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Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases.
Kapellos TS, Bonaguro L, Gemünd I, Reusch N, Saglam A, Hinkley ER, Schultze JL. Kapellos TS, et al. Front Immunol. 2019 Aug 30;10:2035. doi: 10.3389/fimmu.2019.02035. eCollection 2019. Front Immunol. 2019. PMID: 31543877 Free PMC article. Review.
Human monocytes are divided in three major populations; classical (CD14(+)CD16(-)), non-classical (CD14(dim)CD16(+)), and intermediate (CD14(+)CD16(+)). ...Furthermore, we shed light on the role of these plastic immune cells in already recognized and emerging
Human monocytes are divided in three major populations; classical (CD14(+)CD16(-)), non-classical (CD14(dim)CD16(+)), a
Macrophages: versatile players in renal inflammation and fibrosis.
Tang PM, Nikolic-Paterson DJ, Lan HY. Tang PM, et al. Nat Rev Nephrol. 2019 Mar;15(3):144-158. doi: 10.1038/s41581-019-0110-2. Epub 2019 Jan 28. Nat Rev Nephrol. 2019. PMID: 30692665 Review.
Macrophages have important roles in immune surveillance and in the maintenance of kidney homeostasis; their response to renal injury varies enormously depending on the nature and duration of the insult. Macrophages can adopt a variety of phenotypes: at one extreme, M1 pro- …
Macrophages have important roles in immune surveillance and in the maintenance of kidney homeostasis; their response to renal injury varies …
Vascular Macrophages in Atherosclerosis.
Xu H, Jiang J, Chen W, Li W, Chen Z. Xu H, et al. J Immunol Res. 2019 Dec 1;2019:4354786. doi: 10.1155/2019/4354786. eCollection 2019. J Immunol Res. 2019. PMID: 31886303 Free PMC article. Review.
It has been well established that atherosclerosis is not only a metabolic disorder but also a chronic, sterile, and maladaptive inflammatory process encompassing both innate and adaptive immunity. ...This article reviews the functions of macrophages in different sta …
It has been well established that atherosclerosis is not only a metabolic disorder but also a chronic, sterile, and maladaptive in
Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions.
Arruga F, Gyau BB, Iannello A, Vitale N, Vaisitti T, Deaglio S. Arruga F, et al. Int J Mol Sci. 2020 Mar 6;21(5):1825. doi: 10.3390/ijms21051825. Int J Mol Sci. 2020. PMID: 32155826 Free PMC article. Review.
Representing the major cause of morbidity and mortality for chronic lymphocytic leukemia (CLL) patients, immunosuppression is a common feature of the disease. ...Likewise, differentiation of monocytes towards a suppressive M2-like phenotype is i …
Representing the major cause of morbidity and mortality for chronic lymphocytic leukemia (CLL) patients, immunosuppression is …
Altered monocytic phenotypes are linked with systemic inflammation and may be linked to mortality in dialysis patients.
Brandt S, Ewert L, Scurt FG, Reichardt C, Lindquist JA, Gorny X, Isermann B, Mertens PR. Brandt S, et al. Sci Rep. 2019 Dec 13;9(1):19103. doi: 10.1038/s41598-019-55592-y. Sci Rep. 2019. PMID: 31836803 Free PMC article.
The major causes for increased morbidity and mortality among chronic kidney disease patients are cardiovascular diseases and infection. A causal link between an activated immune system and aggravated atherosclerosis has been postulated that skews the s …
The major causes for increased morbidity and mortality among chronic kidney disease patients are cardiovascular dise
Comparative analysis of immune cell subsets in peripheral blood from patients with periodontal disease and healthy controls.
Cheng WC, Saleh F, Abuaisha Karim B, Hughes FJ, Taams LS. Cheng WC, et al. Clin Exp Immunol. 2018 Dec;194(3):380-390. doi: 10.1111/cei.13205. Epub 2018 Oct 21. Clin Exp Immunol. 2018. PMID: 30120837 Free PMC article.
Periodontitis is a chronic inflammatory disease caused by the colonization of teeth by the bacterial plaque biofilm and the resultant host immune responses in adjacent periodontal tissues. ...Additionally, no significant differences were observed in serum lev …
Periodontitis is a chronic inflammatory disease caused by the colonization of teeth by the bacterial plaque biofilm and …
Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset.
Martini H, Iacovoni JS, Maggiorani D, Dutaur M, Marsal DJ, Roncalli J, Itier R, Dambrin C, Pizzinat N, Mialet-Perez J, Cussac D, Parini A, Lefevre L, Douin-Echinard V. Martini H, et al. Aging Cell. 2019 Oct;18(5):e13015. doi: 10.1111/acel.13015. Epub 2019 Jul 29. Aging Cell. 2019. PMID: 31353772 Free PMC article.
Aging is a major risk factor in the development of chronic diseases, especially cardiovascular diseases. ...Aged cMSCs displayed a senescence program characterized by Cdkn2a expression, decreased proliferation and clonogenicity, and acquisition of a se …
Aging is a major risk factor in the development of chronic diseases, especially cardiovascular diseases. ...Aged …
Monocyte-macrophage polarization balance in pre-diabetic individuals.
Fadini GP, Cappellari R, Mazzucato M, Agostini C, Vigili de Kreutzenberg S, Avogaro A. Fadini GP, et al. Acta Diabetol. 2013 Dec;50(6):977-82. doi: 10.1007/s00592-013-0517-3. Epub 2013 Oct 2. Acta Diabetol. 2013. PMID: 24085683
Pre-diabetes is characterized by increased cardiovascular risk and chronic inflammation. The activation of monocyte-macrophages plays major roles in vascular biology. ...Using flow cytometry analysis of peripheral blood cells, we quantified traditional mon
Pre-diabetes is characterized by increased cardiovascular risk and chronic inflammation. The activation of monocyte-macrophage …
Alterations to the frequency and function of peripheral blood monocytes and associations with chronic disease in the advanced-age, frail elderly.
Verschoor CP, Johnstone J, Millar J, Parsons R, Lelic A, Loeb M, Bramson JL, Bowdish DM. Verschoor CP, et al. PLoS One. 2014 Aug 8;9(8):e104522. doi: 10.1371/journal.pone.0104522. eCollection 2014. PLoS One. 2014. PMID: 25105870 Free PMC article.
Cytokine responses following TLR stimulation were also investigated, as well as associations between immunophenotyping parameters and chronic diseases. RESULTS: The advanced-age, frail elderly had significantly fewer CD14(++) and CD14(+)CD16(+), but not CD14(++)CD16 …
Cytokine responses following TLR stimulation were also investigated, as well as associations between immunophenotyping parameters and chr
Mesenchymal Stromal Cells Modulate Peripheral Stress-Induced Innate Immune Activation Indirectly Limiting the Emergence of Neuroinflammation-Driven Depressive and Anxiety-like Behaviors.
Gallagher D, Siddiqui F, Fish J, Charlat M, Chaudry E, Moolla S, Gauthier-Fisher A, Librach C. Gallagher D, et al. Biol Psychiatry. 2019 Nov 1;86(9):712-724. doi: 10.1016/j.biopsych.2019.07.015. Epub 2019 Jul 29. Biol Psychiatry. 2019. PMID: 31521333
BACKGROUND: Hyperactivation of innate immunity has been implicated in the etiology of mood disorders, including major depressive disorder (MDD). Mesenchymal stromal cells (MSCs) have demonstrated potent immunomodulatory capabilities in the context of chronic infl
BACKGROUND: Hyperactivation of innate immunity has been implicated in the etiology of mood disorders, including major depressive diso …
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