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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1920 1
1925 2
1929 1
1930 1
1931 1
1935 1
1938 2
1940 1
1941 1
1946 1
1947 1
1952 1
1953 1
1954 2
1955 1
1956 3
1958 3
1959 3
1960 3
1961 3
1962 2
1963 2
1964 2
1965 10
1966 9
1967 9
1968 10
1969 11
1970 19
1971 13
1972 17
1973 7
1974 10
1975 66
1976 62
1977 53
1978 52
1979 57
1980 62
1981 60
1982 69
1983 67
1984 99
1985 98
1986 85
1987 102
1988 74
1989 100
1990 104
1991 108
1992 115
1993 107
1994 117
1995 124
1996 125
1997 128
1998 129
1999 150
2000 115
2001 149
2002 169
2003 139
2004 157
2005 173
2006 190
2007 183
2008 198
2009 201
2010 210
2011 190
2012 225
2013 249
2014 229
2015 228
2016 238
2017 237
2018 257
2019 268
2020 327
2021 340
2022 347
2023 327
2024 172

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7,365 results

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Page 1
Sorting of lysosomal proteins.
Braulke T, Bonifacino JS. Braulke T, et al. Biochim Biophys Acta. 2009 Apr;1793(4):605-14. doi: 10.1016/j.bbamcr.2008.10.016. Epub 2008 Nov 12. Biochim Biophys Acta. 2009. PMID: 19046998 Free article. Review.
Lysosomes are composed of soluble and transmembrane proteins that are targeted to lysosomes in a signal-dependent manner. ...Other soluble enzymes and non-enzymatic proteins are transported to lysosomes in an M6P-independent manner mediated by alternative rec …
Lysosomes are composed of soluble and transmembrane proteins that are targeted to lysosomes in a signal-dependent manner. ...Other …
Frozen, but no accident - why the 20 standard amino acids were selected.
Doig AJ. Doig AJ. FEBS J. 2017 May;284(9):1296-1305. doi: 10.1111/febs.13982. Epub 2017 Jan 13. FEBS J. 2017. PMID: 27926995 Free article. Review.
Amino acids were not primarily selected for their ability to support catalysis, as the RNA World already had highly effective cofactors to perform reactions, such as oxidation, reduction and transfer of small molecules. Rather, they were selected to enable the formation of sol
Amino acids were not primarily selected for their ability to support catalysis, as the RNA World already had highly effective cofactors to p …
Water-Soluble Vitamin E-Tocopheryl Phosphate.
Zingg JM. Zingg JM. Adv Food Nutr Res. 2018;83:311-363. doi: 10.1016/bs.afnr.2017.12.007. Epub 2018 Feb 12. Adv Food Nutr Res. 2018. PMID: 29477225 Review.
The hydrophobicity of vitamin E poses transport and metabolic challenges to regulate its bioavailability and to prevent its accumulation in lipid-rich tissues such as adipose tissue, brain, and liver. Water-soluble precursors of vitamin E (alpha-tocopherol, alphaT), such a …
The hydrophobicity of vitamin E poses transport and metabolic challenges to regulate its bioavailability and to prevent its accumulation in …
Recent advances in co-amorphous drug formulations.
Dengale SJ, Grohganz H, Rades T, Löbmann K. Dengale SJ, et al. Adv Drug Deliv Rev. 2016 May 1;100:116-25. doi: 10.1016/j.addr.2015.12.009. Epub 2016 Jan 21. Adv Drug Deliv Rev. 2016. PMID: 26805787 Review.
A co-amorphous system is characterized by the use of only low molecular weight components that are mixed into a homogeneous single-phase co-amorphous blend. ...Because of this, several research groups started to investigate the co-amorphous formulation approach, resulting …
A co-amorphous system is characterized by the use of only low molecular weight components that are mixed into a homogeneous single-ph …
Enhancement of the Solubility of Asenapine Maleate Through the Preparation of Co-Crystals.
