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1998 1
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2008 1
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2011 2
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2013 3
2014 2
2015 3
2016 2
2017 3
2018 1
2019 1
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Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis.
Sakhno LV, Shevela EY, Tikhonova MA, Nikonov SD, Ostanin AA, Chernykh ER. Sakhno LV, et al. J Immunol Res. 2015;2015:793292. doi: 10.1155/2015/793292. Epub 2015 Aug 3. J Immunol Res. 2015. PMID: 26339660 Free PMC article.
The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated in vitro macrophages and dendritic cells, were investigated in the patients with pulmonary tuberculosis (TB) differing …
The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated …
BTLA-expressing CD11c antigen presenting cells in patients with active tuberculosis exhibit low capacity to stimulate T cell proliferation.
Wang WD, Gao YC, Lu YB, Zhang JA, Liu GB, Kong B, Xiang WY, Dai YC, Yu SY, Jia Y, Fu XX, Yi LL, Zheng BY, Chen ZW, Zhong J, Xu JF. Wang WD, et al. Cell Immunol. 2017 Jan;311:28-35. doi: 10.1016/j.cellimm.2016.09.015. Epub 2016 Sep 30. Cell Immunol. 2017. PMID: 27717503
Despite past extensive studies on B and T lymphocyte attenuator (BTLA)-mediated negative regulation of T cell activation, the role of BTLA in antigen presenting cells (APCs) in patients with active pulmonary tuberculosis (ATB) remains poorly und …
Despite past extensive studies on B and T lymphocyte attenuator (BTLA)-mediated negative regulation of T cell activation, the role of BTLA i …
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.
Curtis J, Luo Y, Zenner HL, Cuchet-Lourenço D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nürnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S. Curtis J, et al. Nat Genet. 2015 May;47(5):523-527. doi: 10.1038/ng.3248. Epub 2015 Mar 16. Nat Genet. 2015. PMID: 25774636 Free PMC article.
Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary TB and in 5,607 healthy controls. ...Dendritic cells (DCs) showed high ASAP1 expression that was reduced after Mycobacterium tuber
Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary
C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells.
Troegeler A, Mercier I, Cougoule C, Pietretti D, Colom A, Duval C, Vu Manh TP, Capilla F, Poincloux R, Pingris K, Nigou J, Rademann J, Dalod M, Verreck FA, Al Saati T, Lugo-Villarino G, Lepenies B, Hudrisier D, Neyrolles O. Troegeler A, et al. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E540-E549. doi: 10.1073/pnas.1613254114. Epub 2017 Jan 9. Proc Natl Acad Sci U S A. 2017. PMID: 28069953 Free PMC article.
DCIR is abundantly expressed in pulmonary lesions in Mycobacterium tuberculosis-infected nonhuman primates during both latent and active disease. In mice, we found that DCIR deficiency impairs STAT1-mediated type I IFN signaling in DCs, leading to increased p …
DCIR is abundantly expressed in pulmonary lesions in Mycobacterium tuberculosis-infected nonhuman primates during both latent …
Characterization of local memory cells in stage-classified pulmonary tuberculosis: preliminary observations.
Urdaneta E, Feo-Figarella E, Montalvo C, Tálamo C, Castillo Y, Carrasco D, Rivera H, Blanca I, Machado I, Echeverría de Pérez G, De Sanctis JB, Bianco NE. Urdaneta E, et al. Scand J Immunol. 1998 May;47(5):496-501. doi: 10.1046/j.1365-3083.1998.00325.x. Scand J Immunol. 1998. PMID: 9627135 Free article. Clinical Trial.
Immunophenotype analysis and proliferative responses were investigated in bronchoalveolar lavage (BAL) cells from 21 patients with stage-classified tuberculosis: six with localized pulmonary infiltrate (LPI); seven with diffuse pulmonary infiltrate (DP …
Immunophenotype analysis and proliferative responses were investigated in bronchoalveolar lavage (BAL) cells from 21 patients with st …
Impaired phenotype and function of monocyte derived dendritic cells in pulmonary tuberculosis.
