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Year Number of Results
1991 1
1995 1
1996 1
1998 1
2000 1
2002 3
2003 2
2004 1
2005 1
2007 2
2008 1
2009 1
2010 2
2011 5
2012 5
2013 6
2014 3
2015 3
2016 1
2017 1
2018 2
2019 5
2020 2
2022 0
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Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch.
Meixiong J, Anderson M, Limjunyawong N, Sabbagh MF, Hu E, Mack MR, Oetjen LK, Wang F, Kim BS, Dong X. Meixiong J, et al. Immunity. 2019 May 21;50(5):1163-1171.e5. doi: 10.1016/j.immuni.2019.03.013. Epub 2019 Apr 23. Immunity. 2019. PMID: 31027996 Free PMC article.
Compared with IgE-FcepsilonRI stimulation, Mrgprb2 activation of mast cells was distinct in both released substances (histamine, serotonin, and tryptase) and the pattern of activated itch-sensory neurons. Mrgprb2 deficiency decreased itch in multiple p …
Compared with IgE-FcepsilonRI stimulation, Mrgprb2 activation of mast cells was distinct in both released substances (histamin …
A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.
Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, Deane A, Keely S, Horvat JC, Yang M, Oliver BG, van Rooijen N, Inman MD, Adachi R, Soberman RJ, Hamadi S, Wark PA, Foster PS, Hansbro PM. Beckett EL, et al. J Allergy Clin Immunol. 2013 Mar;131(3):752-62. doi: 10.1016/j.jaci.2012.11.053. Epub 2013 Feb 4. J Allergy Clin Immunol. 2013. PMID: 23380220 Free PMC article.
We also sought to use this model to better understand pathogenesis and the roles of macrophages and mast cells (MCs) in patients with COPD. METHODS: Tightly controlled amounts of cigarette smoke were delivered to the airways of mice, and the development of the patho …
We also sought to use this model to better understand pathogenesis and the roles of macrophages and mast cells (MCs) in patien …
Prostaglandin E(2), Produced by Mast Cells in Colon Tissues From Patients With Irritable Bowel Syndrome, Contributes to Visceral Hypersensitivity in Mice.
Grabauskas G, Wu X, Gao J, Li JY, Turgeon DK, Owyang C. Grabauskas G, et al. Gastroenterology. 2020 Jun;158(8):2195-2207.e6. doi: 10.1053/j.gastro.2020.02.022. Epub 2020 Feb 19. Gastroenterology. 2020. PMID: 32084424 Free PMC article.
We measured visceromotor responses to colorectal distension in rodents after intracolonic administration of colon biopsy supernatants, histamine, PGE2, a small interfering RNA against EP2, or an agonist of F2R like trypsin receptor 1 (F2RL1, also called protease-activated recepto …
We measured visceromotor responses to colorectal distension in rodents after intracolonic administration of colon biopsy supernatants, hista …
Genetic deficiency of human mast cell alpha-tryptase.
Soto D, Malmsten C, Blount JL, Muilenburg DJ, Caughey GH. Soto D, et al. Clin Exp Allergy. 2002 Jul;32(7):1000-6. doi: 10.1046/j.1365-2222.2002.01416.x. Clin Exp Allergy. 2002. PMID: 12100045
BACKGROUND: Human alpha- and beta-tryptases are proteases secreted by mast cells. ...By contrast, alpha-transcribing Mono Mac 6 and KU812 cells contain alpha- and beta-genes. CONCLUSIONS: Genetic alpha-tryptase deficiency is …
BACKGROUND: Human alpha- and beta-tryptases are proteases secreted by mast cells. ...By contrast, alpha-transcri …
The emerging role of mast cell proteases in asthma.
Pejler G. Pejler G. Eur Respir J. 2019 Oct 31;54(4):1900685. doi: 10.1183/13993003.00685-2019. Print 2019 Oct. Eur Respir J. 2019. PMID: 31371445 Free article. Review.