Al-Nimry SS, Khanfar MS. Al-Nimry SS, et al. Curr Drug Deliv. 2022;19(7):788-800. doi: 10.2174/1567201818666210805154345. Curr Drug Deliv. 2022. PMID: 34353260
BACKGROUND: Asenapine maleate, an anti-schizophrenic drug, is a class II drug with low solubility and high permeability. This exerts a rate-limiting effect on drug bioavailability. OBJECTIVE: To improve the solubility/dissolution rate of asenapine maleate and hence …
BACKGROUND: Asenapine maleate, an anti-schizophrenic drug, is a class II drug with low solubility and high permeability. This exerts …
Preparation and evaluation of sublingual film of ketorolac tromethamine.
Siddiqui MHB, Islam MS, Razu MR, Zaman AN, Jadi B, Saha T, Pathan MSI. Siddiqui MHB, et al. Drug Dev Ind Pharm. 2022 Sep;48(9):438-445. doi: 10.1080/03639045.2022.2123925. Epub 2022 Sep 27. Drug Dev Ind Pharm. 2022. PMID: 36094414
METHODS: This research produced Ketorolac tromethamine sublingual film by solvent casting method using a variable ratio of polymer and plasticizer but a fixed quantity of other excipients and solvent ratio to evaluate the effect of these components on the overall formulati …
METHODS: This research produced Ketorolac tromethamine sublingual film by solvent casting method using a variable ratio of polymer and plast …
Pharmaceutical Applications of Ionic Liquids: A Personal Account.
Md Moshikur R, Goto M. Md Moshikur R, et al. Chem Rec. 2023 Aug;23(8):e202300026. doi: 10.1002/tcr.202300026. Epub 2023 Apr 12. Chem Rec. 2023. PMID: 37042429 Review.
Ionic liquids (ILs) have been extensively used in drug formulation and delivery as designer solvents and other components because of their inherent tunability and useful physicochemical and biopharmaceutical properties. ...Furthermore, ILs have been recognized as potential …
Ionic liquids (ILs) have been extensively used in drug formulation and delivery as designer solvents and other components because of …
Therapeutic use of curcumin-encapsulated and curcumin-primed exosomes.
Oskouie MN, Aghili Moghaddam NS, Butler AE, Zamani P, Sahebkar A. Oskouie MN, et al. J Cell Physiol. 2019 Jun;234(6):8182-8191. doi: 10.1002/jcp.27615. Epub 2018 Oct 14. J Cell Physiol. 2019. PMID: 30317632 Review.
Curcumin, the bioactive pigment of turmeric which has polyphenolic-hydrophobic components, has been used for the treatment of a variety of diseases. ...Exosomes are capable of transferring lipids, proteins, RNAs and DNAs, both with and without direct cell-to-cell contact. …
Curcumin, the bioactive pigment of turmeric which has polyphenolic-hydrophobic components, has been used for the treatment of a varie …
Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components.
Brown DM, Stone V, Findlay P, MacNee W, Donaldson K. Brown DM, et al. Occup Environ Med. 2000 Oct;57(10):685-91. doi: 10.1136/oem.57.10.685. Occup Environ Med. 2000. PMID: 10984341 Free PMC article.
METHODS: Both in vitro and in vivo models were used to test the imflammogenicity of carbon black (CB) and ultrafine carbon black (UfCB) and the role of transition metals was investigated by treating the particles with desferrioxami …
METHODS: Both in vitro and in vivo models were used to test the imflammogenicity of carbon black (CB) and ultrafine
Elusive affinities.
Janin J. Janin J. Proteins. 1995 Jan;21(1):30-9. doi: 10.1002/prot.340210105. Proteins. 1995. PMID: 7716167
However, estimates of enthalpy and entropy changes in gas phase have excessively large error bars even under the approximation that the components of the complex associate as rigid bodies. No reliable result can be expected at the end. ...It is less generally valid in prot …
However, estimates of enthalpy and entropy changes in gas phase have excessively large error bars even under the approximation that the c
7,365 results