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Baicalin regulates macrophages polarization and alleviates myocardial ischaemia/reperfusion injury via inhibiting JAK/STAT pathway.
Xu M, Li X, Song L. Xu M, et al. Pharm Biol. 2020 Dec;58(1):655-663. doi: 10.1080/13880209.2020.1779318. Pharm Biol. 2020. PMID: 32649845 Free PMC article.
We hypothesized that baicalin-modulated macrophages change from M1 (pro-inflammatory subset) to M2 (anti-inflammatory subset) under I/R stress. ...In addition, the repair of myocardial morphology (reduced neutrophil infiltration) further confirmed its cardiac …
We hypothesized that baicalin-modulated macrophages change from M1 (pro-inflammatory subset) to M2 (anti-inflammatory subset) …
Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways.
Ahmed ST, Ivashkiv LB. Ahmed ST, et al. J Immunol. 2000 Nov 1;165(9):5227-37. doi: 10.4049/jimmunol.165.9.5227. J Immunol. 2000. PMID: 11046056
We analyzed the effects of the inflammatory and stress agents, IL-1, TNF-alpha, LPS, sorbitol, and H(2)O(2), on signaling by IL-6 and IL-10, pleiotropic cytokines that activate the Jak-Stat signaling pathway
We analyzed the effects of the inflammatory and stress agents, IL-1, TNF-alpha, LPS, sorbitol, and H(2)O(2), on signaling
Interleukin-10: a pleiotropic regulator in pregnancy.
Cheng SB, Sharma S. Cheng SB, et al. Am J Reprod Immunol. 2015 Jun;73(6):487-500. doi: 10.1111/aji.12329. Epub 2014 Oct 1. Am J Reprod Immunol. 2015. PMID: 25269386 Free PMC article. Review.
A wide array of cell types including both immune and non-immune cells secret IL-10 in an autocrine and paracrine manner. IL-10 binds to a specific receptor complex and activates JAK-STAT and PI3K-Akt signaling pathways while …
A wide array of cell types including both immune and non-immune cells secret IL-10 in an autocrine and paracrine manner. IL
Bronchial Vascular Remodeling Is Attenuated by Anti-IL-17 in Asthmatic Responses Exacerbated by LPS.
Camargo LDN, Dos Santos TM, de Andrade FCP, Fukuzaki S, Dos Santos Lopes FDTQ, de Arruda Martins M, Prado CM, Leick EA, Righetti RF, Tibério IFLC. Camargo LDN, et al. Front Pharmacol. 2020 Sep 4;11:1269. doi: 10.3389/fphar.2020.01269. eCollection 2020. Front Pharmacol. 2020. PMID: 33013361 Free PMC article.
RESULTS: The OVA-LPS-anti-IL-17 group presented a decrease in several factors [airway resistance and elastance, bronchoalveolar lavage fluid (BALF) cell counts, inflammatory response, eosinophils, TSLP, IL-33, TARC, TNF-alpha, CD4+, CD8+, IL-4, IL-6, IL
RESULTS: The OVA-LPS-anti-IL-17 group presented a decrease in several factors [airway resistance and elastance, bronchoalveolar lavage fluid …
Quercetin inhibits NF-kB and JAK/STAT signaling via modulating TLR in thymocytes and splenocytes during MSG-induced immunotoxicity: an in vitro approach.
Das D, Banerjee A, Mukherjee S, Maji BK. Das D, et al. Mol Biol Rep. 2024 Feb 6;51(1):277. doi: 10.1007/s11033-024-09245-7. Mol Biol Rep. 2024. PMID: 38319443
Q shielded cells by augmenting cell survival and decreasing lactate dehydrogenase leakage during MSG treatment. It decreased IL-1beta, IL-6, IL-8, and TNF-alpha expression and release by hindering NF-kB activation and by inhibiting the JAK/STAT
Q shielded cells by augmenting cell survival and decreasing lactate dehydrogenase leakage during MSG treatment. It decreased IL-1beta, IL
Cathelicidin-BF suppresses intestinal inflammation by inhibiting the nuclear factor-kappaB signaling pathway and enhancing the phagocytosis of immune cells via STAT-1 in weanling piglets.
Yi H, Yu C, Zhang H, Song D, Jiang D, Du H, Wang Y. Yi H, et al. Int Immunopharmacol. 2015 Sep;28(1):61-9. doi: 10.1016/j.intimp.2015.05.034. Epub 2015 Jun 1. Int Immunopharmacol. 2015. PMID: 26044347
We demonstrated that C-BF inhibited the expression of the inflammatory cytokines TNF-alpha, IL-6 and IL-8 but increased the expression of the anti-inflammatory cytokine IL-10 in the intestine. ...In summary, our study demonstrated …
We demonstrated that C-BF inhibited the expression of the inflammatory cytokines TNF-alpha, IL-6 and IL-8 but in …
Protective effects of the melanocortin analog NDP-α-MSH in rats undergoing cardiac arrest.
Ottani A, Neri L, Canalini F, Calevro A, Rossi R, Cappelli G, Ballestri M, Giuliani D, Guarini S. Ottani A, et al. Eur J Pharmacol. 2014 Dec 15;745:108-16. doi: 10.1016/j.ejphar.2014.10.022. Epub 2014 Oct 22. Eur J Pharmacol. 2014. PMID: 25446929
In CA/CPR rats i.v. treated with epinephrine (0.1 mg/kg) and returned to spontaneous circulation (48%) we recorded low values of mean arterial pressure (MAP) and heart rate (HR), alteration of hemogasanalysis parameters, left ventricle low expression of the cardioprotective trans …
In CA/CPR rats i.v. treated with epinephrine (0.1 mg/kg) and returned to spontaneous circulation (48%) we recorded low values of mean arteri …
Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide.
Ricchetti GA, Williams LM, Foxwell BM. Ricchetti GA, et al. J Leukoc Biol. 2004 Sep;76(3):719-26. doi: 10.1189/jlb.0104046. Epub 2004 Jul 7. J Leukoc Biol. 2004. PMID: 15240748
IL-10-induced expression of HO-1 required the activation of signal transducer and activator of transcription (STAT)-3 but not p38 mitogen-activated protein kinase. However, expression of HO-1 also required the activation of
IL-10-induced expression of HO-1 required the activation of signal transducer and activator of transcript