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Immune Dysregulation in Children With Down Syndrome.
Huggard D, Doherty DG, Molloy EJ. Huggard D, et al. Front Pediatr. 2020 Feb 27;8:73. doi: 10.3389/fped.2020.00073. eCollection 2020. Front Pediatr. 2020. PMID: 32175298 Free PMC article. Review.
Down syndrome (DS) is the most common genetic syndrome associated with immune defects. The extent of immune dysregulation in DS is substantial, spanning the innate and adaptive systems and including anomalies in: T and B cells, monocytes, neutro …
Down syndrome (DS) is the most common genetic syndrome associated with immune defects. The extent of immune d
COVID-19 and children with Down syndrome: is there any real reason to worry? Two case reports with severe course.
Kantar A, Mazza A, Bonanomi E, Odoni M, Seminara M, Verde ID, Lovati C, Bolognini S, D'Antiga L. Kantar A, et al. BMC Pediatr. 2020 Dec 18;20(1):561. doi: 10.1186/s12887-020-02471-5. BMC Pediatr. 2020. PMID: 33339516 Free PMC article.
BACKGROUND: Down syndrome (DS) is characterized by a series of immune dysregulations, of which interferon hyperreactivity is important, as it is responsible for surging antiviral responses and the possible initiation of an amplified cytokine storm. This biolo …
BACKGROUND: Down syndrome (DS) is characterized by a series of immune dysregulations, of which interferon hyperreactivi …
Neuroinflammatory Markers in the Serum of Prepubertal Children with Down Syndrome.
Tarani L, Carito V, Ferraguti G, Petrella C, Greco A, Ralli M, Messina MP, Rasio D, De Luca E, Putotto C, Versacci P, Ceccanti M, Fiore M. Tarani L, et al. J Immunol Res. 2020 Mar 23;2020:6937154. doi: 10.1155/2020/6937154. eCollection 2020. J Immunol Res. 2020. PMID: 32280719 Free PMC article.
Down Syndrome (DS) is the most common chromosomal disorder. Although DS individuals are mostly perceived as characterized by some distinct physical features, cognitive disabilities, and cardiac defects, they also show important dysregulations of immune functi …
Down Syndrome (DS) is the most common chromosomal disorder. Although DS individuals are mostly perceived as characterized by some dis …
Increased systemic inflammation in children with Down syndrome.
Huggard D, Kelly L, Ryan E, McGrane F, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Doherty DG, Molloy EJ. Huggard D, et al. Cytokine. 2020 Mar;127:154938. doi: 10.1016/j.cyto.2019.154938. Epub 2019 Nov 27. Cytokine. 2020. PMID: 31785499
Children with Down syndrome (DS) develop more infections, have an increased mortality from sepsis and an increased incidence of chronic inflammatory conditions. ...Children with Down syndrome exhibit significantly greater levels of pro and anti-inflamm
Children with Down syndrome (DS) develop more infections, have an increased mortality from sepsis and an increased incidence o
Altered Toll-Like Receptor Signalling in Children with Down Syndrome.
Huggard D, Koay WJ, Kelly L, McGrane F, Ryan E, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Moreno-Oliveira A, Melo AM, Doherty DG, Molloy EJ. Huggard D, et al. Mediators Inflamm. 2019 Sep 12;2019:4068734. doi: 10.1155/2019/4068734. eCollection 2019. Mediators Inflamm. 2019. PMID: 31611734 Free PMC article.
Children with Down syndrome (DS) are prone to infections from these pathogens and have an increased risk of autoimmunity. ...We conclude that TLR signalling and the TLR2 pathway are dysregulated in DS, and this disparate innate immunity may contribute
Children with Down syndrome (DS) are prone to infections from these pathogens and have an increased risk of autoimmunity. ...W
A Prevalent CXCR3(+) Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome.
