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In vitro anthelmintic efficacy of inhibitors of phosphoethanolamine Methyltransferases in Haemonchus contortus.
Witola WH, Matthews K, McHugh M. Witola WH, et al. Int J Parasitol Drugs Drug Resist. 2016 Jan 18;6(1):44-53. doi: 10.1016/j.ijpddr.2016.01.002. eCollection 2016 Apr. Int J Parasitol Drugs Drug Resist. 2016. PMID: 27054063 Free PMC article.
Herein, we screened compounds from the National Cancer Institute (Developmental Therapeutics Program Open Chemical Repository) for specific inhibitory activity against Haemonchus contortus phosphoethanolamine methyltransferases (HcPMT1 and HcPMT2), and …
Herein, we screened compounds from the National Cancer Institute (Developmental Therapeutics Program Open Chemical Repository) for specific …
Broad-Spectrum Inhibitors for Conserved Unique Phosphoethanolamine Methyltransferases in Parasitic Nematodes Possess Anthelmintic Efficacy.
Zhang X, Sicalo Gianechini L, Li K, Kaplan RM, Witola WH. Zhang X, et al. Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0000823. doi: 10.1128/aac.00008-23. Epub 2023 May 22. Antimicrob Agents Chemother. 2023. PMID: 37212658 Free PMC article.
By complementing a mutant yeast strain lacking the ability to synthesize phosphatidylcholine, the PMTs were validated to catalyze the biosynthesis of phosphatidylcholine. Using an in vitro phosphoethanolamine methyltransferase assay with PMTs as enzyme …
By complementing a mutant yeast strain lacking the ability to synthesize phosphatidylcholine, the PMTs were validated to catalyze the biosyn …
In vivo efficacy of novel phosphoethanolamine methyltransferase inhibitors against Haemonchus contortus in a jird (Meriones unguiculatus) model.
Sicalo Gianechini L, Zhang X, Li K, Witola WH, Kaplan RM. Sicalo Gianechini L, et al. Parasitol Int. 2025 Aug;107:103054. doi: 10.1016/j.parint.2025.103054. Epub 2025 Feb 27. Parasitol Int. 2025. PMID: 40023478
Despite the pressing demand for compounds with novel mechanisms of action, the introduction of new anthelmintics to the market has been scarce. In this study, we investigated the in vivo efficacy of compounds previously demonstrated to be inhibitors of pho …
Despite the pressing demand for compounds with novel mechanisms of action, the introduction of new anthelmintics to the market has be …