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Isoxanthohumol--Biologically active hop flavonoid.
Żołnierczyk AK, Mączka WK, Grabarczyk M, Wińska K, Woźniak E, Anioł M. Żołnierczyk AK, et al. Fitoterapia. 2015 Jun;103:71-82. doi: 10.1016/j.fitote.2015.03.007. Epub 2015 Mar 12. Fitoterapia. 2015. PMID: 25771121
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found in hops. ...It activates apoptosis in human umbilical vein endothelial cells (HUVEC) and human aortic smooth muscle cells (HASMCs). In
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found i
The Multiple Biological Targets of Hops and Bioactive Compounds.
Bolton JL, Dunlap TL, Hajirahimkhan A, Mbachu O, Chen SN, Chadwick L, Nikolic D, van Breemen RB, Pauli GF, Dietz BM. Bolton JL, et al. Chem Res Toxicol. 2019 Feb 18;32(2):222-233. doi: 10.1021/acs.chemrestox.8b00345. Epub 2019 Jan 22. Chem Res Toxicol. 2019. PMID: 30608650 Free PMC article. Review.
The chalcone xanthohumol (XH) is the major prenylated flavonoid in spent hops. Other less abundant but important bioactive prenylated flavonoids are isoxanthohumol (IX), 8-prenylnaringenin (8-PN), and 6-prenylnaringenin (6-PN). ...XH also alkylates IKK and NF …
The chalcone xanthohumol (XH) is the major prenylated flavonoid in spent hops. Other less abundant but important bioactive prenylated …
Highly Cancer Selective Antiproliferative Activity of Natural Prenylated Flavonoids.
Bartmańska A, Tronina T, Popłoński J, Milczarek M, Filip-Psurska B, Wietrzyk J. Bartmańska A, et al. Molecules. 2018 Nov 9;23(11):2922. doi: 10.3390/molecules23112922. Molecules. 2018. PMID: 30423918 Free PMC article.
Xanthohumol (XN) and four minor hops prenylflavonoids: α,β-dihydroxanthohumol (2HXN), isoxanthohumol (IXN), 8-prenylnaringenin (8PN), and 6-prenylnaringenin (6PN), were tested for antiproliferative activity towards human cancer and normal cell lines. ...Xanthohumol, …
Xanthohumol (XN) and four minor hops prenylflavonoids: α,β-dihydroxanthohumol (2HXN), isoxanthohumol (IXN), 8-prenylnaringenin (8PN), …
The hop-derived compounds xanthohumol, isoxanthohumol and 8-prenylnaringenin are tight-binding inhibitors of human aldo-keto reductases 1B1 and 1B10.
Seliger JM, Misuri L, Maser E, Hintzpeter J. Seliger JM, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):607-614. doi: 10.1080/14756366.2018.1437728. J Enzyme Inhib Med Chem. 2018. PMID: 29532688 Free PMC article.
Xanthohumol (XN), a prenylated chalcone unique to hops (Humulus lupulus) and two derived prenylflavanones, isoxanthohumol (IX) and 8-prenylnaringenin (8-PN) gained increasing attention as potential anti-diabetic and cancer preventive compounds. ...activity relations …
Xanthohumol (XN), a prenylated chalcone unique to hops (Humulus lupulus) and two derived prenylflavanones, isoxanthohumol (IX) and 8- …
Insect Antifeedant Potential of Xanthohumol, Isoxanthohumol, and Their Derivatives.
