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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1988 4
1989 9
1990 11
1991 15
1992 12
1993 21
1994 10
1995 21
1996 21
1997 13
1998 21
1999 20
2000 15
2001 30
2002 20
2003 19
2004 14
2005 13
2006 16
2007 8
2008 10
2009 13
2010 9
2011 10
2012 11
2013 13
2014 8
2015 9
2016 13
2017 11
2018 9
2019 5
2020 0
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413 results
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Page 1
Epigenetic synergism between interleukin-4 and aryl-hydrocarbon receptor in human macrophages.
Liao WT, Lu JH, Wang WT, Hung CH, Sheu CC, Huang SK. Liao WT, et al. J Mol Med (Berl). 2017 Apr;95(4):395-404. doi: 10.1007/s00109-016-1493-1. Epub 2016 Nov 25. J Mol Med (Berl). 2017. PMID: 27888289
We used a human THP-1 cell line, monocytes, and mouse peritoneal macrophages to generate M(IFN-gamma/LPS) and M(IL-4) subsets, and the AhR's ligand effect was determined by the use of a combination of chromatin immunoprecipitation, PCR, and ELIS …
We used a human THP-1 cell line, monocytes, and mouse peritoneal macrophages to generate M(IFN-gamma/LPS) and M(IL-4
The C-Type Lectin Receptor DC-SIGN Has an Anti-Inflammatory Role in Human M(IL-4) Macrophages in Response to Mycobacterium tuberculosis.
Lugo-Villarino G, Troegeler A, Balboa L, Lastrucci C, Duval C, Mercier I, Bénard A, Capilla F, Al Saati T, Poincloux R, Kondova I, Verreck FAW, Cougoule C, Maridonneau-Parini I, Sasiain MDC, Neyrolles O. Lugo-Villarino G, et al. Front Immunol. 2018 Jun 12;9:1123. doi: 10.3389/fimmu.2018.01123. eCollection 2018. Front Immunol. 2018. PMID: 29946317 Free PMC article.
DC-SIGN (CD209/CLEC4L) is a C-type lectin receptor (CLR) that serves as a reliable cell-surface marker of interleukin 4 (IL-4)-activated human macrophages [M(IL-4)], which historically represent the most studied subset within the M …
DC-SIGN (CD209/CLEC4L) is a C-type lectin receptor (CLR) that serves as a reliable cell-surface marker of interleukin
IL-4 Induces IL17Rb Gene Transcription in Monocytic Cells with Coordinate Autocrine IL-25 Signaling.
Weathington NM, Kanth SM, Gong Q, Londino J, Hoji A, Rojas M, Trudeau J, Wenzel S, Mallampalli RK. Weathington NM, et al. Am J Respir Cell Mol Biol. 2017 Sep;57(3):346-354. doi: 10.1165/rcmb.2016-0316OC. Am J Respir Cell Mol Biol. 2017. PMID: 28421819 Free PMC article.
Despite the known coexistence of these two cytokines in the Type 2 inflammatory environment, collaborative signaling between the IL-4 and IL-25 axes is poorly explored. Here we demonstrate IL-4 induction of both IL-25 and IL-17Rb protein in human lung tissue …
Despite the known coexistence of these two cytokines in the Type 2 inflammatory environment, collaborative signaling between the IL-4
Interleukin-4 Enhances the Sensitivity of Human Monocytes to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Through Upregulation of Death Receptor 4.
Zhang S, Li Z, Huang W. Zhang S, et al. J Interferon Cytokine Res. 2018 Apr;38(4):186-194. doi: 10.1089/jir.2017.0103. Epub 2018 Mar 19. J Interferon Cytokine Res. 2018. PMID: 29638207
Interleukin (IL)-4 is generally thought to promote tumor cell growth and inhibit apoptosis. ...After incubation with IL-4 for 24 h, death receptor 4 (DR4) was significantly increased without downregulation of TRAIL decoy receptors
Interleukin (IL)-4 is generally thought to promote tumor cell growth and inhibit apoptosis. ...After incubation with IL
The role of cytokines in osteoarthritis pathophysiology.
