Isoxanthohumol--Biologically active hop flavonoid.
Fitoterapia. 2015.
PMID: 25771121
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Isoxanthohumol--Biologically active hop flavonoid.
Fitoterapia. 2015 Jun;103:71-82. doi: 10.1016/j.fitote.2015.03.007. Epub 2015 Mar 12.
Fitoterapia. 2015.
PMID: 25771121
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found in hops. ...In addition, IXN shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV) …
Isoxanthohumol (IXN), apart from xanthohumol (XN) and 8-prenylnaringenin (8PN), is one of the most important prenylflavonoids found i …
Isoxanthohumol improves hepatic lipid metabolism via regulating the AMPK/PPARalpha and PI3K/AKT signaling pathways in hyperlipidemic mice.
Food Sci Nutr. 2024 Sep 10;12(11):8846-8857. doi: 10.1002/fsn3.4449. eCollection 2024 Nov.
Food Sci Nutr. 2024.
PMID: 39619961
Free PMC article.
The purpose of this research is to explore the possible molecular mechanisms of isoxanthohumol (IXN), the major hop flavonoid in beer, in the treatment of hyperlipidemia. ...A protein-protein interaction network was constructed to pinpoint hub targets, and su …
The purpose of this research is to explore the possible molecular mechanisms of isoxanthohumol (IXN), the major hop flavono …
Beer constituents as potential cancer chemopreventive agents.
Eur J Cancer. 2005 Sep;41(13):1941-54. doi: 10.1016/j.ejca.2005.04.012.
Eur J Cancer. 2005.
PMID: 15953717
Review.
Structural classes include simple phenols, benzoic- and cinnamic acid derivatives, coumarins, catechins, di-, tri- and oligomeric proanthocyanidins, (prenylated) chalcones and flavonoids as well as alpha- and iso-alpha-acids derived from hop. Compounds belonging to …
Structural classes include simple phenols, benzoic- and cinnamic acid derivatives, coumarins, catechins, di-, tri- and oligomeric proanthocy …
The Multiple Biological Targets of Hops and Bioactive Compounds.
Chem Res Toxicol. 2019 Feb 18;32(2):222-233. doi: 10.1021/acs.chemrestox.8b00345. Epub 2019 Jan 22.
Chem Res Toxicol. 2019.
PMID: 30608650
Free PMC article.
Review.
Several hop constituents are responsible for distinct effects linked to multiple biological targets, including hormonal, metabolic, inflammatory, and epigenetic pathways. 8-PN is one of the most potent phytoestrogens and is responsible for hops' estrogenic activi …
Several hop constituents are responsible for distinct effects linked to multiple biological targets, including hormonal, metab …
Hop-derived prenylflavonoid isoxanthohumol suppresses insulin resistance by changing the intestinal microbiota and suppressing chronic inflammation in high fat diet-fed mice.
Eur Rev Med Pharmacol Sci. 2020 Feb;24(3):1537-1547. doi: 10.26355/eurrev_202002_20212.
Eur Rev Med Pharmacol Sci. 2020.
PMID: 32096203
Free article.
OBJECTIVE: To assess whether the hop-derived polyphenol isoxanthohumol suppresses insulin resistance by changing the intestinal microbiota. ...CONCLUSIONS: We found that isoxanthohumol can suppress HFD-induced insulin resistance by changing the intestinal mic …
OBJECTIVE: To assess whether the hop-derived polyphenol isoxanthohumol suppresses insulin resistance by changing the intestina …
Tissue distribution and pharmacokinetics of isoxanthohumol from hops in rodents.
Food Sci Nutr. 2023 Dec 29;12(3):2210-2219. doi: 10.1002/fsn3.3900. eCollection 2024 Mar.
Food Sci Nutr. 2023.
PMID: 38455172
Free PMC article.
Vegetables and fruits contain prenylflavonoids with biological functions that might improve human health. The prenylflavonoid isoxanthohumol (IXA) and its derivative, 8-prenylnaringenin (8-PN), have beneficial activities, including anti-cancer effects and sup …
Vegetables and fruits contain prenylflavonoids with biological functions that might improve human health. The prenylflavonoid isox …
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
Phytochemistry. 2004 May;65(10):1317-30. doi: 10.1016/j.phytochem.2004.04.025.
Phytochemistry. 2004.
PMID: 15231405
Review.
Xanthohumol (3'-[3,3-dimethyl allyl]-2',4',4-trihydroxy-6'-methoxychalcone) is the principal prenylated flavonoid of the female inflorescences of the hop plant ('hops'), an ingredient of beer. ...These biological activities suggest that prenylflavonoid …
Xanthohumol (3'-[3,3-dimethyl allyl]-2',4',4-trihydroxy-6'-methoxychalcone) is the principal prenylated flavonoid of the female inflo …
Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication.
Phytomedicine. 2024 Jan;123:155176. doi: 10.1016/j.phymed.2023.155176. Epub 2023 Oct 30.
Phytomedicine. 2024.
PMID: 37976697
Especially, the medicinal plant Humulus lupulus (hop) contains several secondary plant metabolites some of which have previously shown antiviral activities. ...Antiviral activity of hop compounds was assessed using the fluorescently labeled wildtype SA …
Especially, the medicinal plant Humulus lupulus (hop) contains several secondary plant metabolites some of which have previously show …
The hop-derived compounds xanthohumol, isoxanthohumol and 8-prenylnaringenin are tight-binding inhibitors of human aldo-keto reductases 1B1 and 1B10.
J Enzyme Inhib Med Chem. 2018 Dec;33(1):607-614. doi: 10.1080/14756366.2018.1437728.
J Enzyme Inhib Med Chem. 2018.
PMID: 29532688
Free PMC article.
Xanthohumol (XN), a prenylated chalcone unique to hops (Humulus lupulus) and two derived prenylflavanones, isoxanthohumol (IX) and 8-prenylnaringenin (8-PN) gained increasing attention as potential anti-diabetic and cancer preventive compounds. ...The results of this study …
Xanthohumol (XN), a prenylated chalcone unique to hops (Humulus lupulus) and two derived prenylflavanones, isoxanthohumol (IX) and 8- …
Synthesis and biological evaluation of 4'-O-acetyl-isoxanthohumol and its analogues as antioxidant and antiproliferative agents.
Acta Biochim Pol. 2017;64(3):577-583. doi: 10.18388/abp.2017_1608. Epub 2017 Aug 12.
Acta Biochim Pol. 2017.
PMID: 28803257
Free article.
Additionally, the activity of the acylated isoxanthohumols was higher than for 2. To the best of our knowledge this is the first report on bioactivity of monoacylated isoxanthohumol (3) and its ester derivatives as antiproliferative compounds in drug resistant cell …
Additionally, the activity of the acylated isoxanthohumols was higher than for 2. To the best of our knowledge this is the first repo …
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