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Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes.
Werz O, Bürkert E, Fischer L, Szellas D, Dishart D, Samuelsson B, Rådmark O, Steinhilber D. Werz O, et al. FASEB J. 2002 Sep;16(11):1441-3. doi: 10.1096/fj.01-0909fje. Epub 2002 Jul 1. FASEB J. 2002. PMID: 12205041
Here, we demonstrate that extracellular signal-regulated kinases (ERKs) can phosphorylate 5-LO in vitro. ...Finally, the data suggest that ERKs and p38 MAPK-regulated MAPKAPKs can act in conjunction to stimulate 5-LO …
Here, we demonstrate that extracellular signal-regulated kinases (ERKs) can phosphorylate 5-LO in …
5-lipoxygenase: cellular biology and molecular pharmacology.
Werz O. Werz O. Curr Drug Targets Inflamm Allergy. 2002 Mar;1(1):23-44. doi: 10.2174/1568010023344959. Curr Drug Targets Inflamm Allergy. 2002. PMID: 14561204 Review.
Intensive research revealed that on cell stimulation, 5-LO redistributes to the nuclear membrane where it colocalizes with 5-lipoxygenase-activating protein and cytosolic phospholipase A(2). In addition, various cellular proteins interacting wit …
Intensive research revealed that on cell stimulation, 5-LO redistributes to the nuclear membrane where it colocalizes with …
Blockade of cytosolic phospholipase A(2) and 5-lipoxygenase activation in neutrophils by a natural isoflavanquinone abruquinone A.
Hsu MF, Chang LC, Chen SC, Kuo SC, Lee HY, Lu MC, Wang JP. Hsu MF, et al. Eur J Pharmacol. 2008 Nov 19;598(1-3):123-31. doi: 10.1016/j.ejphar.2008.09.007. Epub 2008 Sep 22. Eur J Pharmacol. 2008. PMID: 18834875
Moreover, the phosphorylation of both cPLA(2) and extracellular signal regulated kinases (ERKs) induced by fMLP and A23187 was attenuated by abruquinone A in a parallel concentration-dependent manner. ...These results indicate that the blockade …
Moreover, the phosphorylation of both cPLA(2) and extracellular signal regulated kinases (ERKs) induced b …
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes.
Werz O, Bürkert E, Samuelsson B, Rådmark O, Steinhilber D. Werz O, et al. Blood. 2002 Feb 1;99(3):1044-52. doi: 10.1182/blood.v99.3.1044. Blood. 2002. PMID: 11807011 Free article.
In parallel, cell stress led to activation of p38 MAPK (mitogen-activated protein kinase) and mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) kinases, which can phosphorylate 5
In parallel, cell stress led to activation of p38 MAPK (mitogen-activated protein kinase) and mitogen-activat
Intravenous anesthetic propofol suppresses leukotriene production in murine dendritic cells.
Inada T, Ueshima H, Shingu K. Inada T, et al. J Immunotoxicol. 2013 Jul-Sep;10(3):262-9. doi: 10.3109/1547691X.2012.712066. Epub 2012 Sep 7. J Immunotoxicol. 2013. PMID: 22953970
Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipox
Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), …
MEK-1/2 inhibition prevents 5-lipoxygenase translocation in N-formylpeptide-challenged human neutrophils.
Boden SE, Bertsche T, Ammon HP, Safayhi H. Boden SE, et al. Int J Biochem Cell Biol. 2000 Oct;32(10):1069-74. doi: 10.1016/s1357-2725(00)00049-2. Int J Biochem Cell Biol. 2000. PMID: 11091139
In order to elucidate the role of mitogen-activated protein kinase kinase (MEK-1/2) in 5-lipoxygenase (5-LO) activation we studied the N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced 5-LO translocation in human blood neutrop …
In order to elucidate the role of mitogen-activated protein kinase kinase (MEK-1/2) in 5-lipoxygenase ( …
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid.
Bürkert E, Szellas D, Rådmark O, Steinhilber D, Werz O. Bürkert E, et al. J Leukoc Biol. 2003 Jan;73(1):191-200. doi: 10.1189/jlb.0702354. J Leukoc Biol. 2003. PMID: 12525578
We show that stimulation of polymorphonuclear leukocytes (PMNL), rat basophilic leukemia (RBL)-1, or transfected HeLa cells with arachidonic acid (AA) caused prominent 5-LO product formation that coincided with the activity of extracellular
We show that stimulation of polymorphonuclear leukocytes (PMNL), rat basophilic leukemia (RBL)-1, or transfected HeLa cells wi …
A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis.
Kalhan R, Smith LJ, Nlend MC, Nair A, Hixon JL, Sporn PH. Kalhan R, et al. Clin Exp Allergy. 2008 Jan;38(1):103-12. doi: 10.1111/j.1365-2222.2007.02862.x. Epub 2007 Nov 2. Clin Exp Allergy. 2008. PMID: 17979994 Free PMC article. Clinical Trial.
Mitogen-activated protein (MAP) kinase activation was determined by immunoblot. ...RESULTS: Genistein inhibited eosinophil LTC(4) synthesis (IC(50) 80 nm), blocked phosphorylation of p38 MAP kinase and its downstream target MAPKAP-2, and
Mitogen-activated protein (MAP) kinase activation was determined by immunoblot. ...RESULTS: Genistein inhibited
The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils--implications for asthma.
Sun J, Dahlén B, Agerberth B, Haeggström JZ. Sun J, et al. Allergy. 2013 Mar;68(3):304-11. doi: 10.1111/all.12087. Epub 2013 Jan 18. Allergy. 2013. PMID: 23330796
BACKGROUND: Eosinophils and their products, including leukotrienes and eosinophil cationic protein (ECP), are well-known mediators of inflammation and tissue damage in asthma. ...The release was more prominent in cells primed with the eosinophilopoietic cytokine GM- …
BACKGROUND: Eosinophils and their products, including leukotrienes and eosinophil cationic protein (ECP), are well-known media …
Differential modulation of mediator release from human basophils and mast cells by mizolastine.
Triggiani M, Giannattasio G, Balestrieri B, Granata F, Gelb MH, de Paulis A, Marone G. Triggiani M, et al. Clin Exp Allergy. 2004 Feb;34(2):241-9. doi: 10.1111/j.1365-2222.2004.01851.x. Clin Exp Allergy. 2004. PMID: 14987304
Mizolastine did not influence anti-IgE-induced activation of extracellular signal-regulated kinase-1 and -2 (ERK-1 and -2) in human basophils. CONCLUSIONS: Mizolastine efficiently inhibits LTC4 synthesis in human basophils and mast cells presumably by interfe …
Mizolastine did not influence anti-IgE-induced activation of extracellular signal-regulated kinase-1 and -2 (ERK-1 and …
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