Fernandes JC, Martel-Pelletier J, Pelletier JP. Fernandes JC, et al. Biorheology. 2002;39(1-2):237-46. Biorheology. 2002. PMID: 12082286 Review.
Their antiinflammatory potential, however, appears to depend greatly on the target cell. Interleukin-4 (IL-4) has been tested in vitro in OA tissue and has been shown to suppress the synthesis of both TNF-alpha and IL-1beta in the same manner as low-do …
Their antiinflammatory potential, however, appears to depend greatly on the target cell. Interleukin-4 (IL-4) ha …
Cellular analysis of the histamine H4 receptor in human myeloid cells.
Capelo R, Lehmann C, Ahmad K, Snodgrass R, Diehl O, Ringleb J, Flamand N, Weigert A, Stark H, Steinhilber D, Kahnt AS. Capelo R, et al. Biochem Pharmacol. 2016 Mar 1;103:74-84. doi: 10.1016/j.bcp.2016.01.007. Epub 2016 Jan 13. Biochem Pharmacol. 2016. PMID: 26774453
The human histamine H4 receptor (H4R) is a Galphai/o-coupled receptor which is mainly expressed on hematopoietic cells. ...Therefore, we aimed to assess absolute receptor mRNA expression and functionality (intracellular Ca(2+) release) in variou …
The human histamine H4 receptor (H4R) is a Galphai/o-coupled receptor which is mainly expressed on hematopoietic cel
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.
Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D. Brestoff JR, et al. Nature. 2015 Mar 12;519(7542):242-6. doi: 10.1038/nature14115. Epub 2014 Dec 22. Nature. 2015. PMID: 25533952 Free PMC article.
Obesity is an increasingly prevalent disease regulated by genetic and environmental factors. Emerging studies indicate that immune cells, including monocytes, granulocytes and lymphocytes, regulate metabolic homeostasis and are dysregulated in obesity. …
Obesity is an increasingly prevalent disease regulated by genetic and environmental factors. Emerging studies indicate that immune …
Interleukin 4 receptors on human bronchial epithelial cells. An in vivo and in vitro analysis of expression and function.
van der Velden VH, Naber BA, Wierenga-Wolf AF, Debets R, Savelkoul HF, Overbeek SE, Hoogsteden HC, Versnel MA. van der Velden VH, et al. Cytokine. 1998 Oct;10(10):803-13. doi: 10.1006/cyto.1998.0365. Cytokine. 1998. PMID: 9811535
However, little is known about the presence of IL-4 receptors on human bronchial epithelial cells, or the effects of IL-4 on these cells. ...It is concluded that human bronchial epithelial cells express IL-4 recept
However, little is known about the presence of IL-4 receptors on human bronchial epithelial cells, or the effect …
Unexpected impairment of TNF-alpha-induced maturation of human dendritic cells in vitro by IL-4.
Chabot V, Martin L, Meley D, Sensebé L, Baron C, Lebranchu Y, Dehaut F, Velge-Roussel F. Chabot V, et al. J Transl Med. 2016 Apr 14;14:93. doi: 10.1186/s12967-016-0848-2. J Transl Med. 2016. PMID: 27080531 Free PMC article.
METHODS: Human monocyte-derived iDC were treated for 48 h with GM-CSF and TNF-alpha in the presence (IL-4(+)-DC) or absence (IL-4(-)-DC) of IL-4 and functions of both DC populations were compared. ...Interleukin-4 reduced the ce
METHODS: Human monocyte-derived iDC were treated for 48 h with GM-CSF and TNF-alpha in the presence (IL-4(+)-DC) or abs …
Generation of Human Monocyte-derived Dendritic Cells from Whole Blood.
Posch W, Lass-Flörl C, Wilflingseder D. Posch W, et al. J Vis Exp. 2016 Dec 24;(118):54968. doi: 10.3791/54968. J Vis Exp. 2016. PMID: 28060313 Free PMC article.
Dendritic cells (DCs) recognize foreign structures of different pathogens, such as viruses, bacteria, and fungi, via a variety of pattern recognition receptors (PRRs) expressed on their cell surface and thereby activate and regulate immunity. ...They a …
Dendritic cells (DCs) recognize foreign structures of different pathogens, such as viruses, bacteria, and fungi, via a variety of pat …
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