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Innate immune reconstitution with suppression of HIV-1.
Scully EP, Lockhart A, Garcia-Beltran W, Palmer CD, Musante C, Rosenberg E, Allen TM, Chang JJ, Bosch RJ, Altfeld M. Scully EP, et al. JCI Insight. 2016 Mar 17;1(3):e85433. doi: 10.1172/jci.insight.85433. JCI Insight. 2016. PMID: 27158667 Free PMC article.
Progressive HIV-1 infection leads to both profound immune suppression and pathologic inflammation in the majority of infected individuals. ...These data indicate that suppression of HIV-1 viremia is associated with changes in in
Progressive HIV-1 infection leads to both profound immune suppression and pathologic inflammation in the majorit …
Immune Reconstitution in Severely Immunosuppressed Antiretroviral-Naive HIV-1-Infected Patients Starting Efavirenz, Lopinavir-Ritonavir, or Atazanavir-Ritonavir Plus Tenofovir/Emtricitabine: Final 48-Week Results (The Advanz-3 Trial).
Miro JM, Manzardo C, Ferrer E, Loncà M, Guardo AC, Podzamczer D, Domingo P, Curran A, Clotet B, Cruceta A, Lozano F, Pérez I, Plana M, Gatell JM; Advanz-3 Study Group. Miro JM, et al. J Acquir Immune Defic Syndr. 2015 Jun 1;69(2):206-15. doi: 10.1097/QAI.0000000000000567. J Acquir Immune Defic Syndr. 2015. PMID: 25831464 Clinical Trial.
BACKGROUND: Few randomized clinical trials have investigated antiretroviral regimens in very advanced HIV-1-infected patients. The objective was to study the immune reconstitution in very immunosuppressed antiretroviral-naive, HIV-1-infec …
BACKGROUND: Few randomized clinical trials have investigated antiretroviral regimens in very advanced HIV-1-infected patients. …
SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-kappaB and interferon pathways.
Chen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu L. Chen S, et al. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3798-E3807. doi: 10.1073/pnas.1801213115. Epub 2018 Apr 2. Proc Natl Acad Sci U S A. 2018. PMID: 29610295 Free PMC article.
SAMHD1 has been suggested to down-regulate IFN and inflammatory responses to viral infections, although the functions and mechanisms of SAMHD1 in modulating innate immunity remain unclear. Here, we show that SAMHD1 suppresses the innate immune response …
SAMHD1 has been suggested to down-regulate IFN and inflammatory responses to viral infections, although the functions and mechanisms of SAMH …
Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity.
Krishnan G, Chatterjee N. Krishnan G, et al. Mol Cell Neurosci. 2014 Mar;59:10-23. doi: 10.1016/j.mcn.2014.01.001. Epub 2014 Jan 11. Mol Cell Neurosci. 2014. PMID: 24418364
The HIV-1 Tat protein is implicated in neurodegeneration by eliciting a cytokine response in cells of the CNS, including glia. The current study investigated whether innate immune response in human retinal Muller glia could be immune-modulated t …
The HIV-1 Tat protein is implicated in neurodegeneration by eliciting a cytokine response in cells of the CNS, including glia. …
Characterization of quantitative and functional innate immune parameters in HIV-1-infected Colombian children receiving stable highly active antiretroviral therapy.
Usuga X, Montoya CJ, Landay AL, Rugeles MT. Usuga X, et al. J Acquir Immune Defic Syndr. 2008 Dec 1;49(4):348-57. doi: 10.1097/qai.0b013e31818c16ff. J Acquir Immune Defic Syndr. 2008. PMID: 19186348
The effect of HAART on innate immune cells has not been well established. AIM: To characterize innate immune responses in HAART-treated HIV-1-infected children. ...CONCLUSIONS: HAART administration to HIV-1-infected children …
The effect of HAART on innate immune cells has not been well established. AIM: To characterize innate immune res …
Baseline viral load and immune activation determine the extent of reconstitution of innate immune effectors in HIV-1-infected subjects undergoing antiretroviral treatment.
