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G-protein-independent activation of Tyk2 by the platelet-activating factor receptor.
Lukashova V, Asselin C, Krolewski JJ, Rola-Pleszczynski M, Stanková J. Lukashova V, et al. J Biol Chem. 2001 Jun 29;276(26):24113-21. doi: 10.1074/jbc.M100720200. Epub 2001 Apr 17. J Biol Chem. 2001. PMID: 11309383 Free article.
PAF exerts its activity through a specific heptohelical G-protein coupled receptor, expressed on a variety of cell types, including leukocytes. ...Finally, PAFR mutants that could not couple to G-proteins were found to effectively mediate Tyk2 …
PAF exerts its activity through a specific heptohelical G-protein coupled receptor, expressed on a variety of cell type …
Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus.
Lukashova V, Chen Z, Duhé RJ, Rola-Pleszczynski M, Stanková J. Lukashova V, et al. J Immunol. 2003 Oct 1;171(7):3794-800. doi: 10.4049/jimmunol.171.7.3794. J Immunol. 2003. PMID: 14500680
The PAF receptor (PAFR) belongs to the G protein-coupled, heptahelical receptor superfamily. Recently, we have shown that PAF signals through the Janus kinase (Jak)/STAT pathway and that Tyk2 plays an essential role in PAF-induced PAFR promoter 1 activatio …
The PAF receptor (PAFR) belongs to the G protein-coupled, heptahelical receptor superfamily. Recently, we have shown that PAF …