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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1979 1
1981 1
1984 1
1986 2
1987 1
1989 1
1990 1
1991 2
1992 1
1993 1
1994 6
1995 4
1997 5
1998 9
1999 9
2000 18
2001 30
2002 24
2003 29
2004 37
2005 55
2006 63
2007 67
2008 66
2009 90
2010 107
2011 113
2012 135
2013 124
2014 139
2015 130
2016 126
2017 139
2018 119
2019 103
2020 60
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1,562 results
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Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.
Jin L, Li D, Alesi GN, Fan J, Kang HB, Lu Z, Boggon TJ, Jin P, Yi H, Wright ER, Duong D, Seyfried NT, Egnatchik R, DeBerardinis RJ, Magliocca KR, He C, Arellano ML, Khoury HJ, Shin DM, Khuri FR, Kang S. Jin L, et al. Cancer Cell. 2015 Feb 9;27(2):257-70. doi: 10.1016/j.ccell.2014.12.006. Cancer Cell. 2015. PMID: 25670081 Free PMC article.
How mitochondrial glutaminolysis contributes to redox homeostasis in cancer cells remains unclear. Here we report that the mitochondrial enzyme glutamate dehydrogenase 1 (GDH1) is commonly upregulated in human cancers. ...Mechanistically, fumarate binds to and ac
How mitochondrial glutaminolysis contributes to redox homeostasis in cancer cells remains unclear. Here we report that the mitochondr …
Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases.
Huang JQ, Zhou JC, Wu YY, Ren FZ, Lei XG. Huang JQ, et al. Free Radic Biol Med. 2018 Nov 1;127:108-115. doi: 10.1016/j.freeradbiomed.2018.05.077. Epub 2018 May 22. Free Radic Biol Med. 2018. PMID: 29800654 Free PMC article. Review.
Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and lipid peroxides. While past research explored regulations of gene expression and biochemical function of this selenoperoxidase, GP
Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and
Glutathione peroxidase-1 inhibits transcription of regenerating islet-derived protein-2 in pancreatic islets.
Yun JW, Zhao Z, Yan X, Vatamaniuk MZ, Lei XG. Yun JW, et al. Free Radic Biol Med. 2019 Apr;134:385-393. doi: 10.1016/j.freeradbiomed.2019.01.024. Epub 2019 Jan 28. Free Radic Biol Med. 2019. PMID: 30703484 Free PMC article.
Our group previously demonstrated that overexpression of selenium-dependent glutathione peroxidase-1 (GPX1) in mice (OE) led to escalated glucose-stimulated insulin secretion and hyperinsulinemia. ...Both AP-1 and DBP could bind to the Reg2 prom …
Our group previously demonstrated that overexpression of selenium-dependent glutathione peroxidase-1 (GPX1) in m …
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.
Meng Q, Xu J, Liang C, Liu J, Hua J, Zhang Y, Ni Q, Shi S, Yu X. Meng Q, et al. Cell Death Dis. 2018 Dec 11;9(12):1187. doi: 10.1038/s41419-018-1244-z. Cell Death Dis. 2018. PMID: 30538220 Free PMC article.
In the present study, we first monitored the effect of glucose deprivation on autophagy and on the expression of glutathione peroxidase-1 (GPx1) in PDA cells under the glucose-free environment. ...Both GPx1 overexpression and autophagy in …
In the present study, we first monitored the effect of glucose deprivation on autophagy and on the expression of glutathione perox
Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3β/Snail signaling.
Meng Q, Shi S, Liang C, Liang D, Hua J, Zhang B, Xu J, Yu X. Meng Q, et al. Oncogene. 2018 Nov;37(44):5843-5857. doi: 10.1038/s41388-018-0392-z. Epub 2018 Jul 6. Oncogene. 2018. PMID: 29980787
Glutathione peroxidase-1 (GPx1) plays various roles in the development and progression of multiple tumors, with the exception of pancreatic cancer. ...GPx1 silencing induced a mesenchymal transition phenotype and increased GEM resistance in vitr
Glutathione peroxidase-1 (GPx1) plays various roles in the development and progression of multiple tumors, with
DHA supplementation during prenatal ethanol exposure alters the expression of fetal rat liver genes involved in oxidative stress regulation.
