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2,417 results

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Page 1
The role of glutathione peroxidase-1 in health and disease.
Handy DE, Loscalzo J. Handy DE, et al. Free Radic Biol Med. 2022 Aug 1;188:146-161. doi: 10.1016/j.freeradbiomed.2022.06.004. Epub 2022 Jun 9. Free Radic Biol Med. 2022. PMID: 35691509 Free PMC article. Review.
Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is found in the cytoplasm and mitochondria of mammalian cells. ...Overall, GPx1 is protective against the development and progression of many chronic …
Glutathione peroxidase 1 (GPx1) is an important cellular antioxidant enzyme that is found in the cytoplas …
Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme.
Sharma G, Shin EJ, Sharma N, Nah SY, Mai HN, Nguyen BT, Jeong JH, Lei XG, Kim HC. Sharma G, et al. Food Chem Toxicol. 2021 Feb;148:111945. doi: 10.1016/j.fct.2020.111945. Epub 2020 Dec 29. Food Chem Toxicol. 2021. PMID: 33359022 Review.
Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its own antioxidant role. ...
Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its own antioxidant role. ...
Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases.
Huang JQ, Zhou JC, Wu YY, Ren FZ, Lei XG. Huang JQ, et al. Free Radic Biol Med. 2018 Nov 1;127:108-115. doi: 10.1016/j.freeradbiomed.2018.05.077. Epub 2018 May 22. Free Radic Biol Med. 2018. PMID: 29800654 Free PMC article. Review.
Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and lipid peroxides. While past research explored regulations of gene expression and biochemical function of this selenoperoxidase, GP …
Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and …
Study on antioxidant effect of recombinant glutathione peroxidase 1.
Liu C, Yan Q, Gao C, Lin L, Wei J. Liu C, et al. Int J Biol Macromol. 2021 Feb 15;170:503-513. doi: 10.1016/j.ijbiomac.2020.12.183. Epub 2020 Dec 28. Int J Biol Macromol. 2021. PMID: 33383079
Glutathione peroxidase 1 (GPx1) is an important antioxidant selenium enzyme and has a good prospect for drug development. ...In this study, we established isoproterenol (ISO)-induced oxidative stress injury models to study the antioxidant effect of rhG …
Glutathione peroxidase 1 (GPx1) is an important antioxidant selenium enzyme and has a good prospect for drug dev …
Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.
Lubos E, Loscalzo J, Handy DE. Lubos E, et al. Antioxid Redox Signal. 2011 Oct 1;15(7):1957-97. doi: 10.1089/ars.2010.3586. Epub 2011 Apr 10. Antioxid Redox Signal. 2011. PMID: 21087145 Free PMC article. Review.
Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects. ...This review explores the molecular mechanisms involved in regulating the expression an …
Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to …
PEGylation and antioxidant effects of a human glutathione peroxidase 1 mutant.
Zhang GY, Wang YW, Guo LY, Lin LR, Niu SP, Xiong CH, Wei JY. Zhang GY, et al. Aging (Albany NY). 2022 Jan 12;14(1):443-461. doi: 10.18632/aging.203822. Epub 2022 Jan 12. Aging (Albany NY). 2022. PMID: 35020600 Free PMC article.
Human glutathione peroxidase1 (hGPx1) is a good antioxidant and potential drug, but the limited availability and poor stability of hGPx1 have affected its development and application. To solve this problem, we prepared a hGPx1 mutant (GPx1M) with high activity in an …
Human glutathione peroxidase1 (hGPx1) is a good antioxidant and potential drug, but the limited availability and poor stability of hG …
Glutathione peroxidase-1 as a novel therapeutic target for COPD.
Vlahos R, Bozinovski S. Vlahos R, et al. Redox Rep. 2013;18(4):142-9. doi: 10.1179/1351000213Y.0000000053. Redox Rep. 2013. PMID: 23849338 Free PMC article. Review.
These oxidants give rise to Reactive Oxygen Species (ROS) that are generated enzymatically by inflammatory and epithelial cells within the lung as part of an inflammatory immune response towards a pathogen or irritant. ...However, the normal lung has developed defences to …
These oxidants give rise to Reactive Oxygen Species (ROS) that are generated enzymatically by inflammatory and epithelial cells withi …
Selenium-dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues.
Sun Z, Wu K, Feng C, Lei XG. Sun Z, et al. Free Radic Biol Med. 2023 Nov 1;208:708-717. doi: 10.1016/j.freeradbiomed.2023.09.010. Epub 2023 Sep 17. Free Radic Biol Med. 2023. PMID: 37726091
We have previously shown dysregulated lipid metabolism in tissues of glutathione peroxidase 1 (GPX1) overexpressing (OE) or deficient (KO) mice. This study explored underlying mechanisms of GPX1 in regulating tissue fatty acid (FA) biosyn …
We have previously shown dysregulated lipid metabolism in tissues of glutathione peroxidase 1 (GPX1) overexpress …
Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4.
Cheff DM, Cheng Q, Guo H, Travers J, Klumpp-Thomas C, Shen M, Arnér ESJ, Hall MD. Cheff DM, et al. Redox Biol. 2023 Jul;63:102719. doi: 10.1016/j.redox.2023.102719. Epub 2023 May 16. Redox Biol. 2023. PMID: 37244126 Free PMC article.
Selenoprotein glutathione peroxidases (GPX), like ubiquitously expressed GPX1 and the ferroptosis modulator GPX4, enact antioxidant activities by reducing hydroperoxides using glutathione. ...Our study also identified GPX1/GPX2, GPX4 and/or TXNR …
Selenoprotein glutathione peroxidases (GPX), like ubiquitously expressed GPX1 and the ferroptosis modulator GPX4, enact antiox …
Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells.
Sultan CS, Saackel A, Stank A, Fleming T, Fedorova M, Hoffmann R, Wade RC, Hecker M, Wagner AH. Sultan CS, et al. Redox Biol. 2018 Jun;16:113-122. doi: 10.1016/j.redox.2018.02.018. Epub 2018 Mar 1. Redox Biol. 2018. PMID: 29499564 Free PMC article.
AIMS: High levels of glucose and reactive carbonyl intermediates of its degradation pathway such as methylglyoxal (MG) may contribute to diabetic complications partly via increased generation of reactive oxygen species (ROS). This study focused on glutathione peroxidase …
AIMS: High levels of glucose and reactive carbonyl intermediates of its degradation pathway such as methylglyoxal (MG) may contribute to dia …
2,417 results