Ottaviano G, Gerosa J, Santini M, De Leo P, Vecchione A, Jofra T, Trimarchi C, De Pellegrin M, Agosti M, Aiuti A, Marinoni M, Cicalese MP, Fousteri G. Ottaviano G, et al. J Clin Immunol. 2020 Apr;40(3):447-455. doi: 10.1007/s10875-020-00755-0. Epub 2020 Jan 28. J Clin Immunol. 2020. PMID: 31993866
Patients with Down syndrome (DS) are characterized by increased susceptibility to autoimmunity and respiratory tract infections that are suggestive of humoral immunity impairment. Here, we sought to determine the follicular helper (Tfh) and follicular regulatory (Tf …
Patients with Down syndrome (DS) are characterized by increased susceptibility to autoimmunity and respiratory tract infections that …
Immune dysregulation in Alagille syndrome: A new feature of the evolving phenotype.
Tilib Shamoun S, Le Friec G, Spinner N, Kemper C, Baker AJ. Tilib Shamoun S, et al. Clin Res Hepatol Gastroenterol. 2015 Oct;39(5):566-9. doi: 10.1016/j.clinre.2015.02.003. Epub 2015 May 27. Clin Res Hepatol Gastroenterol. 2015. PMID: 26026399
Alagille syndrome (ALGS) is a rare autosomal dominant, multi-system disease caused by mutations in one of two NOTCH signaling pathway genes. ...Disturbed CD46-Jagged1 interaction may explain recurrent infections among ALGS patients, and could predispose to Th2-driven condi …
Alagille syndrome (ALGS) is a rare autosomal dominant, multi-system disease caused by mutations in one of two NOTCH signaling pathway …
Identification of dysregulated microRNAs in lymphocytes from children with Down syndrome.
Xu Y, Li W, Liu X, Chen H, Tan K, Chen Y, Tu Z, Dai Y. Xu Y, et al. Gene. 2013 Nov 10;530(2):278-86. doi: 10.1016/j.gene.2013.07.055. Epub 2013 Aug 8. Gene. 2013. PMID: 23933415
Given the important roles of miRNAs in post-transcriptional regulation and its implications for the development of immune tissues and cells, characterization of miRNAs promotes us to uncover the molecular mechanisms underlying the pathway of trisomic chromosome 21 that dis …
Given the important roles of miRNAs in post-transcriptional regulation and its implications for the development of immune tissues and …
Peculiarities of autoimmune thyroid diseases in children with Turner or Down syndrome: an overview.
Aversa T, Lombardo F, Valenzise M, Messina MF, Sferlazzas C, Salzano G, De Luca F, Wasniewska M. Aversa T, et al. Ital J Pediatr. 2015 May 15;41:39. doi: 10.1186/s13052-015-0146-2. Ital J Pediatr. 2015. PMID: 25971674 Free PMC article.
Aim of this commentary is to summarize the salient literature news on the relationships between autoimmune thyroid diseases (ATDs) and either Down syndrome (DS) or Turner syndrome (TS).According to literature reports both Hashimoto's thyroiditis (HT) and Grav …
Aim of this commentary is to summarize the salient literature news on the relationships between autoimmune thyroid diseases (ATDs) and eithe …
Thymic Epithelium Abnormalities in DiGeorge and Down Syndrome Patients Contribute to Dysregulation in T Cell Development.
Marcovecchio GE, Bortolomai I, Ferrua F, Fontana E, Imberti L, Conforti E, Amodio D, Bergante S, Macchiarulo G, D'Oria V, Conti F, Di Cesare S, Fousteri G, Carotti A, Giamberti A, Poliani PL, Notarangelo LD, Cancrini C, Villa A, Bosticardo M. Marcovecchio GE, et al. Front Immunol. 2019 Mar 15;10:447. doi: 10.3389/fimmu.2019.00447. eCollection 2019. Front Immunol. 2019. PMID: 30949166 Free PMC article. Clinical Trial.
We sought to evaluate thymic architecture and thymocyte development in DGS and DS patients and to determine the extent to which thymic defects result in immune dysregulation and T cell homeostasis perturbation in these patients. ...Our results provide novel insights …
We sought to evaluate thymic architecture and thymocyte development in DGS and DS patients and to determine the extent to which thymic defec …
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