Chehimi J, Azzoni L, Farabaugh M, Creer SA, Tomescu C, Hancock A, Mackiewicz A, D'Alessandro L, Ghanekar S, Foulkes AS, Mounzer K, Kostman J, Montaner LJ. Chehimi J, et al. J Immunol. 2007 Aug 15;179(4):2642-50. doi: 10.4049/jimmunol.179.4.2642. J Immunol. 2007. PMID: 17675528 Free article. Clinical Trial.
We analyzed dendritic cell (DC) and NK cell compartments in relation to CD4 recovery in 21 HIV-infected subjects followed to <50 copies/ml once starting antiretroviral therapy (ART) and observed for 52 wk of sustained suppression. ...Our data indicate that viremi …
We analyzed dendritic cell (DC) and NK cell compartments in relation to CD4 recovery in 21 HIV-infected subjects followed to <50 c …
Delayed reconstitution of CD4+ iNKT cells after effective HIV type 1 therapy.
Yang OO, Wilson SB, Hultin LE, Detels R, Hultin PM, Ibarrondo FJ, Jamieson BD. Yang OO, et al. AIDS Res Hum Retroviruses. 2007 Jul;23(7):913-22. doi: 10.1089/aid.2006.0253. AIDS Res Hum Retroviruses. 2007. PMID: 17678476
T lymphocytes, CD8+ lymphocyte activation, viremia, and iNKT cell subsets in peripheral blood were compared between 18 HIV-1-uninfected (Control) and 18 seropositive (SP) men initially not on suppressive antiretroviral therapy. ...These results confirm prefer …
T lymphocytes, CD8+ lymphocyte activation, viremia, and iNKT cell subsets in peripheral blood were compared between 18 HIV-1-u …
Sustained impairment of IFN-gamma secretion in suppressed HIV-infected patients despite mature NK cell recovery: evidence for a defective reconstitution of innate immunity.
Azzoni L, Papasavvas E, Chehimi J, Kostman JR, Mounzer K, Ondercin J, Perussia B, Montaner LJ. Azzoni L, et al. J Immunol. 2002 Jun 1;168(11):5764-70. doi: 10.4049/jimmunol.168.11.5764. J Immunol. 2002. PMID: 12023377 Free article.
The impairment of NK cell functions in the course of HIV infection contributes to a decreased resistance against HIV and other pathogens. ...Altogether, our findings support the hypothesis that mature NK cell phenotype may be uncoupled from some mature functions fol …
The impairment of NK cell functions in the course of HIV infection contributes to a decreased resistance against HIV and other …
BLT humanized mice as a small animal model of HIV infection.
Karpel ME, Boutwell CL, Allen TM. Karpel ME, et al. Curr Opin Virol. 2015 Aug;13:75-80. doi: 10.1016/j.coviro.2015.05.002. Epub 2015 Jun 12. Curr Opin Virol. 2015. PMID: 26083316 Free PMC article. Review.
Humanized mice are valuable models for the research and development of vaccine strategies and therapeutic interventions to control or eradicate HIV. The BLT humanized mouse model is particularly promising because the combination of transplantation of human fetal pluripoten …
Humanized mice are valuable models for the research and development of vaccine strategies and therapeutic interventions to control or eradic …
Immune recovery in HIV-infected patients after Candida esophagitis is impaired despite long-term antiretroviral therapy.
Stuehler C, Bernardini C, Elzi L, Stoeckle M, Zimmerli S, Furrer H, Günthard HF, Leibundgut-Landmann S, Battegay M, Khanna N; Swiss HIV Cohort Study. Stuehler C, et al. AIDS. 2016 Jul 31;30(12):1923-33. doi: 10.1097/QAD.0000000000001126. AIDS. 2016. PMID: 27149086 Free PMC article.
OBJECTIVE: Candida esophagitis belongs to the most common AIDS-defining diseases; however, a comprehensive immune pathogenic concept is lacking. DESIGN: We investigated the immune status of 37 HIV-1-infected patients from the Swiss HIV cohort st …
OBJECTIVE: Candida esophagitis belongs to the most common AIDS-defining diseases; however, a comprehensive immune pathogenic concept …
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