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Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia.
Kuhlicke J, Frick JS, Morote-Garcia JC, Rosenberger P, Eltzschig HK. Kuhlicke J, et al. PLoS One. 2007 Dec 26;2(12):e1364. doi: 10.1371/journal.pone.0001364. PLoS One. 2007. PMID: 18159247 Free PMC article.
Furthermore, analysis of the putative TLR2 and TLR6 promoters revealed previously unrecognized binding sites for HIF-1, which were shown by chromatin immunoprecipitation to bind the pivotal hypoxia-regulating transcription factor HIF
Furthermore, analysis of the putative TLR2 and TLR6 promoters revealed previously unrecognized binding sites for HIF- …
Co-upregulation of Toll-like receptors 2 and 6 on peripheral blood cells in patients with obstructive sleep apnea.
Chen YC, Su MC, Liou CW, Liu SF, Chen CJ, Lin HC, Hsiao CC, Wang TY, Wang CC, Chin CH, Huang KT, Lin AS, Lin MC. Chen YC, et al. Sleep Breath. 2015 Sep;19(3):873-82. doi: 10.1007/s11325-014-1116-4. Epub 2015 Jan 22. Sleep Breath. 2015. PMID: 25604476
PURPOSE: Toll-like receptor (TLR) 2 can heterodimerise with TLR6 to detect diacylated lipoproteins. Hypoxia inducible factor-1 α co-ordinates selective induction of TLR2 and TLR6 during persistent hypoxia
PURPOSE: Toll-like receptor (TLR) 2 can heterodimerise with TLR6 to detect diacylated lipoproteins. Hypoxia i
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