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Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes.
Werz O, Bürkert E, Fischer L, Szellas D, Dishart D, Samuelsson B, Rådmark O, Steinhilber D. Werz O, et al. FASEB J. 2002 Sep;16(11):1441-3. doi: 10.1096/fj.01-0909fje. Epub 2002 Jul 1. FASEB J. 2002. PMID: 12205041
Here, we demonstrate that extracellular signal-regulated kinases (ERKs) can phosphorylate 5-LO in vitro. ...Finally, the data suggest that ERKs and p38 MAPK-regulated MAPKAPKs can act in conjunction to stimulate 5-LO by phosphor
Here, we demonstrate that extracellular signal-regulated kinases (ERKs) can phosphorylate 5-LO in vitro. …
5-lipoxygenase: cellular biology and molecular pharmacology.
Werz O. Werz O. Curr Drug Targets Inflamm Allergy. 2002 Mar;1(1):23-44. doi: 10.2174/1568010023344959. Curr Drug Targets Inflamm Allergy. 2002. PMID: 14561204 Review.
Intensive research revealed that on cell stimulation, 5-LO redistributes to the nuclear membrane where it colocalizes with 5-lipoxygenase-activating protein and cytosolic phospholipase A(2). In addition, various cellular proteins interacting with 5-LO …
Intensive research revealed that on cell stimulation, 5-LO redistributes to the nuclear membrane where it colocalizes with 5- …
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes.
Werz O, Bürkert E, Samuelsson B, Rådmark O, Steinhilber D. Werz O, et al. Blood. 2002 Feb 1;99(3):1044-52. doi: 10.1182/blood.v99.3.1044. Blood. 2002. PMID: 11807011 Free article.
In parallel, cell stress led to activation of p38 MAPK (mitogen-activated protein kinase) and mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) kinases, which can phosphorylate 5-LO in vitro …
In parallel, cell stress led to activation of p38 MAPK (mitogen-activated protein kinase) and mitogen-activat
Blockade of cytosolic phospholipase A(2) and 5-lipoxygenase activation in neutrophils by a natural isoflavanquinone abruquinone A.
Hsu MF, Chang LC, Chen SC, Kuo SC, Lee HY, Lu MC, Wang JP. Hsu MF, et al. Eur J Pharmacol. 2008 Nov 19;598(1-3):123-31. doi: 10.1016/j.ejphar.2008.09.007. Epub 2008 Sep 22. Eur J Pharmacol. 2008. PMID: 18834875
Based on the Western blot analysis, the nuclear membrane recruitment of cPLA(2) and 5-LO was inhibited by abruquinone A in A23187- as well as in fMLP-stimulated cells. Moreover, the phosphorylation of both cPLA(2) and extracellular signal regulated
Based on the Western blot analysis, the nuclear membrane recruitment of cPLA(2) and 5-LO was inhibited by abruquinone A in A23187- as well a …
Intravenous anesthetic propofol suppresses leukotriene production in murine dendritic cells.
Inada T, Ueshima H, Shingu K. Inada T, et al. J Immunotoxicol. 2013 Jul-Sep;10(3):262-9. doi: 10.3109/1547691X.2012.712066. Epub 2012 Sep 7. J Immunotoxicol. 2013. PMID: 22953970
Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipox
Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), …
MEK-1/2 inhibition prevents 5-lipoxygenase translocation in N-formylpeptide-challenged human neutrophils.
Boden SE, Bertsche T, Ammon HP, Safayhi H. Boden SE, et al. Int J Biochem Cell Biol. 2000 Oct;32(10):1069-74. doi: 10.1016/s1357-2725(00)00049-2. Int J Biochem Cell Biol. 2000. PMID: 11091139
In order to elucidate the role of mitogen-activated protein kinase kinase (MEK-1/2) in 5-lipoxygenase (5-LO) activation we studied the N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced 5-LO translocation in human blood neutrophils (PMNs). I …
In order to elucidate the role of mitogen-activated protein kinase kinase (MEK-1/2) in 5-lipoxygenase (5- …
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid.
Bürkert E, Szellas D, Rådmark O, Steinhilber D, Werz O. Bürkert E, et al. J Leukoc Biol. 2003 Jan;73(1):191-200. doi: 10.1189/jlb.0702354. J Leukoc Biol. 2003. PMID: 12525578
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. We show that stimulation of polymorphonuclear leukocytes (PMNL), rat basophilic leukemia (RBL)-1, or transfected HeLa cells with arachidonic acid (AA) caused p
5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of proinflammatory leukotrienes. We show that stimulation o
A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis.
Kalhan R, Smith LJ, Nlend MC, Nair A, Hixon JL, Sporn PH. Kalhan R, et al. Clin Exp Allergy. 2008 Jan;38(1):103-12. doi: 10.1111/j.1365-2222.2007.02862.x. Epub 2007 Nov 2. Clin Exp Allergy. 2008. PMID: 17979994 Free PMC article. Clinical Trial.
Mitogen-activated protein (MAP) kinase activation was determined by immunoblot. ...RESULTS: Genistein inhibited eosinophil LTC(4) synthesis (IC(50) 80 nm), blocked phosphorylation of p38 MAP kinase and its downstream target MAPKAP-2, and
Mitogen-activated protein (MAP) kinase activation was determined by immunoblot. ...RESULTS: Genistein inhibited
The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils--implications for asthma.
Sun J, Dahlén B, Agerberth B, Haeggström JZ. Sun J, et al. Allergy. 2013 Mar;68(3):304-11. doi: 10.1111/all.12087. Epub 2013 Jan 18. Allergy. 2013. PMID: 23330796
BACKGROUND: Eosinophils and their products, including leukotrienes and eosinophil cationic protein (ECP), are well-known mediators of inflammation and tissue damage in asthma. ...The release was more prominent in cells primed with the eosinophilopoietic cytokine GM- …
BACKGROUND: Eosinophils and their products, including leukotrienes and eosinophil cationic protein (ECP), are well-known media …
Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis.
Sánchez-Galán E, Gómez-Hernández A, Vidal C, Martín-Ventura JL, Blanco-Colio LM, Muñoz-García B, Ortega L, Egido J, Tuñón J. Sánchez-Galán E, et al. Cardiovasc Res. 2009 Jan 1;81(1):216-25. doi: 10.1093/cvr/cvn277. Epub 2008 Oct 13. Cardiovasc Res. 2009. PMID: 18852255
METHODS AND RESULTS: In cultured monocytic cells, LTB4 induced a rapid phosphorylation of mitogen-activated protein kinases (MAPKs ERK1/2 and JNK1/2) and PI3K/Akt via BLT1 and BLT2 in a pertussis toxin (PTX)-dependent mechanism (assessed via wes …
METHODS AND RESULTS: In cultured monocytic cells, LTB4 induced a rapid phosphorylation of mitogen-activated protein
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