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Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease.
Schröder JB, Pawlowski M, Meyer Zu Hörste G, Gross CC, Wiendl H, Meuth SG, Ruck T, Warnecke T. Schröder JB, et al. Front Neurol. 2018 Dec 18;9:1081. doi: 10.3389/fneur.2018.01081. eCollection 2018. Front Neurol. 2018. PMID: 30619041 Free PMC article.
Background: Parkinson's disease (PD) is a common neurodegenerative disorder. The contribution of the immune system to its pathogenesis remains incompletely understood. Methods: In this study, we performed comprehensive immune cell profili …
Background: Parkinson's disease (PD) is a common neurodegenerative disorder. The contribution of the immune syst …
Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice.
Earls RH, Menees KB, Chung J, Barber J, Gutekunst CA, Hazim MG, Lee JK. Earls RH, et al. J Neuroinflammation. 2019 Dec 3;16(1):250. doi: 10.1186/s12974-019-1636-8. J Neuroinflammation. 2019. PMID: 31796095 Free PMC article.
Parkinson's disease (PD) is characterized by the accumulation of alpha-synuclein (alpha-syn) inclusions, the major component of Lewy bodies. Extracellular alpha-syn aggregates act as a damage-associated molecular pattern (DAMP) and the presence of autoantibod
Parkinson's disease (PD) is characterized by the accumulation of alpha-synuclein (alpha-syn) inclusions, the major comp
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sánchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C. Kleinberger G, et al. Sci Transl Med. 2014 Jul 2;6(243):243ra86. doi: 10.1126/scitranslmed.3009093. Sci Transl Med. 2014. PMID: 24990881 Free article.
Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to Nasu-Hakola disease, Alzheimer's disease (AD), Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia (FTD), …
Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to Nasu-Hakola disease, Alzh …
Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau.
Wilson EN, Swarovski MS, Linortner P, Shahid M, Zuckerman AJ, Wang Q, Channappa D, Minhas PS, Mhatre SD, Plowey ED, Quinn JF, Zabetian CP, Tian L, Longo FM, Cholerton B, Montine TJ, Poston KL, Andreasson KI. Wilson EN, et al. Brain. 2020 Mar 1;143(3):932-943. doi: 10.1093/brain/awaa021. Brain. 2020. PMID: 32065223 Free PMC article.
Although Parkinson's disease commonly manifests with motor symptoms, a majority of patients with Parkinson's disease subsequently develop cognitive impairment, which often progresses to dementia, a major cause of morbidity a …
Although Parkinson's disease commonly manifests with motor symptoms, a majority of patients with Parki
Role of chemokines in Parkinson's disease.
Liu JQ, Chu SF, Zhou X, Zhang DY, Chen NH. Liu JQ, et al. Brain Res Bull. 2019 Oct;152:11-18. doi: 10.1016/j.brainresbull.2019.05.020. Epub 2019 May 25. Brain Res Bull. 2019. PMID: 31136787 Review.
The most common neuropathologic manifestation in patients with Parkinson's disease is dopamine neurons degeneration and loss in substantia nigra of middle brain. ...This review summarizes recent studies on chemokines and their receptors in Parkinson
The most common neuropathologic manifestation in patients with Parkinson's disease is dopamine neurons degenerat …
Immune processes in the pathogenesis of Parkinson's disease - a potential role for microglia and nitric oxide.
Członkowska A, Kurkowska-Jastrzebska I, Członkowski A, Peter D, Stefano GB. Członkowska A, et al. Med Sci Monit. 2002 Aug;8(8):RA165-77. Med Sci Monit. 2002. PMID: 12165754 Review.
It has been known for many years that immune system alterations occur in Parkinson's disease (PD). Changes in lymphocyte populations in cerebrospinal fluid and blood, immunoglobulin synthesis, and cytokine and acute phase protein producti …
It has been known for many years that immune system alterations occur in Parkinson's disease (PD). Changes in ly …
Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease.
Nissen SK, Ferreira SA, Nielsen MC, Schulte C, Shrivastava K, Hennig D, Etzerodt A, Graversen JH, Berg D, Maetzler W, Panhelainen A, Møller HJ, Brockmann K, Romero-Ramos M. Nissen SK, et al. Mov Disord. 2020 Dec 17. doi: 10.1002/mds.28424. Online ahead of print. Mov Disord. 2020. PMID: 33332647
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder with a significant immune component, as demonstrated by changes in immune biomarkers in patients' biofluids. ...Serum-sCD163 increased only in female patients, su …
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder with a significant immune component, as dem …
Role of soluble CD14 in cerebrospinal fluid as a regulator of glial functions.
Yin GN, Jeon H, Lee S, Lee HW, Cho JY, Suk K. Yin GN, et al. J Neurosci Res. 2009 Aug 15;87(11):2578-90. doi: 10.1002/jnr.22081. J Neurosci Res. 2009. PMID: 19360901
Proteomic analysis of cerebrospinal fluid (CSF) samples derived from patients with Alzheimer's disease (AD) or Parkinson's disease (PD) was performed. ...In addition, soluble CD14 moderately enhanced phagocytic activity
Proteomic analysis of cerebrospinal fluid (CSF) samples derived from patients with Alzheimer's disease (A …
Inflammasome signaling at the heart of central nervous system pathology.
Chakraborty S, Kaushik DK, Gupta M, Basu A. Chakraborty S, et al. J Neurosci Res. 2010 Jun;88(8):1615-31. doi: 10.1002/jnr.22343. J Neurosci Res. 2010. PMID: 20127816 Review.
Neuroinflammation is a complex innate response of neural tissue against harmful effects of diverse stimuli viz., pathogens, damaged cells and irritants within the Central Nervous System (CNS). Studies show that multiple inflammatory mediators including cytokines, chemokine …
Neuroinflammation is a complex innate response of neural tissue against harmful effects of diverse stimuli viz., pathogens, damaged cells
Inflammatory process in Parkinson's disease: role for cytokines.
Nagatsu T, Sawada M. Nagatsu T, et al. Curr Pharm Des. 2005;11(8):999-1016. doi: 10.2174/1381612053381620. Curr Pharm Des. 2005. PMID: 15777250 Review.
Parkinson's disease (PD) is a movement disorder caused by degeneration of the nigrostriatal dopamine (DA) neurons in the substantia nigra pars compacta and the resultant deficiency in the neurotransmitter DA at the nerve terminals in the striatum. ...These ch
Parkinson's disease (PD) is a movement disorder caused by degeneration of the nigrostriatal dopamine (DA) neurons in th
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