Feltham BA, Louis XL, Kapourchali FR, Eskin MNA, Suh M. Feltham BA, et al. Appl Physiol Nutr Metab. 2019 Jul;44(7):744-750. doi: 10.1139/apnm-2018-0580. Epub 2018 Dec 6. Appl Physiol Nutr Metab. 2019. PMID: 30521352
Fetal livers were collected at gestational day 20, and free fatty acids and phospholipid profile, as well as glutathione reductase (GR) and glutathione peroxidase-1 (GPx1) gene expressions, were assessed. ...Providing DHA normalized GR and GP
Fetal livers were collected at gestational day 20, and free fatty acids and phospholipid profile, as well as glutathione reductase (G …
Astrocytic mobilization of glutathione peroxidase-1 contributes to the protective potential against cocaine kindling behaviors in mice via activation of JAK2/STAT3 signaling.
Mai HN, Nguyen LTT, Shin EJ, Kim DJ, Jeong JH, Chung YH, Lei XG, Sharma N, Jang CG, Nabeshima T, Kim HC. Mai HN, et al. Free Radic Biol Med. 2019 Feb 1;131:408-431. doi: 10.1016/j.freeradbiomed.2018.12.027. Epub 2018 Dec 25. Free Radic Biol Med. 2019. PMID: 30592974
The present study was performed to elucidate the role of the glutathione peroxidase-1 (GPx-1) in cocaine-induced kindling (convulsive) behaviors in mice. ...Triple-labeling immunocytochemistry indicated that GPx-1-, p-STAT3-, and GFAP-immunoreac …
The present study was performed to elucidate the role of the glutathione peroxidase-1 (GPx-1) in cocaine-induced …
Protective effect of crocin on ultraviolet B‑induced dermal fibroblast photoaging.
Deng M, Li D, Zhang Y, Zhou G, Liu W, Cao Y, Zhang W. Deng M, et al. Mol Med Rep. 2018 Aug;18(2):1439-1446. doi: 10.3892/mmr.2018.9150. Epub 2018 Jun 11. Mol Med Rep. 2018. PMID: 29901204 Free PMC article.
The senescent phenotypes of cells were evaluated, including cell proliferation, cell cycle, senescence‑associated β‑galactosidase (SA‑β‑gal) expression, intracellular ROS, expression of antioxidant protein glutathione peroxidase 1 (GPX‑1) …
The senescent phenotypes of cells were evaluated, including cell proliferation, cell cycle, senescence‑associated β‑gal …
Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium.
Liu Y, Lu F, Kang L, Wang Z, Wang Y. Liu Y, et al. BMC Pulm Med. 2017 Apr 18;17(1):63. doi: 10.1186/s12890-017-0405-7. BMC Pulm Med. 2017. PMID: 28420366 Free PMC article.
The mRNA and protein levels of oxidative stress-related factors Nrf2/Bach1 and their downstream antioxidant factors heme oxygenase-1 (Ho-1) and glutathione peroxidase 1 (Gpx1) were determined by RT-PCR and Western blot. ...CONCLUSIONS: Th …
The mRNA and protein levels of oxidative stress-related factors Nrf2/Bach1 and their downstream antioxidant factors heme oxygenase-1
The association between genetic polymorphism of glutathione peroxidase 1 (rs1050450) and keratoconus in a Turkish population.
Ilhan A, Altun S, Durukan I, Yolcu U, Erdem U. Ilhan A, et al. Arq Bras Oftalmol. 2019 Sep 30;82(6):501-506. doi: 10.5935/0004-2749.20190102. eCollection 2019. Arq Bras Oftalmol. 2019. PMID: 31576926 Free article.
RESULTS: Glutathione peroxidase 1 rs1050450 polymorphism was present in 41% cases compared with 29% controls (OR=1.66; 95% CI=1.11-2.50; p=0.014). ...We found a possible association between glutathione peroxidase 1 rs1050450 …
RESULTS: Glutathione peroxidase 1 rs1050450 polymorphism was present in 41% cases compared with 29% controls (OR=1
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