Stompor M, Dancewicz K, Gabryś B, Anioł M. Stompor M, et al. J Agric Food Chem. 2015 Aug 5;63(30):6749-56. doi: 10.1021/acs.jafc.5b02025. Epub 2015 Jul 27. J Agric Food Chem. 2015. PMID: 26176501
Xanthohumol (14) and isoxanthohumol (6) derived from hop (Humulus lupulus L., Cannabaceae) and selected chalcone and chromene derivatives, obtained by chemical synthesis, were studied for antifeedant activity against the peach-potato aphid (Myzus persicae [Su …
Xanthohumol (14) and isoxanthohumol (6) derived from hop (Humulus lupulus L., Cannabaceae) and selected chalcone and chromene …
Antiproliferative Effects of Hop-derived Prenylflavonoids and Their Influence on the Efficacy of Oxaliplatine, 5-fluorouracil and Irinotecan in Human ColorectalC Cells.
Ambrož M, Lněničková K, Matoušková P, Skálová L, Boušová I. Ambrož M, et al. Nutrients. 2019 Apr 19;11(4):879. doi: 10.3390/nu11040879. Nutrients. 2019. PMID: 31010128 Free PMC article.
Moreover, non-alcoholic beer, owing to its nutritional value and high content of biological active compounds, is sometimes recommended to patients by oncologists. ...Isoxanthohumol increased ROS formation and the activity of caspases-3/7, but 6-prenyln …
Moreover, non-alcoholic beer, owing to its nutritional value and high content of biological active compounds, is sometimes rec …
Synthesis and biological evaluation of 4'-O-acetyl-isoxanthohumol and its analogues as antioxidant and antiproliferative agents.
Stompor M, Świtalska M, Podgórski R, Uram Ł, Aebisher D, Wietrzyk J. Stompor M, et al. Acta Biochim Pol. 2017;64(3):577-583. doi: 10.18388/abp.2017_1608. Epub 2017 Aug 12. Acta Biochim Pol. 2017. PMID: 28803257 Free article.
Additionally, the activity of the acylated isoxanthohumols was higher than for 2. To the best of our knowledge this is the first report on bioactivity of monoacylated isoxanthohumol (3) and its ester derivatives as antiproliferative compounds in drug resistant cell …
Additionally, the activity of the acylated isoxanthohumols was higher than for 2. To the best of our knowledge this is the first repo …
Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes.
Kiyofuji A, Yui K, Takahashi K, Osada K. Kiyofuji A, et al. J Oleo Sci. 2014;63(6):593-7. doi: 10.5650/jos.ess14009. Epub 2014 May 15. J Oleo Sci. 2014. PMID: 24829131 Free article.
Xanthohumol is a major prenylated, hydrophobic flavonoid found in the female inflorescences of the hop plant (Humulus lupulus L.). In this study, we examined the effects of xanthohumol-rich hop extract containing 17.8% xanthohumol and 12.4% isoxanthohumol
Xanthohumol is a major prenylated, hydrophobic flavonoid found in the female inflorescences of the hop plant (Humulus lupulus …
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
Stevens JF, Page JE. Stevens JF, et al. Phytochemistry. 2004 May;65(10):1317-30. doi: 10.1016/j.phytochem.2004.04.025. Phytochemistry. 2004. PMID: 15231405 Review.
Xanthohumol (3'-[3,3-dimethyl allyl]-2',4',4-trihydroxy-6'-methoxychalcone) is the principal prenylated flavonoid of the female inflorescences of the hop plant ('hops'), an ingredient of beer. ...These biological activities suggest that prenylflavonoid …
Xanthohumol (3'-[3,3-dimethyl allyl]-2',4',4-trihydroxy-6'-methoxychalcone) is the principal prenylated flavonoid of the female inflo …
Beer constituents as potential cancer chemopreventive agents.
Gerhäuser C. Gerhäuser C. Eur J Cancer. 2005 Sep;41(13):1941-54. doi: 10.1016/j.ejca.2005.04.012. Eur J Cancer. 2005. PMID: 15953717 Review.
Compounds belonging to different structural classes have distinct profiles of biological activity in in vitro test systems, and in combination might lead to enhanced effects. Scientific evidence has accumulated over the past 10 years pointing to the cancer preventiv …
Compounds belonging to different structural classes have distinct profiles of biological activity in in vitro test systems, an …
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