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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1979 1
1981 1
1984 1
1986 2
1987 1
1989 1
1990 1
1991 2
1992 1
1993 1
1994 6
1995 4
1997 5
1998 9
1999 9
2000 18
2001 30
2002 24
2003 29
2004 37
2005 55
2006 63
2007 67
2008 66
2009 90
2010 107
2011 113
2012 135
2013 124
2014 139
2015 130
2016 127
2017 139
2018 120
2019 109
2020 135
2021 107
2022 15
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1,737 results
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GPX1, a biomarker for the diagnosis and prognosis of kidney cancer, promotes the progression of kidney cancer.
Cheng Y, Xu T, Li S, Ruan H. Cheng Y, et al. Aging (Albany NY). 2019 Dec 16;11(24):12165-12176. doi: 10.18632/aging.102555. Epub 2019 Dec 16. Aging (Albany NY). 2019. PMID: 31844035 Free PMC article.
Glutathione peroxidase 1 (GPX1) has been identified to be highly expressed in a variety of human malignancies. ...Finally, the functional roles of GPX1 were examined using a GPX1 sh-RNA knockdown method in RCC cell lines. ...
Glutathione peroxidase 1 (GPX1) has been identified to be highly expressed in a variety of human malignancies. .
gamma-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor.
Quintana-Cabrera R, Fernandez-Fernandez S, Bobo-Jimenez V, Escobar J, Sastre J, Almeida A, Bolaños JP. Quintana-Cabrera R, et al. Nat Commun. 2012 Mar 6;3:718. doi: 10.1038/ncomms1722. Nat Commun. 2012. PMID: 22395609 Free PMC article.
Knocking down glutathione peroxidase-1 drastically increases superoxide anion in cells synthesizing mitochondrial gamma-glutamylcysteine. In vitro, gamma-glutamylcysteine is as efficient as glutathione in disposing of hydrogen peroxide by glu
Knocking down glutathione peroxidase-1 drastically increases superoxide anion in cells synthesizing mitochondria …
Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme.
Sharma G, Shin EJ, Sharma N, Nah SY, Mai HN, Nguyen BT, Jeong JH, Lei XG, Kim HC. Sharma G, et al. Food Chem Toxicol. 2021 Feb;148:111945. doi: 10.1016/j.fct.2020.111945. Epub 2020 Dec 29. Food Chem Toxicol. 2021. PMID: 33359022 Review.
Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its own antioxidant role. We have demonstrated the protective effects of GPx,/GPx-1, a selenium-dependent enzyme, on various neurodegenerative disorders (i.e., Parkinso
Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its own antioxidant role. We have d
Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases.
Huang JQ, Zhou JC, Wu YY, Ren FZ, Lei XG. Huang JQ, et al. Free Radic Biol Med. 2018 Nov 1;127:108-115. doi: 10.1016/j.freeradbiomed.2018.05.077. Epub 2018 May 22. Free Radic Biol Med. 2018. PMID: 29800654 Free PMC article. Review.
Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and lipid peroxides. ...Clinical data have shown associations of human GPX1 gene variants with elevated risks of diabetes. Knockout and o
Glutathione peroxidase 1 (GPX1) is a selenium-dependent enzyme that reduces intracellular hydrogen peroxide and
Study on antioxidant effect of recombinant glutathione peroxidase 1.
Liu C, Yan Q, Gao C, Lin L, Wei J. Liu C, et al. Int J Biol Macromol. 2021 Feb 15;170:503-513. doi: 10.1016/j.ijbiomac.2020.12.183. Epub 2020 Dec 28. Int J Biol Macromol. 2021. PMID: 33383079
Glutathione peroxidase 1 (GPx1) is an important antioxidant selenium enzyme and has a good prospect for drug development. ...Meanwhile, in order to more accurately reflect the antioxidant effect of rGPx1 in mice, we used the same method to express reco
Glutathione peroxidase 1 (GPx1) is an important antioxidant selenium enzyme and has a good prospect for drug dev
Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.
Lubos E, Loscalzo J, Handy DE. Lubos E, et al. Antioxid Redox Signal. 2011 Oct 1;15(7):1957-97. doi: 10.1089/ars.2010.3586. Epub 2011 Apr 10. Antioxid Redox Signal. 2011. PMID: 21087145 Free PMC article. Review.
Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects. ...As a selenocysteine-containing enzyme, GPx-1 expression is subject to unique forms of
Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen pero
The role of PSMB5 in sodium arsenite-induced oxidative stress in L-02 cells.
Lv Y, Hu Q, Shi M, Wang W, Zheng Y, Yang Z, Peng L, Bi D, Zhang A, Hu Y. Lv Y, et al. Cell Stress Chaperones. 2020 May;25(3):533-540. doi: 10.1007/s12192-020-01104-1. Epub 2020 Apr 16. Cell Stress Chaperones. 2020. PMID: 32301004 Free PMC article.
The oxidative stress indicators, levels of 20S proteasome, the transcription and protein expression levels of PSMB5, Cu-Zn superoxide dismutase (SOD1), and glutathione peroxidase 1 (GPx1) were detected. The results demonstrated that NaAsO(2) could indu …
The oxidative stress indicators, levels of 20S proteasome, the transcription and protein expression levels of PSMB5, Cu-Zn superoxide dismut …
Glutathione peroxidase-1 inhibits transcription of regenerating islet-derived protein-2 in pancreatic islets.
Yun JW, Zhao Z, Yan X, Vatamaniuk MZ, Lei XG. Yun JW, et al. Free Radic Biol Med. 2019 Apr;134:385-393. doi: 10.1016/j.freeradbiomed.2019.01.024. Epub 2019 Jan 28. Free Radic Biol Med. 2019. PMID: 30703484 Free PMC article.
Our group previously demonstrated that overexpression of selenium-dependent glutathione peroxidase-1 (GPX1) in mice (OE) led to escalated glucose-stimulated insulin secretion and hyperinsulinemia. ...Deleting the AP-1 (-143/-137 and -60/-57 bp) …
Our group previously demonstrated that overexpression of selenium-dependent glutathione peroxidase-1 (GPX1) in m …
Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells.
Sultan CS, Saackel A, Stank A, Fleming T, Fedorova M, Hoffmann R, Wade RC, Hecker M, Wagner AH. Sultan CS, et al. Redox Biol. 2018 Jun;16:113-122. doi: 10.1016/j.redox.2018.02.018. Epub 2018 Mar 1. Redox Biol. 2018. PMID: 29499564 Free PMC article.
AIMS: High levels of glucose and reactive carbonyl intermediates of its degradation pathway such as methylglyoxal (MG) may contribute to diabetic complications partly via increased generation of reactive oxygen species (ROS). This study focused on glutathione peroxidase
AIMS: High levels of glucose and reactive carbonyl intermediates of its degradation pathway such as methylglyoxal (MG) may contribute to dia …
Deficiency of glutathione peroxidase-1 and catalase attenuated diet-induced obesity and associated metabolic disorders.
Kim HR, Choi EJ, Kie JH, Lee JH, Seoh JY. Kim HR, et al. Acta Diabetol. 2020 Feb;57(2):151-161. doi: 10.1007/s00592-019-01388-5. Epub 2019 Aug 1. Acta Diabetol. 2020. PMID: 31372751
AIMS: Oxidative stress has been considered to contribute to the development of obesity-related metabolic disorders including insulin resistance. To the contrary, deficiency of an anti-oxidizing enzyme, glutathione peroxidase (GPx)-1, was reported to enhance i …
AIMS: Oxidative stress has been considered to contribute to the development of obesity-related metabolic disorders including insulin resista …
1,737 results