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Functional alterations of myeloid cells during the course of Alzheimer's disease.
Thome AD, Faridar A, Beers DR, Thonhoff JR, Zhao W, Wen S, Pascual B, Masdeu JC, Appel SH. Thome AD, et al. Mol Neurodegener. 2018 Nov 13;13(1):61. doi: 10.1186/s13024-018-0293-1. Mol Neurodegener. 2018. PMID: 30424785 Free PMC article.
BACKGROUND: Neuroinflammation is a hallmark of neurodegenerative disease and a significant component of the pathology of Alzheimer's disease (AD). ...RESULTS: During stages of AD dementia (CDR1 and 2/3) peripheral myeloid cells increase t …
BACKGROUND: Neuroinflammation is a hallmark of neurodegenerative disease and a significant component of the pathology of Alzheimer …
Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.
Condello C, Yuan P, Grutzendler J. Condello C, et al. Biol Psychiatry. 2018 Feb 15;83(4):377-387. doi: 10.1016/j.biopsych.2017.10.007. Epub 2017 Oct 14. Biol Psychiatry. 2018. PMID: 29169609 Free PMC article. Review.
Recent genetic studies have provided overwhelming evidence of the involvement of microglia-related molecular networks in the pathophysiology of Alzheimer's disease (AD). However, the precise mechanisms by which microglia alter the course of AD n …
Recent genetic studies have provided overwhelming evidence of the involvement of microglia-related molecular networks in the pathophysiology …
Drivers of age-related inflammation and strategies for healthspan extension.
Goldberg EL, Dixit VD. Goldberg EL, et al. Immunol Rev. 2015 May;265(1):63-74. doi: 10.1111/imr.12295. Immunol Rev. 2015. PMID: 25879284 Free PMC article. Review.
Aging is the greatest risk factor for the development of chronic diseases such as arthritis, type 2 diabetes, cardiovascular disease, kidney disease, Alzheimer's disease, macular degeneration, frailty, and certain forms of cancers. It is widely …
Aging is the greatest risk factor for the development of chronic diseases such as arthritis, type 2 diabetes, cardiovascular disease, …
Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation.
Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, Fernandes A, Brites D. Caldeira C, et al. Front Aging Neurosci. 2017 Aug 31;9:277. doi: 10.3389/fnagi.2017.00277. eCollection 2017. Front Aging Neurosci. 2017. PMID: 28912710 Free PMC article.
Alzheimer's disease (AD) is characterized by a progressive cognitive decline and believed to be driven by the self-aggregation of amyloid-beta (Abeta) peptide into oligomers and fibrils that accumulate as senile plaques. ...Reduced phagocytosis may derive fro …
Alzheimer's disease (AD) is characterized by a progressive cognitive decline and believed to be driven by the self-aggr …
Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.
Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV Jr, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE. Tagge CA, et al. Brain. 2018 Feb 1;141(2):422-458. doi: 10.1093/brain/awx350. Brain. 2018. PMID: 29360998 Free PMC article.
Unanaesthetized mice subjected to unilateral impact exhibited abrupt onset, transient course, and rapid resolution of a concussion-like syndrome characterized by altered arousal, contralateral hemiparesis, truncal ataxia, locomotor and balance impairments, and neuro …
Unanaesthetized mice subjected to unilateral impact exhibited abrupt onset, transient course, and rapid resolution of a concussion-li …
The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease.
Bonham LW, Sirkis DW, Yokoyama JS. Bonham LW, et al. Front Immunol. 2019 Jun 4;10:1170. doi: 10.3389/fimmu.2019.01170. eCollection 2019. Front Immunol. 2019. PMID: 31214167 Free PMC article.
Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease (AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene expression is regulated in a region-specific manner over the cou …
Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease (AD) pathogen …
Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease.
Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. Wilcock DM, et al. Neurobiol Aging. 2015 Sep;36(9):2468-74. doi: 10.1016/j.neurobiolaging.2015.05.016. Epub 2015 May 30. Neurobiol Aging. 2015. PMID: 26103884 Free PMC article.
The overexpression of amyloid precursor protein gene may be sufficient to drive Alzheimer's disease (AD) neuropathology that is observed in virtually all individuals with DS by the age of 40 years. There is relatively little information about inflammation in …
The overexpression of amyloid precursor protein gene may be sufficient to drive Alzheimer's disease (AD) neuropathology …
Observation of hepatotoxic effects of 2-n-pentylaminoacetamide (Milacemide) in rat liver by a combined in vivo/in vitro approach.
Rogiers V, Vandenberghe Y, Vanhaecke T, Geerts A, Callaerts A, Carleer J, Roba J, Vercruysse A. Rogiers V, et al. Arch Toxicol. 1997;71(5):271-82. doi: 10.1007/s002040050387. Arch Toxicol. 1997. PMID: 9137805
Milacemide or 2-n-pentylaminoacetamide hydrochloride, a new glycine derivative, was found to cause elevations of plasma transaminases in patients suffering from severe depression and Alzheimer's disease. However, no signs of liver toxicity were observed durin …
Milacemide or 2-n-pentylaminoacetamide hydrochloride, a new glycine derivative, was found to cause elevations of plasma transaminases in pat …