It is now well established that mast cells (MCs) play a crucial role in asthma. This is supported by multiple lines of evidence, including both clinical studies and studies on MC-deficient mice. ...When MCs are activated, e.g. in response to IgE receptor cros …
It is now well established that mast cells (MCs) play a crucial role in asthma. This is supported by multiple lines of evidenc …
Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation.
Zhang J, Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP. Zhang J, et al. Circ Res. 2011 May 27;108(11):1316-27. doi: 10.1161/CIRCRESAHA.111.243758. Epub 2011 Apr 14. Circ Res. 2011. PMID: 21493897 Free PMC article.
RATIONALE: Mast cells (MCs) contribute to the formation of abdominal aortic aneurysms (AAAs) by producing biologically active mediators. ...Mechanistic studies demonstrated that tryptase deficiency affected endothelial cell (EC) chemokine and cy …
RATIONALE: Mast cells (MCs) contribute to the formation of abdominal aortic aneurysms (AAAs) by producing biologically active …
Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.
Trivedi NN, Tamraz B, Chu C, Kwok PY, Caughey GH. Trivedi NN, et al. J Allergy Clin Immunol. 2009 Nov;124(5):1099-105.e1-4. doi: 10.1016/j.jaci.2009.07.026. Epub 2009 Sep 12. J Allergy Clin Immunol. 2009. PMID: 19748655 Free PMC article.
BACKGROUND: Mast cell tryptases have proposed roles in allergic inflammation and host defense against infection. ...OBJECTIVE: We sought to compare functional and nonfunctional tryptase allele frequencies and establish haplotypes in human popula …
BACKGROUND: Mast cell tryptases have proposed roles in allergic inflammation and host defense against infection. ...OBJ …
Mast Cell Promotes the Development of Intracranial Aneurysm Rupture.
Furukawa H, Wada K, Tada Y, Kuwabara A, Sato H, Ai J, Lawton MT, Hashimoto T. Furukawa H, et al. Stroke. 2020 Nov;51(11):3332-3339. doi: 10.1161/STROKEAHA.120.030834. Epub 2020 Oct 6. Stroke. 2020. PMID: 33019897 Free PMC article.
Aneurysm formation and rupture were assessed over 3 weeks. Roles of mast cells were assessed using a mast cell stabilizer (cromolyn), a mast cell activator (C48/80), and mice that are genetically lacking mature mast cells
Aneurysm formation and rupture were assessed over 3 weeks. Roles of mast cells were assessed using a mast cell s …
Mastocytosis and allergy.
Greenhawt M, Akin C. Greenhawt M, et al. Curr Opin Allergy Clin Immunol. 2007 Oct;7(5):387-92. doi: 10.1097/ACI.0b013e3282a6443e. Curr Opin Allergy Clin Immunol. 2007. PMID: 17873577 Review.
The genetic deficiency of alpha tryptase has not been found to influence serum tryptase levels in patients with mastocytosis. SUMMARY: Pathologic mast cell activation is a key finding in both allergic diseases and mastocytosis, albeit cau …
The genetic deficiency of alpha tryptase has not been found to influence serum tryptase levels in patients with …
Multidisciplinary Challenges in Mastocytosis and How to Address with Personalized Medicine Approaches.
Valent P, Akin C, Gleixner KV, Sperr WR, Reiter A, Arock M, Triggiani M. Valent P, et al. Int J Mol Sci. 2019 Jun 18;20(12):2976. doi: 10.3390/ijms20122976. Int J Mol Sci. 2019. PMID: 31216696 Free PMC article. Review.
Mastocytosis is a hematopoietic neoplasm defined by abnormal expansion and focal accumulation of clonal tissue mast cells in various organ-systems. The disease exhibits a complex pathology and an equally complex clinical behavior. ...Whereas patients with indolent f …
Mastocytosis is a hematopoietic neoplasm defined by abnormal expansion and focal accumulation of clonal tissue mast cells in v …
46 results