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LRRK2 levels in immune cells are increased in Parkinson's disease.
Cook DA, Kannarkat GT, Cintron AF, Butkovich LM, Fraser KB, Chang J, Grigoryan N, Factor SA, West AB, Boss JM, Tansey MG. Cook DA, et al. NPJ Parkinsons Dis. 2017 Mar 28;3:11. doi: 10.1038/s41531-017-0010-8. eCollection 2017. NPJ Parkinsons Dis. 2017. PMID: 28649611 Free PMC article.
Leucine-rich repeat kinase 2 induction was also increased in monocytes and dividing T cells in Parkinson's disease patients compared to healthy controls. ...In sum, these findings suggest that leucine-rich repeat kinase 2 has a regulatory role i …
Leucine-rich repeat kinase 2 induction was also increased in monocytes and dividing T cells in Parkinson's di
LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients.
Atashrazm F, Hammond D, Perera G, Bolliger MF, Matar E, Halliday GM, Schüle B, Lewis SJG, Nichols RJ, Dzamko N. Atashrazm F, et al. Mov Disord. 2019 Mar;34(3):406-415. doi: 10.1002/mds.27601. Epub 2018 Dec 30. Mov Disord. 2019. PMID: 30597610
Leucine-rich repeat kinase 2 levels in mononuclear cells were the same in controls and Parkinson's disease patients, whereas leucine-rich repeat kinase 2 was significantly increased in Parkinson's disease neutrophils. …
Leucine-rich repeat kinase 2 levels in mononuclear cells were the same in controls and Parkinson's disease
LRRK2 in Infection: Friend or Foe?
Herbst S, Gutierrez MG. Herbst S, et al. ACS Infect Dis. 2019 Jun 14;5(6):809-815. doi: 10.1021/acsinfecdis.9b00051. Epub 2019 Apr 5. ACS Infect Dis. 2019. PMID: 30915830 Free PMC article.
In the field of Parkinson's disease (PD) research, leucine-rich repeat kinase 2 (LRRK2) remains one of the most enigmatic kinases. ...Additionally, LRRK2 gene expression data shows that LRRK2 is expressed at low levels in neurons a …
In the field of Parkinson's disease (PD) research, leucine-rich repeat kinase 2 (LRRK2) remains one of the most …
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.
Weindel CG, Bell SL, Vail KJ, West KO, Patrick KL, Watson RO. Weindel CG, et al. Elife. 2020 Feb 14;9:e51071. doi: 10.7554/eLife.51071. Elife. 2020. PMID: 32057291 Free PMC article.
The Parkinson's disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively in the brain. ...Researchers have identified mutations in several genes that are associated with an increased risk of developing Pa
The Parkinson's disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively i …
Parkinson's disease and immune system: is the culprit LRRKing in the periphery?
Greggio E, Civiero L, Bisaglia M, Bubacco L. Greggio E, et al. J Neuroinflammation. 2012 Jul 9;9:94. doi: 10.1186/1742-2094-9-94. J Neuroinflammation. 2012. PMID: 22594666 Free PMC article. Review.
Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson's disease; Crohn's disease; and leprosy. ...In this review we discuss the most recent find …
Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditi …
Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.
Caesar M, Felk S, Zach S, Brønstad G, Aasly JO, Gasser T, Gillardon F. Caesar M, et al. Glia. 2014 Jul;62(7):1075-92. doi: 10.1002/glia.22663. Epub 2014 Mar 20. Glia. 2014. PMID: 24652679
Increasing evidence suggests that Parkinson's disease (PD)-linked Leucine-rich repeat kinase 2 (LRRK2) has a role in peripheral and brain-resident immune cells. ...Our data suggest that proinflammatory activity of peripheral and br
Increasing evidence suggests that Parkinson's disease (PD)-linked Leucine-rich repeat kinase 2 (LRRK2) ha
LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.
Ma B, Xu L, Pan X, Sun L, Ding J, Xie C, Koliatsos VE, Cai H. Ma B, et al. Hum Mol Genet. 2016 Aug 15;25(16):3515-3523. doi: 10.1093/hmg/ddw194. Epub 2016 Jul 4. Hum Mol Genet. 2016. PMID: 27378696 Free PMC article.
Multiple missense mutations in Leucine-rich repeat kinase 2 (LRRK2) have been linked to Parkinson's disease (PD), the most common degenerative movement disorder. LRRK2 is expressed by both neurons and microglia, the residential immune
Multiple missense mutations in Leucine-rich repeat kinase 2 (LRRK2) have been linked to Parkinson's disease (PD) …
Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells.
Speidel A, Felk S, Reinhardt P, Sterneckert J, Gillardon F. Speidel A, et al. PLoS One. 2016 Nov 3;11(11):e0165949. doi: 10.1371/journal.pone.0165949. eCollection 2016. PLoS One. 2016. PMID: 27812199 Free PMC article.
Mutations in Leucine-rich repeat kinase 2 (LRRK2) are strongly associated with familial Parkinson's disease (PD). High expression levels in immune cells suggest a role of LRRK2 in regulating the immune system. In this …
Mutations in Leucine-rich repeat kinase 2 (LRRK2) are strongly associated with familial Parkinson's disease (PD) …
Leucine-rich repeat kinase 2-sensitive Na+/Ca2+ exchanger activity in dendritic cells.
Yan J, Almilaji A, Schmid E, Elvira B, Shimshek DR, van der Putten H, Wagner CA, Shumilina E, Lang F. Yan J, et al. FASEB J. 2015 May;29(5):1701-10. doi: 10.1096/fj.14-264028. Epub 2015 Jan 21. FASEB J. 2015. PMID: 25609428
Gene variants of the leucine-rich repeat kinase 2 (LRRK2) are associated with susceptibility to Parkinson's disease (PD). Besides brain and periphery, LRRK2 is expressed in various immune cells including dendritic cells (DCs …
Gene variants of the leucine-rich repeat kinase 2 (LRRK2) are associated with susceptibility to Parkinson's disease
Regulation of LRRK2 expression points to a functional role in human monocyte maturation.
Thévenet J, Pescini Gobert R, Hooft van Huijsduijnen R, Wiessner C, Sagot YJ. Thévenet J, et al. PLoS One. 2011;6(6):e21519. doi: 10.1371/journal.pone.0021519. Epub 2011 Jun 27. PLoS One. 2011. PMID: 21738687 Free PMC article.
We found that IFN-γ in particular robustly increased LRRK2 mRNA and protein levels in monocytes concomitant with a shift of CD14(+)CD16(-) cells towards CD14(+)CD16(+) cells. ...Our data might also reflect an involvement of peripheral and brain …
We found that IFN-γ in particular robustly increased LRRK2 mRNA and protein levels in monocytes concomitant with a shif …
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