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Immune Dysregulation in Children With Down Syndrome.
Huggard D, Doherty DG, Molloy EJ. Huggard D, et al. Front Pediatr. 2020 Feb 27;8:73. doi: 10.3389/fped.2020.00073. eCollection 2020. Front Pediatr. 2020. PMID: 32175298 Free PMC article. Review.
Down syndrome (DS) is the most common genetic syndrome associated with immune defects. The extent of immune dysregulation in DS is substantial, spanning the innate and adaptive systems and including anomalies in: T and B cells, monocytes, neutro …
Down syndrome (DS) is the most common genetic syndrome associated with immune defects. The extent of immune d …
Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.
Illouz T, Biragyn A, Iulita MF, Flores-Aguilar L, Dierssen M, De Toma I, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, London J, Mobley W, Strydom A, Okun E. Illouz T, et al. Front Immunol. 2021 Jun 25;12:621440. doi: 10.3389/fimmu.2021.621440. eCollection 2021. Front Immunol. 2021. PMID: 34248930 Free PMC article. Review.
., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS), the most prevalent intellectual disability, is caused by trisomy-21 in ~1:750 live births worldwide. Over the past few decades, a substantial body of e …
., hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS), the most pr …
Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study.
Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant S, Lai F, Rosas HD, Lee JH, Silverman W, Brickman AM, Chhatwal JP, Cruchaga C, Perrin RJ, Xiong C, Hassenstab J, McDade E, Bateman RJ, Ances BM; Alzheimer's Biomarker Consortium-Down Syndrome; Dominantly Inherited Alzheimer Network. Boerwinkle AH, et al. Lancet Neurol. 2023 Jan;22(1):55-65. doi: 10.1016/S1474-4422(22)00408-2. Lancet Neurol. 2023. PMID: 36517172
BACKGROUND: Important insights into the early pathogenesis of Alzheimer's disease can be provided by studies of autosomal dominant Alzheimer's disease and Down syndrome. ...INTERPRETATION: Despite minor differences, amyloid PET changes were similar between pe …
BACKGROUND: Important insights into the early pathogenesis of Alzheimer's disease can be provided by studies of autosomal dominant Al …
A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome.
Ottaviano G, Gerosa J, Santini M, De Leo P, Vecchione A, Jofra T, Trimarchi C, De Pellegrin M, Agosti M, Aiuti A, Marinoni M, Cicalese MP, Fousteri G. Ottaviano G, et al. J Clin Immunol. 2020 Apr;40(3):447-455. doi: 10.1007/s10875-020-00755-0. Epub 2020 Jan 28. J Clin Immunol. 2020. PMID: 31993866
Patients with Down syndrome (DS) are characterized by increased susceptibility to autoimmunity and respiratory tract infections that are suggestive of humoral immunity impairment. Here, we sought to determine the follicular helper (Tfh) and follicular regulatory (Tf …
Patients with Down syndrome (DS) are characterized by increased susceptibility to autoimmunity and respiratory tract infections that …
Increased systemic inflammation in children with Down syndrome.
Huggard D, Kelly L, Ryan E, McGrane F, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Doherty DG, Molloy EJ. Huggard D, et al. Cytokine. 2020 Mar;127:154938. doi: 10.1016/j.cyto.2019.154938. Epub 2019 Nov 27. Cytokine. 2020. PMID: 31785499
Children with Down syndrome (DS) develop more infections, have an increased mortality from sepsis and an increased incidence of chronic inflammatory conditions. ...Children with Down syndrome exhibit significantly greater levels of pro and anti-inflamm …
Children with Down syndrome (DS) develop more infections, have an increased mortality from sepsis and an increased incidence o …
Specific Susceptibility to COVID-19 in Adults with Down Syndrome.
Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E. Illouz T, et al. Neuromolecular Med. 2021 Dec;23(4):561-571. doi: 10.1007/s12017-021-08651-5. Epub 2021 Mar 4. Neuromolecular Med. 2021. PMID: 33660221 Free PMC article.
The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregul …
The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in part …
Altered Toll-Like Receptor Signalling in Children with Down Syndrome.
Huggard D, Koay WJ, Kelly L, McGrane F, Ryan E, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Moreno-Oliveira A, Melo AM, Doherty DG, Molloy EJ. Huggard D, et al. Mediators Inflamm. 2019 Sep 12;2019:4068734. doi: 10.1155/2019/4068734. eCollection 2019. Mediators Inflamm. 2019. PMID: 31611734 Free PMC article.
Children with Down syndrome (DS) are prone to infections from these pathogens and have an increased risk of autoimmunity. ...We conclude that TLR signalling and the TLR2 pathway are dysregulated in DS, and this disparate innate immunity may contribute …
Children with Down syndrome (DS) are prone to infections from these pathogens and have an increased risk of autoimmunity. ...W …
Neuroinflammatory Markers in the Serum of Prepubertal Children with Down Syndrome.
Tarani L, Carito V, Ferraguti G, Petrella C, Greco A, Ralli M, Messina MP, Rasio D, De Luca E, Putotto C, Versacci P, Ceccanti M, Fiore M. Tarani L, et al. J Immunol Res. 2020 Mar 23;2020:6937154. doi: 10.1155/2020/6937154. eCollection 2020. J Immunol Res. 2020. PMID: 32280719 Free PMC article.
Down Syndrome (DS) is the most common chromosomal disorder. Although DS individuals are mostly perceived as characterized by some distinct physical features, cognitive disabilities, and cardiac defects, they also show important dysregulations of immune functi …
Down Syndrome (DS) is the most common chromosomal disorder. Although DS individuals are mostly perceived as characterized by some dis …
Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation.
Liggett LA, Galbraith MD, Smith KP, Sullivan KD, Granrath RE, Enriquez-Estrada B, Kinning KT, Shaw JR, Rachubinski AL, Espinosa JM, DeGregori J. Liggett LA, et al. Blood Adv. 2021 Apr 13;5(7):1791-1796. doi: 10.1182/bloodadvances.2020003858. Blood Adv. 2021. PMID: 33787858 Free PMC article.
Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis. Children with trisomy 21 who exhibit clonal hematopoiesis display cytokine and gene expression profiles indicative of disrupted immunity …
Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis. Childre …
Immune dysregulation in Alagille syndrome: A new feature of the evolving phenotype.
Tilib Shamoun S, Le Friec G, Spinner N, Kemper C, Baker AJ. Tilib Shamoun S, et al. Clin Res Hepatol Gastroenterol. 2015 Oct;39(5):566-9. doi: 10.1016/j.clinre.2015.02.003. Epub 2015 May 27. Clin Res Hepatol Gastroenterol. 2015. PMID: 26026399
Alagille syndrome (ALGS) is a rare autosomal dominant, multi-system disease caused by mutations in one of two NOTCH signaling pathway genes. ...Disturbed CD46-Jagged1 interaction may explain recurrent infections among ALGS patients, and could predispose to Th2-driven condi …
Alagille syndrome (ALGS) is a rare autosomal dominant, multi-system disease caused by mutations in one of two NOTCH signaling pathway …
45 results