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Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch.
Meixiong J, Anderson M, Limjunyawong N, Sabbagh MF, Hu E, Mack MR, Oetjen LK, Wang F, Kim BS, Dong X. Meixiong J, et al. Immunity. 2019 May 21;50(5):1163-1171.e5. doi: 10.1016/j.immuni.2019.03.013. Epub 2019 Apr 23. Immunity. 2019. PMID: 31027996 Free PMC article.
Compared with IgE-FcepsilonRI stimulation, Mrgprb2 activation of mast cells was distinct in both released substances (histamine, serotonin, and tryptase) and the pattern of activated itch-sensory neurons. Mrgprb2 deficiency decreased itch in multiple p …
Compared with IgE-FcepsilonRI stimulation, Mrgprb2 activation of mast cells was distinct in both released substances (histamin …
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase.
Liu G, Haw TJ, Starkey MR, Philp AM, Pavlidis S, Nalkurthi C, Nair PM, Gomez HM, Hanish I, Hsu AC, Hortle E, Pickles S, Rojas-Quintero J, Estepar RSJ, Marshall JE, Kim RY, Collison AM, Mattes J, Idrees S, Faiz A, Hansbro NG, Fukui R, Murakami Y, Cheng HS, Tan NS, Chotirmall SH, Horvat JC, Foster PS, Oliver BG, Polverino F, Ieni A, Monaco F, Caramori G, Sohal SS, Bracke KR, Wark PA, Adcock IM, Miyake K, Sin DD, Hansbro PM. Liu G, et al. Nat Commun. 2023 Nov 14;14(1):7349. doi: 10.1038/s41467-023-42913-z. Nat Commun. 2023. PMID: 37963864 Free PMC article.
This imiquimod-induced emphysema is reduced in mice deficient in mast cell protease-6, or when wild-type mice are treated with the mast cell stabilizer, cromolyn. Furthermore, therapeutic treatment with anti-TLR7 monoclonal antibody suppresses C …
This imiquimod-induced emphysema is reduced in mice deficient in mast cell protease-6, or when wild-type mice are treat …
Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model.
Langhammer M, Schöpf J, Jaquet T, Horn K, Angel M, Spohr C, Christen D, Uhl FM, Maié T, Jacobi H, Feyerabend TB, Huber J, Panning M, Sitaru C, Costa I, Zeiser R, Aumann K, Becker H, Braunschweig T, Koschmieder S, Shoumariyeh K, Huber M, Schemionek-Reinders M, Brummer T, Halbach S. Langhammer M, et al. Leukemia. 2023 Jul;37(7):1474-1484. doi: 10.1038/s41375-023-01916-x. Epub 2023 May 9. Leukemia. 2023. PMID: 37161070 Free PMC article.
Hence, it is of utmost importance to explore the underlying mechanisms to develop new therapeutic approaches to cure CML. Using the genetically engineered ScltTA/TRE-BCR::ABL1 mouse model for chronic phase CML, we previously demonstrated that the loss of the docking protei …
Hence, it is of utmost importance to explore the underlying mechanisms to develop new therapeutic approaches to cure CML. Using the genet
Genetic deficiency of human mast cell alpha-tryptase.
Soto D, Malmsten C, Blount JL, Muilenburg DJ, Caughey GH. Soto D, et al. Clin Exp Allergy. 2002 Jul;32(7):1000-6. doi: 10.1046/j.1365-2222.2002.01416.x. Clin Exp Allergy. 2002. PMID: 12100045
BACKGROUND: Human alpha- and beta-tryptases are proteases secreted by mast cells. ...By contrast, alpha-transcribing Mono Mac 6 and KU812 cells contain alpha- and beta-genes. CONCLUSIONS: Genetic alpha-tryptase deficiency is …
BACKGROUND: Human alpha- and beta-tryptases are proteases secreted by mast cells. ...By contrast, alpha-transcri …
Mast Cell Promotes the Development of Intracranial Aneurysm Rupture.
