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Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia.
Kuhlicke J, Frick JS, Morote-Garcia JC, Rosenberger P, Eltzschig HK. Kuhlicke J, et al. PLoS One. 2007 Dec 26;2(12):e1364. doi: 10.1371/journal.pone.0001364. PLoS One. 2007. PMID: 18159247 Free PMC article.
Studies using loss and gain of function of HIF-1 confirmed a critical role of HIF-1alpha in coordinating TLR2 and TLR6 induction. ...In contrast, hypoxia induction of TLR2 and TLR6 was abolished in condi …
Studies using loss and gain of function of HIF-1 confirmed a critical role of HIF-1alpha in coordinating TLR2
Co-upregulation of Toll-like receptors 2 and 6 on peripheral blood cells in patients with obstructive sleep apnea.
Chen YC, Su MC, Liou CW, Liu SF, Chen CJ, Lin HC, Hsiao CC, Wang TY, Wang CC, Chin CH, Huang KT, Lin AS, Lin MC. Chen YC, et al. Sleep Breath. 2015 Sep;19(3):873-82. doi: 10.1007/s11325-014-1116-4. Epub 2015 Jan 22. Sleep Breath. 2015. PMID: 25604476
PURPOSE: Toll-like receptor (TLR) 2 can heterodimerise with TLR6 to detect diacylated lipoproteins. Hypoxia inducible factor-1 alpha co-ordinates selective induction of TLR2 and TLR6 during persistent hypoxi
PURPOSE: Toll-like receptor (TLR) 2 can heterodimerise with TLR6 to detect diacylated lipoproteins. Hypoxia i