Rajashree P, Krishnan G, Das SD. Rajashree P, et al. Tuberculosis (Edinb). 2009 Jan;89(1):77-83. doi: 10.1016/j.tube.2008.07.006. Epub 2008 Sep 27. Tuberculosis (Edinb). 2009. PMID: 18823820
Pulmonary tuberculosis (PTB) is often associated with impaired immunological functions. Blood monocytes, which can differentiate into dendritic cells upon cytokine stimulation, play a central role in adequate immune reactivity. ...These findings sugges
Pulmonary tuberculosis (PTB) is often associated with impaired immunological functions. Blood monocytes, which can diff
Absence of Annexin A1 impairs host adaptive immunity against Mycobacterium tuberculosis in vivo.
Vanessa KH, Julia MG, Wenwei L, Michelle AL, Zarina ZR, Lina LH, Sylvie A. Vanessa KH, et al. Immunobiology. 2015 May;220(5):614-23. doi: 10.1016/j.imbio.2014.12.001. Epub 2014 Dec 10. Immunobiology. 2015. PMID: 25533809
This has prompted us to further investigate the role of ANXA1 in the pathogenesis of tuberculosis in vivo. Here, we show that ANXA1(-/-) mice are more susceptible to M. tuberculosis infection, as evidenced by a transient increase in the pulmonary bacterial bu …
This has prompted us to further investigate the role of ANXA1 in the pathogenesis of tuberculosis in vivo. Here, we show that ANXA1(- …
Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity.
Benmerzoug S, Bounab B, Rose S, Gosset D, Biet F, Cochard T, Xavier A, Rouxel N, Fauconnier L, Horsnell WGC, Ryffel B, Togbe D, Quesniaux VFJ. Benmerzoug S, et al. Cell Rep. 2019 May 28;27(9):2649-2664.e5. doi: 10.1016/j.celrep.2019.04.110. Cell Rep. 2019. PMID: 31141689 Free article.
Lung inflammation induced by silica impairs host control of tuberculosis, yet the underlying mechanism remains unclear. Here, we show that silica-driven exacerbation of M. tuberculosis infection associates with raised type 2 immunity. Silica increases pulm
Lung inflammation induced by silica impairs host control of tuberculosis, yet the underlying mechanism remains unclear. Here, …
Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.
Carow B, Reuschl AK, Gavier-Widén D, Jenkins BJ, Ernst M, Yoshimura A, Chambers BJ, Rottenberg ME. Carow B, et al. PLoS Pathog. 2013;9(7):e1003442. doi: 10.1371/journal.ppat.1003442. Epub 2013 Jul 4. PLoS Pathog. 2013. PMID: 23853585 Free PMC article.
SOCS3 binding to gp130 in myeloid cells conveyed resistance to M. tuberculosis infection via the regulation of IL-6/STAT3 signalling. ...Socs3(fl/fl) lck cre γδ+ T cells impaired the control of infection with M. tuberculosis. Thus, SOCS3 express …
SOCS3 binding to gp130 in myeloid cells conveyed resistance to M. tuberculosis infection via the regulation of IL-6/STAT3 sign …
Orchestration of pulmonary T cell immunity during Mycobacterium tuberculosis infection: immunity interruptus.
Behar SM, Carpenter SM, Booty MG, Barber DL, Jayaraman P. Behar SM, et al. Semin Immunol. 2014 Dec;26(6):559-77. doi: 10.1016/j.smim.2014.09.003. Epub 2014 Oct 11. Semin Immunol. 2014. PMID: 25311810 Free PMC article. Review.
This is mostly because BCG fails to prevent pulmonary disease--the contagious form of tuberculosis. Although there have been significant advances in understanding how the immune system responds to infection, the qualities that define protective immunity against M. …
This is mostly because BCG fails to prevent pulmonary disease--the contagious form of tuberculosis. Although there have been s …
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