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54 results

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Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch.
Meixiong J, Anderson M, Limjunyawong N, Sabbagh MF, Hu E, Mack MR, Oetjen LK, Wang F, Kim BS, Dong X. Meixiong J, et al. Immunity. 2019 May 21;50(5):1163-1171.e5. doi: 10.1016/j.immuni.2019.03.013. Epub 2019 Apr 23. Immunity. 2019. PMID: 31027996 Free PMC article.
Compared with IgE-FcepsilonRI stimulation, Mrgprb2 activation of mast cells was distinct in both released substances (histamine, serotonin, and tryptase) and the pattern of activated itch-sensory neurons. Mrgprb2 deficiency decreased itch in multiple p …
Compared with IgE-FcepsilonRI stimulation, Mrgprb2 activation of mast cells was distinct in both released substances (histamin …
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Niehues T, von Hardenberg S, Velleuer E. Niehues T, et al. Allergol Select. 2024 Oct 2;8:304-323. doi: 10.5414/ALX02520E. eCollection 2024. Allergol Select. 2024. PMID: 39381601 Free PMC article.
In case of negative WGS results, a re-iteration attitude with re-analyses of the data (using the latest data base annotation)) may eventually lead to PAD diagnosis. PAD, like many other rare genetic diseases, will only be successfully managed, if physicians from different …
In case of negative WGS results, a re-iteration attitude with re-analyses of the data (using the latest data base annotation)) may eventuall …
Genetic deficiency of human mast cell alpha-tryptase.
Soto D, Malmsten C, Blount JL, Muilenburg DJ, Caughey GH. Soto D, et al. Clin Exp Allergy. 2002 Jul;32(7):1000-6. doi: 10.1046/j.1365-2222.2002.01416.x. Clin Exp Allergy. 2002. PMID: 12100045
BACKGROUND: Human alpha- and beta-tryptases are proteases secreted by mast cells. Beta (but not alpha) tryptases are implicated in asthma. ...By contrast, alpha-transcribing Mono Mac 6 and KU812 cells contain alpha- and beta-genes. CONCLU …
BACKGROUND: Human alpha- and beta-tryptases are proteases secreted by mast cells. Beta (but not alpha) trypta …
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase.
Liu G, Haw TJ, Starkey MR, Philp AM, Pavlidis S, Nalkurthi C, Nair PM, Gomez HM, Hanish I, Hsu AC, Hortle E, Pickles S, Rojas-Quintero J, Estepar RSJ, Marshall JE, Kim RY, Collison AM, Mattes J, Idrees S, Faiz A, Hansbro NG, Fukui R, Murakami Y, Cheng HS, Tan NS, Chotirmall SH, Horvat JC, Foster PS, Oliver BG, Polverino F, Ieni A, Monaco F, Caramori G, Sohal SS, Bracke KR, Wark PA, Adcock IM, Miyake K, Sin DD, Hansbro PM. Liu G, et al. Nat Commun. 2023 Nov 14;14(1):7349. doi: 10.1038/s41467-023-42913-z. Nat Commun. 2023. PMID: 37963864 Free PMC article.
This imiquimod-induced emphysema is reduced in mice deficient in mast cell protease-6, or when wild-type mice are treated with the mast cell stabilizer, cromolyn. Furthermore, therapeutic treatment with anti-TLR7 monoclonal antibody suppresses C …
This imiquimod-induced emphysema is reduced in mice deficient in mast cell protease-6, or when wild-type mice are treat …
Mastocytosis and allergy.
Greenhawt M, Akin C. Greenhawt M, et al. Curr Opin Allergy Clin Immunol. 2007 Oct;7(5):387-92. doi: 10.1097/ACI.0b013e3282a6443e. Curr Opin Allergy Clin Immunol. 2007. PMID: 17873577 Review.
The genetic deficiency of alpha tryptase has not been found to influence serum tryptase levels in patients with mastocytosis. SUMMARY: Pathologic mast cell activation is a key finding in both allergic diseases and mastocytosis, albeit cau …
The genetic deficiency of alpha tryptase has not been found to influence serum tryptase levels in patients with …
Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model.
