Glutathione peroxidase-1 but not -4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells.
Biochem J. 2000.
PMID: 10880344
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Glutathione peroxidase 1 but not 4 is involved in the regulation of cellular 5 lipoxygenase activity non monocytic cells
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The role of glutathione peroxidase-1 in health and disease.
Free Radic Biol Med. 2022 Aug 1;188:146-161. doi: 10.1016/j.freeradbiomed.2022.06.004. Epub 2022 Jun 9.
Free Radic Biol Med. 2022.
PMID: 35691509
Review.
Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is found in the cytoplasm and mitochondria of mammalian cells. ...Overall, GPx1 is protective against the development and progression of many chronic …
Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is found in the cytoplas …
PER1 interaction with GPX1 regulates metabolic homeostasis under oxidative stress.
Redox Biol. 2020 Oct;37:101694. doi: 10.1016/j.redox.2020.101694. Epub 2020 Aug 26.
Redox Biol. 2020.
PMID: 32896721
Free PMC article.
Metabolism serves mammalian feeding and active behavior, and is controlled by circadian clock. The molecular mechanism by which clock factors regulate metabolic homeostasis under oxidative stress is unclear. ...Per1 deficiency impaired daily mitochondrial dynamics a …
Metabolism serves mammalian feeding and active behavior, and is controlled by circadian clock. The molecular mechanism by which clock …
GPX1, a biomarker for the diagnosis and prognosis of kidney cancer, promotes the progression of kidney cancer.
Aging (Albany NY). 2019 Dec 16;11(24):12165-12176. doi: 10.18632/aging.102555. Epub 2019 Dec 16.
Aging (Albany NY). 2019.
PMID: 31844035
Free PMC article.
Glutathione peroxidase 1 (GPX1) has been identified to be highly expressed in a variety of human malignancies. ...Finally, the functional roles of GPX1 were examined using a GPX1 sh-RNA knockdown method in RCC cell lines. ...
Glutathione peroxidase 1 (GPX1) has been identified to be highly expressed in a variety of human malignancies. . …
CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury.
Redox Biol. 2021 Oct;46:102067. doi: 10.1016/j.redox.2021.102067. Epub 2021 Jul 17.
Redox Biol. 2021.
PMID: 34315111
Free PMC article.
FJC, NeuN and Hypoxyprobe staining revealed large numbers of neurons damaged by oxidative stress in CCL5-KO mice after mTBI. NADPH oxidase activity show increased ROS generation together with reduced glutathione peroxidase-1 (GPX1) and glutat …
FJC, NeuN and Hypoxyprobe staining revealed large numbers of neurons damaged by oxidative stress in CCL5-KO mice after mTBI. NADPH oxidase …
Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme.
Food Chem Toxicol. 2021 Feb;148:111945. doi: 10.1016/j.fct.2020.111945. Epub 2020 Dec 29.
Food Chem Toxicol. 2021.
PMID: 33359022
Review.
Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its own antioxidant role. We have demonstrated the protective effects of GPx,/GPx-1, a selenium-dependent enzyme, on various neurodegenerative disorders (i.e., Parkinso …
Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its own antioxidant role. We have d …
Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases.
Free Radic Biol Med. 2018 Nov 1;127:108-115. doi: 10.1016/j.freeradbiomed.2018.05.077. Epub 2018 May 22.
Free Radic Biol Med. 2018.
PMID: 29800654
Free PMC article.
Review.
Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and lipid peroxides. ...Clinical data have shown associations of human GPX1 gene variants with elevated risks of diabetes. Knockout and o …
Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and …
Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.
Antioxid Redox Signal. 2011 Oct 1;15(7):1957-97. doi: 10.1089/ars.2010.3586. Epub 2011 Apr 10.
Antioxid Redox Signal. 2011.
PMID: 21087145
Free PMC article.
Review.
Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects. ...As a selenocysteine-containing enzyme, GPx-1 expression is subject to unique forms of …
Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen pero …
PEGylation and antioxidant effects of a human glutathione peroxidase 1 mutant.
Aging (Albany NY). 2022 Jan 12;14(1):443-461. doi: 10.18632/aging.203822. Epub 2022 Jan 12.
Aging (Albany NY). 2022.
PMID: 35020600
Free PMC article.
Human glutathione peroxidase1 (hGPx1) is a good antioxidant and potential drug, but the limited availability and poor stability of hGPx1 have affected its development and application. ...In this study, the GPx1M was conjugated with methoxypolyethylene glycol-succinimidyl s …
Human glutathione peroxidase1 (hGPx1) is a good antioxidant and potential drug, but the limited availability and poor stability of hG …
Study on antioxidant effect of recombinant glutathione peroxidase 1.
Int J Biol Macromol. 2021 Feb 15;170:503-513. doi: 10.1016/j.ijbiomac.2020.12.183. Epub 2020 Dec 28.
Int J Biol Macromol. 2021.
PMID: 33383079
Glutathione peroxidase 1 (GPx1) is an important antioxidant selenium enzyme and has a good prospect for drug development. ...Meanwhile, in order to more accurately reflect the antioxidant effect of rGPx1 in mice, we used the same method to express reco …
Glutathione peroxidase 1 (GPx1) is an important antioxidant selenium enzyme and has a good prospect for drug dev …
Polyalanine polymorphism in the signal peptide of Glutathione peroxidase 1 (GPX1) gene & its association with osteoporosis.
Indian J Med Res. 2022 Oct-Nov;156(4&5):640-647. doi: 10.4103/ijmr.IJMR_208_20.
Indian J Med Res. 2022.
PMID: 36926781
Free PMC article.
The present study focused on mapping polymorphism in an important antioxidant enzyme glutathione peroxidase 1 (GPx1) among osteoporosis and healthy Asian Indians. ...Biochemical parameters such as vitamin D, total oxidant status (TOS), and GPx1 …
The present study focused on mapping polymorphism in an important antioxidant enzyme glutathione peroxidase 1 (GPx1 …
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