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Innate and adaptive immune dysregulation in critically ill ICU patients.
Duggal NA, Snelson C, Shaheen U, Pearce V, Lord JM. Duggal NA, et al. Sci Rep. 2018 Jul 5;8(1):10186. doi: 10.1038/s41598-018-28409-7. Sci Rep. 2018. PMID: 29976949 Free PMC article.
This study aimed to evaluate whether ICU patients who developed persistent critical illness displayed an immune profile similar to an aged immune phenotype and any associations with patient outcomes. Twenty two critically
This study aimed to evaluate whether ICU patients who developed persistent critical illness displayed an immu
Immunosuppression as a Hallmark of Critical COVID-19: Prospective Study.
Kalicińska E, Szymczak D, Zińczuk A, Adamik B, Smiechowicz J, Skalec T, Nowicka-Suszko D, Biernat M, Bogucka-Fedorczuk A, Rybka J, Martuszewski A, Gozdzik W, Simon K, Wróbel T. Kalicińska E, et al. Cells. 2021 May 23;10(6):1293. doi: 10.3390/cells10061293. Cells. 2021. PMID: 34071149 Free PMC article.
We showed decreased levels of Th, Ts cells, Treg cells (both naive and induced), TCRalpha/beta and gamma/delta cells, as well as CD16+CD56+NK cells in ICU compared to non-ICU COVID-19 patients. We observed impaired function of T and NK cells in critically
We showed decreased levels of Th, Ts cells, Treg cells (both naive and induced), TCRalpha/beta and gamma/delta cells, as well as CD16+CD56+N …