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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 2
1987 1
1988 5
1989 5
1990 8
1991 19
1992 24
1993 35
1994 32
1995 44
1996 51
1997 46
1998 69
1999 63
2000 48
2001 58
2002 58
2003 59
2004 68
2005 80
2006 78
2007 79
2008 89
2009 72
2010 85
2011 76
2012 77
2013 94
2014 95
2015 92
2016 71
2017 66
2018 57
2019 48
2020 43
2021 49
2022 11
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1,796 results
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Leukocyte migration into inflamed tissues.
Nourshargh S, Alon R. Nourshargh S, et al. Immunity. 2014 Nov 20;41(5):694-707. doi: 10.1016/j.immuni.2014.10.008. Epub 2014 Nov 20. Immunity. 2014. PMID: 25517612 Free article. Review.
Stimulation of leukocytes is instrumental in this process with enhanced temporally controlled leukocyte adhesiveness and shape-changes promoting leukocyte attachment to the inner wall of blood vessels under hydrodynamic forces. ...Perivascular cells such as m …
Stimulation of leukocytes is instrumental in this process with enhanced temporally controlled leukocyte adhesiveness and shape …
Small GTPase-dependent regulation of leukocyte-endothelial interactions in inflammation.
Chu JY, McCormick B, Vermeren S. Chu JY, et al. Biochem Soc Trans. 2018 Jun 19;46(3):649-658. doi: 10.1042/BST20170530. Epub 2018 May 9. Biochem Soc Trans. 2018. PMID: 29743277 Review.
At the start of an inflammatory response, pro-inflammatory mediators induce changes in the endothelial lining of the blood vessels and in leukocytes. ...Here, we summarise key processes that are dependent upon small GTPases in leukocytes during these e …
At the start of an inflammatory response, pro-inflammatory mediators induce changes in the endothelial lining of the blood ves …
Integrin Regulation during Leukocyte Recruitment.
Herter J, Zarbock A. Herter J, et al. J Immunol. 2013 May 1;190(9):4451-7. doi: 10.4049/jimmunol.1203179. J Immunol. 2013. PMID: 23606722 Free article. Review.
Integrins are recognized as vital players in leukocyte recruitment. ...Additionally, we discuss endogenous mechanisms that balance and counteract integrin activation and limit leukocyte recruitment at the site of inflammation. ...
Integrins are recognized as vital players in leukocyte recruitment. ...Additionally, we discuss endogenous mechanisms that bal
Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors.
Subramanian P, Mitroulis I, Hajishengallis G, Chavakis T. Subramanian P, et al. Curr Opin Hematol. 2016 Jan;23(1):36-43. doi: 10.1097/MOH.0000000000000198. Curr Opin Hematol. 2016. PMID: 26554893 Free PMC article. Review.
Neutrophil trafficking to the site of inflammation requires adhesion and transmigration through blood vessels, which is orchestrated by adhesion molecules, such as beta2 and beta1-integrins, chemokines, and cytokines. The review focuses on recent advances in understanding …
Neutrophil trafficking to the site of inflammation requires adhesion and transmigration through blood vessels, which is orchestrated by adhe …
Regulation of neutrophil function by selective targeting of glycan epitopes expressed on the integrin CD11b/CD18.
Kelm M, Lehoux S, Azcutia V, Cummings RD, Nusrat A, Parkos CA, Brazil JC. Kelm M, et al. FASEB J. 2020 Feb;34(2):2326-2343. doi: 10.1096/fj.201902542R. Epub 2019 Dec 23. FASEB J. 2020. PMID: 31907993 Free PMC article.
However, dysregulated mucosal trafficking of PMNs and associated epithelial tissue damage is a pathological hallmark of numerous inflammatory conditions including inflammatory bowel disease. The glycoprotein CD11b/CD18 plays a well-described role in regulating
However, dysregulated mucosal trafficking of PMNs and associated epithelial tissue damage is a pathological hallmark of numerous inflamma
CD8+CD103+ tissue-resident memory T cells convey reduced protective immunity in cutaneous squamous cell carcinoma.
Lai C, Coltart G, Shapanis A, Healy C, Alabdulkareem A, Selvendran S, Theaker J, Sommerlad M, Rose-Zerilli M, Al-Shamkhani A, Healy E. Lai C, et al. J Immunother Cancer. 2021 Jan;9(1):e001807. doi: 10.1136/jitc-2020-001807. J Immunother Cancer. 2021. PMID: 33479027 Free PMC article.
BACKGROUND: Tumor infiltrating lymphocytes play a key role in antitumor responses; however, while several memory T-cell subtypes have been reported in inflammatory and neoplastic conditions, the proportional representation of the different subsets of memory T cells and the …
BACKGROUND: Tumor infiltrating lymphocytes play a key role in antitumor responses; however, while several memory T-cell subtypes have been r …
Regulation and Role of αE Integrin and Gut Homing Integrins in Migration and Retention of Intestinal Lymphocytes during Inflammatory Bowel Disease.
Keir ME, Fuh F, Ichikawa R, Acres M, Hackney JA, Hulme G, Carey CD, Palmer J, Jones CJ, Long AK, Jiang J, Klabunde S, Mansfield JC, Looney CM, Faubion WA, Filby A, Kirby JA, McBride J, Lamb CA. Keir ME, et al. J Immunol. 2021 Nov 1;207(9):2245-2254. doi: 10.4049/jimmunol.2100220. Epub 2021 Sep 24. J Immunol. 2021. PMID: 34561227 Free PMC article.
Targeting interactions between alpha4beta7 integrin and endothelial adhesion molecule MAdCAM-1 to inhibit lymphocyte migration to the gastrointestinal tract is an effective therapy in inflammatory bowel disease (IBD). ...The factors governing lymphocyte migration in …
Targeting interactions between alpha4beta7 integrin and endothelial adhesion molecule MAdCAM-1 to inhibit lymphocyte migration to the …
Neutrophils in acute inflammation: current concepts and translational implications.
Margraf A, Lowell CA, Zarbock A. Margraf A, et al. Blood. 2022 Apr 7;139(14):2130-2144. doi: 10.1182/blood.2021012295. Blood. 2022. PMID: 34624098 Review.
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to sites of infection to combat invading pathogens while, at the same time, limiting host tissue injury or autoimmunity. The underlying mechanisms regulating recruit …
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to sites of infection to combat …
The role of integrins in the pathogenesis of inflammatory bowel disease: Approved and investigational anti-integrin therapies.
Dotan I, Allez M, Danese S, Keir M, Tole S, McBride J. Dotan I, et al. Med Res Rev. 2020 Jan;40(1):245-262. doi: 10.1002/med.21601. Epub 2019 Jun 19. Med Res Rev. 2020. PMID: 31215680 Free PMC article. Review.
The underlying pathobiology of IBD includes an increase in infiltrating gut-homing lymphocytes. Although lymphocyte homing is typically a tightly regulated and stepwise process involving multiple integrins and adhesion molecules expressed on endothelial cells, the d …
The underlying pathobiology of IBD includes an increase in infiltrating gut-homing lymphocytes. Although lymphocyte homing is typically a ti …
Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes.
Fan ST, Edgington TS. Fan ST, et al. J Immunol. 1993 Apr 1;150(7):2972-80. J Immunol. 1993. PMID: 8095957
The role of cognate interactions between integrin and its ligands in the regulation of cellular responses important to inflammation can be extended to the effect on the enhancement of TNF-alpha mRNA accumulation and protein secretion by Mo once stimulated by an init …
The role of cognate interactions between integrin and its ligands in the regulation of cellular responses important to inflamm …
1,796 results