. 2006.
PMID: 16830104
METHODS: Reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot were used to evaluate the expression and production of several complement proteins. RESULTS: We show that DCs produce C3, C5, C9, Factor (F)I, FH, FB, FD and properdin at levels simil …
METHODS: Reverse transcriptase polymerase chain reaction (RT-PCR) and Western blot were used to evaluate the expression and productio …
Complement activation by CpG in a human whole blood loop system: mechanisms and immunomodulatory effects.
J Immunol. 2009 Nov 15;183(10):6724-32. doi: 10.4049/jimmunol.0902374. Epub 2009 Oct 28.
J Immunol. 2009.
PMID: 19864604
Free PMC article.
In a human blood loop system, both backbone and sequence-specific effects by CpG were counteracted by selective inhibition of C3. Furthermore, DNA backbone-mediated CD40 and CD83 expression on monocytes and sequence-specific IL-6 and TNF production were reduc …
In a human blood loop system, both backbone and sequence-specific effects by CpG were counteracted by selective inhibition of C3. Fur …
Complement alternative pathway acts as a positive feedback amplification of neutrophil activation.
Blood. 2011 Jan 27;117(4):1340-9. doi: 10.1182/blood-2010-05-283564. Epub 2010 Nov 9.
Blood. 2011.
PMID: 21063021
This occurred independently of neutrophil proteases, oxidants, or apoptosis. Neutrophil-secreted properdin was detected on the cell surface and could focus "in situ" the alternative pathway activation. Importantly, complement, in turn, led to further activation of neutroph …
This occurred independently of neutrophil proteases, oxidants, or apoptosis. Neutrophil-secreted properdin was detected on the cell s …