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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1976 1
1978 1
1981 1
1984 1
1985 1
1986 2
1987 2
1988 7
1989 3
1990 8
1991 9
1992 12
1993 12
1994 19
1995 22
1996 30
1997 23
1998 31
1999 28
2000 30
2001 45
2002 31
2003 44
2004 54
2005 61
2006 62
2007 65
2008 79
2009 86
2010 104
2011 124
2012 122
2013 160
2014 240
2015 312
2016 331
2017 341
2018 406
2019 375
2020 421
2021 71
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3,346 results
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Page 1
Macrophages and Cardiovascular Health.
Frodermann V, Nahrendorf M. Frodermann V, et al. Physiol Rev. 2018 Oct 1;98(4):2523-2569. doi: 10.1152/physrev.00068.2017. Physiol Rev. 2018. PMID: 30156496 Free PMC article. Review.
In this review, we will highlight signals that regulate macrophage supply and function, imaging applications that can detect changes in cell numbers and phenotype, and opportunities to modulate cardiovascular inflammation by targeting macrophage biology. ...W …
In this review, we will highlight signals that regulate macrophage supply and function, imaging applications that can detect changes …
Atherosclerosis.
Rahman MS, Woollard K. Rahman MS, et al. Adv Exp Med Biol. 2017;1003:121-144. doi: 10.1007/978-3-319-57613-8_7. Adv Exp Med Biol. 2017. PMID: 28667557 Free article. Review.
In this chapter, we discuss the manner through which the immune system regulates the cardiovascular system in health and disease. We define the cardiovascular system and elements of atherosclerotic disease, the main focus in this chapter. …
In this chapter, we discuss the manner through which the immune system regulates the cardiovascular system in health
Mechanisms of Organ Injury and Repair by Macrophages.
Vannella KM, Wynn TA. Vannella KM, et al. Annu Rev Physiol. 2017 Feb 10;79:593-617. doi: 10.1146/annurev-physiol-022516-034356. Epub 2016 Dec 7. Annu Rev Physiol. 2017. PMID: 27959618 Review.
However, dysregulated macrophage function impairs wound healing and contributes to the development of fibrosis. Consequently, the mechanisms that regulate these different macrophage activation states have become active areas of research. In this review, we discuss t …
However, dysregulated macrophage function impairs wound healing and contributes to the development of fibrosis. Consequently, the mec …
Using High-Dimensional Approaches to Probe Monocytes and Macrophages in Cardiovascular Disease.
Dick SA, Zaman R, Epelman S. Dick SA, et al. Front Immunol. 2019 Sep 12;10:2146. doi: 10.3389/fimmu.2019.02146. eCollection 2019. Front Immunol. 2019. PMID: 31572369 Free PMC article. Review.
Single cell RNA sequencing, combined with functional analyses have demonstrated that at least three populations of resident cardiac macrophages exist, and after tissue injury, there is significant diversification of the tissue macrophage pool driven by recruited mon …
Single cell RNA sequencing, combined with functional analyses have demonstrated that at least three populations of resident cardiac macro
An update on lipid oxidation and inflammation in cardiovascular diseases.
Zhong S, Li L, Shen X, Li Q, Xu W, Wang X, Tao Y, Yin H. Zhong S, et al. Free Radic Biol Med. 2019 Nov 20;144:266-278. doi: 10.1016/j.freeradbiomed.2019.03.036. Epub 2019 Apr 1. Free Radic Biol Med. 2019. PMID: 30946962 Review.
Cardiovascular diseases (CVD), including ischemic heart diseases and cerebrovascular diseases, are the leading causes of morbidity and mortality worldwide. ...Overwhelming evidence demonstrates that these oxidized lipids are actively involved in the inflammatory responses
Cardiovascular diseases (CVD), including ischemic heart diseases and cerebrovascular diseases, are the leading causes of morbidity an
Vascular Macrophages in Atherosclerosis.
Xu H, Jiang J, Chen W, Li W, Chen Z. Xu H, et al. J Immunol Res. 2019 Dec 1;2019:4354786. doi: 10.1155/2019/4354786. eCollection 2019. J Immunol Res. 2019. PMID: 31886303 Free PMC article. Review.
Atherosclerosis is the main pathological basis for the occurrence of most cardiovascular diseases, the leading global health threat, and a great burden for society. ...This article reviews the functions of macrophages in different stages of atherosclerosis, a …
Atherosclerosis is the main pathological basis for the occurrence of most cardiovascular diseases, the leading global health t …
Cells of the adult human heart.
Litviňuková M, Talavera-López C, Maatz H, Reichart D, Worth CL, Lindberg EL, Kanda M, Polanski K, Heinig M, Lee M, Nadelmann ER, Roberts K, Tuck L, Fasouli ES, DeLaughter DM, McDonough B, Wakimoto H, Gorham JM, Samari S, Mahbubani KT, Saeb-Parsy K, Patone G, Boyle JJ, Zhang H, Zhang H, Viveiros A, Oudit GY, Bayraktar OA, Seidman JG, Seidman CE, Noseda M, Hubner N, Teichmann SA. Litviňuková M, et al. Nature. 2020 Dec;588(7838):466-472. doi: 10.1038/s41586-020-2797-4. Epub 2020 Sep 24. Nature. 2020. PMID: 32971526 Free PMC article.
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. ...Furthermore, analyses of cell-to-cell interactio
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies
The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature.
Qin Z. Qin Z. Atherosclerosis. 2012 Mar;221(1):2-11. doi: 10.1016/j.atherosclerosis.2011.09.003. Epub 2011 Sep 9. Atherosclerosis. 2012. PMID: 21978918 Review.
Since their establishment thirty years ago, THP-1 cells have become one of most widely used cell lines to investigate the function and regulation of monocytes and macrophages in the cardiovascular system. However, because this cell line was derived from the b …
Since their establishment thirty years ago, THP-1 cells have become one of most widely used cell lines to investigate the function and regul …
Cross-talk between macrophages and atrial myocytes in atrial fibrillation.
Sun Z, Zhou D, Xie X, Wang S, Wang Z, Zhao W, Xu H, Zheng L. Sun Z, et al. Basic Res Cardiol. 2016 Nov;111(6):63. doi: 10.1007/s00395-016-0584-z. Epub 2016 Sep 22. Basic Res Cardiol. 2016. PMID: 27660282 Free PMC article.
However, the phenotype and functions of the macrophages in AF remain unclear. We investigated the macrophage-atrial myocyte interaction in AF patients and found that the increased macrophages were mainly pro-inflammatory macrophages (iNOS(+), Arg1(-)). …
However, the phenotype and functions of the macrophages in AF remain unclear. We investigated the macrophage-atrial myocyte in …
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove ML, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV. Guo L, et al. J Clin Invest. 2018 Mar 1;128(3):1106-1124. doi: 10.1172/JCI93025. Epub 2018 Feb 19. J Clin Invest. 2018. PMID: 29457790 Free PMC article.
Here, we reveal an unexpected but important pathogenic role for these macrophages in atherosclerosis. Using human atherosclerotic samples, cultured cells, and a mouse model of advanced atherosclerosis, we investigated the role of intraplaque hemorrhage on macrophage
Here, we reveal an unexpected but important pathogenic role for these macrophages in atherosclerosis. Using human atherosclerotic sam …
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