Furukawa H, Wada K, Tada Y, Kuwabara A, Sato H, Ai J, Lawton MT, Hashimoto T. Furukawa H, et al. Stroke. 2020 Nov;51(11):3332-3339. doi: 10.1161/STROKEAHA.120.030834. Epub 2020 Oct 6. Stroke. 2020. PMID: 33019897 Free PMC article.
Aneurysm formation and rupture were assessed over 3 weeks. Roles of mast cells were assessed using a mast cell stabilizer (cromolyn), a mast cell activator (C48/80), and mice that are genetically lacking mature mast cells
Aneurysm formation and rupture were assessed over 3 weeks. Roles of mast cells were assessed using a mast cell s …
The emerging role of mast cell proteases in asthma.
Pejler G. Pejler G. Eur Respir J. 2019 Oct 31;54(4):1900685. doi: 10.1183/13993003.00685-2019. Print 2019 Oct. Eur Respir J. 2019. PMID: 31371445 Free article. Review.
It is now well established that mast cells (MCs) play a crucial role in asthma. This is supported by multiple lines of evidence, including both clinical studies and studies on MC-deficient mice. ...When MCs are activated, e.g. in response to IgE receptor cros …
It is now well established that mast cells (MCs) play a crucial role in asthma. This is supported by multiple lines of evidenc …
Mastocytosis and allergy.
Greenhawt M, Akin C. Greenhawt M, et al. Curr Opin Allergy Clin Immunol. 2007 Oct;7(5):387-92. doi: 10.1097/ACI.0b013e3282a6443e. Curr Opin Allergy Clin Immunol. 2007. PMID: 17873577 Review.
The genetic deficiency of alpha tryptase has not been found to influence serum tryptase levels in patients with mastocytosis. SUMMARY: Pathologic mast cell activation is a key finding in both allergic diseases and mastocytosis, albeit cau …
The genetic deficiency of alpha tryptase has not been found to influence serum tryptase levels in patients with …
Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation.
Zhang J, Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP. Zhang J, et al. Circ Res. 2011 May 27;108(11):1316-27. doi: 10.1161/CIRCRESAHA.111.243758. Epub 2011 Apr 14. Circ Res. 2011. PMID: 21493897 Free PMC article.
RATIONALE: Mast cells (MCs) contribute to the formation of abdominal aortic aneurysms (AAAs) by producing biologically active mediators. ...Mechanistic studies demonstrated that tryptase deficiency affected endothelial cell (EC) chemokine and cy …
RATIONALE: Mast cells (MCs) contribute to the formation of abdominal aortic aneurysms (AAAs) by producing biologically active …
Extrinsic and Intrinsic Modulators of Anaphylaxis.
Carter MC, Park J, Vadas P, Worm M. Carter MC, et al. J Allergy Clin Immunol Pract. 2023 Jul;11(7):1998-2006. doi: 10.1016/j.jaip.2023.05.015. Epub 2023 May 24. J Allergy Clin Immunol Pract. 2023. PMID: 37230384
Moreover, the severity can be modulated further by intrinsic and extrinsic factors. Among these, the genetic predisposition, certain comorbidities such as uncontrolled asthma, and hormonal fluctuations have been proposed as intrinsic and antihypertensive medications or phy …
Moreover, the severity can be modulated further by intrinsic and extrinsic factors. Among these, the genetic predisposition, certain …
Multidisciplinary Challenges in Mastocytosis and How to Address with Personalized Medicine Approaches.
Valent P, Akin C, Gleixner KV, Sperr WR, Reiter A, Arock M, Triggiani M. Valent P, et al. Int J Mol Sci. 2019 Jun 18;20(12):2976. doi: 10.3390/ijms20122976. Int J Mol Sci. 2019. PMID: 31216696 Free PMC article. Review.
Mastocytosis is a hematopoietic neoplasm defined by abnormal expansion and focal accumulation of clonal tissue mast cells in various organ-systems. The disease exhibits a complex pathology and an equally complex clinical behavior. ...Whereas patients with indolent f …
Mastocytosis is a hematopoietic neoplasm defined by abnormal expansion and focal accumulation of clonal tissue mast cells in v …
50 results