Langhammer M, Schöpf J, Jaquet T, Horn K, Angel M, Spohr C, Christen D, Uhl FM, Maié T, Jacobi H, Feyerabend TB, Huber J, Panning M, Sitaru C, Costa I, Zeiser R, Aumann K, Becker H, Braunschweig T, Koschmieder S, Shoumariyeh K, Huber M, Schemionek-Reinders M, Brummer T, Halbach S. Langhammer M, et al. Leukemia. 2023 Jul;37(7):1474-1484. doi: 10.1038/s41375-023-01916-x. Epub 2023 May 9. Leukemia. 2023. PMID: 37161070 Free PMC article.
Using the genetically engineered ScltTA/TRE-BCR::ABL1 mouse model for chronic phase CML, we previously demonstrated that the loss of the docking protein GAB2 counteracts the infiltration of mast cells (MCs) in the bone marrow (BM) of BCR::ABL1 positive mice. …
Using the genetically engineered ScltTA/TRE-BCR::ABL1 mouse model for chronic phase CML, we previously demonstrated that the loss of …
The emerging role of mast cell proteases in asthma.
Pejler G. Pejler G. Eur Respir J. 2019 Oct 31;54(4):1900685. doi: 10.1183/13993003.00685-2019. Print 2019 Oct. Eur Respir J. 2019. PMID: 31371445 Free article. Review.
It is now well established that mast cells (MCs) play a crucial role in asthma. This is supported by multiple lines of evidence, including both clinical studies and studies on MC-deficient mice. ...When MCs are activated, e.g. in response to IgE receptor cros …
It is now well established that mast cells (MCs) play a crucial role in asthma. This is supported by multiple lines of evidenc …
Prevalence of mast cell activation disorders and hereditary alpha tryptasemia among patients with postural orthostatic tachycardia syndrome and Ehlers-Danlos syndrome: A systematic review.
Farley M, Estrada-Mendizabal RJ, Gansert EA, Voelker D, Marks LA, Gonzalez-Estrada A. Farley M, et al. Ann Allergy Asthma Immunol. 2025 Jul;135(1):97-102. doi: 10.1016/j.anai.2025.03.022. Epub 2025 Apr 2. Ann Allergy Asthma Immunol. 2025. PMID: 40185471
BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) and Ehlers-Danlos syndrome (EDS) are often reported to occur concurrently with mast cell activation disorders (MCADs) and hereditary alpha tryptasemia (HAT). However, it remains unclear whether evidence su …
BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) and Ehlers-Danlos syndrome (EDS) are often reported to occur concurrently with …
Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.
Trivedi NN, Tamraz B, Chu C, Kwok PY, Caughey GH. Trivedi NN, et al. J Allergy Clin Immunol. 2009 Nov;124(5):1099-105.e1-4. doi: 10.1016/j.jaci.2009.07.026. Epub 2009 Sep 12. J Allergy Clin Immunol. 2009. PMID: 19748655 Free PMC article.
BACKGROUND: Mast cell tryptases have proposed roles in allergic inflammation and host defense against infection. ...African and Asian populations are especially enriched in genes encoding functional and nonfunctional tryptases, respectively. Strong lin …
BACKGROUND: Mast cell tryptases have proposed roles in allergic inflammation and host defense against infection. ...Afr …
DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis.
Janssen E, Das M, Butts J, Alasharee M, Mukherjee S, Lozano GL, Rao C, Livingston AF, Woods B, Smith E, Peters Z, Milin E, Beamer MA, Wilkie H, Leyva-Castillo JM, Kam C, Sobh A, Dasouki M, Wakim RH, Dbaibo G, Al-Herz W, Chatila TA, Finkelman FD, Rakoff-Nahoum S, Geha RS. Janssen E, et al. Immunity. 2025 Jul 8;58(7):1794-1810.e5. doi: 10.1016/j.immuni.2025.06.004. Epub 2025 Jun 25. Immunity. 2025. PMID: 40570852
Immunoglobulin E (IgE)-mediated release of mediators from mast cells (MCs) drives food allergy, and intestinal MC load is an important determinant of disease severity. Dedicator of cytokinesis 8 (DOCK8)-deficient patients are highly susceptible to food allerg …
Immunoglobulin E (IgE)-mediated release of mediators from mast cells (MCs) drives food allergy, and intestinal MC load is an i …
54 results